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Serum squamous cell carcinoma antigen is a predictive factor of outcomes in patients with locally advanced unresectable esophageal squamous cell carcinoma treated by definitive chemoradiotherapy

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Journal of Cancer Metastasis and Treatment 2022年第1期8卷 81-90页

作者： Takeshi suzuki Akihiko Okamura Masayuki Watanabe Takao Asari Izuma Nakayama Mariko Ogura Akira Ooki daisuke Takahari Kensei Yamaguchi Keisho Chin Department of Gastroenterological Medicine Cancer Institute Hospital of the Japanese Foundation for Cancer ResearchKoto-kuTokyo 135-8550Japan Department of Gastroenterological Surgery Cancer Institute Hospital of the Japanese Foundation for Cancer ResearchKoto-kuTokyo 135-8550Japan Department of Radiation Oncology Cancer Institute Hospital of the Japanese Foundation for Cancer ResearchKoto-kuTokyo 135-8550Japan

Aim:Definitive chemoradiotherapy(dCRT)is the standard treatment for locally advanced unresectable esophageal squamous cell carcinoma(LU-ESCC).This study aimed to describe the results of dCRT for T4 ESCC and evaluate the pretherapeutic predictive factors of the ***:A total of 133 patients with T4 ESCC who received dCRT were grouped into those who achieved a complete response(CR)or those who had residual disease(RD).The clinicopathologic variables were compared between the groups and the overall survival(OS)was *** predictive factor of RD was assessed and the prognostic factor for OS was ***:Among the 133 patients,31(23%)achieved *** CR group had a significantly better OS than the RD group(89.9 months vs.10.7 months;hazard ratio=0.096;95%confidence interval:0.05-0.19;P1.6 ng/mL)(OR=2.86;P=0.018),and metastatic node invasion(OR=3.19;P=0.048)were independent predictors of *** increased level of pretherapeutic serum squamous cell carcinoma antigen(>1.6 ng/mL)(OR=1.61;P=0.022)was an independent predictor of poor ***:Among the patients who underwent dCRT for LU-ESCC,23%achieved CR,and the long-term outcome of these patients was *** levels of pretherapeutic serum squamous cell carcinoma antigen were also found to be predictive of treatment failure.

关键词： Esophageal cancer chemoradiotherapy esophageal squamous cell carcinoma predictive factor

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Synthesis and Molecular Structures of Two Novel π-Conjugation Extended Dithia[3.3]metacyclophanes

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Crystal Structure Theory and Applications 2017年第1期6卷 1-10页

作者： Tetsuji Moriguchi daisuke Yakeya Venkataprasad Jalli Akihiko Tsuge Kenji Yoza Department of Applied Chemistry Faculty of Engineering Kyushu Institute of Technology Kitakyushu Japan Bruker AXS Yokohama Japan

Two novel dithia[3.3]metacyclophanes substituted with ethynyl groups were synthesized as small-sized metacyclophanes from the corresponding brominated dithia-metacyclophanes via C-C bond formation reaction. These compounds were characterized by using 1H NMR, mass spectrometry and elemental analyses. The exact structures were determined by using X-ray diffraction analyses. X-ray diffraction analysis results revealed that these compounds have anti conformations because of existence of intermolecular π-π interaction and some short contacts in the crystal. The long wavelength fluorescence was observed for one of the compound having a pyrene moiety in solid state because of the existence of the intermolecular π-π interaction between two pyrene units.

关键词： Cyclophane X-Ray Analysis suzuki Coupling π-Conjugation

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Prevalence of Chronic Pain, Especially Headache, and Relationship with Health-Related Quality of Life in Middle-Aged Japanese Residents

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Health 2016年第1期8卷 116-124页

作者： Junko Mitoma Masami Kitaoka Hiroki Asakura Enoch Olando Anyenda daisuke Hori Nguyen Thi Thu Tao Toshio Hamagishi Koichiro Hayashi Fumihiko suzuki Yukari Shimizu Hiromasa Tsujiguchi Yasuhiro Kambayashi Yuri Hibino Tadashi Konoshita Takiko Sagara Aki Shibata Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Science Kanazawa University Ishikawa Japan Third Department of Internal Medicine Fukui University School of Medicine Fukui Japan

