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Field survey on enersy consumption due to hot water supply and cookin8 in Nanjin8 and Hefei, China

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Frontiers of Architectural Research 2013年第2期2卷 134-146页

作者： Shuichi Hokoi daisuke ogura Xiuzhang Fu Yong Rao Department of Architecture and Architectural Engineering Kyoto University Kyoto 606-8501 Japan School of Architecture Southeast University Nanjing 210096 China College of Architecture & Art Hefei University of Technology Hefei 230009 China

Afield survey on energy consumption by hot water supply and cooking was conducted in two cities in China, Nanjing, and Hefei. In each city, 5 housing complexes were selected, and approximately 100 or 200 residential units were selected from each of them. The fol（owing items were surveyed：（1） fundamental information, such as number of fami[y members, data on residents, etc., （2） bathing style, and （3） frequency of cooking and cooking time. Most of the residents take showers seven times a week in the summer, but tess frequently in the winter. In contrast, the frequency of taking baths increases to several times a week during the winter, compared with 0 or 1 times a week in the summer. These results differ slightly depending on the heating and cooling systems used in the houses. The frequency with which people cook in their own houses ranges from 4 to 7 times a week, which means that ＂eating out＂ is relatively frequent, although the result differs significantly among the housing complexes. Distribution of the cooking time has usuat[y two peaks at 20 to 30 min and 50 to 60 min （or 30 to 40 min and longer than 60 min） for lunch and dinner, respectively. The high energy consumption for cooking might be due to the tong cooking time.

关键词： Energy consumptionHot water supp(y Cooking Fie[d survey Chinese city

Study on conservation of mural paintings in Tumulus： Numerical analysis of heat behaviors of stone chamber after excavation

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Frontiers of Architectural Research 2012年第4期1卷 375-379页

作者： Yonghui Li daisuke ogura Shuichi Hokoi Takeshi Ishizaki School of Architecture Key Laboratory of Architectural and Urban Heritage Conservation Southeast University Nanjing 210096 China Graduate School of Engineering Kyoto University Kyoto 606-8501 Japan Department of Research Support and Promotion National Research Institute for Cultural Properties Tokyo 110-8713 Japan

In 1972 mural paintings of Takamatsuzuka tumulus were discovered and have been conserved on site for 35 years, but fungi growth on the mural paintings was not suppressed. In 2007 the stone chamber was dismantled and removed to the facility for conservation and restoration. The purposes of our study are to clarify the main cause of the deterioration and to propose a suitable method to prevent the deterioration for preserving them on site. In this paper, we developed the two-dimensional analysis model by considering the actual change of the surrounding mound because of the excavation in 1972, and perform the analysis of heat behavior of Takamatsuzuka tumulus before and after excavation and compare effects of different sun-shading methods on heat behavior of the stone chamber. The main results are as follows：（1） after the excavation, the inside surface temperature distribution of the stone chamber and the amplitude of indoor temperature become larger. （2） Using the sun-shading panel in the area of excavation is an effective method to reduce the average indoor temperature; however, it has no influence on reducing the temperature distribution of the stone chamber and the temperature difference between the inside wall and indoor.

关键词： Effect Excavation Heat transfer Sun-shading Conservation

Improvement of thermal environment and reduction of energy consumption for coolin8 and heating by retrofitting windows

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Frontiers of Architectural Research 2013年第1期2卷 1-10页

作者： Mochidome Takashi Hokoi Shuichi ogura daisuke Takamura Masahiko Suzuki Jun Kyoto University Kyoto 606-8501 Japan VEC Japan LIXIL Japan

Various techniques for creating a comfortable thermal environment and saving energy have been proposed and employed in residential buildings in many countries, including Japan. For these techniques to be introduced, existing houses should be renovated. Among the techniques available, installation of additional inner windows is effective in creating a comfortable and energy-efficient living environment. In the present research, the effect of additional inner windows on the thermal environment and energy saving was investigated by measuring indoor climates. Windows were renovated in two rooms on the fourth floor of a four-story reinforced concrete building. Air temperatures, the humidity, the global solar radiation on horizontal and vertical surfaces, radiant temperatures, and the electricity consumption of air-conditioners were measured. A comparison of these vatues before and after the installation of inner- windows showed that the thermal environment and energy saving had improved. Results obtained from a thermal model agreed well with measured results by changing the value of solar transmittance and heat transmission coefficient of the glazing forlowing renovation. Furthermore, in a questionnaire survey conducted in summer, more than half of the occupants answered ＂cornfortabte＂ to a question on the overall thermal comfort.

关键词： Double-skin windows Retrofitting windows Thermat environ-ment Energy saving

Inverse relationship between platelet Akt activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhiko Tokuda Takamitsu Hori daisuke Mizutani Tomoyuki Hioki Kumi Kojima Takashi Onuma Yukiko Enomoto Tomoaki Doi Rie Matsushima-Nishiwaki Shinji ogura Hiroki Iida Toru Iwama Takashi Sakurai Osamu Kozawa Department of Metabolic Research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACKGROUND Akt plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(T2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without *** To investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in T2DM *** Platelet-rich plasma(PRP)was prepared from the venous blood of patients with T2DM or age-matched *** pellet lysate of the centrifuged PRP was subjected to western blotting to analyse the phosphorylation of Akt,p38 mitogen-activated protein(MAP)kinase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** The levels of phosphorylated Akt corrected with phosphorylated p38 MAP kinase were inversely correlated with the Z-scores in the T2DM subjects,whereas the levels of phosphorylated Akt corrected with GAPDH were ***,this relationship was not observed in the control *** These results suggest that an inverse relationship may exist between platelet Akt activation and hippocampal atrophy in T2DM *** findings provide insight into the molecular mechanisms underlying T2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

