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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 163-178页

作者： Wu Houli Guo Endong Wang Jingyi dai Xin dai chenxi Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin 150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin 150080China

As an important part of nonstructural components,the seismic response of indoor water supply pipes deserves much *** paper presents shaking table test research on water supply pipes installed in a full-scale reinforced concrete(RC)frame *** material pipes and different methods for penetrating the reinforced concrete floors are combined to evaluate the difference in seismic *** response spectra and pipe acceleration amplification factors based on test data are discussed and compared with code provisions.A seismic fragility study of displacement demand is conducted based on numerical *** acceleration response and displacement response of different combinations are *** results show that the combination of different pipe materials and different passing-through methods can cause obvious differences in the seismic response of indoor riser pipes.

关键词： water supply pipe different materials shaking table test amplification factor seismic fragility

马克思恩格斯人口理论视角下我国应对人口老龄化的策略与启示

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老龄化研究 2024年第4期11卷 1396-1402页

作者：代晨曦南京林业大学马克思主义学院江苏南京

当前,我国正面临着比较严重的人口老龄化问题。人口老龄化是我国人口发展的必然趋势和规律,也是我国今后较长一段时间的基本国情。积极应对人口老龄化,事关国家发展战略全局,事关广大人民群众福祉。马克思恩格斯人口理论建立在批判资产... 详细信息

当前,我国正面临着比较严重的人口老龄化问题。人口老龄化是我国人口发展的必然趋势和规律,也是我国今后较长一段时间的基本国情。积极应对人口老龄化,事关国家发展战略全局,事关广大人民群众福祉。马克思恩格斯人口理论建立在批判资产阶级人口理论的基础上,这一理论内容丰富,主要包括:“两种生产”理论、人口质量理论、人是生产者和消费者的统一体等方面。基于马克思恩格斯的人口理论,我们可以从完善生育配套政策、着力提高人口素质以及充分释放“银发经济”的潜在红利等方面探寻应对我国人口老龄化的具体对策。

关键词：马克思恩格斯人口理论人口老龄化启示意义

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噪声干扰下的轨道车辆信息估计方法研究

机械设计与研究 2024年第4期40卷 123-129页

作者：孙效杰代晨曦陶强许聪上海应用技术大学轨道交通学院上海201418 天津航天瑞莱科技有限公司上海201100 和辉光电有限公司上海201500

准确、可靠的车辆状态信息和线路信息是轨道车辆主动控制系统的关键输入信号,也是轨道车辆故障检测的重要技术手段之一。针对轨道车辆主动控制所需信息获取这一问题,基于噪声扰动下的独立车轮车辆,研究其车辆状态和未知输入估计的新方... 详细信息

准确、可靠的车辆状态信息和线路信息是轨道车辆主动控制系统的关键输入信号,也是轨道车辆故障检测的重要技术手段之一。针对轨道车辆主动控制所需信息获取这一问题,基于噪声扰动下的独立车轮车辆,研究其车辆状态和未知输入估计的新方法。首先,为排除测量噪声扰动的影响,重新构造系统测量输出,设计新型降维观测器。其次,基于上一步估计的状态信息,对未知输入进行重构,完成未知输入即线路曲率的估计。然后,在MATLAB/SIMULINK中搭建轨道车辆模型,并通过在信号中添加噪声扰动来进一步模拟实际信号。最后,通过不同噪声类型、等级下的车辆状态估计结果与实际状态进行对比,完成估计方法的仿真验证。研究结果表明:在可测/随机噪声的干扰下,该估计方法能够较好地估计车辆状态信息和线路曲率信息;相较于其它信息估计技术,该方法仅需测量左右车轮转速,所需传感器数量少且基本已覆盖安装,对轨道车辆的主动控制有一定的价值。

关键词：轨道车辆状态估计降维观测器噪声干扰线路曲率

扶解化瘀颗粒调控线粒体自噬途径对脓毒症小鼠心功能的影响

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江苏医药 2024年第9期50卷 870-873,F0003页

作者：李琛戴晨希阚建英天津市中医药研究院附属医院重症医学科 300120 天津市河东区上杭路街社区卫生服务中心

目的探讨扶解化瘀颗粒调控线粒体自噬途径对脓毒症小鼠心功能的影响。方法 45只雄性C57BL/6小鼠随机分为五组,每组9只。A、B、M、C组行盲肠结扎穿孔术建立脓毒症模型,S组为假手术组。A组和B组分别于6和12h后灌胃扶解化瘀颗粒2mL·mg^(... 详细信息

