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Evolution of Monkeypox C9L RNA G-Quadruplex Elevates the Translation of Its Only Kelch-like Protein by Accelerating G-Quadruplex Unfolding Kinetics

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CCS Chemistry 2024年第4期6卷 953-963页

作者： Yicong dai Xucong Teng Difei Hu Qiushuang Zhang jinghong Li Department of Chemistry Center for Bioanalytical ChemistryKey Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084 New Cornerstone Science Laboratory Shenzhen 518054 Beijing Life Science Academy Beijing 102209 Center for Bioanalytical Chemistry Hefei National Laboratory of Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026

Genomic surveillance of monkeypox virus(MPXV)is essential to explore the reason of its unusual *** phylogenomic analysis of the MPXV genome mainly focuses on the effect of amino acid ***,we explore the evolutionary variation of RNA G-quadruplex(RG4)of MPXV and find that the genome evolution of MPXV can also produce new effects through changes in the RG4 *** RG4 is located in MPXV’s only Kelch-like C9L gene,which encodes for an antagonist of the innate immune *** evolution of this virus increases the unfolding kinetic constant of C9L RG4 and promotes the C9 protein level in living ***,all reported MPXV genomes in 2022 carry the C9L-RG4-5 pattern with the highest unfolding kinetic ***,the RG4 ligand,RGB-1,can impede the unfolding of C9L-RG4-5 and thereby reduce the C9 protein *** findings carve out a new path to comprehensively understanding MPXV virology.

关键词： G-quadruplex RNA secondary structure unfolding kinetics monkeypox virus genomic evolution immune evasion

Idiopathic pulmonary fibrosis associated with circulating autoantibodies:a Chinese cohort of a long-term follow-up study

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Chinese Medical Journal 2022年第2期135卷 216-218页

作者： Hui Wang Haoran Chen Yin Liu Xin Yan Yujuan Gao Hourong Cai jinghong dai Department of Pulmonary and Critical Care Medicine Nanjing University Medical School Affiliated Drum Tower HospitalNanjingJiangsu 210008China

The term of interstitial pneumonia with autoimmune features(IPAF),based on a combination of clinical,serological,and morphological domains(specific chest imaging features,histopathological features,or multi-compartment involvement,including non-specific interstitial pneumonia[NSIP],organizing pneumonia,NSIP with organizing pneumonia overlap and lymphoid interstitial pneumonia).

关键词： involvement Idiopathic clinical

Giant cell interstitial pneumonia： unusual lung disorder and an update

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Chinese Medical Journal 2014年第15期127卷 2819-2823页

作者： dai jinghong Huang Mei Cao Min Miao Liyun Xiao Yonglong Shi Yi Meng Fanqing Cai Hourong Department of Respiratory Medicine Nanjing Drum Tower Hospital affiliated to Medical School ofNanjing University Nanjing Jiangsu 210008 China Department of Pathology Nanjing Drum Tower Hospital affiliated to Medical School ofNanjing University Nanjing Jiangsu 210008 China Department of Respiratory and Critical Care Medicine JinlingHospital Medical School of Nanjing University Nanjing Jiangsu210002 China

Background Giant cell interstitial pneumonia （GIP） was a rare form of pneumoconiosis,associated with exposure to hard metals,which had been reported mostly as isolated case *** described eight cases of GIP diagnosed in our hospital during the past seven years,with particular reference to new *** Eight patients with GIP confirmed by biopsy in the Nanjing Drum Tower Hospital affiliated to Medical School of Nanjing University from 2005 to 2011 were retrospectively *** each patient,the occupy histories and medical records were thoroughly reviewed and clinic data were *** radiologists,without knowledge of any of the clinical and functional findings,independently reviewed the HRCT scans of all ***-up data were *** Among the eight patients,seven had a history of exposure to hard metal dusts,one denied an exposure *** most common manifestations were cough and *** patient initiated with pneumothorax and another pleural effusion,both of which were uncommon to *** main pathologic appearances were the presence of macrophages and multinucleated giant cells in the alveolar *** clinical symptoms and radiographic abnormalities were obviously improved after cessation of exposure and receiving corticosteroid treatments,recurrences were observed in two patients when they resumed *** spite of exposure cessation and corticosteroid treatment,one patient developed pulmonary fibrosis at seven years *** Awareness of the patients＇ occupational history often provided clues to the diagnosis of *** examinations were necessary to establish the right *** cessation was of benefit to most patients; however,pulmonary fibrosis was possible in spite of exposure cessation and corticosteroid *** ways should be found out to improve the outcome and quality of life.

