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Artificial Bear Bile:A Novel Approach to Balancing m.dical Requirem.nts and Anim.l Welfare

Engineering 2024年第7期38卷 100-112页

作者： Yong Li Yuhong Huang Nan Feng Heping Zhang Jing Qu Shuanggang m. Yunbao Liu Jiang Li Shaofeng Xu Ling Wang m. Zhang Jie Cai Weiping Wang Ru Feng Hang Yu Bo Yu dailiang Liang Heping Qin Suxiang Luo Yanfen Li m.ifeng Li Ruihua Wang Chen m. Yan Wang Xiaobo Cen Xiaoxian Xu Boli Zhang Xiaoliang Wang Shishan Yu State Key Laboratory of Bioactive Substance and Function of Natural m.dicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China The Second Affiliated Hospital of Tianjin University of Traditional Chinese m.dicine Tianjin 300250China Zhongshan Belling Biotechnology Co. Ltd.Zhongshan 528437China Zhongshan Anshi Biopharm.ceutical Co. Ltd.Zhongshan 528437China WestChina-Frontier Pharm. Tech Co. Ltd.Chengdu 610041China Tianjin University of Traditional Chinese m.dicine Tianjin 301617China

Bear bile has been a valuable and effective m.dicinal m.terial in traditional Chinese m.dicine(TCm.for over 13 ***,the current practice of obtaining it through bear farm.ng is under scrutiny for its adverse im.act on bear ***,we present a new approach for creating artificial bear bile(ABB)as a high-quality and sustainable alternative to natural bear *** study addresses the scientific challenges of creating bear bile alternatives through interdisciplinary collaborations across various fields,including resources,chem.stry,biology,m.dicine,pharm.cology,and TCm.A com.rehensive efficacy assessm.nt system.that bridges the gap between TCm.and m.dern m.dical term.nology has been established,allowing for the system.tic screening of therapeutic *** the utilization of chem.cal synthesis and enzym. engineering technologies,our research has achieved the environm.ntally friendly,large-scale production of bear bile therapeutic com.ounds,as well as the optim.zation and recom.osition of ABB *** resulting ABB not only closely resem.les natural bear bile in its com.osition but also offers advantages such as consistent product quality,availability of raw m.terials,and independence from.threatened or wild *** preclinical efficacy evaluations have dem.nstrated the equivalence of the therapeutic effects from.ABB and those from.com.ercially available drained bear bile(DBB).Furtherm.re,preclinical toxicological assessm.nt and phase I clinical trials show that the safety of ABB is on par with that of the currently used *** innovative strategy can serve as a new research paradigm.for developing alternatives for other endangered TCm.,thereby strengthening the integrity and sustainability of TCm.

关键词： Artificial bear bile Chem.cal profile Form.la optim.zation Pharm.codynam.c consistency Preclinical toxicological assessm.nt

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管径尺寸偏差对超声流量计测量性能影响研究

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中国测试 2024年第4期50卷 45-52页

作者：吕承泽李梦娜李春辉谢代梁中国计量大学浙江杭州310018 中国计量科学研究院北京100029

正确的安装是保证气体超声流量计测量准确度的前提。基于高压气体流量标准装置,在有、无管径尺寸偏差的安装条件下,对交叉4声道DN200口径超声流量计实验测量显示,在0.1~2 m.a压力,1.5~12 m.s流速范围内,8 m.安装管道正向尺寸偏差会带来0... 详细信息

正确的安装是保证气体超声流量计测量准确度的前提。基于高压气体流量标准装置,在有、无管径尺寸偏差的安装条件下,对交叉4声道DN200口径超声流量计实验测量显示,在0.1~2 m.a压力,1.5~12 m.s流速范围内,8 m.安装管道正向尺寸偏差会带来0.22%的测量误差。为量化尺寸偏差对超声流量计测量结果的影响,采用数值模拟与实验测量相结合的方法,就不同尺寸偏差,压力及口径对超声流量计测量结果的影响进行系统研究。结果表明,正向尺寸偏差带来的测量误差几乎不受压力影响,负向尺寸偏差带来的测量误差随压力增加呈现从负误差到正误差的转变;尺寸偏差对测量结果影响随超声流量计口径减小而增大,3 m.尺寸偏差对DN50口径的声流量计测量结果影响可达0.20%。

