检索结果-南通市图书馆

Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang xiang Zhang Henrik Biverstål Nicolas GBazan Shuai Tan Nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

SOD2 Alleviates Hearing Loss Induced by Noise and Kanamycin in Mitochondrial DNA4834-deficient Rats by Regulating PI3K/MAPK Signaling

引用

Current Medical Science 2021年第3期41卷 587-596页

作者： Yan ZHANG Shan HUANG xiang dai Zhong-fang XIA Han XIAO Xue-lian HE rong YANG Jun LI Department of Otorhinolaryngology Wuhan Children's Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Reproductive Laboratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Biological Sample Bank Wuhan Children's Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Central Laboratory Wuhan Children's Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Health Care Department Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China

Superoxide dismutase 2(SOD2)-mediated gene therapy has significant protective effects against kanamycin-induced hearing loss and hair cell loss in the inner ear,but the underlying mechanisms are still ***,an in vivo aging model of mitochondrial DNA(mtDNA)4834 deletion mutation was established using D-galactose,and the effects of noise or kanamycin on inner ear injury was *** subjected to mtDNA4834 mutation via D-galactose administration showed hearing loss characterized by the disruption of inner ear structure(abnormal cell morphology,hair cell lysis,and the absence of the organ of Corti),increased SOD2 promoter methylation,and an increase in the degree of *** to noise or kanamycin further contributed to the effects of ***2 overexpression induced by viral injection accordingly counteracted the effects of noise and kanamycin and ameliorated the symptoms of hearing loss,suggesting the critical involvement of SOD2 in preventing deafness and hearing-related *** PI3K and MAPK signaling pathways were also regulated by noise/kanamycin exposure and/or SOD2 overexpression,indicating that they may be involved in the therapeutic effect of SOD2 against age-related hearing loss.

关键词： hearing loss methylation mtDNA4834 deletion mutation superoxide dismutase 2

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Stability analysis of slope in strain-softening soils using local arc-length solution scheme

引用

Journal of Mountain Science 2017年第1期14卷 175-187页

作者： WANG xiang-rong rong Qi-guo SUN Shu-li WANG Hui College of Engineering Peking University Graduate School AICES RWTH Aachen University

Soils with strain-softening behavior — manifesting as a reduction of strength with increasing plastic strain — are commonly found in the natural environment. For slopes in these soils,a progressive failure mechanism can occur due to a reduction of strength with increasing strain. Finite element method based numerical approaches have been widely performed for simulating such failure mechanism,owning to their ability for tracing the formation and development of the localized shear strain. However,the reliability of the currently used approaches are often affected by poor convergence or significant mesh-dependency,and their applicability is limited by the use of complicated soil models. This paper aims to overcome these limitations by developing a finite element approach using a local arc-length controlled iterative algorithm as the solution strategy. In the proposed finite element approach,the soils are simulated with an elastoplastic constitutive model in conjunction with the Mohr-Coulomb yield function. The strain-softening behavior is represented by a piece-wise linearrelationship between the Mohr-Coulomb strength parameters and the deviatoric plastic strain. To assess the reliability of the proposed finite element approach,comparisons of the numerical solutions obtained by different finite element methods and meshes with various qualities are presented. Moreover,a landslide triggered by excavation in a real expressway construction project is analyzed by the presented finite element approach to demonstrate its applicability for practical engineering problems.

关键词： Strain-softening Progressive failure Slope stability Local arc-length scheme Numerical simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Discrete Capability of the Lempel-Ziv Complexity Algorithm on a Vibration Sequence

引用

Chinese Physics Letters 2010年第6期27卷 20-23页

作者： LI Jian-Kang SONG xiang-rong YIN Ke Department of Engineering Mechanics Faculty of Science Jiangsu University Zhenjiang 212013 School of Naval Architecture and Ocean Engineering Jiangsu University of Science and Technology Zhenjiang 212003

The Lempel Ziv complexity （LZC） method is used to analyze the acceleration response of the T-shaped plate. The response is converted into symbolic sequences with the multi-segmented coarse-grained method. The LZC of the response of 240 points located in different areas near the center is calculated. The results show that LZC arithmetic applied to elastomer vibration can satisfy the discreteness condition.

