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Science China Chemistry 2024年

作者： Ying-Qi Zhang Gan-Lu Qian Yun Liu Jia-Hui Li Xin Hong Zhou Xu Bo Zhou Long-wu Ye State Key Laboratory of Physical Chemistry of Solid Surfaces Key Laboratory of Chemical Biology of Fujian Province and College of Chemistry and Chemical Engineering Xiamen University Center of Chemistry for Frontier Technologies Department of Chemistry State Key Laboratory of Clean Energy Utilization Zhejiang University Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy School of Pharmacy Xuzhou Medical University State Key Laboratory of Elemento-Organic Chemistry Nankai University State Key Laboratory of Organometallic Chemistry Chinese Academy of Sciences

Herein, we disclose a highly regio-/chemoselective tandem asymmetric dearomatized halofunctionalization reaction of phenoltethered ynamides with diverse electrophilic halogenation sources in a catalyst-free manner for the practical and rapid assembly of a series of halogenated spirocyclic enones. Besides, the related dearomatized selenation and protonation are also achieved,affording the corresponding selenated and protonated spirocycles in high efficiency. Moreover, the enantioselectivities of these products can be perfectly induced by Evans auxiliaries (99%ees). Significantly, this protocol not only represents the first tandem asymmetric halofunctionalization reaction of phenol derivatives, but also constitutes the first asymmetric halogenation/selenation of ynamides. Theoretical calculations indicate a remote induction model of Evans chiral auxiliary-attached keteniminium.

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超高效液相色谱法测定食品接触材料中5种丙烯酸类化合物的迁移量及其迁移规律探讨

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理化检验（化学分册） 2024年第9期60卷 915-921页

作者：吴敏莲黄伟乾吴国利吴俊发叶玲广州检验检测认证集团有限公司国家加工食品质量检验中心(广东)广州511447

提出了超高效液相色谱法测定食品接触材料中丙烯酸、丙烯酸甲酯、丙烯酸-2-羟乙基酯、甲基丙烯酸、2-羟乙基-2-甲基-2-丙烯酸酯等5种丙烯酸类化合物迁移量的方法。以水、20%(体积分数,下同)乙醇溶液、4%(体积分数)乙酸溶液、橄榄油作食... 详细信息

提出了超高效液相色谱法测定食品接触材料中丙烯酸、丙烯酸甲酯、丙烯酸-2-羟乙基酯、甲基丙烯酸、2-羟乙基-2-甲基-2-丙烯酸酯等5种丙烯酸类化合物迁移量的方法。以水、20%(体积分数,下同)乙醇溶液、4%(体积分数)乙酸溶液、橄榄油作食品模拟物,按照GB 31604.1—2015和GB 5009.156—2016的要求,水基模拟物的浸泡液过0.22μm有机滤膜直接进样分析;取橄榄油浸泡液5 g置于50 mL离心管中,加入5 mL甲醇,涡旋2 min,以转速8 000 r·min^(-1)离心5 min,过0.22μm有机滤膜,滤液上机分析。以Xbridge BEH C_(18)色谱柱为固定相,以不同体积比的0.1%(体积分数)磷酸溶液-乙腈混合液为流动相进行梯度洗脱,在210 nm处用光电二极管阵列检测器测定。结果表明,水基模拟物中丙烯酸类化合物的质量浓度均在0.3~10.0 mg·L^(-1)内与对应的峰面积呈线性关系,检出限(3S/N)均为0.1 mg·L^(-1),橄榄油中丙烯酸类化合物的质量分数均在0.3~10.0 mg·kg^(-1)内与对应的峰面积呈线性关系,检出限(3S/N)均为0.1 mg·kg^(-1);按照标准加入法进行回收试验,回收率为80.6%~99.8%,测定值的相对标准偏差(n=6)均小于8.0%;方法用于食品接触材料样品的分析,其中1份样品中检出丙烯酸甲酯。探究阳性食品接触材料中丙烯酸甲酯在不同模拟物、不同迁移温度和不同迁移时间下的迁移规律,结果表明,丙烯酸类化合物在20%乙醇溶液和橄榄油中迁移能力较强,迁移量随迁移温度的升高而增大,达到最大值后增幅趋于平稳,迁移量达到最大值所需迁移时间也随迁移温度的升高而缩短。

关键词：超高效液相色谱法食品接触材料丙烯酸类化合物迁移规律

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Resistance to the Strawberry Neopestalotiopsis Crown Rot of Collections from National Germplasm Repository for Strawberry in JAAS

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Resistance to the Strawberry Neopestalotiopsis Crown Rot of ...