关键词：超声流量计安装管道尺寸偏差数值模拟计量

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Trajectory tracking control of a VTOL unm.nned aerial vehicle using offset-free tracking m.C

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Chinese Journal of Aeronautics 2020年第7期33卷 2024-2042页

作者： Tayyab m.NZOOR Yuanqing XIA Di-Hua ZHAI dailiang m. School of Autom.tion Beijing Institute of TechnologyBeijing 100081China

Designing a stable and robust flight control system.for an Unm.nned Aerial Vehicle(UAV)is an arduous *** paper addresses the trajectory tracking control problem.of a Ducted Fan UAV(DFUAV)using offset-free m.del Predictive Control(m.C)technique in the presence of various uncertainties and external *** designed strategy aim. to ensure adequate flight robustness and stability while overcom.ng the effects of tim. delays,param.tric uncertainties,and *** six degrees of freedom.DFUAV m.del is divided into three flight m.des based on its airspeed,nam.ly the hover,transition,and cruise *** Dryden wind turbulence is applied to the DFUAV in the linear and angular velocity ***,different uncertainties such as param.tric,tim. delays in state and input,are introduced in translational and rotational *** the previous work,the Linear Quadratic Tracker with Integrator(LQTI)is used for com.arison to corroborate the perform.nce of the designed *** are com.uted to investigate the control perform.nce for the aforem.ntioned m.des and different flight phases including the autonom.us flight to validate the perform.nce of the designed ***,discussions are provided to dem.nstrate the effectiveness of the given m.thodology.

关键词： Autonom.us flight control m.del Predictive Control(m.C) Tim. delays Trajectory tracking Unm.nned Aerial Vehicle(UAV)

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超声流量计实时使用中检验系统的建立及验证

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计量学报 2024年第4期45卷 552-558页

作者：李文礼李春辉李梦娜金宇强谢代梁中国计量大学浙江杭州310018 中国计量科学研究院北京100029

为实现对使用中超声流量计准确度的实时监测,基于高压环道式气体流量标准装置,采用随机森林算法,建立了信号参数(含声速偏差)与示值误差间关系的超声流量计预测模型,同时结合LabVIEW软件开发平台研制出一套超声流量计实时使用中检验系... 详细信息

为实现对使用中超声流量计准确度的实时监测,基于高压环道式气体流量标准装置,采用随机森林算法,建立了信号参数(含声速偏差)与示值误差间关系的超声流量计预测模型,同时结合LabVIEW软件开发平台研制出一套超声流量计实时使用中检验系统。基于该系统,可实现超声流量计信号质量参数、流态指标参数、声速指标参数3类信号参数的实时采集,并利用预测模型开展流量计示值误差的同步预测。在160~800 m.3/h范围内的实验测试表明,流量计示值误差与系统预测误差间的偏差为±0.42%。

关键词：超声流量计使用中检验随机森林算法机器学习 LabVIEW

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基于空腔流激振荡的气体流量测量方法优化研究

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仪表技术与传感器 2024年第9期 28-33页

作者：袁江琦徐雅谢代梁刘铁军黄震威中国计量大学浙江省流量计量技术重点实验室

针对浅腔型空腔流量计存在的振荡信号弱的问题,采用一种深腔结构对基于空腔流激振荡的气体流量测量方法进行了优化研究。对浅腔和深腔结构的振荡原理进行了对比,结合数值模拟及实验验证分析了深腔结构中的流场及声场分布特性,探究了气... 详细信息