关键词： giant cell interstitial pneumonia high-resolution computed tomography cobalt corticosteroids surgical lung biopsy

Load Cluster Characteristic and Modeling of EV Charge Station in Residential District

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中国电机工程学报 2012年第22期32卷 I0005-I0005,21页

作者： ZHENG jinghong dai Mengting ZHANG Man WANG Wenzhuo ZHUShouzhen Tsinghua University

电动汽车的大规模发展将会对配电网带来较大影响,开展电动汽车充电的负荷特性研究是保证电网安全运行的前提,是引导电动汽车进行有序充电的基础。在简化锂电池恒流–恒压2阶段充电模型的基础上,得到单个电动汽车的充电模型,以此为基本元... 详细信息

电动汽车的大规模发展将会对配电网带来较大影响,开展电动汽车充电的负荷特性研究是保证电网安全运行的前提,是引导电动汽车进行有序充电的基础。在简化锂电池恒流–恒压2阶段充电模型的基础上,得到单个电动汽车的充电模型,以此为基本元素,从充电汽车电池的初始荷电状态（initial state-of-charge,SOC0）和车辆到达充电站时间的随机分布为出发点,提出2阶段泊松分布的电动汽车充电站集聚模型进行充电站集聚特性的模拟,并提出基于充电站的日充电负荷曲线的电动汽车充电站负荷集聚模型的建模方法,最后通过仿真算例验证了其有效性。

关键词：电动汽车住宅小区充电特性充电站建模集群负载智能调度

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin Chen jinghong Xu Bin Jiang Lei Li Yawei Li Yuliang dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

Vertical distribution of zooplankton in centre of South China Sea

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Acta Oceanologica Sinica 1989年第1期8卷 158-159页

作者： Chen Ruixiang, Cai Bingji, Lin Mao,Lin jinghong, dai Yanyu, Lian Guangshan,Lin Yuhui and Wang ZhiyuanThird Institute of Oceanography.State Oceanic Administration, Xiamen, China

Four comprehensive surveys with different depths and subjects were performed byState Oceanic Administration (SOA), China in the centre of the South China Sea(12°-19°30′N, 111°-118°E) from September 1983 to January 1985. According to the data,the vertical distribution pattern of the total biomass and species of zooplankton down to a4000 m depth was for the first time reported and analysed, and the vertical composition ofpopulation was studied.

关键词： SOA Vertical distribution of zooplankton in centre of South China Sea

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现代远程高等教育质量保障策略探究

教育与职业 2007年第9期 22-24页

作者：童少颖戴静鸿湖州职业技术学院

根据现代远程高等教育的特点及其所面临的诸多问题，文章提出制定统一完善的质量标准、强化教师信息素养培养、构建有效的学习支持服务系统、优化及共建共享网上教学资源、提高学生在线学习质量、加大教学管理力度等六大策略，以期保障... 详细信息

根据现代远程高等教育的特点及其所面临的诸多问题，文章提出制定统一完善的质量标准、强化教师信息素养培养、构建有效的学习支持服务系统、优化及共建共享网上教学资源、提高学生在线学习质量、加大教学管理力度等六大策略，以期保障现代远程高等教育的质量。

关键词：现代远程高等教育教学质量保障

间质性肺疾病继发肺孢子菌肺炎50例患者的临床分析

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中国呼吸与危重监护杂志 2023年第11期22卷 789-795页

作者：刘玲代静泓邱玉英南京大学医学院附属鼓楼医院呼吸与危重症医学科江苏南京210008

目的总结间质性肺疾病(interstitial lung disease,ILD)继发肺孢子菌肺炎(pneumocystis pneumonia,PCP)患者的临床特征,以提高临床医生对该类疾病的预防与诊治水平。方法收集2015年1月—2022年12月就诊于南京鼓楼医院呼吸与危重症医学科... 详细信息