Corrigendum to“3Cpro of FMDV inhibits type II interferon-stimulated JAK-STAT signaling pathway by blocking STAT1 nuclear translocation”[Virol Sin 38(2023)387–397]

中国植物病理学会2024年学术年会

作者： wu Ejiao YANG Huijuan PANG Fuhua ZHAO Mizhen QIAO Yushan Institute of Pomology Jiangsu Academy of Agricultural Sciences/Jiangsu Key Laboratory for Horticultural Crop Genetic Improvement College of Horticulture Nanjing Agricultural University

In recent years strawberry crown rot caused by Neopestalotiopsis *** occurred in many places in China,leading to an increasing economic *** order to understand the resistance level of strawberry germplasm resources,321 cultivated varieties selected from the demonstration bases and National Germplasm Repository for Strawberry in Jiangsu Academy of Agricultural Sciences were determined for resistance to Neopestalotiopsis crown rot by a detached leaf assay through pathogen plugs and conidia suspension *** lesion growth rate was calculated by the AUDPC(Area Under the Disease Progress Curve) and the number of conidia production was collected by the hemocytometer under optical electron microscopy for five *** results showed that strawberry germplasm resources from different geographical sources was different,strawberry cultivars from Japanese such as ' Benihoppe''Kaorino' generally exhibit higher resistance,whereas cultivars from European and American such as' Sweet Charlie' 'Mara des Bois' tend to display lower *** total AUDPC was ranging from0.00 to 5.73 and 0.00 to 5.78,with the average of 1.10 and 1.19 for the pathogen plugs and conidia suspension inoculation,*** average conidia production was 20.87,with the highest number of 172.25 for 'Mara des Bois',and lowest number of 0.08 for 'jiuxiang'.The immunity(I),high resistance(HR),resistance(R),moderate resistance(MR),susceptibility(S),and high susceptibility(HS) was account for 0.01%,27.10%,11.46%,26.79%,6.23% and26.79%,*** results provide a scientific basis for selection of resistance varieties in practical production and breeding disease-resistant strawberry cultivars in the future.

关键词： Neopestalotiopsis crown rot resistance area under the disease progress curve conidia production

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Virologica Sinica 2024年第2期39卷 351-354页

作者： Xiangju wu Lei Chen Chao Sui Yue Hu Dandan Jiang Fan Yang Laura C.Miller Juntong Li Xiaoyan Cong Nataliia Hrabchenko Changhee Lee Yijun Du Jing Qi Shandong Key Laboratory of Animal Disease Control and Breeding Key Laboratory of Livestock and Poultry Multi-omics of MARAInstitute of Animal Science and Veterinary MedicineInstitute of Crop Germplasm ResourcesShandong Academy of Agricultural SciencesJinan250100China College of Life Science Shandong Normal UniversityJinan250358China State Key Laboratory of Veterinary Etiological Biology National Foot and Mouth Disease Reference LaboratoryKey Laboratory of Animal Virology of Ministry of AgricultureLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou730050China Department of Diagnostic Medicine and Pathobiology College of Veterinary MedicineKansas State UniversityManhattanKS66506USA College of Veterinary Medicine and Virus Vaccine Research Center Gyeongsang National UniversityJinju52828Republic of Korea

Due to our negligence,the original version of this article,published online on Mar 14,2023,contained some mistakes in several *** Fig.2D,the positions of the bands for protein 3A and 3B were incorrectly *** has been m... 详细信息

关键词： STAT1 FMDV bands

环境高浓度多离子饮水和高温暴露诱导小鼠肾脏功能损伤

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环境与职业医学 2024年第5期41卷 546-551,559页

