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Microstructures and mechanical properties of as-cast Mg-Sm-Zn-Zr alloys with varying Gd contents

Journal of Magnesium and Alloys 2022年第5期10卷 1220-1234页

作者： Kai Guan daisuke Egusa Eiji Abe Jinghuai Zhang Xin Qiu Qiang Yang Jian Meng Department of Materials Science&Engineering The University of TokyoTokyo 113-8656Japan Key Laboratory of Superlight Material and Surface Technology Ministry of EducationCollege of Material Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001PR China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022PR China Research Center for Structural Materials National Institute for Materials ScienceTsukuba 305-0047Japan

The effect of Gd content on the microstructure and tensile properties of as-cast Mg-Sm-Zn-Zr alloy has been systematically *** the Mg-3Sm-0.5Zn-0.5Zr alloy, the intermetallic compounds with multiple morphologies are identified as Mg_(3)Sm phase. In addition to Mg_(3)RE phase, Mg_(5)RE phase originated from Gd addition is observed in Gd-modified alloys. It should be noted that the lattice parameters of all the observed intermetallic compounds are significantly reduced by Zn segregation. The segregation behavior of Zn in Mg_(3)Sm phase is inhibited to some extent by Gd addition due to the electronegativity difference between Sm/Gd and Zn elements. In addition, the increased Gd content effectively leads to much more accumulation of solute atoms in front of the liquid-solid interface during solidification, which can prominently promote nucleation in liquid region and then refine grains. The tensile yield stress of the present alloys is thus improved with increasing Gd addition. Finally, Gd-modified alloys exhibit significantly age-hardening effect, which can be mainly attributed to the high-volume fraction and high density nano-scale precipitates.

关键词： Magnesium alloys Microstructure characterization Mechanical properties Transmission electron microscopy(TEM)

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Field survey on enersy consumption due to hot water supply and cookin8 in Nanjin8 and Hefei, China

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Frontiers of Architectural Research 2013年第2期2卷 134-146页

作者： Shuichi Hokoi daisuke Ogura Xiuzhang Fu Yong Rao Department of Architecture and Architectural Engineering Kyoto University Kyoto 606-8501 Japan School of Architecture Southeast University Nanjing 210096 China College of Architecture & Art Hefei University of Technology Hefei 230009 China

Afield survey on energy consumption by hot water supply and cooking was conducted in two cities in China, Nanjing, and Hefei. In each city, 5 housing complexes were selected, and approximately 100 or 200 residential units were selected from each of them. The fol（owing items were surveyed：（1） fundamental information, such as number of fami[y members, data on residents, etc., （2） bathing style, and （3） frequency of cooking and cooking time. Most of the residents take showers seven times a week in the summer, but tess frequently in the winter. In contrast, the frequency of taking baths increases to several times a week during the winter, compared with 0 or 1 times a week in the summer. These results differ slightly depending on the heating and cooling systems used in the houses. The frequency with which people cook in their own houses ranges from 4 to 7 times a week, which means that ＂eating out＂ is relatively frequent, although the result differs significantly among the housing complexes. Distribution of the cooking time has usuat[y two peaks at 20 to 30 min and 50 to 60 min （or 30 to 40 min and longer than 60 min） for lunch and dinner, respectively. The high energy consumption for cooking might be due to the tong cooking time.

关键词： Energy consumptionHot water supp(y Cooking Fie[d survey Chinese city

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Immune regulation by protein ubiquitination: roles of the E3 ligases VHL and Itch

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Protein & Cell 2019年第6期10卷 395-404页

作者： daisuke Aki Qian Li Hui Li Yun-Cai Liu Jee Ho Lee Institute for Immunology Tsinghua-Peking Center for Life Sciences School of Medicine Tsinghua University Beijing 100084 China La Jolla Institute for Allergy and Immunology La Jolla CA 92037 USA

Protein ubiquitination is an important means of posttranslational modification which plays an essential role in the regulation of various aspects of leukocyte development and function. The specificity of ubiquitin tagging to a protein substrate is determined by E3 ubiquitin ligases via defined E3-substrate interactions. In this review, we will focus on two E3 ligases, VHL and Itch, to discuss the latest progress in understanding their roles in the differentiation and function of CD4+ T helper cell subsets, the stability of regulatory T cells, effector function of CD8+ T cells, as well as the development and maturation of innate lymphoid cells. The biological implications of these E3 ubiquitin ligases will be highlighted in the context of normal and dysregulated immune responses including the control of homeostasis, inflammation, auto-immune responses and anti-tumor immunity. Further elucidation of the ubiquitin system in immune cells will help in the design of new therapeutic interventions for human immunological diseases and cancer.

