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整合医学宣言

中华烧伤与创面修复杂志 2024年第7期40卷 601-603页

作者：中国整合医学发展战略研究院樊代明不详中国整合医学发展战略研究院西安710032

整体整合医学(简称为整合医学)自2012年正式提出,其理论体系不断完善,实践方法日趋丰富,成为医学发展新时代的必然选择和必由之路。本文提出整合医学的十大主张,从认识论和方法学阐述了整合医学的内涵和外延,以期实现现代医学的升维转... 详细信息

整体整合医学(简称为整合医学)自2012年正式提出,其理论体系不断完善,实践方法日趋丰富,成为医学发展新时代的必然选择和必由之路。本文提出整合医学的十大主张,从认识论和方法学阐述了整合医学的内涵和外延,以期实现现代医学的升维转型和自适应进化。

关键词：整体整合医学医学发展知识体系

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整合医学宣言

国际眼科杂志 2024年第09期24卷 1355-1356页

作者： China Institute for Development Strategy of Holistic Integrative Medicine Integrative Medicine 中国整合医学发展战略研究院

整体整合医学(holistic integrative medicine,HIM)简称整合医学,自2012年正式提出,其理论体系不断完善,实践方法日趋丰富,成为医学发展新时代的必然选择和必由之路。文章提出整合医学的十大主张,从认识论和方法学上阐述了整合医学的内... 详细信息

整体整合医学(holistic integrative medicine,HIM)简称整合医学,自2012年正式提出,其理论体系不断完善,实践方法日趋丰富,成为医学发展新时代的必然选择和必由之路。文章提出整合医学的十大主张,从认识论和方法学上阐述了整合医学的内涵和外延,以期实现现代医学的升维转型和自适应进化。

关键词：整体整合医学(HIM) 整合医学医学发展

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药品和医疗器械上市后研究概述

中国临床研究 2024年第6期37卷 968-971页

作者：秦妮平高柳村海沙尔江·吾守尔杨志平樊代明中国整合医学发展战略研究院陕西西安710032 山西医科大学山西太原030001 上海明品整合医学研究院上海201600 北京大学药学院北京100191 空军军医大学西京医院陕西西安710032

药品和医疗器械上市后研究是产品全生命周期管理的重要环节。本文在文献调研和专家咨询基础上,提出药械产品上市后研究的概念体系,即什么是上市后研究(What)、为什么要开展上市后研究(Why)、谁开展上市后研究(Who)、如何开展上市后研究(... 详细信息

药品和医疗器械上市后研究是产品全生命周期管理的重要环节。本文在文献调研和专家咨询基础上,提出药械产品上市后研究的概念体系,即什么是上市后研究(What)、为什么要开展上市后研究(Why)、谁开展上市后研究(Who)、如何开展上市后研究(How)、上市后研究的目的和目标(Objective)的3WHO框架。

关键词：上市后研究药品医疗器械真实世界研究数字化

Fourth-order phase-field modeling for brittle fracture in piezoelectric materials

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 837-856页

作者： Yu TAN fan PENG Chang LIU daiming PENG Xiangyu LI State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China College of Science Chang'an UniversityXi'an 710064China Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province School of Mechanics and Aerospace EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Failure analyses of piezoelectric structures and devices are of engineering and scientific *** this paper,a fourth-order phase-field fracture model for piezoelectric solids is developed based on the Hamilton *** typical electric boundary conditions are involved in the present model to characterize the fracture behaviors in various physical situations.A staggered algorithm is used to simulate the crack *** polynomial splines over hierarchical T-meshes(PHT-splines)are adopted as the basis function,which owns the *** numerical simulations are performed to study the influence of the electric boundary conditions and the applied electric field on the fracture behaviors of piezoelectric *** electric boundary conditions may influence crack paths and fracture loads *** present research may be helpful for the reliability evaluation of the piezoelectric structure in the future applications.

关键词： isogeometric analysis(IGA) brittle fracture fourth-order phase-field model piezoelectric solid

Holistic integrative medicine： toward a new era of medical advancement

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Frontiers of Medicine 2017年第1期11卷 152-159页

作者： daiming fan Xijing Hospital of Digestive Diseases the Fourth Military Medical University Xi'an 710032 China Chinese Academy of Engineering Beijing 100088 China

Medicine has encountered unprecedented problems associated with changes in nature, society, and environment, as well as with new human quests for survival, longevity, and health. In the meantime, the development of medicine is facing challenges that resulted from the over-division and specialization of disciplines and the fragmentation of medical knowledge. To construct a new medical system that is more suitable for human health and disease treatment, holistic integrative medicine （HIM）, which regards the human body as a holistic entity, organically integrates the most advanced knowledge and theories in each medical field and the most effective practices in various clinical specialties to revise and adjust on the basis of social, environmental, and psychological conditions. HIM is the inevitable and necessary direction for the future development of medicine. In this article, we illustrated the connotation of HIM, the differences between HIM and other medical conceptions, and the practice of HIM in recent years.

