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Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB

Food Science and Human Wellness 2024年第1期13卷 211-224页

作者： Xianshe Meng Shihong Zheng Zequn Yin Xuerui Wang daigang yang Tingfeng Zou Huaxin Li Yuanli Chen Chenzhong Liao Zhouling Xie Xiaodong Fan Jihong Han Yajun Duan Xiaoxiao yang Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes College of Food and Biological EngineeringHefei University of TechnologyHefei 230601China Tianjin Key Laboratory of human Development and Reproductive Regulation Department of General GynecologyTianjin Central Hospital of Gynecology and ObstetricsTianjin 300100China Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials of Ministry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China

Psoriasis is a chronic autoimmune disease featured by patches on the skin.It is caused by malfunction of immune cells and keratinocytes with inflammation as one of its key features.Apigenin(API)is a natural flavonoid with anti-inflammatory and immunoregulatory properties.Therefore,we speculated that API can ameliorate psoriasis,and determined its effect on the development of psoriasis by using imiquimod(IMQ)-induced psoriasis mouse model.Our results showed that API attenuated IMQ-induced phenotypic changes,such as erythema,scaling and epidermal thickening,and improved splenic hyperplasia.Abnormal differentiation of immune cells was restored in API-treated mice.Mechanistically,we revealed that API is a key regulator of signal transducer activator of transcription 3(STAT3).API regulated immune responses by reducing interleukin-23(IL-23)/STAT3/IL-17A axis.Moreover,it suppressed IMQ-caused cell hyperproliferation by inactivating STAT3 through regulation of extracellular signal-regulated kinase 1/2 and nuclear factor-κB(NF-κB)pathway.Furthermore,API reduced expression of inflammatory cytokines through inactivation of NF-κB.Taken together,our study demonstrates that API can ameliorate psoriasis and may be considered as a strategy for psoriasis treatment.

关键词： Psoriasis Apigenin Imiquimod Inflammation Signal transducer activator of transcription 3 (STAT3) Nuclear factor-κB(NF-κB)

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Genomic divergence in cotton germplasm related to maturity and heterosis

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Journal of Integrative Plant Biology 2019年第8期61卷 929-942页

作者： Shoupu He Gaofei Sun Longyu Huang daigang yang Panhong Dai Dayun Zhou Yuzhen Wu Xiongfeng Ma Xiongming Du Shoujun Wei Jun Peng Meng Kuang Research Base State Key Laboratory of Cotton BiologyAnyang Institute of TechnologyAnyang 455000China Institute of Cotton Research of the Chinese Academy of Agricultural Sciences Anyang 455000China Department of Computer Science and Information Engineering/Data Mining Institute Anyang Institute of TechnologyAnyang 455000China

Commercial varieties of upland cotton(Gossypium hirsutum)have undergone extensive breeding for agronomic traits,such as fiber quality,disease resistance,and yield.Cotton breeding programs have widely used Chinese upland cotton source germplasm(CUCSG)with excellent agronomic traits.A better understanding of the genetic diversity and genomic characteristics of these accessions could accelerate the identification of desirable alleles.Here,we analyzed 10,522 high-quality singlenucleotide polymorphisms(SNP)with the CottonSNP63 K microarray in 137 cotton accessions(including 12 hybrids of upland cotton).These data were used to investigate the genetic diversity,population structure,and genomic characteristics of each population and the contribution of these loci to heterosis.Three subgroups were identified,in agreement with their knownpedigrees,geographical distributions,and times since introduction.For each group,we identified lineagespecific genomic divergence regions,which potentially harbor key alleles that determine the characteristics of each group,such as early maturity-related loci.Investigation of the distribution of heterozygous loci,among 12 commercial cotton hybrids,revealed a potential role for these regions in heterosis.Our study provides insight into the population structure of upland cotton germplasm.Furthermore,the overlap between lineagespecific regions and heterozygous loci,in the high-yield hybrids,suggests a role for these regions in cotton heterosis.