目的探讨扶解化瘀颗粒调控线粒体自噬途径对脓毒症小鼠心功能的影响。方法 45只雄性C57BL/6小鼠随机分为五组,每组9只。A、B、M、C组行盲肠结扎穿孔术建立脓毒症模型,S组为假手术组。A组和B组分别于6和12h后灌胃扶解化瘀颗粒2mL·mg^(-1)·kg^(-1),C组6h后尾静脉注射自噬抑制剂3-甲基腺嘌呤2mg/kg, M组和S组6h后尾静脉均注射等量生理盐水。24h后,检测五组血流动力学指标评估心功能,Western blot法检测五组自噬相关蛋白表达,HE染色观察心肌组织病理学改变,TUNEL染色检测心肌细胞凋亡情况。结果与S组比较,A、B、C、M组血流动力学指标更差,自噬相关蛋白表达降低,心肌细胞凋亡率均升高(P<0.05)。与M组比较,A、B组血流动力学指标改善,自噬相关蛋白表达升高,心肌细胞凋亡率降低,但C组血流动力学指标较差,自噬相关蛋白表达降低,心肌细胞凋亡率升高(P<0.05)。A组上述指标改善优于B组(P<0.05)。结论扶解化瘀颗粒调控线粒体自噬途径改善脓毒症小鼠心功能障碍,减轻心肌损伤,减少心肌细胞凋亡。

关键词：脓毒症扶解化瘀颗粒线粒体自噬心功能

Bioactive citrate-based polyurethane tissue adhesive for fast sealing and promoted wound healing

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Regenerative Biomaterials 2024年第1期3卷 69-81页

作者： Yan Li Jiawei Liu chenxi Lian He Yang Mingjiang Zhang Youfa Wang Honglian dai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan University of TechnologyWuhan 430070China Chaozhou Branch of Chemistry and Chemical Engineering Guangdong Laboratory Chaozhou 521000China Shenzhen Research Institute of Wuhan University of Technology Shenzhen 518000China

As a superior alternative to sutures,tissue adhesives have been developed significantly in recent ***,existing tissue adhesives struggle to form fast and stable adhesion between tissue interfaces,bond weakly in wet environments and lack *** this study,a degradable and bioactive citrate-based polyurethane adhesive is constructed to achieve rapid and strong tissue *** hydrophobic layer was created with polycaprolactone to overcome the bonding failure between tissue and adhesion layer in wet environments,which can effectively improve the wet bonding *** citrate-based polyurethane adhesive provides rapid,non-invasive,liquid-tight and seamless closure of skin incisions,overcoming the limitations of sutures and commercial tissue *** addition,it exhibits biocompatibility,biodegradability and hemostatic *** degradation product citrate could promote the process of angiogenesis and accelerate wound *** study provides a novel approach to the development of a fast-adhering wet tissue adhesive and provides a valuable contribution to the development of polyurethane-based tissue adhesives.

关键词： tissue adhesive polyurethane citrate wet adhesion

RESEARCH ON STRUCTURE-CARCINOGENIC ACTIVITY RELATIONSHIP OF ALKYL SUBSTITUTED POLYCYCLIC AROMATIC HYDROCARBONS BY PATTERN RECOGNITION ON COMPUTER

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Chinese Science Bulletin 1985年第1期30卷 52-57页

作者：戴乾圜施晨曦 Beijing Industrial University

In terms of metabolic experimental facts and calculation of quantum chemical parameters on catabolic intermediate and with extrathermodynamic method by taking it as a medium with the structure-carcinogenic activity relationship (SCAR) of parent polycyclic aromatic hydrocarbons (PAH), we have evidenced the importance of di-functional cross-linking between the double strands of complementary DNA base-pairs for complete carcinogenesis. We have discussed quantitatively the comprehensive catabolic

关键词： hydrocarbons quantitatively carcinogenesis polycyclic parent aromatic linking complementary alkyl iterative

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基于响应面优化杏仁蛋白酶解工艺的研究

食品工业 2018年第7期39卷 141-146页

作者：代晨曦程卫东石河子大学食品学院石河子832000

以新疆甜杏仁为原料,选用碱性蛋白酶和风味蛋白酶分步水解杏仁蛋白,采用响应面优化双酶水解杏仁蛋白的工艺条件。结果表明,底物浓度2.5%,杏仁蛋白酶解的最佳工艺条件为:碱性蛋白酶添加量3 500 U,酶解时间3.5h;风味蛋白酶添加量2 000 U,... 详细信息

以新疆甜杏仁为原料,选用碱性蛋白酶和风味蛋白酶分步水解杏仁蛋白,采用响应面优化双酶水解杏仁蛋白的工艺条件。结果表明,底物浓度2.5%,杏仁蛋白酶解的最佳工艺条件为:碱性蛋白酶添加量3 500 U,酶解时间3.5h;风味蛋白酶添加量2 000 U,酶解时间3.0 h。在此条件下,杏仁蛋白最大水解度为24.65%。

关键词：杏仁蛋白响应面法酶解水解度

Josephin domain containing 2(JOSD2)promotes lung cancer by inhibiting LKB1(Liver kinase B1)activity

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Signal Transduction and Targeted Therapy 2024年第2期9卷 693-708页