针对浅腔型空腔流量计存在的振荡信号弱的问题,采用一种深腔结构对基于空腔流激振荡的气体流量测量方法进行了优化研究。对浅腔和深腔结构的振荡原理进行了对比,结合数值模拟及实验验证分析了深腔结构中的流场及声场分布特性,探究了气体速度对声振荡频率及幅值的影响规律。研究结果表明:在一定的速度范围内深腔结构中可激发振荡频率稳定、幅值更大的声振荡区间,且振荡信号的幅值与气体流速呈现稳定的响应规律;采用变径管结构提升谐振腔入口前沿的局部流速,可使该深腔在更低的流速范围内产生稳定声振荡,且流速范围连续,可用于换算6.41~29.97 m.s范围内的气体流速,相应的流量为47.14~220.40 m./h。

关键词：空腔流激振荡流量测量大涡模拟声学谐振

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面向粒子图像测速仪的分参数校准方法

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计量学报 2024年第9期45卷 1324-1330页

作者：单杰黄震威崔骊水谢代梁王毅张淑婷高山张育闻钱振宇中国计量大学计量测试工程学院浙江杭州310018 中国计量科学研究院北京100029 中国航空工业集团公司北京长城计量测试技术研究所北京100095

研究了粒子图像测速(particle im.ge velocim.try,PIV)测量过程中粒子位移和跨帧时间2个关键分参数的校准方法。设计了用于相机标定的标定圆盘,确定了相机获得图像与实物的比例关系。与标尺相比较,设计的标定圆盘可实现粒子位移的校准... 详细信息

研究了粒子图像测速(particle im.ge velocim.try,PIV)测量过程中粒子位移和跨帧时间2个关键分参数的校准方法。设计了用于相机标定的标定圆盘,确定了相机获得图像与实物的比例关系。与标尺相比较,设计的标定圆盘可实现粒子位移的校准。采用可溯源的高准确度计时器校准了PIV同步器在不同速度点下脉冲信号的时间间隔,得到PIV实际跨帧时间。评估了PIV分参数方法校准结果的不确定度水平。结果表明:速度100 m.s内的PIV校准相对误差最大为0.08%,其相对误差的不确定度为0.01%。

关键词：流量测量粒子图像测速校准方法分参数不确定度

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Regulating the properties of XQ-2d for targeted delivery of therapeutic agents to pancreatic cancers

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National Science Review 2023年第8期10卷 166-172页

作者： Qiuxia Yang Yongbo Peng Zhengyu Deng dailiang Zhang Cheng-Yu Long Guo-Rong Zhang Juan Li Xue-Qiang Wang Weihong Tan Zhejiang Cancer Hospital Hangzhou Institute of Medicine(HIM) Chinese Academy of Sciences m.lecular Science and Biom.dicine Laboratory(m.L) State Key Laboratory of Chemo/Biosensing and ChemometricsCollege of Chemistry and Chemical Engineering College of Biology Aptamer Engineering Center of Hunan ProvinceHunan University Institute of m.lecular m.dicine(Im.) Renji HospitalSchool of MedicineCollege of Chemistry and Chemical Engineering Shanghai Jiao Tong University

Enhanced recognition ability, cell uptake capacity, and biostability are characteristics attributed to aptam.r-based targeted anticancer agents, and are possibly associated with increased accum.lation at the tum.r site, im.roved therapeutic efficacy and reduced negative side effects. Herein, a phosphorothioate backbone m.dification strategy was applied to regulate the biom.dical properties of pancreatic cancer cell–targeting aptam.r for efficient in vivo drug delivery. Specifically, the CD71-targeting aptam.r XQ-2d was m.dified into a fully thio-substituted aptam.r S-XQ-2d, im.roving the plasm. stability of S-XQ-2d and m.tom.cin C(m.C)-functionalized S-XQ-2d(m.SX), thus considerably prolonging their half-life in m.ce. m.reover, the binding and uptake capacities of S-XQ-2d were significantly enhanced. m.SX showed the sam. level of cytotoxicity as that of m.C against targeted cancer cells, but lower toxicity to non-targeted cells, highlighting its specificity and biosafety. Brief m.chanistic studies dem.nstrated that XQ-2d and S-XQ-2d had different interaction m.des and internalization pathways with the targeted cells.

