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Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms

Stroke & Vascular Neurology 2019年第1期4卷 36-42页

作者： Edgar A Samaniego Emilee Gibson daichi nakagawa Santiago Ortega-Gutierrez Mario Zanaty Jorge A Roa Pascal Jabbour David M Hasan Department of Neurology Neurosurgery and RadiologyUniversity of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurology University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurosurgery Thomas Jefferson UniversityPhiladelphiaPennsylvaniaUSA

Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling(SAC)and flow *** IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy(DAPT)are required to prevent thromboembolic complications *** sought to determine the safety of tirofiban and DAPT in these *** We conducted a retrospective analysis of our database for patients with intracranial aneurysms who underwent SAC or flow *** tirofiban-DAPT protocol used is *** regarding duration of infusion,placement of external ventricular devices(EVDs),complications,haemoglobin levels and platelet count before and 24 hours after antiplatelet therapy were collected and *** One-hundred and forty-one patients with 148 aneurysms/procedures were included.110 aneurysms were treated acutely and 38 *** and major haemorrhagic events were recognised in 20%(30/148)*** 5(3.4%)intracerebral haemorrhages were symptomatic:3 cortical/SAH and 2 *** average blood volume in symptomatic haemorrhages was 24.8 cc versus 5.42 cc in asymptomatic haemorrhages(p=0.002).The rate of EVD-related haemorrhages was 15.7%(19/121)and only 2(1.7%)were *** haemorrhagic events occurred in ruptured aneurysms(90.1%,p=0.01).No significant change in platelet count or haemoglobin levels before and 24 hours after administration of tirofiban and DAPT was *** administration of heparin did not increase haemorrhagic *** The use of the GP IIb/IIIa inhibitors tirofiban and DAPT in this series was *** and DAPT did not affect platelet count or haemoglobin levels and did not increase rate of symptomatic haemorrhages or thromboembolic complications.

关键词： aneurysm intracranial infusion

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Evolution of Microstructure from the Surface to the Interior of Cr-Mo Steel by Water Jet Peening

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Materials Sciences and Applications 2017年第10期8卷 708-715页

作者： Masataka Ijiri daichi Shimonishi Daisuke nakagawa Toshihiko Yoshimura Tokyo University of Science Yamaguchi Japan

The microstructure and hardness on and below the surface of Cr-Mo steel (SCM435) treated by water jet peening (WJP) were investigated using scanning electron microscopy and micro Vickers hardness measurements. The change of the surface residual stress caused by the WJP treatment influenced the surface microstructure and surface hardness of the SCM435 steel. Cementite in the pearlite phase tended to protrude as the duration of WJP was increased. Voids were formed in the area 0.5 - 1.0 mm below the surface and also at grain boundaries between ferrite and pearlite grains, whereas no voids were formed in the depth range from 2.0 to 3.0 mm below the surface.

关键词： Water Jet Peening Cr-Mo Steel Surface Reforming Microstructure Voids

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Surface Modification of Ni-Cr-Mo Steel by Multifunction Cavitation

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材料科学与工程（中英文A版） 2017年第6期7卷 290-296页

作者： Masataka Ijiri daichi Shimonishi Daisuke nakagawa Kumiko Tanaka Toshihiko Yoshimura Tokyo University of Science Yamaguchi 1-1-1 Daigaku-Dori Sanyo-Onoda Yamaguchi 756-0084 Japan

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