关键词： upland cotton fiber quality genetic diversity

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钌粉粒度对硬质合金性能的影响研究

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工具技术 2024年第7期58卷 70-73页

作者：李代刚何清勇杨万夏朱国丽贾喜庆周应涛成都工具研究所有限公司

分别添加不同粒度钌粉制备硬质合金,采用光学金相显微镜、洛氏硬度计、抗弯强度检测仪、扫描电镜及能谱分析等方法对比研究了添加不同粒度钌粉硬质合金的性能和钌在钴中的固溶量。结果表明:随着钌粉粒度的降低,合金的抗弯强度、洛氏硬... 详细信息

分别添加不同粒度钌粉制备硬质合金,采用光学金相显微镜、洛氏硬度计、抗弯强度检测仪、扫描电镜及能谱分析等方法对比研究了添加不同粒度钌粉硬质合金的性能和钌在钴中的固溶量。结果表明:随着钌粉粒度的降低,合金的抗弯强度、洛氏硬度和断裂韧性均有所提高,钌粉越细,增幅越大;随着钌粉粒度的降低,钌在β相中的固溶量有明显提高;添加不同粒度钌粉制备的硬质合金显微组织无明显差异,金相无异常。

关键词：钌粉粒度固溶度贵金属硬质合金

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Patterns of presence-absence variants in Upland cotton

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Science China(Life Sciences) 2020年第10期63卷 1600-1603页

作者： Junfang Liu Xianliang Zhang Lingling Dou Wei Li Xiaojian Zhou yangai Liu Xiaoyu Pei Zhongying Ren Wensheng Zhang Huaizhu Li Wenbo Wang Changsong Zou Kunlun He Fei Zhang Wenyu Ma Haihong Shang Hongbin Li daigang yang Guanghui Xiao Xiongfeng Ma State Key Laboratory of Cotton Biology Institute of Cotton ResearchChinese Academy of Agricultural SciencesAnyang 455000China School of Chemistry and Chemical Engineering Xianyang Normal UniversityXianyang 712000China Key Laboratory of Plant Stress Biology State Key Laboratory of Cotton BiologySchool of Life SciencesHenan UniversityKaifeng 475004China Key Laboratory of the Ministry of Education for Medicinal Plant Resources and Natural Pharmaceutical Chemistry National Engineering Laboratory for Resource Development of Endangered Crude Drugs in the Northwest of ChinaCollege of Life SciencesShaanxi Normal UniversityXi’an 710119China Zhengzhou Research Base State Key Laboratory of Cotton BiologyZhengzhou UniversityZhengzhou 450001China College of Life Sciences Shihezi UniversityShihezi 832003China

Dear Editor,Sources of genetic variations in genomes include small-scale sources(such as single-nucleotide polymorphisms(SNPs),insertions/deletions(InDels),and simple sequence repeats and larger-scale structural variations(mainly presence-absence variants(PAVs))and copy number variants).PAVs are sequences that are either inserted or missing in genomes in comparison with a reference sequence or genome.PAVs can have a much longer sequence than SNPs and InDels,as illustrated in the human genome(Conrad et al.,2010).PAVs are important genomic structural variations that can directly affect genomic structure and key functional genes in the genome(Kumar et al.,2007).Moreover,the use of PAVs for studying quantitative traits has been valuable(Lam et al.,2010).

关键词： traits sequence insertion

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Gh_D11G050000参与棉花黄萎病抗性的功能分析

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棉花学报 2024年第3期36卷 211-224页

作者：黄俊森王星星杨力裴小雨贺昆仑刘艳改张飞张先亮王军马雄风杨代刚高俊山安徽农业大学生命科学学院合肥230000 中国农业科学院棉花研究所/棉花生物育种与综合利用全国重点实验室/农业农村部棉花生物学与遗传育种重点实验室河南安阳455000

【目的】克隆Gh_D11G050000基因,解析其在棉花黄萎病抗性反应中的功能和作用机制,为开展棉花抗病分子育种提供理论依据。【方法】利用生物信息学方法分析Gh_D11G050000基因的序列特征和系统进化关系。通过实时荧光定量聚合酶链式反应(qu... 详细信息