关键词： ubiquitin E3ligase VHL HIF Itch WWP2 Cbl-b inflammation autoimmunity

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Rikkunshito increases peripheral incretin-hormone levels in humans and rats

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World Journal of Methodology 2024年第1期14卷 102-113页

作者： Hiroshi Kono Shinji Furuya Hidenori Akaike Katsutoshi Shoda Yoshihiko Kawaguchi Hidetake Amemiya Hiromichi Kawaida daisuke Ichikawa The First Department of Surgery University of YamanashiChuoYamanashi 409-3898Japan

BACKGROUND It was reported that rikkunshito(TJ-43)improved the cisplatin-induced decreases in the active form of ghrelin in plasma;however,other effects on gastrointestinal hormones have not been *** To investigate the effects of TJ-43 on peripheral levels of incretin hormones,including gastric inhibitory polypeptide(GIP)and glucagon-like polypeptide-1(GLP-1),in humans and *** Patients were divided into two groups,namely patients who received TJ-43 immediately following surgery[TJ-43(+)group]and those who received TJ-43 on postoperative day 21[TJ-43(-)group],and the plasma levels of active GIP and active GLP-1 were *** animal experiments,rats were treated with TJ-43[rat(r)TJ-43(+)group]or without[rTJ-43(−)group]by gavage for 4 wk,and the plasma active GIP and active GLP-1 levels were *** expression of incretin hormones in the gastrointestinal tract and insulin in the pancreas were investigated by ***,the cyclic adenosine monophosphate activities were assessed in pancreatic tissues from rats treated with or without TJ-43 in vivo,and the blood glucose levels and plasma insulin levels were measured in rats treated with or without TJ-43 in oral glucose tolerance *** In humans,the active incretin hormone levels increased,and values were significantly greater in the TJ-43(+)group compared those in the TJ-43(-)*** rats,the plasma active incretin levels significantly increased in the rTJ-43(+)group compared with those in the rTJ-43(-)*** and GLP-1 expressions were enhanced by TJ-43 ***,plasma insulin levels increased and blood glucose levels were blunted in the rTJ-43(+)*** The results show that TJ-43 may be beneficial for patients who undergo pancreatic surgery.

关键词： Incretin hormone Japanese traditional herbal medicine Gastric inhibitory polypeptide Glucagon-like polypeptide-1 Islet cells Insulin

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In silico screening for As/Se-free ovonic threshold switching materials

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npj Computational Materials 2023年第1期9卷 1359-1366页

作者： Sergiu Clima daisuke Matsubayashi Taras Ravsher Daniele Garbin Romain Delhougne Gouri Sankar Kar Geoffrey Pourtois imec Kapeldreef 75B-3001 LeuvenBelgium Device Technology Research&Development Center Future Memory Development DepartmentKIOXIA CorporationShin-sugita-cho 8Isogo-kuYokohamaJapan KU Leuven Celestijnenlaan 200DB-3001 LeuvenBelgium

Restricted use of hazardous environmental chemicals is one important challenge that the semiconductor industry needs to face to improve its *** threshold switching(OTS)ternary compound materials used in memory selector devices contain As and *** these elements out of these materials requires significant research *** facilitate this process,we performed systematic material screening for As/Se-free ternary materials,based on ab-initio *** limit the large amount of possible chemical compositions to fewer promising candidates,we used physics-based material parameter filters like material stability,electronic properties,or change in *** OTS gauge concept is introduced as a computed parameter to estimate the probability of a material to show an OTS *** a result,we identified 35 As/Se-free ternary alloy compositions for stand-alone OTS memory applications,as well as 12 compositions for RRAM selector *** work aims seeding the development of As/Se-free OTS materials.

