检索结果-南通市图书馆

Food Science and Human Wellness 2024年第2期13卷 1065-1078页

作者： dai cheng Qianqian yu Kexin Zhu Dingdong Bu Zijian Wu State Key Laboratory of Food Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China School of Biotechnology and Food Science Tianjin University of CommerceTianjin 300134China

Epicatechin(EC)was used in this study to antagonize the cognitive dysfunction caused by lead(Pb)exposure in ***-week-old male Kunming mice were treated with PbCl_(2)(20 mg/kg)and/or EC(50 mg/kg)by gavage administration for 4 *** water maze test showed that EC could improve memory dysfunction induced by *** antagonized Ca^(2+)overload,activated Nrf2 signaling pathway and reduced the accumulation of Pb in the brain and serum,which suggested that EC might alter Pb distribution in *** vitro,spectroscopic analysis,potentiometric titration and docking studies were applied to inquiry into the interaction between bovine serum albumin(BSA)and Pb^(2+)in presence or absence of *** was proved to chelate Pb^(2+)and reduced the interaction between BSA and Pb^(2+).In summary,EC might protect Pb-induced cognitive impairment by activating Nrf2 signaling pathway,and suppressing Pb accumulation via interference on the binding of Pb to albumin.

关键词： Lead Epicatechin Bovine serum albumin Interaction Oxidative stress

Two polypores from yunnan new to China

在线全文

学校读者我要写书评

暂无评论

菌物学报 2008年第1期27卷 145-150页

作者： yu Chang-Jun LIJuan dai yu-cheng Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

1 INTRODUCTION Wood-rotting fungi have been intensively studied in China (dai & Niemel? 2002; dai et al. 2003, 2004a, 2004b; dai & Penttil? 2006), and some new species and new records were found

关键词：云南热带雨林多孔菌新记录种

Advances and outlook of integrated reservoir-wellbore-pipe network simulation technology

在线全文

学校读者我要写书评

暂无评论

Energy Geoscience 2024年第4期5卷 1-7页

作者： Hongmin yu Youqi Wang Chuanjie cheng Quanqi dai Jingjing Sun Qingxin Zhang SINOPEC Petroleum Exploration and Production Research Institute Beijing102206China Research and Development Center for the Sustainable Development of Continental Sandstone Mature Oilfield National Energy AdministrationBeijing102206China

The integrated simulation and optimization technology of reservoir-wellbore-pipe network is developed to reflect the mutual influence and restriction among reservoir engineering,oil production engineering and surface engineering,and to obtain the scheme with minimum conflict and optimal benefit in each *** technology is based on the concept of global optimization to maximize production and profit,reduce costs and increase *** paper elaborates the current situation of integrated simulation technology of reservoir-wellbore-pipe network both at home and abroad,discusses its correlation with the primary business of Sinopec and its development from three aspects of modeling,cloud platform and *** on its future development are put forward from underlying data,software platform,popularization and application,and cross-border integration to provide means and guidance for the construction of intelligent oil and gas *** results show that the integrated simulation of reservoir-wellbore-pipe network can better reflect the optimization requirements of each step,avoid the ineffective operation of field equipment,and effectively improve the efficiency of research and *** solution,global optimization method and pressure fitting,which can make the simulation results reflect the real situation,are the key technologies for the *** theoretical technology and main function research of integrated simulation technology have been mature,but the large-scale application and local function improvement of oil and gas fields are yet to be *** the future,the integrated simulation of reservoir-wellbore-pipe network will develop from digitalization to modeling and intellectualization,from local simulation to cloud computing,and from manual intervention to intelligent *** suggest speeding up the construction of the unified database and model base of the whole underlying platform,strengthening the constr

关键词： Reservoir-wellbore-pipe network Integrated production modelling Prospect Development suggestion Simulation

CO_(2)flooding in shale oil reservoir with radial borehole fracturing for CO_(2)storage and enhanced oil recovery

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第1期21卷 519-534页

作者： Jia-cheng dai Tian-yu Wang Jin-Tao Weng Kang-Jian Tian Li-Ying Zhu Gen-Sheng Li State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China China National Oil and Gas Exploration and Development Company Limited Beijing100034China

