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Hypomethylation of Thyroid Peroxidase as a Biomarker for Hepatocellular Carcinoma with Tumor Thrombosis

Current Medical Science 2022年第6期42卷 1248-1255页

作者： Ru-ting XIE Qian-yu LI Xue-chen SUN Qing-jun ZHI Xiang-xiang HUANG Xing-chen ZHU Qi-zeng MIAO Dai-zhan zhou Dong-yan HAN Department of Pathology Shanghai Tenth People’s HospitalTongji University School of MedicineShanghai200072China Bio-X Center Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong UniversityShanghai200000China

Objective Thyroid hormones(THs)regulate multiple physiological activities in the liver,including cellular metabolism,differentiation,and cell growth,and play important roles in the pathogenesis of hepatocellular carcinoma(HCC).Thyroid peroxidase(TPO)is a key molecule involved in the THs synthesis and signaling pathway.As an epigenetic modification,DNA methylation has a critical role in tumorigenesis with diagnostic potential.However,the connection between THs and DNA methylation has been rarely investigated.Methods The methylation of key TH-related genes was analyzed by in-house epigenome-wide scanning,and we further analyzed the methylation levels of the TPO promotor in 164 sample pairs of HCC and adjacent non-cancerous tissues by Sequenom EpiTYPER assays,and evaluated their clinical implications.Results We identified that the methylation of the TPO promoter was downregulated in the HCC tissues(P<0.0001)with a mean difference ranging from 18.5%to 22.3%.This methylation pattern correlated with several clinical factors,including a multi-satellite tumor,fibrous capsule,and the presence of tumor thrombus.The receiver operator characteristic(ROC)curve analysis further confirmed that the percent methylated reference(PMR)values for TPO were predictive of the tumor[the area under the curve(AUC)ranged from 0.755 to 0.818]and the thrombosis in the HCC patients(the AUC ranged from 0.706 to 0.777).Conclusion These findings demonstrated that epigenetic alterations of TPO,as indicated by the PMR values,were a potential biomarker for HCC patients with tumor thrombosis.

关键词： thyroid hormones thyroid peroxidase hepatocellular carcinoma methylation tumor thrombosis

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Low-temperature catalytic combustion of trichloroethylene over MnO_(x)-CeO_(2)mixed oxide catalysts

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稀土学报：英文版 2023年第4期41卷 523-530页

作者： Kai Shen Mingxiang Jiang Xinwei Yang Weizhong zhou Qiguang dai Xingyi Wang Li Wang Yun Guo Yanglong Guo Wangcheng zhan Key Laboratory for Advanced Materials Research Institute of Industrial CatalysisSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Hudong Heavy Machinery Co. Ltd.Shanghai 200237China

The cerium-based catalysts were investigated for the catalytic co mbustion of trichlo roethylene(TCE)and exhibit a surprising catalytic activity.MnO_(x)was doped into CeO_(2)by a citric acid(CA)sol-gel method,and the effect of Mn content on the physicochemical properties and catalytic activities of MnO_(x)-CeO_(2)mixed oxides was investigated systemically.The introduction of MnO_(x)into CeO_(2)can evidently improve the catalytic activity and reaction stability of the CeO_(2)catalyst,and the catalytic activity can be maintained for more than 100 h at 250℃under air atmosphere.Moreover,a possible reaction mechanism and a catalytic cycle for the catalytic combustion of TCE over the MnO_(x)-CeO_(2)mixed oxide catalysts are proposed.

关键词： Catalytic combustion Trichloroethylene Cerium oxide Manganese oxide Rare Earths

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Surface tuning of LaCoO_(3) perovskite by acid etching to enhance its catalytic performance

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Rare Metals 2021年第3期40卷 555-562页

作者： Lu dai Xin-Bo Lu Guo-Hai Chu Cheng-Huan He Wang-Cheng zhan Guo-Jun zhou China Tobacco Zhejiang Industrial Co. LtdHangzhou 310024China Research Institute Catalysis School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

The stoichiometric LaCoO_(3) and nonstoichiometric LaCo_(1.2)O_(3) perovskite catalysts were prepared by citric acid sol-gel method,and then,LaCoO_(3) perovskite was etched with nitric acid.The structure,surface composition and reducibility of the catalyst were studied by X-ray diffraction(XRD),nitrogen desorption,transmission electron microscope(TEM),temperature program reduction of H_(2)(H_(2)-TPR) and X-ray photoelectron spectroscopy(XPS).It was found that nitric acid etching did not change the crystal structure and the overall morphology of the LaCoO_(3) catalyst,but it can cause the exposure of B-site Co metal to the surface of the catalyst.As a result,after acid etching,the reducibility of the LaCoO_(3) catalyst was improved,leading to the improvement in the catalytic activity of the LaCoO_(3) catalyst for CO oxidation and C_(3)H_(8) combustion.Moreover,the catalytic activity of the LaCoO_(3) catalyst after acid etching was higher than that of LaCo_(1.2)O_(3) and CoOx/LaCoO_(3) catalyst.