【目的】克隆Gh_D11G050000基因,解析其在棉花黄萎病抗性反应中的功能和作用机制,为开展棉花抗病分子育种提供理论依据。【方法】利用生物信息学方法分析Gh_D11G050000基因的序列特征和系统进化关系。通过实时荧光定量聚合酶链式反应(quantitative real-time polymerase chain reaction, qRT-PCR)分析该基因的表达模式以及大丽轮枝菌(Verticillium dahliae)侵染后的表达量变化。利用病毒诱导的基因沉默(virus-induced gene silencing, VIGS)技术初步验证该基因的功能。通过转录组测序分析和相关基因的表达量测定初步解析其抗病机制。【结果】Gh_D11G050000与Gh_A11G049600和Gr_11G034620蛋白的亲缘关系最近。qRT-PCR分析发现,Gh_D11G050000在棉花根部的表达量最高;该基因的表达量在大丽轮枝菌侵染后显著增加。Gh_D11G050000沉默植株对大丽轮枝菌的抗性减弱,具体表现为茎秆维管束褐变加重,有病菌繁殖的茎段数量明显增加,病株率和病情指数显著升高。转录组及qRT-PCR分析表明,Gh_D11G050000沉默棉株中茉莉酸、乙烯信号通路和木质素合成途径中相关基因的转录水平降低。【结论】Gh_D11G050000通过影响木质素合成基因、茉莉酸和乙烯信号通路相关基因的表达正调控棉花对黄萎病的抗性。

关键词：陆地棉黄萎病 Gh_D11G050000 抗病基因病毒诱导的基因沉默茉莉酸乙烯木质素

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UPWIND FINITE VOLUME ELEMENT METHODS FOR ONE-DIMENSIONAL SEMICONDUCTOR DEVICE

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Journal of Systems Science & Complexity 2011年第5期24卷 1007-1019页

作者： Chuanjun CHEN Wei LIU daigang LU Department of Mathematics and Information Science Yantai University Yantai 264005 China School of Statistics and Mathematics Shandonq Economic University Jinan 250014 China

一个充分分离的含蓄的 Euler 迎风的有限体积元素方法为一个维的半导体设备被导出并且学习。迎风的计划被介绍在半导体模型处理传送对流主导的散开方程。与为静电的潜力和另外的未知数量的不同时间步骤，方法的计算过程被获得。本地集... 详细信息

一个充分分离的含蓄的 Euler 迎风的有限体积元素方法为一个维的半导体设备被导出并且学习。迎风的计划被介绍在半导体模型处理传送对流主导的散开方程。与为静电的潜力和另外的未知数量的不同时间步骤，方法的计算过程被获得。本地集体能量守恒定律在迎风的有限体积元素计划的框架下面被保存。在 L 2 标准的一阶的精确性被证明。数字实验被给验证方法的实用性和效率。

关键词：有限体积元方法半导体器件迎风一维计划项目高等教育基金资助自然科学

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Study of the Surface Morphology of Gas Hydrate

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Journal of Ocean University of China 2020年第2期19卷 331-338页

作者： SUN Jianye LI Chengfeng HAO Xiluo LIU Changling CHEN Qiang WANG daigang The Key Laboratory of Gas Hydrate Ministry of Natural ResourcesQingdao Institute of Marine GeologyQingdao 266071China Laboratory for Marine Mineral Resources Pilot National Laboratory for Marine Science and TechnologyQingdao 266071China International Center for Gas Hydrate Peking UniversityBeijing 100871China

Study of the surface morphology of gas hydrate is of great importance in understanding its physical properties and occurrence.In order to investigate the surface morphology of different types(sI and sII)and occurrences(pore-filling and fracture-filling)of gas hydrate,both lab-synthesized and drilled-gas hydrate samples were measured using cryo-scanning electron microscopy(cryo-SEM).Results showed that the surface of s I hydrate was relatively smooth,and spongy nano-pores(200–400 nm)gradually occurred at the surface during continuous observation.The surface of sII hydrate was more compact,showing a tier-like structure.Hydrate occurred in quartz sand and usually filled the pores of the sediments and both hydrate and sediments were cemented with each other.SEM observation of the gas hydrates collected from the South China Sea showed that the surface morphology and contact relation with sediments varied with hydrate occurrence.For instance,hydrates dispersed in sediments mainly filled the pores of the sediments.The existence of microorganism shells,such as foraminifera,was beneficial to the formation of gas hydrate.When hydrate occurred as a massive or vein structure,it was easily distinguished from the surrounding sediments.The surface of hydrate with massive or vein structure showed two distinct characters:one was dense and smooth,the other is porous(several to tens of micrometers in diameter).The occurrence of different hydrate morphologies was probably caused by the supplement rates of methane gas.

