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Endoscopic papillary large balloon dilation for bile duct stones in elderly patients

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World Journal of Clinical Cases 2015年第4期3卷 353-359页

作者： Yuji Sakai Toshio Tsuyuguchi Harutoshi Sugiyama Reina Sasaki dai sakamoto Masato Nakamura Yuuto Watanabe Takao Nishikawa Shin Yasui Rintaro Mikata Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University

AIM: To investigate whether endoscopic papillary large balloon dilation(EPLBD) can be safety and effectively performed in patients aged ≥ 80 years. METHODS: Lithotomy by EPLBD was conducted in 106 patients with bile duct stones ≥ 13 mm in size or with three or more bile duct stones ≥ 10 mm. The patients were divided into group A(< 80 years) and group B(≥ 80 years). Procedure success rate, number of endoscopic retrograde cholangiopancreatographies(ERCP), and incidence of complications were examined in both ***: Group B tended to include significantly more patients with peripapillary diverticulum, hypertension, hyperlipemia, cerebrovascular disease/dementia, respiratory disease/cardiac disease, and patients administered an anticoagulant or antiplatelet agent(P < 0.05). The success rate of the initial lithotomy was 88.7(94/106)%. The final lithotomy rate was 100(106/106)%. Complications due to treatment procedure occurred in 4.72(5/106)% of the patients. There was no significant difference in procedure success rate, number of ERCP, or incidence of complications between group A and group ***: EPLBD can be safely performed in elderly patients, the same as in younger patients.

关键词： Elderly patients Endoscopic papillary large balloon dilation Endoscopic sphincterotomy Large bile duct stones Choledocholithiasis

Endoscopic papillary large balloon dilation for removal of bile duct stones

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World Journal of Gastroenterology 2014年第45期20卷 17148-17154页

作者： Yuji Sakai Toshio Tsuyuguchi Yoshiaki Kawaguchi Nobuto Hirata So Nakaji Katsuya Kitamura Shigeru Mikami Tatsuya Fujimoto Masashi Ijima Eishin Kurihara Shuhei Oana Takayoshi Nishino Ryo Tamura dai sakamoto Masato Nakamura Takao Nishikawa Harutoshi Sugiyama Hitoshi Yoshida Tetsuya Mine Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of Medicine Chiba University Department of Gastroenterology Tokai University Hospital Department of Gastroenterology Kameda Medical Center Division of Gastroenterology Department of Medicine Showa University School of Medicine Department of Internal Medicine Kikkoman General Hospital Department of Gastroenterology Kimitsu Central Hospital Department of Gastroenterology Isesaki Municipal Hospital Department of Gastroenterology Iwate Medical University Hospital Department of Gastroenterology Tokyo Women’s Medical University Yachiyo Medical Center

AIM:To investigate the efficacy and outcomes of endoscopic papillary large balloon dilation(EPLBD)for bile duct stones in a multicenter prospective ***:Lithotomy by EPLBD was conducted in 124patients with bile duct stones≥13 mm in size or with three or more bile duct stones≥10 *** endoscopic sphincterotomy,the papilla was dilated using balloons 12-20 mm in diameter fitting the bile duct ***:The success rate of first-time lithotomy was 86.3%(107/124)and the final lithotomy success rate was 100%(124/124).Lithotripsy was needed in10 of the 124(13.6%)*** events due to the treatment procedure occurred in 6(4.8%)patients,all of which were *** large balloon dilation after endoscopic sphincterotomy in patients with large stones or multiple stones in the bile duct is considered to ensure the safety of treatment and to reduce the need for ***:It is suggested that treatment by EPLBD for large bile duct stones may be safe and useful.

关键词： Endoscopic retrograde cholangiopancrea-tography En

Current status of preoperative drainage for distal biliary obstruction

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World Journal of Hepatology 2015年第18期7卷 2171-2176页

作者： Harutoshi Sugiyama Toshio Tsuyuguchi Yuji Sakai Rintaro Mikata Shin Yasui Yuto Watanabe dai sakamoto Masato Nakamura Reina Sasaki Jun-ichi Senoo Yuko Kusakabe Masahiro Hayashi Osamu Yokosuka Department of Gastroen- terology and Nephrology Graduate School of Medicine Chiba University

Preoperative biliary drainage(PBD) was developed to improve obstructive jaundice, which affects a number of organs and physiological mechanisms in patients waiting for surgery. However, its role in patients who will undergo pancreaticoduodenectomy for biliary obstruction remains controversial. This article aims to review the current status of the use of preoperative drainage for distal biliary obstruction. Relevant articles published from 1980 to 2015 were identified by searching MEDLINE and Pub Med using the keywords "PBD", "pancreaticoduodenectomy", and "obstructive jaundice". Additional papers were identified by a manual search of the references from key articles. Current studies have demonstrated that PBD should not be routinely performed because of the postoperative complications. PBD should only be considered in carefully selected patients, particularly in cases where surgery had to be delayed. PBD may be needed in patients with severe jaundice, concomitant cholangitis, or severe malnutrition. The optimal method of biliary drainage has yet to be confirmed. PBD should be performed by endoscopic routes rather than by percutaneous routes to avoid metastatic tumor seeding. Endoscopic stenting or nasobiliary drainage can be selected. Although more expensive, the use of metallic stents remains a viable option to achieve effective drainage without cholangitis and reintervention.