关键词： alloy ternary free

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The Effect of Bioturbation Activity of the Ark Clam Scapharca subcrenata on the Fluxes of Nutrient Exchange at the Sediment–Water Interface

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Journal of Ocean University of China 2020年第1期19卷 232-240页

作者： ZHANG Shuo FANG Xin ZHANG Junbo YIN Fang ZHANG Hu WU Lizhen KITAZAWA daisuke College of Marine Sciences Shanghai Ocean UniversityShanghai 201306China Key Laboratory of Sustainable Exploitation of Oceanic Fisheries Resources Ministry of EducationShanghai Ocean UniversityShanghai 201306China National Demonstration Center for Experimental Fisheries Science Education(Shanghai Ocean University Shanghai 201306China National Engineering Research Center for Oceanic Fisheries Shanghai Ocean UniversityShanghai 201306China College of Ocean Science and Engineering Shanghai Maritime UniversityShanghai 201306China Maine Fisheries Research Institution of Jiangsu Nantong 226000China Lianyungang City Oceanic and Fishery Administration Lianyungang 222002China Institute of Industrial Science The University of Tokyo5-1-5 KashiwanohaKashiwaJapan

Filter-feeding shellfish are common benthos and significantly affect the biogeochemical cycle in the shallow coastal *** clam Scapharca subcrenata is one of the widely cultured bivalve species in many coastal areas owing to its tremendous economic ***,there is little information regarding the effects of the bioturbation of *** on the fluxes of nutrient exchange in the sediment-water interface(SWI).In this regard,*** was sampled during October 2016 to determine the effects of its bioturbation activity on the nutrient exchange flux of the *** results showed that the biological activity of *** could increase the diffusion depth and the rate of the nutrients exchange in the *** bioturbation of *** could allow the nutrients to permeate into the surface sediments at 6-10cm and increase the release rate of nutrients at the *** releasing fluxes of DIN and PO43−-P in the culture area were found to be around three times higher than that in the non-cultured *** culture of *** has been proved to be an important contributor to nutrient exchange across the SWI in the farming area of Haizhou *** exchange in the SWI contributes a part of 86%DIN,71%PO43−-P and 18%SiO32−-Si for the aquaculture farm.

关键词： bioturbation nutrients exchange flux ark clam sediment-water interface

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Information geometry in neural spike sequences

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Frontiers of Electrical and Electronic Engineering in China 2011年第1期6卷 146-150页

作者： Kazushi IKEDA daisuke KOMAZAWA Hiroyuki FUNAYA Nara Institute of Science and Technology Nara 630-0192Japan Kyoto University Kyoto 606-8501Japan

An information geometrical method is developed for characterizing or classifying neurons in cortical areas whose spike rates fluctuate in *** interspike intervals(ISIs)of a spike sequence of a neuron is modeled as a gamma process with a time-variant spike rate,a fixed shape parameter and a fixed absolute refractory *** formulate the problem of estimating the fixed parameters as semiparametric estimation and apply an information geometrical method to derive the optimal estimators from a statistical viewpoint.

关键词： information geometry neural spikes semiparametric estimation interspike intervals(ISIs)

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Study on conservation of mural paintings in Tumulus： Numerical analysis of heat behaviors of stone chamber after excavation

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Frontiers of Architectural Research 2012年第4期1卷 375-379页

作者： Yonghui Li daisuke Ogura Shuichi Hokoi Takeshi Ishizaki School of Architecture Key Laboratory of Architectural and Urban Heritage Conservation Southeast University Nanjing 210096 China Graduate School of Engineering Kyoto University Kyoto 606-8501 Japan Department of Research Support and Promotion National Research Institute for Cultural Properties Tokyo 110-8713 Japan

In 1972 mural paintings of Takamatsuzuka tumulus were discovered and have been conserved on site for 35 years, but fungi growth on the mural paintings was not suppressed. In 2007 the stone chamber was dismantled and removed to the facility for conservation and restoration. The purposes of our study are to clarify the main cause of the deterioration and to propose a suitable method to prevent the deterioration for preserving them on site. In this paper, we developed the two-dimensional analysis model by considering the actual change of the surrounding mound because of the excavation in 1972, and perform the analysis of heat behavior of Takamatsuzuka tumulus before and after excavation and compare effects of different sun-shading methods on heat behavior of the stone chamber. The main results are as follows：（1） after the excavation, the inside surface temperature distribution of the stone chamber and the amplitude of indoor temperature become larger. （2） Using the sun-shading panel in the area of excavation is an effective method to reduce the average indoor temperature; however, it has no influence on reducing the temperature distribution of the stone chamber and the temperature difference between the inside wall and indoor.