作者：刘盈莹丁凡王若静吴璇张林吴庆复旦大学公共卫生学院/公共卫生安全教育部重点实验室上海200032

[背景]慢性肾病(CKD)的全球疾病负担日益严重。环境因素是不明原因慢性肾病(CKDu)的诱发因素之一。然而,饮用环境高浓度多离子水和高温暴露对肾脏功能的影响尚无确凿毒理学证据。[目的]初步探究饮用环境高浓度氟钙钠溴离子水和高温暴露... 详细信息

[背景]慢性肾病(CKD)的全球疾病负担日益严重。环境因素是不明原因慢性肾病(CKDu)的诱发因素之一。然而,饮用环境高浓度多离子水和高温暴露对肾脏功能的影响尚无确凿毒理学证据。[目的]初步探究饮用环境高浓度氟钙钠溴离子水和高温暴露对小鼠肾脏功能的影响。[方法]将雄性ICR小鼠(8周龄)随机分组。以3 mg·L^(-1)氟离子、250 mg·L^(-1)钙离子、400 mg·L^(-1)钠离子和1 mg·L^(-1)溴离子(模拟斯里兰卡CKDu高发地区地下水高浓度离子)及32℃高温建立小鼠饮水暴露模型,分为氟钙钠溴离子与高温混合暴露组,各离子和高温单独暴露组,氟钙钠离子暴露组,氟钙钠溴离子暴露组。对照组动物给予一般纯净水,正常室温环境(23±2)℃。连续暴露12周后,测定体重和肝(肾)脏器系数,通过苏木精-伊红染色法(HE)染色和病理评分评估肾组织病理学损伤。收集暴露12周末的24 h尿,测定肌酐(UCr)、白蛋白(ALB)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)和β2-微球蛋白(β2-MG)水平。使用TUNEL法检测细胞凋亡。[结果]与对照组相比,氟钙钠溴离子与高温混合暴露组的小鼠体重显著下降,肾组织病理学损伤评分和尿β2-MG水平均显著升高(P0.05),但肾脏组织病理学损伤评分增加(P0.05)。氟钙钠离子暴露组与氟钙钠溴离子暴露组小鼠肾组织病理学损伤评分差异也无统计学意义(P>0.05)。溴离子与氟钙钠离子对肾组织病理损伤的交互作用无统计学意义(P>0.05)。TUNEL实验发现,氟钙钠离子暴露可诱导肾小管上皮细胞凋亡(P<0.05)。[结论]环境高浓度氟钙钠离子饮水混合暴露可导致肾脏组织病理损伤,高温单独暴露不影响肾脏组织病理损伤,但与高氟钙钠离子饮水混合暴露时可加剧肾小管功能损伤。

关键词：氟钙钠溴高温混合暴露肾损伤凋亡

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基于光学隐藏视觉密码的欺骗追踪系统

物理学报 2024年第14期73卷 78-86页

作者：吴承哲刘睿泽史祎诗河北工程大学数理科学与工程学院邯郸056038 中国科学院大学光电学院北京100049 中国科学院空天信息创新研究院北京100094

提出了一种基于光学隐藏视觉密码的欺骗追踪系统.该系统将秘密图像分解为多幅有实际意义的掩饰图像,将其中一张掩饰图像嵌入脆弱水印,作为检验密钥,检验密钥单独传输.然后将其余掩饰图像隐藏在相位密钥中,进行传输时有很好的不可见性.... 详细信息

提出了一种基于光学隐藏视觉密码的欺骗追踪系统.该系统将秘密图像分解为多幅有实际意义的掩饰图像,将其中一张掩饰图像嵌入脆弱水印,作为检验密钥,检验密钥单独传输.然后将其余掩饰图像隐藏在相位密钥中,进行传输时有很好的不可见性.掩饰图像的像素排列若被不诚实的参与者篡改,则称为欺骗图像.将每张相位密钥分发给不同的参与者,以保证在追踪到欺骗图像时可找到对应的欺骗者.在提取过程中,只需要对该相位密钥进行傅里叶变换,即可得到掩饰图像.检验时,将检验密钥与任一掩饰图像进行非相干叠加,以是否出现验证图像为条件,就可检验掩饰图像是否被篡改,以达到欺骗追踪的目的,将数量大于等于门限k的掩饰图像和检验密钥进行非相干叠加即可得到秘密图像,仿真实验结果表明,该系统可应用于利用不可见视觉密码术传递实际信息时,对内部欺骗者的追踪.