关键词： Perovskite oxide Acid etching CO oxidation Propane combustion

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Endoplasmic Reticulum Stress-induced Endothelial Dysfunction Promotes Neointima Formation after Arteriovenous Grafts in Mice on High-fat Diet

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Current Medical Science 2023年第1期43卷 115-122页

作者： Yan-xia ZHONG Chen-chen zhou Ying-fang ZHENG Hong-kai dai Ren-yu CHEN Yu-rou WANG Cheng-ye zhan Jin-long LUO Ai-ni XIE Emergency and Intensive Care Unit Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Divison of Cardiothoracic and Vascular Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Endothelial dysfunction is one candidate for triggering neointima formation after arteriovenous grafts(AVGs),but the factors mediating this process are unclear.The purpose of this study was to investigate the role of endoplasmic reticulum stress(ERS)-induced endothelial dysfunction in neointima formation following AVGs in high-fat diet(HFD)mice.Methods CCAAT-enhancer-binding protein-homologous protein(CHOP)knockout(KO)mice were created.Mice were fed with HFD to produce HFD model.AVGs model were applied in the groups of WT ND,WT HFD,and CHOP KO HFD.Human umbilical vein endothelial cells(HUVECs)were cultured with oxidized low density lipoprotein(ox-LDL)(40 mg/L)for the indicated time lengths(0,6,12,24 h).ERS inhibitor tauroursodeoxycholic acid(TUDCA)was used to block ERS.Immunohistochemical staining was used to observe the changes of ICAM1.Changes of ERS were detected by real-time RT-PCR.Protein expression levels and ERS activation were detected by Western blotting.Endothellial cell function was determined by endothelial permeability assay and transendothelial migration assay.Results HFD increased neointima formation in AVGs associated with endothelial dysfunction.At the same time,ERS was increased in endothelial cells(ECs)after AVGs in mice consuming the HFD.In vitro,ox-LDL was found to stimulate ERS,increase the permeability of the EC monolayer,and cause endothelial dysfunction.Blocking ERS with TUDCA or CHOP siRNA reversed the EC dysfunction caused by ox-LDL.In vivo,knockout of CHOP(CHOP KO)protected the function of ECs and decreased neointima formation after AVGs in HFD mice.Conclusion Inhibiting ERS in ECs could improve the function of AVGs.

关键词： endoplasmic reticulum stress endothelial dysfunction neointima formation arteriovenous grafts high-fat diet

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Hydrogen-Bonded Dopant-Free Hole Transport Material Enables Efficient and Stable Inverted Perovskite Solar Cells

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CCS Chemistry 2022年第9期4卷 3084-3094页

作者： Rui Li Chongwen Li Maning Liu Paola Vivo Meng Zheng Zhicheng dai Jingbo zhan Benlin He Haiyan Li Wenjun Yang Zhongmin zhou Haichang zhang Key Laboratory for Rubber-Plastics of Ministry of Education/Shandong Province School of Polymer Science and TechnologyQingdao University of Science and TechnologyQingdao 266042 Institute of Materials Science and Engineering Ocean University of ChinaQingdao 266100 Hybrid Solar Cells Faculty of Engineering and Natural SciencesTampere UniversityFI-33014 Tampere

Although many dopant-free hole transport materials(HTMs)for perovskite solar cells(PSCs)have been investigated in the literature,novel and useful molecular designs for high-performance HTMs are still needed.In this wo... 详细信息

关键词： hydrogen bonding dopant-free hole transport material inverted perovskite solar cell high efficiency stability

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Spatiotemporal hemodynamic monitoring via configurable skin-like microfiber Bragg grating group

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Opto-Electronic Advances 2023年第11期6卷 17-27页

作者： Hengtian Zhu Junxian Luo Qing dai Shugeng Zhu Huan Yang Kanghu zhou Liuwei zhan Biao Xu Ye Chen Yanqing Lu Fei Xu College of Engineering and Applied Sciences and Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210023China School of Physics Nanjing UniversityNanjing 210023China Department of Cardiology Affiliated Drum Tower HospitalMedical School of Nanjing UniversityNanjing 210008China

