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Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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REAL ROOT ISOLATION OF SPLINE FUNCTIONS

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Journal of Computational Mathematics 2008年第1期26卷 69-75页

作者： Renhong Wang jinming Wu Institute of Mathematical Sciences Dalian University of Technology Dalian 116024 China

In this paper, we propose an algorithm for isolating real roots of a given univariate spline function, which is based on the use of Descartes＇ rule of signs and de Casteljau algorithm. Numerical examples illustrate t... 详细信息

关键词： Real root isolation Univariate spline Descartes' rule of signs de Casteljau algorithm

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APPROXIMATE IMPLICITIZATION BASED ON RBF NETWORKS AND MQ QUASI-INTERPOLATION

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Journal of Computational Mathematics 2007年第1期25卷 97-103页

作者： Renhong Wang jinming Wu Institute of Mathematical Sciences Dalian University of Technology Dalian 116024 China

In this paper, we propose a new approach to solve the approximate implicitization problem based on RBF networks and MQ quasi-interpolation. This approach possesses the advantages of shape preserving, better smoothness, good approximation behavior and relatively less data etc. Several numerical examples are provided to demonstrate the effectiveness and flexibility of the proposed method.

关键词： RBF networks MQ quasi-interpolation Approximate implicitization Rationalcurves,

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聚乙烯醇水溶液对多壁碳纳米管分散性的研究

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精细石油化工进展 2011年第5期12卷 32-34,51页

作者：马彦龙张凯莉侯文生戴晋明王帅范海宾太原理工大学材料科学与工程学院太原030024 太原理工大学轻纺工程与美术学院榆次031200

采用超声波辅助溶液共混的方法,将多壁碳纳米管(MWNTs)分散在聚乙烯醇(PVA)溶液中,制备了MWNTs/PVA混合悬浮液。通过紫外可见分光光度计、电导率的变化和傅里叶红外光谱等对悬浮液的稳定性进行表征。结果表明,PVA对MWNTs强烈的包覆作用... 详细信息

采用超声波辅助溶液共混的方法,将多壁碳纳米管(MWNTs)分散在聚乙烯醇(PVA)溶液中,制备了MWNTs/PVA混合悬浮液。通过紫外可见分光光度计、电导率的变化和傅里叶红外光谱等对悬浮液的稳定性进行表征。结果表明,PVA对MWNTs强烈的包覆作用改善了MWNTs在PVA水溶液中的分散性,质量分数为0.5%的PVA水溶液对0.2 g的MWNTs分散性能最好。

关键词：多壁碳纳米管聚乙烯醇分散性

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海上电动潜油螺杆泵井井筒温度分布规律研究

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石化技术 2022年第6期29卷 76-78页

作者：马增华王通孙红杰戴金明刘陈伟张国栋中海油田服务股份有限公司油田生产事业部天津300459 中国石油大学(华东) 石油工程学院山东青岛266555 青岛科技大学机电工程学院山东青岛266045

实例计算表明:相较于潜油电机,螺杆泵对井筒产液有更显著的增温效应;随着产液量及含水率的增加,螺杆泵的增温和增压幅度更大,对应的井口温度也越高,而随下泵深度的增加,螺杆泵的增温效果减弱。

关键词：潜油螺杆泵优化设计增温效应温度场模型敏感参数

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A new mechanism of atmospheric CO2 absorption promoted by iron-nitrogen coupling in low-latitude oceans during ice age

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Science China Earth Sciences 2020年第1期63卷 167-168页

作者： jinming SONG Qidong WANG CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Marine Ecology and Environmental Science Laboratory Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China University of Chinese Academy of Sciences Beijing 100049China Center for Mega-Science Chinese Academy of SciencesQingdao 266071China

It has been confirmed by a large number of studies that iron can significantly improve the carbon fixation level in the high-latitude oceans (Martinez-Garcia et al., 2014). Although there are many studies on the mechanism of ironcarbon coupling in the modem ocean, the research on ironnitrogen-carbon coupling is rare (Tagliabue et al., 2014;Song, 2010). It is of great significance for the prediction of future ocean changes to identify the key processes of modem ocean and analyze the past ocean changes.

