检索结果-南通市图书馆

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker chen chen Heqiao dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

New scoring system for the evaluation obstructive degrees based on computed tomography for obstructive colorectal cancer

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2025年第3期17卷 122-132页

作者： Xin-Chang Shang-Guan Jun-rong Zhang Chao-Nan Lin Shuai chen Yong Wei Wen-Xuan chen Lin Pan Li-Qin Huang Shao-Hua Zheng Xian-Qiang chen Department of Emergency Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina College of Physics and Information Engineering Fuzhou UniversityFuzhou 350001Fujian ProvinceChina

BACKGROUND The degree of obstruction plays an important role in decision-making for obstructive colorectal cancer(OCRC).The existing assessment still relies on the colorectal obstruction scoring system(CROSS)which is based on a comprehensive analysis of patients’complaints and eating *** data collection relies on subjective descriptions and lacks objective ***,a scoring system for the evaluation of computed tomography-based obstructive degree(CTOD)is urgently required for *** To explore the relationship between CTOD and CROSS and to determine whether CTOD could affect the short-term and long-term *** Of 173 patients were *** was obtained using k-means,the ratio of proximal to distal obstruction,and the proportion of nonparenchymal areas at the site of *** was integrated with the CROSS to analyze the effect of emergency intervention on ***-term and long-term outcomes were compared between the *** CTOD severe obstruction(CTOD grade 3)was an independent risk factor[odds ratio(OR)=3.390,95%confidence interval(CI):1.340-8.570,P=0.010]via multivariate analysis of short-term outcomes,while CROSS grade was *** the CTOD-CROSS grade system,for the non-severe obstructive(CTOD 1-2 to CROSS 1-4)group,the complication rate of emergency interventions was significantly higher than that of non-emergency interventions(71.4%vs 41.8%,P=0.040).The postoperative pneumonia rate was higher in the emergency intervention group than in the non-severe obstructive group(35.7%vs 8.9%,P=0.020).However,CTOD grade was not an independent risk factor of overall survival and progression-free *** CTOD was useful in preoperative decision-making to avoid unnecessary emergency interventions and complications.

关键词： Obstructive colorectal cancer Scoring system Computed tomography-based obstructive degree Colorectal obstruction scoring system Emergency intervention

Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge dai Li rongrong Zhong Qiang Liu Fanglian chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Multi-layer Optimal Control Strategy for Traction Photovoltaic and Energy Storage System Based on Interphase Bridging Inverter-railway Energy Router

在线全文

学校读者我要写书评

暂无评论

Zhongguo Dianji Gongcheng Xuebao/Proceedings of the Chinese Society of Electrical Engineering 2025年第4期45卷 1477-1487页

作者： Lian, Jingru dai, Chaohua Yao, Zhigang chen, Weirong School of Electrical Engineering Southwest Jiaotong University Sichuan Province Chengdu611756 China

The railway energy router(RER) is a crucial device in electrified railway systems, serving to improve power quality, recover braking energy, and utilize renewable energy. However, the conventional topology of RER requires transformers and inverters with doubled operational power capacity, leading to high costs and limiting industrial applicability. To tackle this issue, this paper proposes a novel interphase bridging inverter structure-based railway energy router(IBI-RER), with its AC side bridging the α-phase and βphase traction bus and its DC side integrating photovoltaic power and energy storage. First, the operation principle and energy transfer mode of this structure are analyzed. To address the active and reactive power coupling resulting from the transition of the inverter’s traditional two-port mode to the IBI-RER’s three-port mode, a hardware decoupling method with reactive power compensation devices is proposed. Additionally, to manage multi-directional energy flows among the three ports for the IBI-RER, a multi-layer optimal control strategy is introduced. Finally, based on the typical operation conditions and the measured data, a comparative analysis with the conventional RER is performed. The results show that, under the same function, the proposed IBI-RER has the advantages of simple structure and lower cost. ©2025 *** ***.