Systemic blood circulation is one of life activity’s most important physiological functions.Continuous noninvasive hemodynamicmonitoring is essential for the management of cardiovascular status.However,it is difficult to achieve systemichemodynamic monitoring with the daily use of current devices due to the lack of multichannel and time-synchronized operationcapability over the whole body.Here,we utilize a soft microfiber Bragg grating group to monitor spatiotemporalhemodynamics by taking advantage of the high sensitivity,electromagnetic immunity,and great temporal synchronizationbetween multiple remote sensor nodes.A continuous systemic hemodynamic measurement technique is developedusing all-mechanical physiological signals,such as ballistocardiogram signals and pulse waves,to illustrate the actualmechanical process of blood circulation.Multiple hemodynamic parameters,such as systemic pulse transit time,heartrate,blood pressure,and peripheral resistance,are monitored using skin-like microfiber Bragg grating patches conformallyattached at different body locations.Relying on the soft microfiber Bragg grating group,the spatiotemporal hemodynamicmonitoring technique opens up new possibilities in clinical medical diagnosis and daily health management.

关键词： spatiotemporal hemodynamic monitor skin-like photonic devices microfiber Bragg grating

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Dedifferentiated human umbilical cord mesenchymal stem cell reprogramming of endogenous hSDF-1a expression participates in neural restoration in hypoxic-ischemic brain damagerats

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Genes & Diseases 2021年第3期8卷 331-343页

作者： zhou Xiaoqin Liu Jia dai Mengjie Gu Jialu Bi Yang Wang Yuting Hu Huajian Liu Bo zhang Xiaojun Li Zhongyue Chen Jie Li Tingyu zhan Xue Department of Gastroenterology Ministry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and Disorders(Chongqing)401122PR China International Science and Technology Cooperation Base of Child Development and Critical Disorders Children’sHospital of Chongqing Medical UniversityChongqing401122PR China Department of Pediatric Research Institute Chongqing Key Laboratory of Child Health and NutritionChildren’s Hospital of Chongqing Medical UniversityChongqing401122PR China Department of Neonatology Chongqing Health Center for Womenand Children400021PR China Child Health Centre of Northwest Women and Children’s Hospital USA

The transplantation of human umbilical cord mesenchymal stem cells(hUC-MSCs)can promote hypoxic-ischemic brain damage(HIBD)nerve repair,but finding suitable seed cells to optimize transplantation and improve treatment efficiency is an urgent problem to be solved.In this study,we induced hUC-MSCs into dedifferentiated hUC-MSCs(De-hUC-MSCs),and the morphology,stem cell surface markers,proliferation and tri-directional differentiation ability of the De-hUC-MSCs and hUC-MSCs were detected.A whole-gene chip was utilized for genome cluster,gene ontology and KEGG pathway analyses of differentially expressed genes.De-hUC-MSCs were transplanted into HIBD rats,and behavioral experiments and immunofluorescence assays were used to assess the therapeutic effect.A lentivirus vector for human stromal cell-derived factor-1(hSDF-1a)was constructed,and the role of hSDF-1a in the neuroprotective effect and mechanism of De-hUC-MSCs was verified.De-hUC-MSCs displayed similar cell morphology,stem cell surface marker expression,cell proliferation and even three-dimensional differentiation ability as hUC-MSCs but exhibited greater treatment potential in vivo.The reprogramming mechanism of hSDF-1a participated in the dedifferentiation process.By successfully constructing a stable hSDF-1a cell line,we found that De-hUC-MSCs might participate in nerve repair through the hSDF-1a/CXCR4/PI3K/Akt pathway.De-hUC-MSCs reprogramming of endogenous hSDF-1a expression may mediate the hSDF-1a/CXCR4/PI3K/Akt pathway involved in nerve repair in HIBD rats.

关键词： Dediffer entiation Human umbilicalcord mesenchymal stem cells Hypoxic-ischemic brain damage Neurorestoration Reprogramming Stromal cell-derived factor-1

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clusterProfiler 4.0:A universal enrichment tool for interpreting omics data

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The Innovation 2021年第3期2卷 51-61页

作者： Tianzhi Wu Erqiang Hu Shuangbin Xu Meijun Chen Pingfan Guo Zehan dai Tingze Feng Lang zhou Wenli Tang Li zhan Xiaocong Fu Shanshan Liu Xiaochen Bo Guangchuang Yu Department of Bioinformatics School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Biotechnology Beijing Institute of Radiation MedicineBeijing 100850China Guangdong Provincial Key Laboratory of Proteomics School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510515China

Functional enrichment analysis is pivotal for interpreting highthroughput omics data in life science.It is crucial for this type of tool to use the latest annotation databases for as many organisms as possible.To meet these requirements,we present here an updated version of our popular Bioconductor package,clusterProfiler 4.0.This package has been enhanced considerably compared with its original version published 9 years ago.The new version provides a universal interface for functional enrichment analysis in thousands of organisms based on internally supported ontologies and pathways as well as annotation data provided by users or derived from online databases.It also extends the dplyr and ggplot2 packages to offer tidy interfaces for data operation and visualization.Other new features include gene set enrichment analysis and comparison of enrichment results from multiple gene lists.We anticipate that clusterProfiler 4.0 will be applied to a wide range of scenarios across diverse organisms.