作者： Tao Yuan Chenming Zeng Jiawei Liu chenxi Zhao Fujing Ge Yuekang Li Meijia Qian Jiamin Du Weihua Wang Yonghao Li Yue Liu Xiaoyang dai Jianya Zhou Xueqin Chen Shenglin Ma Hong Zhu Qiaojun He Bo Yang Institute of Pharmacology&Toxicology Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Innovation Institute for Artificial Intelligence in Medicine Zhejiang UniversityHangzhou 311199China Ministry of Education Key Laboratory of Chinese Medicinal Plants Resource from Lingnan Research Center of Medicinal Plants Resource Science and EngineeringGuangzhou University of Chinese MedicineGuangzhou 510006China Center for Drug Safety Evaluation and Research of Zhejiang University Hangzhou 310058China Department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310006China Department of Oncology Hangzhou Cancer HospitalHangzhou 310002China Cancer Center of Zhejiang University HangzhouChina Engineering Research Center of Innovative Anticancer Drugs Ministry of EducationHangzhouChina

Non-small cell lung cancer(NSCLC)ranks as one of the leading causes of cancer-related deaths *** the prominence and effectiveness of kinase-target therapies in NSCLC treatment,these drugs are suitable for and beneficial to a mere~30%of NSCLC ***,the need for novel strategies addressing NSCLC remains ***(DUBs),a group of diverse enzymes with well-defined catalytic sites that are frequently overactivated in cancers and associated with tumorigenesis and regarded as promising therapeutic ***,the mechanisms by which DUBs promote NSCLC remain poorly *** a global analysis of the 97 DUBs’contribution to NSCLC survival possibilities using The Cancer Genome Atlas(TCGA)database,we found that high expression of Josephin Domain-containing protein 2(JOSD2)predicted the poor prognosis of *** of JOSD2 significantly impeded NSCLC growth in both cell/patient-derived xenografts in ***,we found that JOSD2 restricts the kinase activity of LKB1,an important tumor suppressor generally inactivated in NSCLC,by removing K6-linked polyubiquitination,an action vital for maintaining the integrity of the LKB1-STRAD-MO25 ***,we identified the first small-molecule inhibitor of JOSD2,and observed that its pharmacological inhibition significantly arrested NSCLC proliferation in vitro/in *** findings highlight the vital role of JOSD2 in hindering LKB1 activity,underscoring the therapeutic potential of targeting JOSD2 in NSCLC,especially in those with inactivated LKB1,and presenting its inhibitors as a promising strategy for NSCLC treatment.

关键词： LKB1 inhibiting removing

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通过式车轮踏面滚动圆直径测量算法的设计

机械制造与自动化 2023年第3期52卷 164-167页

作者：代晨曦西南交通大学牵引动力国家重点实验室四川成都610031

轮对的滚动圆直径是评价轮对能否继续服役的重要指标。采取激光位移检测法,设置2个激光位移传感器,并将其按照规定安装到相关轨道处。当列车轮对行驶通过此装置后,可检测到列车轮对的轮廓外形数据。通过Origin绘制出轮对的外形图,选择... 详细信息

轮对的滚动圆直径是评价轮对能否继续服役的重要指标。采取激光位移检测法,设置2个激光位移传感器,并将其按照规定安装到相关轨道处。当列车轮对行驶通过此装置后,可检测到列车轮对的轮廓外形数据。通过Origin绘制出轮对的外形图,选择轮对基点处的数据进行曲线拟合得到2条轮对滚动圆曲线。采用MATLAB设计算法得到轮对滚动圆的实际坐标点,通过最小二乘法对数据点进行拟合求圆,从而得到列车滚动圆的直径。将测出的轮对滚动圆直径与真实的轮对滚动圆直径进行对比,验证该测量方法的可行性。

关键词：列车轮对滚动圆直径激光位移检测法曲线拟合最小二乘法

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基于市政导则的水池震害评估模型研究

西安建筑科技大学学报（自然科学版） 2023年第2期55卷 293-300页

作者：戴晨曦郭恩栋刘智闫培雷甘霖中国地震局工程力学研究所地震工程与工程振动重点实验室地震灾害防治应急管理部重点实验室黑龙江哈尔滨150080 广东省地震局广东广州510070

历年以来,国内外学者根据供水设施中的水池基础调查数据的不同,提出了基于不同基础调查数据的地震破坏评估模型.在2021年住房和城乡建设部发布《市政设施承灾体普查技术导则FXPC/ZJ G-01》以后,调查得到的水池的基础数据发生了变化,传... 详细信息

历年以来,国内外学者根据供水设施中的水池基础调查数据的不同,提出了基于不同基础调查数据的地震破坏评估模型.在2021年住房和城乡建设部发布《市政设施承灾体普查技术导则FXPC/ZJ G-01》以后,调查得到的水池的基础数据发生了变化,传统的生命线工程系统中水池的地震破坏评估方法所需的基础调查资料与现有的有所不同,不能满足现有评估方法的需求.针对该问题,本文基于水池历史震害资料,结合水池基于震害资料的统计回归模型方法,建立了新的基于市政导则调查数据的水池的震害评估模型,并与实际震害结果和原模型进行比较判断其可靠性,从而实现了对基于技术导则对水池的地震破坏情况的评估.

关键词：生命线工程水池地震灾害破坏风险评估导则模型