关键词： holistic integrative medicine precision medicine general practice medicine

Foreword tothe Holistic Integrative Oncology

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Holistic Integrative Oncology 2022年第1期1卷 1-2页

作者： daiming fan China Anti-Cancer Association TianjinChina

There are three phenomena that deserve our attention in today’s cancer prevention and treatment field:1 First,the effect of cancer prevention and treatment needs to be improved The disease of cancer has long existed since ancient times,and the evolution of human civilization is also ac-companied by a protracted struggle between human be-ings and cancer.

关键词： prevention cancer

Biological properties and clinical applications of berberine

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Frontiers of Medicine 2020年第5期14卷 564-582页

作者： Danyang Song Jianyu Hao daiming fan Department of Gastroenterology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China State key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi'an 710032China

Berberine,an isoquinoline alkaloid isolated from the Chinese herb Coptis chinens is and other Berber is plants,has a wide range of pharmacological *** can be used to treat many diseases,such as cancer and digestive,metabolic,cardiovascular,and neurological *** has protective capacities in digestive *** can inhibit toxins and bacteria,including Helicobac terpylo riprotect the intestinal epithelial barrier from injury,and ameliorate liver *** also inhibits the proliferation of various types of cancer cells and impedes invasion and *** evidence has confirmed that berberine improves the efficacy and safety of *** addition,berberine regulates glycometabolism and lipid metabolism,improves energy expenditure,reduces body weight,and alleviates nonalcoholic fatty liver *** also improves cardiovascular hemodynamics,suppresses ischemic arrhythmias,attenuates the development of atherosclerosis,and reduces *** shows potent neuroprotective effects,including antioxidative,antiapoptotic,and ***,berberine exerts protective effects against other *** mechanisms of its functions have been extensively explored,but much remains to be *** article summarizes the main pharmacological actions of berberine and its mechanisms in cancer and digestive,metabolic,cardiovascular,and neurological diseases.

关键词： berberine Coptis chinensis pharmacological properties mechanism clinical applications

Barriers and countermeasures in developing traditional Chinese medicine in Europe

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Frontiers of Medicine 2016年第3期10卷 360-376页

作者： Yunfang Liu Zhiping Yang Jing Cheng daiming fan Projeet Department Consultancy Program Center Chinese Academy of Engineering Beijing 100088 China Department of Biomedical Engineering School of Medicine Tsinghua University Beijing 100084 China Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi 'an 710032 China

Traditional Chinese medicine （TCM） is one of the unique cultural treasures of Chinese; it represents a significant feature and prominent advantage of the healthcare cause in China. Data in this paper were from World Health Organization, Chinese Bureau of Statistics, China National Knowledge Infrastructure, and PubMed. In recent years, TCM has established a solid foundation in Europe, which made great strides in legislation, education, research, and international exchange, and has enjoyed a vast development space in the continent. Now, TCM is embracing unprecedented development opportunities in Europe. At the same time, the stiff international competition poses a grave threat to China＇s TCM industry. With multiple cultural, legal, and institutional challenges, as well as talent shortages in the way, TCM is now facing many difficulties in Europe. To fully prepare and enact active and vigorous steps to seize opportunities, we should have a clear picture about the serious challenges hampering TCM development in Europe. The TCM development at overseas markets has shifted from a spontaneous trade activity into a national strategy spearheaded by the government and participated in by multiple stakeholders. We should make a systematic, comprehensive, and sustainable push in fields such as TCM therapy, healthcare, education, research, culture, and industry development. The ultimate goal is to bring TCMs to the global market and allow them to play a role in safeguarding public health along with modern medicines.

关键词： traditional Chinese medicine Europe development

Holistic Integrated Medicine

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医学争鸣 2013年第1期4卷 4-21页

作者： fan daiming Xijing Hospital of Digestive Diseases Fourth Military Medical University Chinese Academy of Engineering

Many people engagingin medical scienceasked me,"You’ve beenworking on the exploration of Holistic Integrated Medicine(HIM)for quite *** is the progressyou have made in your research?Have you got your article publishe... 详细信息

关键词：医疗卫生行业医学工作医学研究医疗卫生