目的总结间质性肺疾病(interstitial lung disease,ILD)继发肺孢子菌肺炎(pneumocystis pneumonia,PCP)患者的临床特征,以提高临床医生对该类疾病的预防与诊治水平。方法收集2015年1月—2022年12月就诊于南京鼓楼医院呼吸与危重症医学科的50例ILD继发PCP患者的临床资料,采用SPSS26.0统计软件对资料进行分析。结果共纳入50例ILD继发PCP的患者。其中男23例,女27例,中位年龄64岁。48例(96%)患者有糖皮质激素使用史,中位时间为3个月,31例(30/40,77.5%)患者在开始激素治疗半年内发生PCP;34例(68%)患者同时有激素及免疫抑制剂使用史。所有ILD患者发生PCP前均未使用预防PCP的药物。ILD继发PCP患者的主要症状为气喘、咳嗽加重或发热;38例(76.0%)患者实验室检验可见外周血总淋巴细胞计数200 pg/mL,35例(70.0%)患者乳酸脱氢酶>350 U/L,41例(82.0%)患者有Ⅰ型呼吸衰竭;胸部高分辨率CT可见在原有ILD病变基础上新增磨玻璃影、实变影;36例患者通过二代测序技术检出肺孢子菌,标本主要来源于支气管肺泡灌洗液,2例患者经支气管肺泡灌洗液涂片染色镜检检出肺孢子菌;所有患者均选用复方新诺明抗肺孢子菌治疗。经治疗后29例好转出院,10例死亡,11例因治疗无效、病情恶化等原因自动出院。结论ILD患者使用激素及免疫抑制剂治疗后容易继发致命性的PCP,早期诊断尤为重要。应结合患者症状、外周血淋巴细胞计数、G试验及乳酸脱氢酶水平及影像学改变来综合考虑,并在患者早期能耐受纤维支气管镜时行灌洗液二代测序以确定诊断,防止漏诊、误诊。PCP常发生于ILD患者使用激素及免疫抑制剂治疗的半年内,在随访过程中需定期监测外周血CD4^(+)T淋巴细胞计数及CD3^(+)T淋巴细胞计数,及时预防PCP。

关键词：间质性肺疾病肺孢子菌肺炎二代测序 CD4^(+)T淋巴细胞 CD3^(+)T淋巴细胞 G试验乳酸脱氢酶

慢性脑供血不足患者认知功能障碍的磁共振波谱研究

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中华老年心脑血管病杂志 2021年第2期23卷 136-139页

作者：戴京红张颖苏增锋王书安徽医科大学第三附属医院合肥市第一人民医院老年病科合肥230061

目的采用磁共振波谱(magnetic resonance spectroscopy,MRS)技术检测慢性脑供血不足(CCCI)患者脑内物质代谢的变化。方法选择我院住院确诊的CCCI患者45例,根据简易智能状态检查量表(MMSE)和蒙特利尔认知评估量表(MoCA)评分将患者分为单... 详细信息

目的采用磁共振波谱(magnetic resonance spectroscopy,MRS)技术检测慢性脑供血不足(CCCI)患者脑内物质代谢的变化。方法选择我院住院确诊的CCCI患者45例,根据简易智能状态检查量表(MMSE)和蒙特利尔认知评估量表(MoCA)评分将患者分为单纯CCCI组29例和认知障碍组16例。另选健康志愿者21例作为对照组。入选者行MRS检查,获得优势侧额叶、颞叶、半卵圆中心为感兴趣区(ROI)的N-乙酰天门冬氨酸(NAA)、肌酸和胆碱峰的波幅下面积,计算NAA/肌酸、NAA/胆碱和胆碱/肌酸比值,采用Pearson相关性分析。结果认知障碍组MMSE、MoCA评分明显低于单纯CCCI组和对照组(P0.05)。MMSE、MoCA评分与额叶、颞叶、半卵圆中心NAA/肌酸比值(r=0.812和0.657、0.636和0.620、0.482和0.308)、NAA/胆碱比值(r=0.575和0.479、0.565和0.594、0.602和0.404)呈正相关(P<0.05,P<0.01)。结论CCCI认知功能障碍患者认知功能评分与其物质代谢异常具有相关性,对早期诊断CCCI继发认知功能障碍及指导临床治疗具有一定的指导意义。

关键词：椎底动脉供血不足认知功能障碍脑缺血磁共振波谱学胆碱肌酸早期诊断