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多发性硬化与视神经脊髓炎谱系疾病的临床治疗进展

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中国医师杂志 2018年第8期20卷 1260-1266页

作者：刘代强郝延磊山东省济宁医学院研究生院 272000 山东省济宁医学院附属医院神经内科 272029

中枢神经系统脱髓鞘疾病以多发性硬化(MS)和视神经脊髓炎谱系疾病(NMOSDs)最常见。在MS及NMOSD急性期,激素、静脉注射大剂量免疫球蛋白、血浆置换似乎都是有效的疗法;而在缓解期,免疫调节剂和免疫抑制剂为MS的常规治疗药物,此外单克隆... 详细信息

中枢神经系统脱髓鞘疾病以多发性硬化(MS)和视神经脊髓炎谱系疾病(NMOSDs)最常见。在MS及NMOSD急性期,激素、静脉注射大剂量免疫球蛋白、血浆置换似乎都是有效的疗法;而在缓解期,免疫调节剂和免疫抑制剂为MS的常规治疗药物,此外单克隆抗体、静脉注射免疫球蛋白G、雌激素、他汀类药物、疫苗接种及中医中药等治疗也被逐渐运用于临床。小剂量激素和免疫抑制剂的联合维持治疗将使NMOSD患者得到更大获益。由于发病机制的不同,MS和NMOSD在治疗上存在明显差异。现就二者的临床治疗进展进行综述。

关键词：多发性硬化/治疗视神经脊髓炎/治疗综述

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激光武器反无人机集群作战运用及关键技术

航空学报 2024年第12期45卷 239-253页

作者：刘伟张琳王代强孟宪良张搏空军工程大学防空反导学院西安710051 中国人民解放军63768部队西安710000 航天工程大学基础部北京110400

激光武器具有作战成本低、转移火力快、杀伤可控等显著优势,被认为是目前反无人机(UAV)集群作战中最具技术可行性的定向能武器。随着激光武器逐步从试验验证进入作战运用阶段,对激光武器反无人机集群作战运用关键技术进行综述分析迫在... 详细信息

激光武器具有作战成本低、转移火力快、杀伤可控等显著优势,被认为是目前反无人机(UAV)集群作战中最具技术可行性的定向能武器。随着激光武器逐步从试验验证进入作战运用阶段,对激光武器反无人机集群作战运用关键技术进行综述分析迫在眉睫。通过梳理激光武器毁伤作用机理及发展现状,分析激光武器反无人机集群作战运用关键问题,并总结归纳激光武器-集群目标分配技术、激光毁伤效能评估技术的研究进展,最后对激光武器反无人机集群作战运用关键技术研究方向进行展望,以期为激光武器尽早投入作战运用提供借鉴和参考。

关键词：激光武器反无人机集群作战运用激光武器-集群目标分配技术激光毁伤效能评估技术

Frequency Regulation of VSC-MTDC System with Offshore Wind Farms

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 275-286页

作者： Haoyu liu Chongru liu North China Electric Power University Beijing 102206China

Frequency regulation of voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC)system with offshore wind farms enhances the frequency stability by compensating the power for a disturbed AC ***,it is difficult to reasonably allocate frequency-regulation resources due to a lack of coordination mechanisms between wind farms and the MTDC ***,it is difficult for the frequency control of the wind farms to manage changes in wind speed;and the risk of wind-turbine stalls is ***,based on the kinetic energy of wind turbines and the power margin of the converters,the frequency-regulation capability of wind turbines is evaluated,and a dynamic frequency-support scheme considering the real-time frequency-support capability of the wind turbines and system frequency evolution is proposed to improve the frequency-support performance.A power adaptation technique at variable wind speeds is developed;the active power in the frequency-support stage and restoration stage is switched according to the wind speed.A hierarchical zoning frequency-regulation scheme is designed to use the frequency-regulation resources of different links in the MTDC system with wind *** simulation results show that the novel frequency-regulation strategy maintains frequency stability with wind-speed changes and avoids multiple frequency dips.

关键词： Wind generation voltage source converter-based multi-terminal high-voltage direct current(VSC-MTDC) frequency regulation cooperative control adaptive control variable wind speed

单色绿光和蓝光对七氟烷麻醉致小鼠脑电爆发抑制的影响

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中华麻醉学杂志 2020年第12期40卷 1451-1455页

作者：刘代强黄宇婕李家艳张霜吴家懿梅伟华中科技大学同济医学院附属同济医院麻醉科武汉430030

目的评价单色绿光和蓝光对七氟烷麻醉致小鼠脑电爆发抑制的影响。方法SPF级健康雄性C57BL/6J小鼠22只,体重22~26 g,10~12周龄,采用随机数字表法分为4组:绿光对照组(G-Con组,n=5)、单色绿光组(Green组,n=6)、蓝光对照组(B-Con组,n=5)和... 详细信息