关键词： latitude ocean prediction

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F-rough law and the discovery of rough law

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Journal of Systems Engineering and Electronics 2009年第1期20卷 81-89页

作者： Qiu jinming Shi Kaiquan Dept. of Mathematics and Computer Science Sanming Univ. Sanming 365004 P. R. China School of Mathematics and System Science Shandong Univ. Jinan 250100 P. R. China

By using function one direction S-rough sets （function one direction singular rough sets）, this article presents the concepts of F-law, F-rough law, and the relation metric of rough law; by using these concepts, this article puts forward the theorem of F-law relation metric, two orders theorem of F-rough law relation metric, the attribute theorem of F-rough law band, the extremum theorem of F-rough law relation metric, the discovery principle of F-rough law and the application of F-rough law.

关键词： function one direction S-rough sets F-rough law rough law relation metric the theorem of relationmetric the discovery principle ofF-rough law application.

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稀硝酸对多壁碳纳米管的表面修饰

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精细石油化工进展 2011年第3期12卷 38-41页

作者：罗秋兰戴晋明相增辉范海宾张凯莉侯文生太原理工大学轻纺工程与美术学院榆次031200 太原理工大学材料科学与工程学院太原030024

采用稀硝酸氧化法对多壁碳纳米管(MWNTs)进行表面修饰。利用扫描电镜(SEM)、傅里叶红外光谱(FTIR)以及X射线衍射(XRD)表征了样品的形貌与结构,采用Boehm滴定法测定了MWNTs表面的羧基含量。结果表明,经稀硝酸表面修饰后,MWNTs的晶体结构... 详细信息

采用稀硝酸氧化法对多壁碳纳米管(MWNTs)进行表面修饰。利用扫描电镜(SEM)、傅里叶红外光谱(FTIR)以及X射线衍射(XRD)表征了样品的形貌与结构,采用Boehm滴定法测定了MWNTs表面的羧基含量。结果表明,经稀硝酸表面修饰后,MWNTs的晶体结构遭到一定程度的破坏,但并没有影响其石墨结构,在MWNTs的表面引入了—COOH基团。

关键词：多壁碳纳米管硝酸表面修饰羧基

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Machine Learning Spectroscopy Using a 2-Stage,Generalized Constituent Contribution Protocol

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Research 2023年第4期2023卷 765-775页

作者： jinming Fan Chao Qian Shaodong Zhou College of Chemical and Biological Engineering Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture TechnologyZhejiang University310027 HangzhouP.R.China Institute of Zhejiang University-Quzhou Zheda Rd.#99324000 QuzhouP.R.China

A corrected group contribution(CGC)-molecule contribution(MC)-Bayesian neural network(BNN)protocol for accurate prediction of absorption spectra is *** combination of BNN with CGC methods,the full absorption spectra of various molecules are afforded accurately and efficiently—by using only a small dataset for ***,with a small training sample(1,000 samples to ensure the accuracy of ***,with2,000)to achieve comparable ***,by employing an MC method designed specifically for CGC that properly interprets the mixing rule,the spectra of mixtures are obtained with high *** logical origins of the good performance of the protocol are discussed in *** that such a constituent contribution protocol combines chemical principles and data-driven tools,most likely,it will be proven efficient to solve molecular-property-relevant problems in wider fields.

关键词： prediction absorption properly

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A learning-based approach for solving shear stress vector distribution from shear-sensitive liquid crystal coating images

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Chinese Journal of Aeronautics 2022年第4期35卷 55-65页

作者： Jisong ZHAO jinming ZHANG Boqiao WANG College of Astronautics Nanjing University of Aeronautics and AstronauticsNanjing 210016China Faculty of Rocket and Space Technology Kharkiv Aviation InstituteNational Aerospace UniversityKharkiv 61070Ukraine

A learning-based approach for solving wall shear stresses from Shear-Sensitive Liquid Crystal Coating(SSLCC) color images is presented in this paper. The approach is able to learn and establish the mapping relationship between the SSLCC color-change responses in different observation directions and the shear stress vectors, and then uses the mapping relationship to solve wall shear stress vectors from SSLCC color images. Experimental results show that the proposed approach can solve wall shear stress vectors using two or more SSLCC images, and even using only one image for symmetrical flow field. The accuracy of the approach using four or more observations is found to be comparable to that of the traditional multi-view Gauss curve fitting approach;the accuracy is slightly reduced when using two or fewer observations. The computational efficiency is significantly improved when compared with the traditional Gauss curve fitting approach, and the wall shear stress vectors can be solved in nearly real time. The learning-based approach has no strict requirements on illumination direction and observation directions and is therefore more flexible to use in practical wind tunnel measurement when compared with traditional liquid crystal-based methods.

关键词： Shear stress Measurement Shear-sensitive liquid crystal Learning-based approach Calibration

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