关键词： Preoperative drainage Biliary drainage Distal bili

Flexible visualization framework for head-mounted display with gesture interaction interface

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International Journal of Modeling, Simulation, and Scientific Computing 2018年第3期9卷 22-41页

作者： Pierre J.Jarsaillon Naohisa sakamoto Akira Kageyama Computer Science Department INSA Lyon 20 avenue Albert EinsteinVilleurbanne Cedex 69621France Graduate School of System Informatic Kobe University 1-1 Rokko-daiNada-ku Kobe 657-8501Japan Department of Computational Science Kobe University 1-1 Rokko-dai Nada-kuKobe 657-8501Japan

As the development of new visualization systems,within the field of simulation,offers their users more insights from their simulations,immersive systems are becoming a part of the visualization *** the recent advancements of the Head-Mounted Displays(HMDs)and popularity of motion sensors,human beings and computer become more *** study aims to evaluate the potential of such systems as a visualization tool through the development of a new flexible framework for visualization within virtual reality(VR)environment,using an Oculus Rift and a Leap *** approaches are then compared:high-3D object rendering within the virtual scene approach and a user experience-oriented system with an intuitive *** assess the quality of the interface and its relevance for the user,different types of gestures are implemented and *** an experiment on users to evaluate the developed system as a proper visualization tool,the HMDs,paired with a motion sensor to make a gesture-controlled interface seem to be promising mediums despite various constraints on development regarding the technology limitations.

关键词： Virtual reality motion sensor interactive tool user experience immersive visualization.

不同海拔高度藏汉族老年人血压变化的特点及影响因素

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高原医学杂志 2011年第4期21卷 14-18页

作者：代青湘李占全王红心许慧宁高继东杨爱荣仝海英奥宫清人松林公藏坂本龙泰木村友美张永寿王建萍才仁松保尼玛乔海生青海大学附属医院 810001 日本综合环境地球研究所青海省海北州海晏县人民医院 812200 青海省玉树州玉树县人民医院 815000 青海省畜牧兽医科学院 810016

目的:通过对不同海拔地区藏汉族老年人进行健康调查,进一步了解高原地区老年人血压变化的特点及影响因素。方法:采用随机抽样的方法,对青海省玉树县(平均海拔3 700m)、海晏县(平均海拔3 000m以上)两地区506例60岁～87岁世居藏族及移居... 详细信息

目的:通过对不同海拔地区藏汉族老年人进行健康调查,进一步了解高原地区老年人血压变化的特点及影响因素。方法:采用随机抽样的方法,对青海省玉树县(平均海拔3 700m)、海晏县(平均海拔3 000m以上)两地区506例60岁～87岁世居藏族及移居汉族的血压进行健康调查。结果:①玉树县老年人高血压的患病率显著高于海晏县,收缩压(SBP)、舒张压(DBP)及体质指数(BMI)显著高于海晏县老年人,P<0.05;玉树县藏族老年人高血压的患病率显著高于海晏县藏族,同时SBP、DBP及BMI均显著高于海晏县藏族,均P<0.05;②海晏县汉族老年人高血压的患病率显著高于海晏县藏族,同时汉族SBP、DBP均显著高于藏族,均P<0.05;③高原地区老年人高血压患病率为50.6%,男、女患病率无明显差异;高血压组的BMI、脉率(HR)及血红蛋白(Hb)显著高于血压正常组,血氧饱和度(SpO2)低于血压正常组,P<0.05。结论:高原地区老年人高血压的患病率高于海拔较低的地区,汉族高血压的患病率高于藏族;高原低氧、低温环境是高原地区老年人血压增高的重要影响因素,移居汉族、超重及牧区镇城居民更易患高血压病。

关键词：高原老年人藏族血压低氧环境

Observatory science with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao dai Filippo D'Ammando Massimiliano De Pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig SRON Netherlands Institute for Space Research Department of Astronomy University of Geneva Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science Nanjing University INAF-IASF Bologna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e Planetologie Spaziali Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NASA Goddard Space Flight Center ICREA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPAR SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Observatory Leiden University Anton Pannekoek Institute University of Amsterdam ASTRON Netherlands Institute for Radio Astronomy Universitat Politecnica de Catalunya(UPC-IEEC) Universitádegli Studi di Urbino‘Carlo Bo’ Max-Planck-Institut für Radioastronomie Dr.Karl-Remeis-Sternwarte and Erlangen Centre for Astroparticle Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple Mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CSIC Department of Physics and Astronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Center for Relativistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di Brera Tata Institute of Fundamental Research Dipartimento di Matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de Pesquisas Espaciais-INPE National Space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational waves