关键词： Energy transfer

Surface-confined persistent luminescence with amplified FRET efficiency for cell-cell communication monitoring

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Ziyun Miao Wenjing dai Yubin Jin Bing Qi Jiayi chen Lingling Qiu Yurong Wei Jie Wang The Key Lab of Health Chemistry&Molecular Diagnosis of Suzhou College of ChemistryChemical Engineering&Materials ScienceSoochow University

Microbial communication monitoring is vital for understanding the mechanisms beneath gut microbiota equilibrium, infections,and biomanufacturing. Herein, we reported monitoring bacterial communication by surface-confined persistent ***, we constructed core-shell structured Zn1.4Ga1.2Ge0.4O4@Zn1.4Ga1.2Ge0.4O4:Cr（ZGGO@ZGGO:Cr） persistent luminescence nanoparticles（PLNPs） with amplified FRET efficiency for the detection of azoreductase（AzoR） that participates in bacterial communication. ZGGO@ZGGO:Cr nanoparticles were functionalized with an azo black hole quencher（ZGGO@ZGGO:Cr-BHQ-3）. Due to the proximity of surface-confined persistent luminescence with the surface-bound BHQ-3,ZGGO@ZGGO:Cr-BHQ-3 exhibited a FRET efficiency up to 1.6 times that of traditional ZGGO:Cr-BHQ-3. Further, the specific catalytic reduction of azo bonds in BHQ-3 by bacterial extracellular AzoR recovers the persistent luminescence of ZGGO@ZGGO:Cr. ZGGO@ZGGO:Cr-BHQ-3 displayed superior sensitivity and speed in detecting extracellular AzoR over ZGGO:Cr-BHQ-3, attributed to its surface-confined persistent luminescence. We found that the peak secretion of AzoR occurs during the exponential growth period of bacteria including S. aureus and E. coli based on the persistent luminescence recovery rate of ZGGO@ZGGO:Cr-BHQ-3. Furthermore, ZGGO@ZGGO:Cr-BHQ-3 was used to probe the communication between different bacterial species. R. palustris is a kind of lycopene-production bacteria. We found that the cohabitation of R. palustris and S. putrefaciens boosted both AzoR secretion and lycopene production. Moreover, the secretion and activity of AzoR positively correlated with lycopene production, suggesting that AzoR may participate in the communication between R. palustris and S. putrefaciens to promote lycopene production. This study offers a robust method to enhance PLNP-based biosensing sensitivity and provides a promising strategy for microbial communication monitoring.

关键词：

动态描述逻辑动作系统的Petri网自动生成方法

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

系统仿真学报 2008年第S2期20卷 72-75页

作者：马炳先于代荣陈宇济南大学信息科学与工程学院济南250022

动态描述逻辑的动作理论对动作的静态描述和动态执行提供了良好的基础和方法。作为对动态描述逻辑的扩充,可以利用Petri网对多个动态描述逻辑动作间的关系进行很好的描述和分析。具体讨论了动态描述逻辑动作系统对应的Petri网模型自动... 详细信息

动态描述逻辑的动作理论对动作的静态描述和动态执行提供了良好的基础和方法。作为对动态描述逻辑的扩充,可以利用Petri网对多个动态描述逻辑动作间的关系进行很好的描述和分析。具体讨论了动态描述逻辑动作系统对应的Petri网模型自动生成问题,利用领域本体对动态描述逻辑动作的条件进行本体定义,通过本体推理,得到不同动作间的条件定义中的相同或等价元素,进一步,自动构造得到动作系统的Petri网的PNML+OWL描述。

关键词：动态描述逻辑动作 Petri网 PNML OWL

Targeting IGF1 to alleviate obesity through regulating energy expenditure and fat deposition

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年

作者： Ping rong Yinqiu Mu Meiqin Wang Liang chen Fangtong Liu Yuxin Jin Weikuan Feng Kun Zhou Hui Liang Hongyu Wang Shuai chen State Key Laboratory of Pharmaceutical Biotechnology Department of Endocrinology Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Model Animal Research Center Nanjing University MOE Key Laboratory of Model Animal for Disease Study Model Animal Research Center School of Medicine Nanjing University College of Life Sciences Anhui Medical University Department of General Surgery First Affiliated Hospital Nanjing Medical University

Insulin-like growth factor 1 (IGF1) is a regulator of both cellular hypertrophy and lipogenesis,which are two key processes for pathogenesis of ***,the in vivo role of IGF1 in the development of obesity remains ***,we show that IGF1 expression is increased in adipose tissue in obese human patients and animal *** of IGF1 is associated with increased lipogenic gene expression and decreased energy *** down-regulation of IGF1 normalizes lipogenic gene expression,restores aberrant energy metabolism and alleviates obese phenotype of a genetic mouse model with ***,genetic down-regulation of IGF1 exerts similar effects on development of diet-induced ***,berberine that is an AMP-activated protein kinase (AMPK) activator in medicinal herbs inhibits IGF1 secretion,decreases lipogenic gene expression and alleviates diet-induced ***,our findings demonstrate that hypersecretion of IGF1 is a critical factor for the development of obesity and can be targeted using AMPK activators to alleviate obesity.

