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Open Journal of Nursing 2021年第7期11卷 566-577页

作者： daisuke sato Faculty of Health Sciences Komatsu University Ishikawa Japan

Objective: The aim of the study is to evaluate the long-term changes in fatigue of cancer patients receiving outpatient chemotherapy after a disaster such as the Great Earthquake. Methods: From 2012 to 2014, we measured subjective fatigue, autonomic function, and physical activity with reference to the criteria for chronic fatigue syndrome. Results: The participants were 13, 9 males (69.2%) and 4 females (30.8%). The most common cancer among the participants was lung cancer 4 patients (30.8%). In 2012, eight patients (61.6%) received anti-cancer drugs and three (23.0%) received the drug by intravenous drip and oral administration. Physical fatigue (p = 0.004), mental fatigue (p = 0.002), comprehensive fatigue (p = 0.012), and comprehensive evaluations (p = 0.032) were significantly different. Significant differences in the autonomic nervous function were observed during the three years from 2012 to 2014 (log LF [p = 0.017], log HF [p = 0.023] and log LF/HF [p = 0.039]). Similar to Subjective fatigue, Significant differences in physical activity were observed during the three years from 2012 to 2014 (DA [p = 0.042], TST [p = 0.037], SE [p = 0.018], AW [p = 0.023] and Naps [p = 0.014]). Conclusions: The participants fatigue worsened at one time, but showed improvement over time. In the event of an emergency such as a disaster, it is necessary to evaluate the physical and mental condition based on objective indicators of cancer patients receiving anti-cancer drug treatment and provide nursing support.

关键词： Cancer Survivors Outpatient Chemotherapy Fatigue The Great East Japan Earthquak

Effects of docosahexaenoic acid or arachidonic acid supplementation on the behavior of cardiomyocytes derived from human pluripotent stem cells

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BIOCELL 2023年第5期47卷 1095-1106页

作者： MIZUNA YANO KOTA HIROI TETSUYA YUASA KENJI INOUE OSAMU YAMAMOTO TAKAO NAKAMURA daisuke sato ZHONGGANG FENG Graduate School of Science and Engineering Yamagata UniversityYonezawa9928510Japan Faculty of Health Sciences Japan Healthcare UniversitySapporo0620053Japan

Background:Human heart changes its energetic substrates from lactate and glucose to fatty acids during the neonatal *** the lack of fatty acids in media for the culture of cardiomyocytes derived from human pluripotent stem cells(hiPS-CM),researchers have supplemented mixtures of fatty acids to hiPS-CM and reported the enhancement in the maturation of *** our previous studies,we separately supplemented two polyunsaturated fatty acids(PUFAs),docosahexaenoic acid(DHA)or arachidonic acid(AA),to rat fetal cardiomyocytes and found that the supplementations upregulated the expressions of mRNAs for cardiomyocyte differentiation,fatty acid metabolism,and cellular *** enhancement in cellular contractility was attributed to the improvement in intercellular connection rather than a direct enhancement of the contractile ***:This study reports the successive results of the effects of DHA or AA supplementation on *** addition to the contractile force and mRNA measurements used in the previous study,we further investigated the effect of different cellular aggregations on the contractile force output by means of finite element analysis,measured glucose and fatty acids metabolites,and assessed cTNT and MLC2v expressions through immunofluorecsence ***:It showed that the sole supplementation of albumin-conjugated DHA or AA can be taken up by hiPS-CM without other uptake-enhancing factors,and the supplementations may activate the CD36_ERRγmetabolic *** or AA supplementation increased the cellular contractile ratio on collagen gels and AA supplementation stimulated hiPS-CM aggregation to form cellular *** enhancement effect on the hiPS-CM contractile force was modest since the increase in contractile force was not *** supplementation was more effective than DHA supplementation because it significantly upregulated mRNA expressions of P300 and ***,finite element analysis showed that the formati

关键词： Human iPS cells Cardiomyocytes Polyunsaturated fatty acid mRNA expression Contractility Fatty acid metabolism

Effectiveness of a Telenursing System to Prevent the Exacerbation of Symptoms in Patients with Cancer Undergoing Outpatient Chemotherapy

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Open Journal of Nursing 2021年第6期11卷 466-476页

作者： daisuke sato Makoto Shimoyama Faculty of Health Sciences Komatsu University Ishikawa Japan Faculty of Nursing Miyagi University Miyagi Japan