关键词： Effect Excavation Heat transfer Sun-shading Conservation

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Activated carbon enhanced ozonation of oxalate attributed to HO·oxidation in bulk solution and surface oxidation: Effect of activated carbon dosage and pH

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Journal of Environmental Sciences 2014年第10期26卷 2095-2105页

作者： Linlin Xing Yongbing Xie daisuke Minakata Hongbin Cao Jiadong Xiao Yi Zhang John C. Crittenden National Engineering Laboratory for Hydrometallurgical Cleaner Production Technology Key Laboratory of Green Process and Engineering Institute of Process Engineering Chinese Academy of Sciences Beijing Engineering Research Center of Process Pollution Control University of Chinese Academy of Sciences Department of Civil and Environmental Engineering Michigan Technological UniversityHoughton MI 49931 United States School of Civil and Environmental Engineering Brook Byers Institute for Sustainable Systems Georgia Institute of TechnologyAtlantaGA 30332 United States

Ozonation of oxalate in aqueous phase was performed with a commercial activated carbon（AC）in this work. The effect of AC dosage and solution pH on the contribution of hydroxyl radicals（HOU） in bulk solution and oxidation on the AC surface to the removal of oxalate was studied. We found that the removal of oxalate was reduced by tert-butyl alcohol（tBA） with low dosages of AC,while it was hardly affected by tBA when the AC dosage was greater than 0.3 g/L. tBA also inhibited ozone decomposition when the AC dosage was no more than 0.05 g/L, but it did not work when the AC dosage was no less than 0.1 g/L. These observations indicate that HOUin bulk solution and oxidation on the AC surface both contribute to the removal of oxalate. HOU oxidation in bulk solution is significant when the dosage of AC is low, whereas surface oxidation is dominant when the dosage of AC is high. The oxalate removal decreased with increasing pH of the solution with an AC dosage of 0.5 g/L. The degradation of oxalate occurs mainly through surface oxidation in acid and neutral solution, but through HOUoxidation in basic bulk solution. A mechanism involving both HOUoxidation in bulk solution and surface oxidation was proposed for AC enhanced ozonation of oxalate.

关键词： Activated carbon Oxalate Ozonation Hydroxyl radicals Surface oxidation Catalytic ozonation

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Photothermal therapy of tumors in lymph nodes using gold nanorods and near-infrared laser light with controlled surface cooling

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Nano Research 2015年第12期8卷 3842-3852页

作者： Tessai Sugiura daisuke Matsuki Junnosuke Okajima Atsuki Komiya Shiro Mori Shigenao Maruyama Tetsuya Kodama Department of Mechanical Systems and Design Graduate School of Engineering Tohoku University Sendai 980-8579 Japan Laboratory of Biomedical Engineering for Cancer Department of Biomedical Engineering Graduate School of Biomedical Engineering Tohoku University Sendai 980-8575 Japan Institute of Fluid Science Tohoku University 2-1-I Katahira Aoba Ward Sendai 980-8577 Japan Department of Oral and Maxillofacial Surgery Tohoku University Hospital Sendai 980-8575 Japan

Photothermal therapy （PTT） using near-infrared （NIR） laser light and gold nanorods （GNRs） shows promise as a novel cancer treatment modality. However, the laser intensity required to destroy tumor cells located beneath the skin is greater than the threshold intensity that causes skin damage; thus, irradiation with laser light damages the skin as well as the tumor. Here, we show that a temperature control system allows metastatic lymph nodes （LNs） to be treated by PTT using NIR laser light and GNRs, without skin damage. A mouse model of LN metastasis was developed by injection of tumor cells, and the tumor-bearing proper axillary LN was treated with NIR laser light after injection of GNRs. The skin temperature was maintained at 45 ~C during irradiation by using a temperature control system. Bioluminescence imaging revealed that tumor progression was less in LNs exposed to NIR laser light and GNRs than in LNs exposed to NIR laser light alone or controls （no irradiation or GNRs）. Furthermore, the skin and LN capsule were macroscopically intact on day 9 after irradiation with NIR laser light, whereas tumor cells within the LN showed apoptosis. A numerical analysis demonstrated that the high-temperature zone and the LN region showing damage were localized to an area up to 3 mm in depth. The proposed novel PTT technique, using NIR laser light and GNRs with controlled surface cooling, could be applied clinically to treat metastatic LNs located within or outside the area accessible for surgical dissection.

关键词： lymph node metastasis photothermal therapy goId nanorods temperature control

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