This study introduces a novel method integrating CO_(2)flooding with radial borehole fracturing for enhanced oil recovery and CO_(2)underground storage,a solution to the limited vertical stimulation reservoir volume in horizontal well fracturing.A numerical model is established to investigate the production rate,reservoir pressure field,and CO_(2)saturation distribution corresponding to changing time of CO_(2)flooding with radial borehole fracturing.A sensitivity analysis on the influence of CO_(2)injection location,layer spacing,pressure difference,borehole number,and hydraulic fractures on oil production and CO_(2)storage is *** CO_(2)flooding process is divided into four *** in layer spacing will significantly improve oil production rate and gas storage ***,serious gas channeling can occur when the spacing is lower than 20 *** the pressure difference between the producer and injector,the borehole number,the hydraulic fracture height,and the fracture width can also increase the oil production rate and gas storage *** analysis shows that layer spacing and fracture height greatly influence gas storage and oil *** outcomes are expected to provide a theoretical basis for the efficient development of shale oil reservoirs in the vertical direction.

关键词： Shale oil Radial borehole fracturing Embedded discrete fracture model Enhanced oil recovery Carbon storage

Strategies that regulate LSD1 for novel therapeutics

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第4期14卷 1494-1507页

作者： Meng Li Mengge dai Bing cheng Shaotong Li Enhui Guo Junwei Fu Ting Ma Bin yu School of Pharmaceutical Sciences&Key Laboratory of Advanced Drug Preparation Technologies Ministry of EducationZhengzhou UniversityZhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China Tianjian Laboratory of Advanced Biomedical Sciences Institute of Advanced Biomedical SciencesZhengzhou UniversityZhengzhou 450000China Pingyuan Laboratory State Key Laboratory of Antiviral DrugsHenan Normal UniversityXinxiang 453007China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Histone methylation plays crucial roles in regulating chromatin structure and gene transcrip-tion in epigenetic ***-specific demethylase 1(LSD1),the first identified histone de-methylase,is universally overexpressed in various ***1 dysregulation is closely associated with cancer,viral infections,and neurodegenerative diseases,etc.,making it a promising therapeutic *** LSD1 inhibitors and two small-molecule degraders(UM171 and BEA-17)have entered the clinical ***1 can remove methyl groups from histone 3 at lysine 4 or lysine 9(H3K4 or H3K9),resulting in either transcription repression or *** the roles of LSD1 in transcrip-tional regulation are well-established,studies have revealed that LSDl can also be dynamically regulated by other *** example,the expression or activity of LSD1 can be regulated by many proteins that form transcriptional corepressor complexes with ***,some post-transcriptional modifica-tions and cellular metabolites can also regulate LSD1 expression or its demethylase ***,in this review,we will systematically summarize how proteins involved in the transcriptional corepressor complex,various post-translational modifications,and metabolites act as regulatory factors for LSD1 ac-tivity.

关键词： LSD1 regulation Transcription repression Transcription activation the Corepressor complex Post-transcriptional modifications Metabolites

Hydnaceous fungi of China 1. Stecchericium （Aphyllophorales）, a genus new to China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

菌物学报 2008年第1期27卷 57-61页

作者： yuAN Hai-Sheng dai yu-cheng Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China

The hydnaceous genus Stecchericium is newly recorded from southeast of China. It is characterized by imbricate basidiocarps, tubular and thick-walled gloeocystidia, and small, ellipsoid, finely asperulate, strongly amyloid basidiospores. An illustrated description of Stecchericium seriatum is given based on the materials collected from yunnan Province.

关键词：中国齿状真菌刺孢齿耳属非褶菌目新记录属

Two species in Hymenochaetaceae （Basidiomycota） new to China

在线全文

学校读者我要写书评

暂无评论

菌物学报 2008年第1期27卷 151-155页

作者： yuAN Hai-Sheng dai yu-cheng Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China

1 INTRODUCTION Wood-inhabiting fungi from northern China were investigated extensively during last ten years, and the species in the area are relatively well known (dai 2000; dai et al. 2006, 2007; Wei et al. 2005;

关键词：中国锈革孔菌科新记录新种

Study on the optimal incident proton energy of ^(7)Li(p,n)^(7)Be neutron source for boron neutron capture therapy