关键词： COMPUTATIONAL complexity VIBRATION (Mechanics) ALGORITHMS ACCELERATION (Mechanics) ELASTOMERS PLATES (Engineering)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A cortical bone milling force model based on orthogonal cutting distribution method

引用

Advances in Manufacturing 2020年第2期8卷 204-215页

作者： Qi-Sen Chen Li dai Yu Liu Qiu-xiang Shi School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819People's Republic of China

In orthopedic surgery,the bone milling force has attracted attention owing to its significant influence on bone cracks and the breaking of *** is necessary to build a milling force model to improve the process of bone *** paper proposes a cortical bone milling force model based on the orthogonal cutting distribution method(OCDM),explaining the effect of anisotropic bone materials on milling *** to the model,the bone milling force could be represented by the equivalent effect of a transient cutting force in a rotating period,and the transient milling force could be calculated by the transient milling force coefficients,cutting thickness,and cutting *** on the OCDM,the change in transient cutting force coefficients during slotting can be described by using a quadratic ***,the force model is updated for robotic bone milling,considering the low stiffness of the robot ***,an experimental platform for robotic bone milling is built to simulate the milling process in clinical operation,and the machining signal is employed to calculate the milling ***,according to the experimental result,the rationality of the force model is verified by the contrast between the measured and predicted *** milling force model can satisfy the accuracy requirement for predicting the milling force in the different processing directions,and it could promote the development of force control in orthopedic surgery.

关键词： Robotic milling force Cortical bone Cutting force coefficient Orthogonal cutting distribution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Palladium-catalysed stereoselective[3+2]annulation of vinylethylene carbonates and tryptanthrin-based ketones

引用

Organic Chemistry Frontiers 2022年第1期9卷 197-203页

作者： Yang Fan Qing-Zhu Li Jun-Long Li Bin Zhang Zhen dai Ke Xie rong Zeng Liang Zou xiang Zhang College of Pharmacy Dali UniversityDali 671003PR China Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province Sichuan Industrial Institute of AntibioticsSchool of PharmacyChengdu UniversityChengdu 610106PR China School of Food and Biological Engineering Chengdu UniversityChengdu 610106PR China

The palladium-catalysed[3+2]annulation of vinylethylene carbonates(VECs)and ketones remains challenging in organic ***,we successfully achieved the[3+2]annulation of tryptanthrin-based ketones and VECs for the efficient synthesis of indoloquinazolinone derivatives with generally excellent yields and good ***,the asymmetric version of this[3+2]annulation can also be achieved by using a chiral spiroketal-based diphosphine *** addition,preliminary biological studies reveal that some of the products exhibit promising antibacterial activity.

关键词： synthesis vinyl Palladium

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

引用

Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li Cui Chang xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

引用

Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting xiang xiangxin Xing Xuyun Hua Yuwen Zhang Xin Xue Jiajia Wu Mouxiong Zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Static load test and load transfer mechanism study of squeezed branch and plate pile in collapsible loess foundation

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第7期8卷 1110-1117页

作者： GAO Xiao-juan WANG Jin-chang ZHU xiang-rong College of Civil Engineering and Architecture Zhejiang University Hangzhou 310027 China Institute of Architecture Engineering Henan University of Science and Technology Luoyang 471003 China Ningbo Institute of Technology Zhejiang University Ningbo 315005 China

As a special geological phenomenon, the character of collapsible loess foundation is collapsible when penetrated by water. This character leads to the soil losing load bearing capacity largely and may lead to foundation failure. Pile is a popular foundation used in collapsible loess. The squeezed branch and plate pile is a new type of pile developed in recent years and has not be used in a project before. In this paper three squeezed branch and plate piles are tested in collapsible loess after immersion processing. The results may be used for reference in similar construction project, and to provide theoretical references for de- signing of the squeezed branch and plate piles in engineering practice.

关键词： Collapsible loess foundation Squeezed branch and plate pile Immersion processing Full-scale static load test

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Expansion of spherical cavity of strain-softening materials with different elastic moduli of tension and compression

引用

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第9期8卷 1380-1387页

作者： LUO Zhan-you ZHU xiang-rong GONG Xiao-nan Ningbo Institute of Technology. Zhejiang University Ningbo 315100 China Geotechnical Engineering Institute Zhejiang University of Science and Technology Hangzhou 310012 China Geotechnical Engineering Institute Zhejiang University Hangzhou 310027 China

An expansion theory of spherical cavities in strain-softening materials with different moduli of tension and com-pression was presented. For geomaterials,two controlling parameters were introduced to take into account the different moduli and strain-softening properties. By means of elastic theory with different moduli and stress-softening models,general solutions cal-culating Tresca and Mohr-Coulomb materials' stress and displacement fields of expansion of spherical cavity were derived. The effects caused by different elastic moduli in tensile and compression and strain-softening rates on stress and displacement fields and development of plastic zone of expansion of cavity were analyzed. The results show that the ultimate expansion pressure,stress and displacement fields and development of plastic zone vary with the different elastic moduli and strain-softening prop-erties. If classical elastic theory is adopted and strain-softening properties are neglected,rather large errors may be the result.

关键词： Expansion of spherical cavity Tresca material Mohr-Coulomb material Elastic theory with different moduli of tension and compression Stress-dropping softening model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：