关键词： gas hydrate surface morphology cryo-SEM grain contacts

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A new approach to dissecting complex traits by combining quantitative trait transcript (QTT) mapping and diallel cross analysis

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Chinese Science Bulletin 2012年第21期57卷 2695-2700页

作者： yang daigang YE ChengYin MA XiongFeng ZHU ZhiHong ZHOU XiaoJian WANG HaiFeng MENG QingQin PEI XiaoYu YU ShuXun ZHU Jun Cotton Research Institute Chinese Academy of Agricultural SciencesState Key Laboratory of Cotton BiologyAnyang 455000China Department of Agronomy Zhejiang UniversityHangzhou 310058China

A promising way to uncover the genetic architectures underlying complex traits may lie in the ability to recognize the genetic variants and expression transcripts that are responsible for the traits' inheritance.However,statistical methods capable of investigating the association between the inheritance of a quantitative trait and expression transcripts are still limited.In this study,we described a two-step approach that we developed to evaluate the contribution of expression transcripts to the inheritance of a complex trait.First,a mixed linear model approach was applied to detect significant trait-associated differentially expressed transcripts.Then,conditional analysis were used to predict the contribution of the differentially expressed genes to a target trait.Diallel cross data of cotton was used to test the application of the approach.We proposed that the detected differentially expressed transcripts with a strong impact on the target trait could be used as intermediates for screening lines to improve the traits in plant and animal breeding programs.It can benefit the discovery of the genetic mechanisms underlying complex traits.

关键词：双列杂交分析数量性状成绩差异表达基因映射解剖混合线性模型遗传变异

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共同富裕目标下西南民族山区农业现代化:理论、政策与实践

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重庆社会科学 2023年第5期 30-46页

作者：黄厅厅黄庆华徐代刚广西大学公共管理学院广西南宁530004 铜仁学院经济管理学院贵州铜仁554300 西南大学经济管理学院重庆400715 铜仁市农业农村局现代农业产业发展招商服务中心贵州铜仁554300

西南民族山区农业现代化的实现程度极大影响着国家现代化的整体性、全面性与协调性,尤其是西南民族山区评价体系构建与指标选取,需因时而新、因地而异、因需而进。立足问题与需求导向,诠析共同富裕目标下农业现代化的理论拟合与价值意涵... 详细信息

西南民族山区农业现代化的实现程度极大影响着国家现代化的整体性、全面性与协调性,尤其是西南民族山区评价体系构建与指标选取,需因时而新、因地而异、因需而进。立足问题与需求导向,诠析共同富裕目标下农业现代化的理论拟合与价值意涵,阐释改革开放以来党对农业现代化的顶层谋划与创新发展,为西南民族山区的铜仁市建构包含3大目标层、10类要素层、30项指标层的农业现代化综合评价体系,夯实理论逻辑与政策逻辑,进而重塑西南民族山区农业现代化的体系建构与实践依据。研究结果为铜仁市推动农业现代化工作提供监测工具与决策依据,为西南民族山区推动农业现代化进程提供逻辑基础与智慧支撑。

关键词：农业现代化共同富裕逻辑机理评价体系西南民族山区

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草甘膦致桑树药害的安全风险评价分析

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江苏农业科学 2010年第6期38卷 476-479页

作者：王代钢安康学院/陕西省蚕桑重点实验室陕西安康725000

草甘膦有导致桑树发生药害的重大风险,风险程度因受害器官不同而有差异。模拟药害试验结果表明:叶芽受药害风险最高,其次是新梢绿茎部位;茎干药害对新芽产生轻微影响,对树体发生药害的风险低;桑根发生药害的风险极低。使用有定向喷头的... 详细信息

草甘膦有导致桑树发生药害的重大风险,风险程度因受害器官不同而有差异。模拟药害试验结果表明:叶芽受药害风险最高,其次是新梢绿茎部位;茎干药害对新芽产生轻微影响,对树体发生药害的风险低;桑根发生药害的风险极低。使用有定向喷头的低压喷雾器、药液浓度适当偏稀、不添加其他助剂,能够降低药害风险,保障除草作业安全。

关键词：桑树草甘膦药害安全风险

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