The aim of this study was to evaluate the prevalence of chronic pain (CP) and the relationship between CP, especially headache adjusted for CP at other sites, and health-related quality of life (HRQoL) in middle-aged Japanese residents. We examined the prevalence of CP (defined as pain persisting for 3 months or more) and HRQoL (SF-36) in 1117 middle-aged residents of Japan. We assessed the eight dimensions of health status and the 3 component SF-36 summary score to evaluate HRQoL. The prevalence of CP was 15.3% among men and 15.1% among women. Multiple linear regression analysis demonstrated that lumbar pain (p β = -0.132), knee pain (p β = -0.115), foot pain (p = 0.042, β = -0.065), and age (p β = -0.154) were independently correlated with a lower physical component score (PCS). Older age (ppβ = -0.096), knee pain (p β = -0.109), upper limb pain (p β = -0.098), and lumbar pain (p = 0.022, β = -0.077) all showed a significant negative correlation with MCS. The presence of chronic headache (p = 0.011, β = -0.082) was the only factor significantly correlated with a lower role component score (RCS). We identified a negative correlation between chronic headache and RCS, unlike the relation between musculoskeletal pain and PCS or MCS, suggesting that RCS was an independently influenced by CP differently from PCS or MCS in Japanese residents.

关键词： Quality of Life Chronic Pain Headache SF-36 Pain

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The Association of Autism Spectrum Disorders and Symptoms of Asthma, Allergic Rhinoconjunctivitis and Eczema among Japanese Children Aged 3 - 6 Years

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Health 2017年第8期9卷 1235-1250页

作者： daisuke Hori Hiromasa Tsujiguchi Yasuhiro Kambayashi Toshio Hamagishi Masami Kitaoka Junko Mitoma Hiroki Asakura Fumihiko suzuki Enoch Olando Anyenda Nguyen Thi Thu Thao Yohei Yamada Satoko Tamai Koichiro Hayashi Yuri Hibino Aki Shibata Takiko Sagara Shinichiro Sasahara Ichiyo Matsuzaki Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Science Kanazawa University Kanazawa Japan Faculty of Medicine University of Tsukuba Tsukuba Japan International Institute for Integrative Sleep Medicine University of Tsukuba Tsukuba Japan

There is insufficient epidemiological evidence on the relationship between autism spectrum disorder (ASD) and allergic diseases. We performed a cross-sectional survey to elucidate the associations between them using validated screening tools. The participants were children aged 3 - 6 years attending kindergarten or nursery school in Shika Town, Japan (n = 417;valid response rate = 80.4%). Autism spectrum features were scored on the Social Communication Questionnaire (SCQ). Allergic symptoms (asthma, allergic rhinoconjunctivitis, and eczema) were determined according to the criteria of the International Study of Asthma and Allergies in Childhood. A total of 15 children (4.5%) had an SCQ score of 11 points or higher. The prevalence of symptoms was 14.7% for asthma, and 5.3% for allergic rhinoconjunctivitis, and 11.4% for eczema. Logistic regression indicated that symptoms of eczema were significantly associated with SCQ scores of 11 points or higher [odds ratio (OR), 4.38;95% confidence interval (CI), 1.41 - 13.59]. The association persisted after adjustment for age, sex, and BMI (OR, 3.84;95% CI, 1.20 - 12.24). Moreover, asthmatic symptoms were significantly associated with male sex (OR, 2.09;95% CI, 1.12 - 3.92) and overweight status (OR, 2.45;95% CI, 1.03 - 5.83). This suggests that higher SCQ scores, which imply more autism spectrum features, are associated with higher prevalence of eczema symptoms. While no causal relationships can be made, ASD might be associated with eczema.