During outpatient chemotherapy, adverse events occurring at home must be carefully monitored. We have developed a tele-nursing system that can store physical information such as blood pressure and pulse measured by cancer patients in the cloud by using Bluetooth, which is wireless communication technology, and collect information from remote locations. The tele-nursing system name is T-SCOT. The purpose of this study is to conduct a randomized controlled trial to investigate the efficacy of T-SCOT intervention. Participants are those who receive T-SCOT intervention plus Care as usual as the intervention group, and those who receive only Care as usual as the control group. T-SCOT includes the following five steps: 1) Answer questions related to side effects of chemotherapy [10 items];2) Measure blood pressure, pulse, body temperature, and SPO2. The measured data is automatically saved in the cloud via Bluetooth;3) Watch a video of coping behavior for side effects;4) The data entered by the patient is visualized as a line graph;5) Utilize the videophone function with researchers if you have any problems or troubles. Utilization of ICT in telenursing makes it possible to visualize patient’s physical information and contributes to the reduction of medical expenses.

关键词： Telenursing Outpatient Chemotherapy Symptoms Complications Prevention

Effectiveness of a Telenursing System on Side Effects of Chemotherapy by a Crossover Trial

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Open Journal of Nursing 2022年第12期12卷 817-830页

作者： daisuke sato Makoto Shimoyama Faculty of Medical Sciences Division of Nursing University of Fukui Fukui Japan School of Nursing Miyagi University Miyagi Japan

Background: This crossover trial aimed to examine the efficacy of the Tele-nursing Symptom Management System for Chemotherapy in Outpatient Treatment (T-SCOT) in reducing the side effects in patients undergoing out-patient chemotherapy. Methods: Using a tablet computer, participants were asked to provide information on various items, including fever, nausea, hair loss, fatigue, and vital signs. Both the participants and researchers automati-cally monitored time-dependent changes in symptoms, and the researchers proposed concrete measures to reduce patients’ complications. The primary endpoint was the M. D. Anderson Symptom Inventory (MDASI-J) score. The secondary endpoint, Quality of Life (QOL) was evaluated using the Quality of Life Questionnaire for Cancer Patients Treated with Anticancer Drugs (QOL- ACD). Results: This study included 20 patients who met all the inclusion cri-teria, 14 of whom agreed to participate in the study. There was no significant difference between the MDASI-J and QOL-ACD pre- and post-comparison of the primary and secondary evaluations in the intervention group. The control group had significantly higher scores 3 months after the intervention for symptom intensity (p = 0.04) and symptom-induced disruption to life (p = 0.03), and the symptoms worsened. The QOL-ACD had significantly lower scores for activity (p = 0.03), overall QOL (p = 0.04), and total QOL score (p = 0.02), resulting in a lower quality of life. Conclusions: Participants used the Internet to obtain information on treatments and side effects and changed their behavior in daily life. It is speculated that the Information and Commu-nications Technology (ICT) literacy in older adults has improved, and they are benefiting from digital utilization.

关键词： Telenursing Outpatient Chemotherapy Symptoms Complications Prevention

Effects of docosahexaenoic acid or arachidonic acid supplementation on gene expression and contractile force of rat cardiomyocytes in primary culture

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BIOCELL 2021年第5期45卷 1213-1229页

作者： MIZUNA YANO YUTA UMEHARA TOMOKAZU KUDO TAKAO NAKAMURA TADASHI KOSAWADA ATSUYOSHI NISHINA MASAKI SAZUKA daisuke sato ZHONGGANG FENG Graduate School of Science and Engineering Yamagata UniversityYonezawa9928510Japan Graduate School of Medical Science Yamagata UniversityYamagata9909585Japan Department of Materials and Applied Chemistry College of Science and TechnologyNihon UniversityTokyo1018308Japan Department of Health and Nutrition Yamagata Prefectural Yonezawa University of Nutrition SciencesYonezawa9920025Japan