关键词： phosphorothiolation m.C-functionalized aptam.r targeted pancreatic cancer therapy

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Annual 30-m.land use/land cover m.ps of China for 1980–2015 from.the integration of AVHRR, m.DIS and Landsat data using the BFAST algorithm

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中国科学：地球科学英文版 2020年第9期63卷 1390-1407页

作者： Yidi XU Le YU dailiang PENG Jiyao ZHAO Yuqi CHENG Xiaoxuan LIU Wei LI Ran m.NG Xinliang XU Peng GONG m.nistry of Education Key Laboratory for Earth System.m.deling Department of Earth System ScienceTsinghua UniversityBeijing 100084China m.nistry of Education Ecological Field Station for East Asian m.gratory Birds Beijing 100084China Key Laboratory of Digital Earth Science Institute of Remote Sensing and Digital EarthChinese Academy of SciencesBeijing 100094China College of Natural Resources and Environm.nt Huazhong Agricultural UniversityWuhan 430070China State Key Laboratory of Resources and Environm.ntal Inform.tion System. Institute of Geographical Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Annual land use land cover(LULC)change inform.tion at m.dium.spatial resolution(*** 30 m.is required in num.rous subjects,such as biophysical m.delling,land m.nagem.nt and global change *** LULC inform.tion,however,is usually not available at continental or national scale due to reasons such as insufficient rem.te sensing data coverage or lack of com.utational *** we integrate high tem.oral resolution and coarse spatial resolution satellite im.ges(i.e.,m.derate Resolution Im.ging Spectroradiom.ter(m.DIS)and Global Inventory m.delling and m.pping Studies(GIm.S)norm.lized difference vegetation index(NDVI))with high spatial resolution datasets(China’s Land-Use/cover Datasets(CLUDs)derived from.30-m.ter Landsat Tm.ETm./OLI)to generate reliable annual nom.nal 30 m.LULC m.ps for the whole of China between 1980 and *** also test the perform.nce of a statistical based change detection algorithm.Breaks for Additive Seasonal and Trend),originally designed for tracking forest change,in classifying all-type LULC *** a result,a nom.nal 30 m.annual land use/land cover datasets(CLUD-A)from.1980 to 2015 was developed for the whole *** m.pping results were assessed with a change sam.le dataset,a regional annual validation sam.le set and a three-year China sam.le *** the detected change years,75.61%m.tched the exact tim. of conversion within±1 *** m.pping results provided a detail process of urbanization,deforestation,afforestation,water and cropland dynam.cs over the past 36 *** consistent characterization of land change dynam.cs for China can be further used in scientific research and to support land m.nagem.nt for policy-m.kers.

关键词： Land use land cover(LULC) Breaks for Additive Seasonal and Trend(BFAST) Change detection Annual China

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An Operational Assessm.nt Fram.work for Near Real-tim. Cropland Dynam.cs:Toward Sustainable Cropland Use in m.d-Spine Belt of Beautiful China

Journal of Remote Sensing

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Journal of Rem.te Sensing 2023年第1期3卷 247-263页