关键词：光学隐藏视觉密码相位密钥欺骗追踪

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Liver abscess and tracheal fistula induced by transcatheter arterial chemoembolization for hepatocellular carcinoma:A case report

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World Journal of Clinical Cases 2024年第16期12卷 2911-2916页

作者： Fu-Long Zhang Jing Xu Yu-Hong Jiang Yuan-Dong Zhu Qian-Neng wu Yan Shi Fang-Yuan Zhu Jing-Wen Chen Liang-Xiao wu Department of Gastroenterology Hangzhou Xixi HospitalHangzhou 310023Zhejiang ProvinceChina Department of Hepatopathy Hangzhou Xixi HospitalHangzhou 310023Zhejiang ProvinceChina

BACKGROUND Transarterial chemoembolization(TACE)is a standard treatment for intermediate-stage hepatocellular carcinoma(HCC).The complications of TACE include biliary tract infection,liver dysfunction,tumor lysis syndrome,biloma,partial intestinal obstruction,cerebral lipiodol embolism,*** are few reports about tracheal fistula induced by *** SUMMARY A 42-year-old man came to our hospital with cough and expectoration for 1 month after TACE for *** test results showed abnormalities of albumin,hemoglobin,prothrombin time,C-reactive protein,D-dimer,and *** of both phlegm and liver pus revealed growth of Citrobacter *** tomography showed infection in the inferior lobe of the right lung and a low-density lesion with gas in the right *** ultrasound showed that there was a big hypoechoic liquid lesion without blood flow *** for liver abscess by needle puncture under ultrasonic guidance was *** 1 month of drainage and anti-infection therapy,the abscess in the liver and the infection in the lung were reduced obviously,and the symptom of expectoration was *** Clinicians should be alert to the possibility of complications of liver abscess and tracheal fistula after TACE for *** for liver abscess by needle puncture under ultrasonic guidance could relieve the liver abscess and tracheal fistula.

关键词： Tracheal fistula Liver abscess Transcatheter arterial chemoembolization Hepatocellular carcinoma Drainage Case report

Fecal microbiota transplantation from blueberry and blackberry anthocyanins-supplemented mice ameliorated metabolic syndrome by regulating gut microbiota in a high-fat diet model

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Food Science and Human Wellness 2024年

作者： Lanlan Du Xiaoqin Ding Yan Chen Han Chen Han Lü Yanan Gai Tunyu Jian Wenlong wu Jian Chen Weilin Li Co-Innovation Center for Sustainable Forestry in Southern China， College of Forestry， Nanjing Forestry University Jiangsu Key Laboratory for the Research and Utilization of Plant Resources， Institute of Botany， Jiangsu Province and Chinese Academy of Sciences

Blueberry anthocyanins (VA) and blackberry anthocyanins (RA) showed benefits on metabolic syndrome (MS) induced by high-fat diet in mice. In this study， we investigated whether the therapeutic effects of VA and RA were achieved by the gut microbiota regulation and whether these effects could be replicated through fecal microbiota transplantation (FMT) using the high-fat diet caused MS model in pseudo-germ-free (PGF) mice. The results demonstrated that the beneficial effects of VA and RA on MS， including reducing body weight gain and fat accumulation， improving glucose and lipid metabolism， and mitigating intestinal barrier damage， were attributed to the gut microbiota and could be replicated by FMT. 16S rRNA sequencing analysis suggested that FMT from donor mice supplemented with VA and RA could regulate the gut microbiota composition. Particularly， FMT from RA supplemented mice displayed the potential to restore the diversity of gut microbiota and the ratio of Firmicutes to Bacteroidetes. Meanwhile， FMT from VA supplemented mice appeared to exert its effects by selectively influencing specific gut microbiota， such as the genus Akkermansia. Furthermore， our analysis identified 10 common differential ASVs among groups compared to HFD-HFD group. Notably， ASV＿36450 was negatively associated with metabolic parameters， suggesting that Lactobacillus might be the potential bacteria in regulating MS. Overall， our study demonstrated that FMT from VA and RA supplemented mice could ameliorate MS induced by high-fat diet in mice through regulating specific gut microbiota.