关键词： clusterProfiler biological knowledge mining functional analysis enrichment analysis visualization

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Enhanced segmentation of gastrointestinal polyps from capsule endoscopy images with artifacts using ensemble learning

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World Journal of Gastroenterology 2022年第41期28卷 5931-5943页

作者： Jun-Xiao zhou zhan Yang Ding-Hao Xi Shou-Jun dai Zhi-Qiang Feng Jun-Yan Li Wei Xu Hong Wang Department of Gastroenterology and Hepatology Guangzhou First People’s HospitalGuangzhou 510180Guangdong ProvinceChina School of Information Renmin University of ChinaBeijing 100872China

BACKGROUND Endoscopy artifacts are widespread in real capsule endoscopy(CE)images but not in high-quality standard datasets.AIM To improve the segmentation performance of polyps from CE images with artifacts based on ensemble learning.METHODS We collected 277 polyp images with CE artifacts from 5760 h of videos from 480 patients at Guangzhou First People’s Hospital from January 2016 to December 2019.Two public high-quality standard external datasets were retrieved and used for the comparison experiments.For each dataset,we randomly segmented the data into training,validation,and testing sets for model training,selection,and testing.We compared the performance of the base models and the ensemble model in segmenting polyps from images with artifacts.RESULTS The performance of the semantic segmentation model was affected by artifacts in the sample images,which also affected the results of polyp detection by CE using a single model.The evaluation based on real datasets with artifacts and standard datasets showed that the ensemble model of all state-of-the-art models performed better than the best corresponding base learner on the real dataset with artifacts.Compared with the corresponding optimal base learners,the intersection over union(IoU)and dice of the ensemble learning model increased to different degrees,ranging from 0.08%to 7.01%and 0.61%to 4.93%,respectively.Moreover,in the standard datasets without artifacts,most of the ensemble models were slightly better than the base learner,as demonstrated by the IoU and dice increases ranging from-0.28%to 1.20%and-0.61%to 0.76%,respectively.CONCLUSION Ensemble learning can improve the segmentation accuracy of polyps from CE images with artifacts.Our results demonstrated an improvement in the detection rate of polyps with interference from artifacts.

关键词： Artifacts Capsule endoscopy Polyps Ensemble learning Segmentation Robustness

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Cytoplasmic and nuclear genome variations of rice hybrids and their parents inform the trajectory and strategy of hybrid rice breeding

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Molecular Plant 2021年第12期14卷 2056-2071页

作者： zhoulin Gu zhou Zhu Zhen Li Qilin zhan Qi Feng Congcong zhou Qiang Zhao Yan Zhao Xiaojian Peng Bingxin dai Rongrong Sun Yan Li Hengyun Lu Lei zhang Tao Huang Junyi Gong Danfeng Lv Xuehui Huang Bin Han National Center for Gene Research State Key Laboratory of Plant Molecular GeneticsCenter for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200233China University of Chinese Academy of Sciences Beijing 100049China College of Life Sciences Anhui Normal UniversityWuhuAnhui 241000China School of Life Sciences Anhui Agricultural UniversityHefeiAnhui 230036China School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China State Key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhou 310006China College of Life Sciences Shanghai Normal UniversityShanghai 200234China

The male sterility(MS)line is a prerequisite for efficient production of hybrid seeds in rice,a self-pollinating species.MS line breeding is pivotal for hybrid rice improvement.Understanding the historical breeding tra-jectory will help to improve hybrid rice breeding strategies.Maternally inherited cytoplasm is an appro-priate tool for phylogenetic reconstruction and pedigree tracing in rice hybrids.In this study,we analyzed the cytoplasmic genomes of 1495 elite hybrid rice varieties and identified five major types of cytoplasm,which correspond to different hybrid production systems.As the cytoplasm donors for hybrids,461 MS lines were also divided into five major types based on cytoplasmic and nuclear genomic architecture.Spe-cific core accessions cooperating with different fertility-associated genes drove the sequence divergence of MS lines.Dozens to hundreds of convergent and divergent selective sweeps spanning several agro-nomic trait-associated genes were identified among different types of MS lines.We further analyzed the cross patterns between different types of MS lines and their corresponding restorers.This study system-atically analyzed the cytoplasmic genomes of rice hybrids revealed their relationships with nuclear ge-nomes of MS lines,and illustrated the trajectory of hybrid rice breeding and the strategies for breeding different types of MS lines providing new insights for future improvement of hybrid rice.

关键词： rice hybrid cytoplasm cytoplasmic male sterile environment-sensitive genic male sterile breeding

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