关键词： Asthma Autism Spectrum Disorder Eczema Early Screening Social Communication Questionnaire

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The Association between Activity of Daily Living and the Combination of Alzheimer’s Disease and Cataract in Elderly Requiring Nursing Care

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Health 2016年第10期8卷 994-1003页

作者： Toshio Hamagishi Toshimitsu Inagawa Yasuhiro Kambayashi Hiromasa Tsujiguchi Masami Kitaoka Junko Mitoma Hiroki Asakura Fumihiko suzuki daisuke Hori Enoch Olando Anyenda Nguyen Thi Thu Thao Yuri Hibino Koichi Hayashi Aki Shibata Takiko Sagara Jiro Okochi Kiyoshi Takamoku Kotaro Hatta Tadashi Konoshita Hiroyuki Nakamura Department of Environmental and Preventive Medicine Graduate School of Medical Science Kanazawa University Ishikawa Japan Department of Food Sciences and Nutrition School of Human Environmental Sciences Mukogawa Women’s University Hyogo Japan Department of Lifestyle Studies Kobe Shoin Women’s University Hyogo Japan Department of Nutritional Sciences for Well-Being Kansai University of Welfare Sciences Osaka Japan Japan Association of Geriatric Health Service Facilities Tokyo Japan Department of Psychiatry Juntendo University Nerima Hospital Tokyo Japan Third Department of Internal Medicine Fukui University School of Medicine Fukui Japan

Some clinical and epidemiological studies have suggested that Alzheimer’s Disease (AD) and cataract, may share common pathogenetic mechanisms, subsequently a positive association between the prevalence of AD and cataract, although other studies found no significant relationship between dementia and visual impairment including cataract in the elderly. Little is known about the association between Activity of Daily Living (ADL) and the combination of AD and cataract. To examine the association between ADL and the combination of AD and cataract, we performed a national survey in nursing care institutions in Japan, examining the decreased ADL in elderly with and without AD and cataract for 453 elderly aged 85.0 ± 8.13 years. The proportion, 43.5% of AD in subjects without cataract was significantly higher than that, 23.5% with cataract. Almost all ADL in AD with cataract was significantly lower than that without cataract, although all ADL in cataract patients receiving surgery in AD was significantly (all p < 0.002) higher than that in cataract patients without surgery in AD, as was confirmed by the multiple regression analysis incorporating into the relevant factors as independent variables. These results showed that ADL scores including cognitive functions decreased by cataract were increased by the surgery in the patients with AD. A significantly negative association between AD and cataract seen in our data, which was inconsistent with the previous result, might lead to the necessities of the clinical diagnosis for slight severity of cataract for patients with AD.

关键词： Alzheimer’s Disease Cataract Elderly Activity of Daily Living Cognitive Function

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《日本钢铁协会》Vol．55（2015），No．12，P2667—2676 氢对弹簧钢疲劳性能的影响

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水钢科技 2016年第2期 57-66页

作者： Manabu KUBOTA Takahisa suzuki daisuke HIRAKAMI Kohsaku USHIODA 高长益刘立德张东升叶雅妮赵光凤日本新日铁住友金属公司钢铁研究实验室日本新日铁住友金属公司室兰研究开发实验室首钢水钢技术中心贵州六盘水553028

为了提高弹簧钢的强度级别、减轻弹簧钢的重量，则提高腐蚀疲劳性能是最重要的任务。本文研究残余应力、腐蚀坑深度、氢含量对双喷丸和三喷丸试样的旋转弯曲疲劳性能的影响，得到如下结果：（1）对于人工腐蚀坑深度为250um的试样，无论... 详细信息

为了提高弹簧钢的强度级别、减轻弹簧钢的重量，则提高腐蚀疲劳性能是最重要的任务。本文研究残余应力、腐蚀坑深度、氢含量对双喷丸和三喷丸试样的旋转弯曲疲劳性能的影响，得到如下结果：（1）对于人工腐蚀坑深度为250um的试样，无论是含氢或不舍氢，三喷丸都明显地提高疲劳极限；（2）对于含氢试样，夹杂物鱼眼疲劳开裂通常是疲劳断裂的起源；（3）无论人工腐蚀坑的深浅如何。喷丸试样的疲劳极限与人工腐蚀坑底部的残余压应力之间具有很好的对应关系。

关键词：高强度低合金钢腐蚀疲劳喷丸残余应力氢鱼眼疲劳开裂

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