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Antioxidant antileishmanial cytotoxic and antimicrobial activities of a local plant Myrtus nivellei from Algeria Sahara

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Asian Pacific Journal of Tropical Biomedicine 2017年第8期7卷 702-707页

作者： Farah Ramdane Rym Essid Nadia Fares dahmane el ouassis Sana Aziz Mahfoud Hadj Mahammed Mohamed Didi Ould Hadj Ferid Limam Biogeochemistry Laboratory in Desert Environments Kasdi Merbah University Faculty of Natural and Life Sciences El Oued University Laboratory of Bioactive Substances Biotechnology Center of Borj-Cedria Technopole National Institute of Forest Research Protection Laboratory of Ecosystem in Arid and Semi Arid Zone Kasdi Merbah University

Objective: To study the phytochemical constituents and in vitro biological activities of hydromethanolic extract and fractions from Algerian Sahara Myrtus nivellei(M. nivellei)collected in Hoggar region and to identify the active fraction that can act as an alternative of commonly used antibiotics and as antileishmanial or antioxidant ***: Phytochemical screening of M. nivellei aerial parts was realised according to the literature. Extract was firstly prepared by using aqueous methanol then fractionated with ethyl acetate and butanol solvents. Total phenolics, tannis and flavonoids, of the hydromethanolic extract and their fractions were determined by Folin-Ciocalteu method as gallic acid equivalents and by aluminium chloride as rutin equivalent *** and fractions were tested for their antimicrobial and antiparasital activities against standard bacteria using agar diffusion method and two kinds of leishmania visceral and cutaneous. The antioxidant activities were realized using phosphomolybdenum, FRAP and DPPH ***: Preliminary phytochemical screening exhibited the presence of flavonoids,tannins, saponins, and alkaloids. The experimental results showed that plant extract and fractions were high in phenolic compounds and exhibited an important role as antioxidant,antimicrobial and had a moderate antileishmanial ***: These observations lead us toward more studies in this field, so that we can get more benefits from our local Algerian medicinal plants.

关键词：酉分的混合物 Flavonoids 抗氧化剂活动抗菌剂活动 Antileishmanial 活动 Myrtus nivellei

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Chemical composition,antioxidant and antimicrobial activities of the essential oil of Santolina chamaecyparissus *** Algeria

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Journal of Coastal Life Medicine 2015年第3期3卷 220-227页

作者： Nouasri Ahmed Dob Tahar Krimats Soumia dahmane dahmane Toumi Mohamed Lynda Lamari Chelgoume Chabane Racheme Farida Bioactive Molecules Laboratory and Valorisation of Biomass Ecole Normale SupérieureB.P.9216500 KoubaAlgersAlgeria Microbiology Laboratory Ecole Normale SupérieureB.P.9216500 KoubaAlgersAlgeria Chromatography Laboratory USTHBAlgersAlgeria Microbiology Laboratory CRD Saidal El MohamdiaAlgesAlgeria

Objective:To investigate the chemical composition,antioxidant and antimicrobial activities of essential oil of Santolina chamaecyparissus *** in ***:The chemical composition of hydrodistilled essential oil from flowering aerial parts has been analyzed by gas chromatograph and gas chromatograph-mass spectrometer *** antioxidant activities conducted by 2,2-diphenyl-1-picrylhydrazyl scavenging test andβ-carotene bleaching *** antimicrobial activity was realised by agar disc diffusion method and cornell medical index was determined by agar dilution method in solid ***:About 36 components accounting more than 82%of the total oil were *** monoterpenes was the main fraction(54.66%)and was represented by artemisia ketone(40.33%)as major component of this *** other major constituents were(Z)-thujone(9.82%),(2Z,6E)-farnesol(7.30%)and limonene(6.87%)and concerning antiradical scavenging test(2,2-diphenyl-1-picrylhydrazyl)had demonstrated a weak activity obtained with an EC_(50) of(43.01±8.04)and moderate activity for β-carotene bleaching test(47.00±3.13)at 120 *** the other hand,this oil was found effective against all tested strains except Pseudomonas aeruginosa and Aspergillus *** activity was ranging from 10 mm to 24 mm with the lowest minimum inhibitory concentration value between under 0.070μg/mL to upper 9μg/***:The results provided evidence that the studied plant might indeed be potential sources of natural antioxidant and antimicrobial agents.

关键词： Chemical composition Antioxidant and antimicrobial activities Artemisia ketone Essential oil Santolina chamaecyparissus L

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