While fatty acids play essential roles in the physiology of the myocardium,conventional culture media contain little *** previously revealed that rat neonatal myocardium mainly contains docosahexaenoic(DHA),linoleic(LA),and arachidonic(AA)acids as polyunsaturated fatty acids(PUFAs),and these contents in cultured cardiomyocytes derived from fetal rats were markedly lower than those in the neonatal *** this study,we first assessed the effects of supplementation of DHA,LA,or AA on the fatty acid contents and the percentage change of contractile area in primarily cultured rat *** on this assessment,we then evaluated the effects of DHA or AA supplementation on mRNA expression and further directly measured the contractile force of cardiomyocytes with the *** study revealed that percentage change of contractile area was maximized under 20μM DHA or 50μM AA supplementation while LA supplementation did not affect this contraction index,and that a widespread upregulation tendency of the mRNA expression related to differentiation,maturity,fatty acid metabolism,and cell adhesion was seen in the cultured cardiomyocytes with supplementation of DHA or *** particular,upregulation of the gene expression of cellular adhesion molecules connexin43 and N-cadherin were remarkable,whereas the effects on differentiation and maturation were less ***,the increase of the percentage change of the contractile area of cardiomyocyte clusters in culture dishes with the supplementations was significant,whereas the enhancement of the contractile force was *** results suggest that supplementation of DHA or AA to the fetal cardiomyocyte culture may play effective roles in preventing the de-differentiation of the cardiomyocytes in culture and that the enhancement of the contractile performance may be mainly attributed to the improvement of intercellular connection.

关键词： Cardiomyocyte culture Polyunsaturated fatty acid mRNA expression Contractile force Intercellular connection

Lipoprotein lipase and obesity

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Health 2012年第12期4卷 1405-1412页

作者： Masataka Kusunoki Kazuhiko Tsutsumi daisuke sato Takao Nakamura Department of Biomedical Information Engineering Graduate School of Medical Science Yamagata University Yamagata Japan Department of Internal Medicine Medical Clinic Aichi Medical University Nagoya Japan Okinaka Memorial Institute for Medical Research Tokyo Japan

Obesity is one of the fast-growing major diseases in developed and developing countries. As has been persuasively argued, long-term imbalance between intake and expenditure of fat is a central factor in the etiology of obesity. Obesity aggravates insulin resistance and promotes cardiovascular diseases and atherosclerosis. We hypothesized that elevating lipoprOtein lipase (LPL) activity in skeletal muscle would cause an improvement of obesity. To test this hypothesis, we studied the effects of the LPL activator NO-1886 inobese animals. NO-1886 elevated LPL activity in skeletal muscle, and improved obesity as well as insulin resistance in obese rats. Furthermore, NO-1886 mitigated body weight gain induced by pioglitazone without suppressive effect on the adiponectin-increasing action of pioglitazone. LPL activators hold a lot of promise of curing several diseases shown above in clinical scene.

关键词： Lipoprotein Lipase Lipoprotein Lipase Activator Insulin Resistance Lipid Metabolism

Effects of Fasting on Plasma Lipoprotein(a) in Cynomolgus Monkeys: Preliminary Experiments Results

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Open Journal of Animal Sciences 2014年第5期4卷 222-227页

作者： Masataka Kusunoki Kazuhiko Tsutsumi daisuke sato Tetsuro Miyata Takao Nakamura Department of Internal Medicine Medical Clinic Aichi Medical University Nagoya Japan Okinaka Memorial Institute for Medical Research Tokyo Japan Department of Biomedical Information Engineering Graduate School of Medical Science Yamagata University Yamagata Japan Vascular Center Sanno Medical Center Tokyo Japan

Plasma lipoprotein(a) (Lp(a)) is known to be a strong independent risk factor for ischemic heart disease. However, it is not easily modulated by drugs that are presently available. Lp(a) is not present in many experimental animals except for Old World monkeys. In this study, we examined whether cynomolgus monkeys are useful model for research of human plasma Lp(a), and observed that plasma Lp(a) in cynomolgus monkeys varied as much as humans. As a result of 4 day-fasting in cynomolgus monkeys, the plasma Lp(a) level decreased in a monkey with originally high Lp(a) level. The Lp(a) level continued to decrease even 3 days after banana feeding, but returned to the original level 3 days after monkey chow feeding. On the other hand, in a monkey with low Lp(a) level, fasting had no effect on the Lp(a) level. However, in the third monkey having originally high Lp(a) level, the Lp(a) was not affected by decreasing the amount of monkey chow feeding by 50%. In summary, we found that cynomolgus monkeys may be an useful model for studying the effects of food on plasma Lp(a) in place of humans, and that high Lp(a) level may be controllable by strict diet regulation.