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Deriving skeletal muscle cells from adipose-derived stem cells:Current differentiation strategies

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Chinese Medical Journal 2024年第12期137卷 1498-1500页

作者： Wei Liang Meng Han Huiting wu Wanwen Dang Xiaoyu Meng Yonghuan Zhen Yang An Department of Plastic Surgery Peking University Third HospitalBeijing 100191China

To the Editor:Adipose-derived stem cells(ASCs)are promising multipotent stem cells for regeneration of skeletal muscle(SM)tissues.[1]However,the low myogenic differentiation ability limits the application.[2]Therefore,it is necessary to summarize the current differentiation strategy to improve the differentiation *** methods(biochemical induction)and non-traditional strategies(co-culture,biomechanical approaches,and biomaterial utilization)are commonly used for the differentiation of ASCs into myogenic *** both strategies can effectively induce differentiation of myogenic cells,cellular unhealthy or immature myogenic differentiation status is still the greatest challenge for ***,the combination of non-traditional methods and traditional methods has the potential to significantly enhance myogenesis of ASCs with remarkable efficacy,however,evidence is currrently *** review discusses the traditional and non-traditional strategies,as well as several combination motheds of above strategies,for inducing ASCs differentiation into myogenic cells[Figure 1].

关键词： skeletal Figure strategies

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Cratonic Strike-Slip Faults in the Southwest Ordos Basin(Central China)， and Their Influence on Hydrocarbon Accumulation

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Journal of Earth Science 2024年

作者： Zhao Wang Lei Huang Chiyang Liu Faqi He Huichong Jia Fubin Wang Peng Yang Fei Yang Xiaowei Li Sixuan wu State Key Laboratory of Continental Dynamics， Northwest University Institute of Oil and Gas Basin， Northwest University Xi'an Sinopec North China Oil and Gas Branch Geology and Geophysics Program， Missouri University of Science and Technology Exploration and Development Research Institute， PetroChina Southwest Oil & Gasfield Company

Cratonic strike-slip fault， despite its potentially significant influence on hydrocarbon accumulation， has attracted limited attention. This study investigates the geometry and kinematics of the cratonic strike-slip faults newly identified within the southwest Ordos Basin， Central China， based on 3D seismic reflection data. We recognized three dominant sets of faults with strike-slip nature trending respectively in NW， ENE， and N–S directions in the study area. These faults exhibit a stratified style characterized by distinct trends across various strata， with ENE-trending faults in the Mesozoic strata (Area A)， N-S-trending faults in the Paleozoic strata， and vertically discontinuous structures in the Mesozoic and Paleozoic strata (NW-trending Yudu fault zone and ENE-trending Yulinzi and Zaosheng fault zones). The contrasting kinematics of strike-slip faults observed in deep and shallow layers further confirm such fault stratification， suggesting isolated fault evolution within respective layers. The quantified fault parameters obtained from seismic reflection data， including length， width and displacement， suggest that these cratonic strike-slip faults in the Ordos Basin are immature. Comparisons with strike-slip faults in other cratonic basins and active tectonic settings suggest that the strike-slip faults within the Ordos Basin are representative of cratonic strike-slip faults， characterized by low maturity and a stratified faulting style， and they have special propagation mechanism (preferentially occurring in the shallow strata of the interior of the basin). Moreover， these fault characteristics have dual impacts on petroleum accumulation in the southwest Ordos Basin. The low faulty maturity makes the fault zone a special hydrocarbon reservoir (fault-fracture volume) in tight sandstone， while the stratified faulting style vertically separates the Mesozoic and Paleozoic petroleum systems in the southwest Ordos Basin. Our findings therefore contribute significa

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