目的评价单色绿光和蓝光对七氟烷麻醉致小鼠脑电爆发抑制的影响。方法SPF级健康雄性C57BL/6J小鼠22只,体重22~26 g,10~12周龄,采用随机数字表法分为4组:绿光对照组(G-Con组,n=5)、单色绿光组(Green组,n=6)、蓝光对照组(B-Con组,n=5)和单色蓝光组(Blue组,n=6)。G-Con组和Green组于2.0%七氟烷麻醉30 min后,分别在无其他光源的圆柱形玻璃麻醉室内暴露于800 lux的复合白光和单色绿光(530 nm),继续2.0%七氟烷麻醉30 min;B-Con组和Blue组于2.5%七氟烷麻醉30 min后,分别暴露于800 lux的复合白光和单色蓝光(460 nm),继续2.5%七氟烷麻醉30 min。采用脑电图监测小鼠的脑电信号,计算单色光暴露前后各30 min时段脑电能量以及光暴露前10 min时段(T0)、光暴露后0~10 min时段(T1)、10~20 min时段(T2)和20~30 min时段(T3)爆发抑制率(BSR)。结果与G-Con组比较,Green组T0时段BSR差异无统计学意义(P>0.05),T1、T2和T3时段BSR增加(P0.05),T1、T2和T3时段BSR减少(P<0.05)。与光暴露前比较,Green组光暴露后δ波、θ波、α波、β波及γ波能量均降低,Blue组δ波和γ波能量升高(P<0.05)。结论单色绿光可促进七氟烷麻醉致小鼠脑电爆发抑制,加深麻醉深度;单色蓝光可减少脑电爆发抑制,减浅麻醉深度。

关键词：麻醉药,吸入脑电描记术单色绿光单色蓝光爆发抑制

A Novel Design of a Pre-separation Panel Structure to Protect Against the Impact of an Explosion in an Aircraft Plenum Chamber

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Acta Mechanica Solida Sinica 2024年第1期37卷 166-180页

作者： Zongxing liu Xiang Yang Jun liu School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China COMAC Shanghai Aircraft Design and Research Institute Shanghai 201210China

To reduce the damage of the pressurizing panel structure of a fuselage caused by an explosion at the“least risk bomb location”in an aircraft structure,a new pre-separation panel structure was designed to resist blast ***,the dynamic strain response and morphology of impact damage of the new pre-separation panel were measured in an impact damage ***,the commercial software LS-DYNA was used to calculate the propagation of the blast shock wave,and the results were compared with empirical equations to verify the rationality of the numerical calculation ***,the fluid–structure coupling method was used to calculate the damage process of the pre-separation panel structure under the impact of an explosion wave and an impact *** calculated results were in good agreement with the test results,which showed the rationality of the calculation method and the *** residual strength of the damaged pre-separation panel was significantly higher than that of the original damaged *** results show that the new pre-separation panel structure is reasonable and has certain significance for guiding the design of plenum chambers with strong resistance to implosion for aircraft fuselages.

关键词： Pre-separation panel structure Explosive response Residual strength Aircraft plenum chamber Least risk bomb location

Effectiveness and safety of acupuncture in treatment of pregnancyrelated symptoms:a systematic review and Meta-analysis

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Journal of Traditional Chinese Medicine 2024年第1期44卷 16-26页

作者： liu Tingting liu Tongou liu Mingfu School of Traditional Chinese Medicine Clinical Medicine Hubei University of Traditional Chinese MedicineWuhan 430000China First Clinical College of Hubei University of Traditional Chinese Medicine Wuhan 430000China Department of Acupuncture and Tuina Affiliated Hospital of Hubei University of Traditional Chinese MedicineHubei Provincial Hospital of Traditional Chinese MedicineWuhan 430000China

OBJECTIVE:To systematically evaluate the efficacy and safety of acupuncture(AM)in the treatment of pregnancyrelated symptoms such as acute vomiting during ***:We comprehensively searched the available literature up to November 2021,including Pub Med,Embase,Cochrane Library,Chinese Biomedical Literature Database,and China National Knowledge Infrastructure Database,for randomized controlled trials(RCTs)on AM for the treatment of severe vomiting,insomnia,pharyngeal and pelvic pain,mood abnormalities,and dyspepsia during ***:Sixteen RCTs with a cumulative sample size of 1178 cases were *** these,964 patients were included in the *** Meta-analysis results showed that AM was more efficient than Western medicine in treating discomfort during pregnancy[odds ratio(OR)=1.19,95%confidence interval(CI)(1.11,1.28),P<0.01].AM was better than the control group in improving the visual analog scale scores[standard mean difference(SMD)=0.62,95%CI(0.53,0.71),P<0.01].AM was superior to the control group in improving Numerical Rating Scale(NRS)symptom scores[OR=7.31,95%CI(3.36,15.94),P<0.01].There was no significant difference in adverse effects between the AM and sham-AM groups and the analgesic drug group[OR=0.70,95%CI(0.39,1.28),P=0.25],but the treatment and control groups had mild adverse effects with a low ***:AM is more effective than other treatments or pharmacotherapy alone in the treatment of pregnancy-related symptoms,and is relatively ***,the quality of the included trials was rather poor,and high-quality studies are required to confirm our findings.