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2024年第3期35卷 170-180页

作者： Yi-Nan Zhu Zuo-Kang Lin Hai-Yan yu Ye dai Zhi-Min dai Xiao-Han yu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Science Beijing 100049China

Boron neutron capture therapy(BNCT)is recognized as a precise binary targeted radiotherapy technique that effectively eliminates tumors through the^(10)B(n,α)^(7)Li nuclear *** various neutron sources,accelerator-based sources have emerged as particularly promising for BNCT ***^(7)Li(p,n)^(7)Be reaction is highly regarded as a potential neutron source for BNCT,owing to its low threshold energy for the reaction,significant neutron yield,appropriate average neutron energy,and additional *** study utilized Monte Carlo simulations to model the physical interactions within a lithium target subjected to proton bombardment,including neutron moderation by an MgF_(2)moderator and subsequent BNCT dose analysis using a Snyder head *** study focused on calculating the yields of epithermal neutrons for various incident proton energies,finding an optimal energy at 2.7 ***,the Snyder head phantom was employed in dose simulations to validate the effectiveness of this specific incident energy when utilizing a^(7)Li(p,n)^(7)Be neutron source for BNCT purposes.

关键词： Boron neutron capture therapy ^(7)Li(p,n)7Be neutron source Incident proton energy Monte Carlo simulation

Reduction of unactivated alkyl chlorides enabled by light-induced single electron transfer

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第2期67卷 471-481页

作者： Lei dai Zhao-Fei Zhang Xiang-yu Chen School of Chemical Sciences University of the Chinese Academy of SciencesBeijing100049China Institute of Chemistry Chinese Academy of SciencesBeijing100190China Binzhou Institute of Technology Weiqiao-UCAS Science and Technology ParkBinzhou256606China

Alkyl chlorides are abundant and easily accessible starting ***,due to the high reduction potentials associated with unactivated alkyl chlorides,achieving their single electron reduction remains a persistent *** challenge has spurred the exploration of efficient activation methods to overcome this *** recent years,photocatalysis has emerged as a mild and potent tool for the single electron reduction of unactivated alkyl chlorides,opening up new possibilities in this *** the rapid advancements in this area,a comprehensive review that provides a conceptual understanding of this emerging field,with a specific focus on reaction design and catalytic mechanisms,would be timely and highly ***,we present an overview of various synthetic techniques for photoinduced single electron reduction of unactivated alkyl ***,we also discuss the limitations of the present methods and future directions that lie ahead in this field.

关键词： photocatalysis unactivated alkyl chlorides single electron transfer radical reactions

The Rate of Convergence of Augmented Lagrangian Method for Minimax Optimization Problems with Equality Constraints

在线全文

学校读者我要写书评

暂无评论

Journal of the Operations Research Society of China 2024年第2期12卷 265-297页

作者： yu-Hong dai Li-Wei Zhang LSEC ICMSECAMSSChinese Academy of SciencesBeijing 100190China Institute of Operations Research and Control Theory School of Mathematical SciencesDalian University of TechnologyDalian 116024China

The augmented Lagrangian function and the corresponding augmented Lagrangian method are constructed for solving a class of minimax optimization problems with equality *** prove that,under the linear independence constraint qualification and the second-order sufficiency optimality condition for the lower level problem and the second-order sufficiency optimality condition for the minimax problem,for a given multiplier vectorμ,the rate of convergence of the augmented Lagrangian method is linear with respect to||μu-μ^(*)||and the ratio constant is proportional to 1/c when the ratio|μ-μ^(*)||/c is small enough,where c is the penalty parameter that exceeds a threshold c_(*)>O andμ^(*)is the multiplier corresponding to a local ***,we prove that the sequence of multiplier vectors generated by the augmented Lagrangian method has at least Q-linear convergence if the sequence of penalty parameters(ck)is bounded and the convergence rate is superlinear if(ck)is increasing to ***,we use a direct way to establish the rate of convergence of the augmented Lagrangian method for the minimax problem with a quadratic objective function and linear equality constraints.

关键词： Minimax optimization Augmented Lagrangian method Rate of convergence Second-order sufficiency optimality