Overexpression of c-met in the early stage of pancreatic carcinogenesis; altered expression is not sufficient for progression from chronic pancreatitis to pancreatic cancer

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World Journal of Gastroenterology 2006年第24期12卷 3878-3882页

作者： Kenoki Ohuchida Kazuhiro Mizumoto Nami Ishikawa Yasuhiro ogura daisuke Yamada Takuya Egami Hayato Fujita Seiji Ohashi Eishi Nagai Masao Tanaka Department of Surgery and Oncology Graduate School of Medical Sciences Kyushu UniversityFukuokaJapan

AIM： To investigate c-met expression during early pancreatic carcinogenesis. METHODS： We used 46 bulk tissues and 36 microdissected samples, including normal pancreas, chronic pancreatitis, and pancreatic cancer, for quantitative realtime reverse transcription-polymerase chain reaction. RESULTS： In bulk tissue analyses, pancreatic cancer tissues expressed significantly higher levels of c-met than did chronic pancreatitis and normal pancreas tissues. c-met levels did not differ between chronic pancreatitis and normal pancreas tissues. In microdissection-based analyses, c-met was expressed at higher levels in microclissected pancreatic cancer cells and pancreatitisaffected epithelial cells than in normal ductal epithelial cells （both, P 〈 0.01）. Interestingly, pancreatitis-affected epithelial cells expressed levels of c-met similar to those of pancreatic cancer cells. CONCLUSION： Overexpression of c-met occurs during the early stage of pancreatic carcinogenesis, and a single alteration of c-met expression is not sufficient for progression of chronic pancreatitis-affected epithelial cells to pancreatic cancer cells.

关键词： c-met', Pancreatic cancer Chronic pancreatitis Pancreatic carcinogenesis

Serum squamous cell carcinoma antigen is a predictive factor of outcomes in patients with locally advanced unresectable esophageal squamous cell carcinoma treated by definitive chemoradiotherapy

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 81-90页

作者： Takeshi Suzuki Akihiko Okamura Masayuki Watanabe Takao Asari Izuma Nakayama Mariko ogura Akira Ooki daisuke Takahari Kensei Yamaguchi Keisho Chin Department of Gastroenterological Medicine Cancer Institute Hospital of the Japanese Foundation for Cancer ResearchKoto-kuTokyo 135-8550Japan Department of Gastroenterological Surgery Cancer Institute Hospital of the Japanese Foundation for Cancer ResearchKoto-kuTokyo 135-8550Japan Department of Radiation Oncology Cancer Institute Hospital of the Japanese Foundation for Cancer ResearchKoto-kuTokyo 135-8550Japan

Aim:Definitive chemoradiotherapy(dCRT)is the standard treatment for locally advanced unresectable esophageal squamous cell carcinoma(LU-ESCC).This study aimed to describe the results of dCRT for T4 ESCC and evaluate the pretherapeutic predictive factors of the ***:A total of 133 patients with T4 ESCC who received dCRT were grouped into those who achieved a complete response(CR)or those who had residual disease(RD).The clinicopathologic variables were compared between the groups and the overall survival(OS)was *** predictive factor of RD was assessed and the prognostic factor for OS was ***:Among the 133 patients,31(23%)achieved *** CR group had a significantly better OS than the RD group(89.9 months vs.10.7 months;hazard ratio=0.096;95%confidence interval:0.05-0.19;P1.6 ng/mL)(OR=2.86;P=0.018),and metastatic node invasion(OR=3.19;P=0.048)were independent predictors of *** increased level of pretherapeutic serum squamous cell carcinoma antigen(>1.6 ng/mL)(OR=1.61;P=0.022)was an independent predictor of poor ***:Among the patients who underwent dCRT for LU-ESCC,23%achieved CR,and the long-term outcome of these patients was *** levels of pretherapeutic serum squamous cell carcinoma antigen were also found to be predictive of treatment failure.

关键词： Esophageal cancer chemoradiotherapy esophageal squamous cell carcinoma predictive factor

Lymphoepithelioma-like esophageal carcinoma with macroscopic reduction

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World Journal of Gastrointestinal Endoscopy 2014年第8期6卷 385-389页

作者： Masaya Uesato Tuguaki Kono Tooru Shiratori Yasunori Akutsu Isamu Hoshino Kentarou Murakami daisuke Horibe Tetsurou Maruyama Yoshihide Semba Ryuma Urahama Yukiko ogura Takashi Oide Toru Tanizawa Hisahiro Matsubara Department of Frontier Surgery Chiba University Graduate School of Medicine Department of Diagnostic Pathology Chiba University Graduate School of Medicine

Esophageal lymphoepithelioma-like carcinoma(LELC) is extremely rare. We report the first case of esopha-geal LELC showing macroscopic reduction. A 67-year-old male presented with dysphagia and, by endoscopic examination, was found to have a significantly raised tumor of 10 mm in diameter in the thoracic esophagus. The biopsied material showed esophageal cancer. We performed endoscopic submucosal dissection. However, the tumor became flattened, similar to a scar, in only 2 mo. Histologically, the carcinoma cells had infiltrated the submucosal layer. Prominent infiltration of T lymphoid cells that stained positive for CD8 was observed aroundthe carcinoma cells. Therefore, this lesion was consid-ered to be an LELC with poorly differentiated squamous cells. Because the margin was positive, an esophagec-tomy was performed. Carcinoma cells were detected in the neck in one lymph node. The staging was T1N0M1 b. However, the patient has been well, without adjuvant therapy or recurrence, for more than 5 years.

关键词： Esophageal cancer Lymphoepithelioma-like carcinoma Lymphoid stroma Tumor-infiltrating lym-phocyte Cytotoxic T lymphocyte Reduction