关键词： acupuncture pregnancy nausea vomiting sleep initiation and maintenance disorders low back pain pelvic pain mood abnormalities Meta-analysis systematic review

Stochastic Unit Commitment with High-Penetration Offshore Wind Power Generation in Typhoon Scenarios

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 535-546页

作者： Yanqi liu Dundun liu Hongcai Zhang State Key Laboratory of Internet of Things for Smart City and Department of Electrical and Computer Engineering University of MacaoMacao 999078China University of Macao Zhuhai UM Science and Technology Research Institute ZhuhaiChina

To tackle the energy crisis and climate change,wind farms are being heavily invested in across the *** China's coastal areas,there are abundant wind resources and numerous offshore wind farms are being *** secure operation of these wind farms may suffer from typhoons,and researchers have studied power system operation and resilience enhancement in typhoon ***,the intricate movement of a typhoon makes it challenging to evaluate its spatial-temporal *** published papers only consider predefined typhoon trajectories neglecting *** address this challenge,this study proposes a stochastic unit commitment model that incorporates high-penetration offshore wind power generation in typhoon *** adopts a data-driven method to describe the uncertainties of typhoon trajectories and considers the realistic anti-typhoon mode in offshore wind farms.A two-stage stochastic unit commitment model is designed to enhance power system resilience in typhoon *** formulate the model into a mixed-integer linear programming problem and then solve it based on the computationally-efficient progressive hedging algorithm(PHA).Finally,numerical experiments validate the effectiveness of the proposed method.

关键词： Unit commitment two-stage stochastic programming offshore wind farm typhoon

Devolatilization of high viscous fluids with high gravity technology

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Chinese Journal of Chemical Engineering 2024年第7期71卷 249-257页

作者： Jibing Qi Youzhi liu Yandong liu Taiyuan University Taiyuan 030032China Shanxi Province Key Laboratory of Higee-Oriented Chemical Engineering North University of ChinaTaiyuan 030051China

Volatile organic compounds(VOCs)are generally toxic and harmful substances that can cause health and environmental *** removal of VOCs from polymers has become a key *** effective devolatilization to remove VOCs from high viscous fluids such as polymer is necessary and is of great *** this study,the devolatilization effect of a rotating packed bed(RPB)was studied by using polydimethylsiloxane as the viscous fluid and acetone as the *** devolatilization rate and liquid phase volume(KLa)have been *** results indicated that the optimum conditions were the high-gravity factor of 60,liquid flow rate of 10 L·h^(-1),and vacuum degree of 0.077 *** dimensionless correlation of KLa was established,and the deviations between predicted and experimental values were less than±28%.The high-gravity technology will result in lower mass transfer resistance in the devolatilization process,enhance the mass transfer process of acetone,and improve the removal effect of *** work provides a promising path for the removal of volatiles from polymers in combination with high-gravity *** can provide the basis for the application of RPB in viscous fluids.

关键词： High-gravity technology Devolatilization rate High viscous fluid Volatile organic compounds(VOCs)

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贵州香猪内源氮与内源氨基酸代谢规律研究

动物营养学报 2010年第6期22卷 1523-1528页

作者：李伟杨正德刘代强许万里贵州大学动物科学学院贵阳550025 贵州大学动物营养与饲料科学研究所贵阳550025

选择3.5～4.0月龄、遗传来源相似、体重(12±2)kg的贵州从江香猪、剑白香猪去势公猪各6头,采用无氮饲粮(NFD)法和NFD+5%酶解酪蛋白(EHC)法进行代谢试验,测定贵州香猪内源氮与内源氨基酸的代谢规律,探索贵州香猪的维持蛋白质和氨基酸需... 详细信息

选择3.5～4.0月龄、遗传来源相似、体重(12±2)kg的贵州从江香猪、剑白香猪去势公猪各6头,采用无氮饲粮(NFD)法和NFD+5%酶解酪蛋白(EHC)法进行代谢试验,测定贵州香猪内源氮与内源氨基酸的代谢规律,探索贵州香猪的维持蛋白质和氨基酸需要量。研究显示,贵州香猪内源氮排泄量为0.212 g/d W0.75,内源氨基酸排泄量为1.463 g/d W0.75。结果表明,贵州香猪可消化粗蛋白质维持需要量(DCPm)为1.91 g/d W0.75,可消化氨基酸维持需要量为2.10 g/d W0.75,以Lys为100建立贵州香猪维持需要可消化氨基酸模型为:Lys 100、Thr 54、Val 188、Met 40、Ile 79、Leu 126、Phe 101、His 25、Arg 58、Trp 17。

关键词：贵州香猪内源氮内源氨基酸无氮饲粮