关键词：

Layered Double Hydroxide Nanosheets Incorporated Hierarchical Hydrogen Bonding Polymer Networks Coatings

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第5期17卷 374-390页

作者： Bifan Guo Yimin He Yongming chen Tianci Yang Chaohua Peng Weiang Luo Birong Zeng Yiting Xu Lizong dai Fujian Provincial Key Laboratory of Fire Retardant Materials College of MaterialsXiamen UniversityXiamen 361000People’s Republic of China Xiamen Key Laboratory of Fire Retardant Materials Xiamen UniversityXiamen 361000People’s Republic of China

In recent decades,annual urban fire incidents,including those involving ancient wooden buildings burned,transportation,and solar panels,have increased,leading to significant loss of human life and *** this issue without altering the surface morphology or interfering with optical behavior of flammable materials poses a substantial ***,we present a transparent,low thickness,ceramifiable nanosystem coating composed of a highly adhesive base(poly(SSS1-co-HEMA1)),nanoscale layered double hydroxide sheets as ceramic precursors,and supramolecular melamine di-borate as an *** demonstrate that this hybrid coating can transform into a porous,fire-resistant protective layer with a highly thermostable vitreous phase upon exposure to flame/heat source.A nanosystem coating of just~100μm thickness can significantly increase the limiting oxygen index of wood(Pine)to 37.3%,dramatically reduce total heat release by 78.6%,and maintain low smoke toxicity(CIT_G=0.016).Detailed molecular force analysis,combined with a comprehensive examination of the underlying flame-retardant mechanisms,underscores the effectiveness of this *** work offers a strategy for creating efficient,environmentally friendly coatings with fire safety applications across various industries.

关键词： Nanocomposites Supramolecular Flame retardancy Ceramic-like char layer Fire protection

Cerium Oxide Nanoparticles Alleviate Enhanced UV-B Radiation-Induced Stress in Wheat Seedling Roots by Regulating Reactive Oxygen Species

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2025年第2期94卷 455-479页

作者： cheng Sun chen Zhao Guohua Wang Qianwen Mao rong Han College of Chemistry and Materials Science Shanxi Normal UniversityTaiyuan030000China College of Life Sciences Shanxi Normal UniversityTaiyuan030000China Shanxi Provincial Key Laboratory of Plant Macromolecular Adversity Taiyuan030000China

Enhanced UV-B radiation represents a major environmental factor impacting global cereal *** have explored various approaches to reduce the detrimental impact of UV-B radiation on ***,engineered nanoparticles,particularly cerium oxide nanoparticles(CeO_(2)-NPs),have attracted widespread interest for their ability to boost plant tolerance to a range of abiotic *** study investigates how CeO_(2)-NPs application affects the morphology,physiology,biochemistry,and transcriptomics profiles of wheat seedling roots subjected to enhanced UV-B *** findings demonstrate that CeO_(2)-NPs notably promoted root length,fresh and dry weights,and root activity(p<0.05)under enhanced UV-B ***_(2)-NP treatment reduced the content of hydrogen peroxide<(H_(2)O_(2))and malondialdehyde(MDA)in wheat,alleviating oxidative damage in seedling roots and partially restoring the root *** non-UV-B stress conditions,CeO_(2)-NP treatment triggered the difference of 237 transcripts in plants relative to the control *** enhanced UV-B stress,CeO_(2)-NP treatment exhibited differentially expressed genes(DEGs)linked to the antioxidant defense mechanism responsible for reactive oxygen species(ROS)scavenging,compared to the non-nanoparticle *** suggests that ROS scavenging may be a key mechanism by which CeO_(2)-NPs enhance wheat resistance to enhanced UV-B *** study elucidates a potential molecular mechanism through which CeO_(2)nanoparticles may enhance wheat tolerance to UV-B stress.

关键词： Cerium oxide nanoparticles UV-B stress ROS scavenging transcriptomics analysis