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Serum squamous cell carcinoma antigen is a predictive factor of outcomes in patients with locally advanced unresectable esophageal squamous cell carcinoma treated by definitive chemoradiotherapy

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 81-90页

作者： Takeshi Suzuki Akihiko Okamura Masayuki Watanabe Takao Asari Izuma Nakayama Mariko Ogura Akira Ooki daisuke takahari Kensei Yamaguchi Keisho Chin Department of Gastroenterological Medicine Cancer Institute Hospital of the Japanese Foundation for Cancer ResearchKoto-kuTokyo 135-8550Japan Department of Gastroenterological Surgery Cancer Institute Hospital of the Japanese Foundation for Cancer ResearchKoto-kuTokyo 135-8550Japan Department of Radiation Oncology Cancer Institute Hospital of the Japanese Foundation for Cancer ResearchKoto-kuTokyo 135-8550Japan

Aim:Definitive chemoradiotherapy(dCRT)is the standard treatment for locally advanced unresectable esophageal squamous cell carcinoma(LU-ESCC).This study aimed to describe the results of dCRT for T4 ESCC and evaluate the pretherapeutic predictive factors of the ***:A total of 133 patients with T4 ESCC who received dCRT were grouped into those who achieved a complete response(CR)or those who had residual disease(RD).The clinicopathologic variables were compared between the groups and the overall survival(OS)was *** predictive factor of RD was assessed and the prognostic factor for OS was ***:Among the 133 patients,31(23%)achieved *** CR group had a significantly better OS than the RD group(89.9 months vs.10.7 months;hazard ratio=0.096;95%confidence interval:0.05-0.19;P1.6 ng/mL)(OR=2.86;P=0.018),and metastatic node invasion(OR=3.19;P=0.048)were independent predictors of *** increased level of pretherapeutic serum squamous cell carcinoma antigen(>1.6 ng/mL)(OR=1.61;P=0.022)was an independent predictor of poor ***:Among the patients who underwent dCRT for LU-ESCC,23%achieved CR,and the long-term outcome of these patients was *** levels of pretherapeutic serum squamous cell carcinoma antigen were also found to be predictive of treatment failure.

关键词： Esophageal cancer chemoradiotherapy esophageal squamous cell carcinoma predictive factor

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