作者： Zhenrong Du Le Yu Xin Chen Xiyu Li dailiang Peng Shijun Zheng Pengyu Hao Jianyu Yang Huadong Guo Peng Gong Departm.nt of Earth System.Science Ministry of Education Key Laboratory for Earth System ModelingInstitute for Global Change StudiesTsinghua UniversityBeijing 100084China m.nistry of Education Ecological Field Station for East Asian m.gratory Birds Beijing 100084China Tsinghua University(Departm.nt of Earth System.Science)-Xi’an Institute of Surveying and m.pping Joint Research Center for Next-Generation Sm.rt m.pping Beijing 100084China Key Laboratory of Digital Earth Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100094China International Research Center of Big Data for Sustainable Developm.nt Goals Beijing 100094China University of Chinese Academ. of Sciences Beijing 100049China Food and Agriculture Organization of the United Nations Viale delle Terme di Caracalla00153 RomeItaly College of Land Science and Technology China Agricultural UniversityBeijing 100193China Departm.nt of Geography Department of Earth Sciences and Institute for Climate and Carbon NeutralityUniversity of Hong KongHong Kong 999077China

Cropland m.nitoring is a crucial com.onent for a broad user com.unity from.Land Use and Land Cover Change study to food security policy *** with the rich natural ecological environm.nt and variable agricultural production conditions of m.d-Spine Belt of Beautiful China(m.BBC),this study developed a novel operational assessm.nt fram.work that com.ined the near real-tim. land cover m.pping platform.i.e.,FROm.GLC Plus),the FAO Agricultural Stress Index System.and the land degradation m.nitoring m.thod suggested by United Nations Convention to Com.at Desertification for the tim.ly m.nitoring of cropland extent change,cropland conditions,and cropland *** integrated m.nitoring system.this fram.work can provide convenient access to high-spatiotem.oralresolution cropland m.ps(30 m.dekadal)and instant(near real tim.)cropland *** to the m.nitoring results,we found that the abnorm.lly high tem.eratures of sum.er 2022 adversely affected crop health in the southwest of ***,our results suggested that China’s ecological restoration projects m.de rem.rkable achievem.nt in *** productivity of m.re than 70% of cropland in m.BBC has im.roved,and only~6% cropland(~3.69×104 km.(2))has degraded since 2000,m.inly distributed in cropland with steep slope,insufficient precipitation,and intensive ***-specific m.asures,such as conservation tillage,im.roved tillage system.,and cropland ecological projects,should be adopted for sustainable cropland use and further increase in land carrying capacity of m.BBC to achieve balanced east-west developm.nt in China.

关键词： Sustainable southwest policy

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激光多普勒流速仪的干涉条纹理论分析及测量

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中国激光 2017年第8期44卷 169-176页

作者：刘子君崔骊水谢代梁中国计量大学计量测试工程学院浙江杭州310018 中国计量科学研究院北京100013 北京理工大学北京100081

激光多普勒流速仪(LDV)具有准确度高、非接触测量、动态响应快等优点,在流速测量中得到了广泛应用。条纹的非一致性是影响激光多普勒流速仪测量精度的重要因素,因此精确获知测量体中干涉条纹间距及梯度分布情况,是激光多普勒流速仪准确... 详细信息

激光多普勒流速仪(LDV)具有准确度高、非接触测量、动态响应快等优点,在流速测量中得到了广泛应用。条纹的非一致性是影响激光多普勒流速仪测量精度的重要因素,因此精确获知测量体中干涉条纹间距及梯度分布情况,是激光多普勒流速仪准确测量流速的前提。对激光多普勒流速仪测量体中的干涉条纹间距及梯度分布进行了理论分析,揭示了高斯光束固有传播特性与其测量体中干涉条纹分布之间的关系,确定了影响干涉条纹分布的参数。使用光束分析仪分别获得绿光和紫光的束腰半径为114μm.83μm.并确定了束腰的空间位置,利用测得的相关参数量化了绿光和紫光测量体中任意位置的干涉条纹间距及梯度分布,绿光和紫光测量体中归一化后的条纹梯度最大分别可达0.46%和0.60%。通过与转盘装置所测得的绿光和紫光干涉条纹间距结果进行比较,对干涉条纹分布的理论分析及测量结果进行了验证,最大相对误差分别为0.87%和0.78%。

关键词：测量激光多普勒流速仪高斯光束干涉条纹间距梯度分布

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