关键词： Lipoprotein(a) Fasting Cynomolgus Monkey Banana

Measuring luminal esophageal temperature during pulmonary vein isolation of atrial fibrillation

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World Journal of Cardiology 2012年第5期4卷 188-194页

作者： daisuke sato Kunihiro Teramoto Hiroki Kitajima Naoto Nishina Yoshitomi Kida Hiroki Mani Masahiro Esato Yeong-Hwa Chun Toshiji Iwasaka Arrhythmia Care Center Takeda HospitalKyoto 600-8558Japan Second Department of Internal Medicine Kansai Medical UniversityMoriguchi 570-8506Japan

AIM:To investigate the luminal esophageal temperature(LET) at the time of delivery of energy for pulmonary vein isolation(PVI).METHODS:This study included a total of 110 patients with atrial fibrillation who underwent their first PVI procedure in our laboratory between March 2010 and February *** LET was monitored in all *** measured the number of times that LET reached the cut-off temperature,the time when LET reached the cut-off temperature,the maximum temperature(T max) of the LET,and the time to return to the original preenergy delivery temperature once the delivery of energy was ***:Seventy-eight patients reached the cut-off *** took 6 s at the shortest time for the LET to reach the cut-off temperature,and 216.5 ± 102.9 s for the temperature to return to the level before the de-livery of *** patients experienced a transient drop in the LET(TDLET) just before energy *** at these sites always produced a rise to the LET cut-off *** was not observed at sites where the LET did not ***,the TDLET before the energy delivery was useful to distinguish a high risk of esophageal injury before delivery of ***:Sites with a TDLET before energy delivery should be ablated with great caution or,perhaps,not at all.

关键词： Radiofrequency catheter ablation Atrioesophageal fistula Esophageal injury Real time luminal esophageal temperature monitoring Open irrigation

Role of PV-Powered Vehicles in Low-Carbon Society and Some Approaches of High-Efficiency Solar Cell Modules for Cars

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Energy and Power Engineering 2020年第6期12卷 375-395页

作者： Masafumi Yamaguchi Taizo Masuda Kenji Araki daisuke sato Kan-Hua Lee Nobuaki Kojima Tatsuya Takamoto Kenichi Okumura Akinori satou Kazumi Yamada Takashi Nakado Yusuke Zushi Mitsuhiro Yamazaki Hiroyuki Yamada Toyota Technological Institute Nagoya Japan Toyota Motor Corporation Susono Japan Sharp Corporation Nara Japan Toyota Motor Corporation Toyota Japan Nissan Motor Corporation Yokosuka Japan New Energy and Industrial Technology Development Organization Kawasaki Japan

Development of highly-efficient photovoltaic (PV) modules and expanding its application fields are significant for the further development of PV technologies and realization of innovative green energy infrastructure based on PV. Especially, development of solar-powered vehicles as a new application is highly desired and very important for this end. This paper presents the impact of PV cell/module conversion efficiency on reduction in CO2 emission and increase in driving range of the electric based vehicles. Our studies show that the utilization of a highly-efficient (higher than 30%) PV module enables the solar-powered vehicle to drive 30 km/day without charging in the case of light weight cars with electric mileage of 17 km/kWh under solar irradiat

Application of the Solvothermal Process in the Synthesis of High-performance Ag/γ-Al_2O_3 Catalysts

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过程工程学报 2006年第4期6卷 633-638页

作者：唐清李锐星殷澍 Shingo Goto daisuke Nagai Tsugio sato Institute of Process Engineering Chinese Academy of Sciences Institute of Multidisciplinary Research for Advanced Materials Tohoku UniversitySendai 980-8577Japan

Ag/γ-Al2O3 is a kind of promising catalyst with the relatively lower cost compared with those using noble metals,good resistance against catalytic poisoning and excellent behaviour for NOx *** the present study,Ag/γ-Al2O3 catalysts were synthesized by the solvothermal process and characterized by XRD,TG?DTA,TEM,UV?Vis and FT?*** was found that high-performance Ag/γ-Al2O3 catalysts could be synthesized by properly selecting starting materials,controlling the composition of solvent and other reaction *** microstructure evolution of the catalysts was also discussed.

关键词： Ag/γ-Al2O3 solvothermal process catalyst microstructure