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Diabetes, its impact on peripheral nerve regeneration： lessons from pre-clinical rat models towards nerve repair and reconstruction

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Neural Regeneration Research 2018年第1期13卷 65-66页

作者： Kirsten Haastert-Talini Lars B. dahlin Institute of Neuroanatomy and Cell Biology Hannover Medical School Hannover Germany Center for Systems Neuroscience (ZSN) Hannover Germany Department of Translational Medicine-Hand Surgery Lund University Lund Sweden Department of Hand Surgery Skane University Hospital Malmo Sweden

The global number of patients with type 1 and type 2 diabetes is about to increase substantially in the coming decades. The reasons for this are two-fold, at first there is actual increase in incidence of type 1 diabetes and at second there is global increase in living expectancy and a high prevalence of patients with type 2 diabetes among the elderly. The diabetic condition is affiliated with reduced peripheral nervous system maintenance, such as peripheral neuropathies （Juster-Switlyk and Smith, 2016） that may be more common in men.

关键词： Diabetes length

Ca^(2＋) involvement in activation of extracellular-signal- regulated-kinase 1/2 and m-calpain after axotomy of the sciatic nerve

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Neural Regeneration Research 2017年第4期12卷 623-628页

作者： Lisa B. Martensson Charlotta Lindwall Blom Lars B. dahlin Department of Translational Medicine-Hand Surgery Lund UniversityMalmoSweden Cellectricon AB MolndalSweden Department of Hand Surgery Skane University HospitalMalmoSweden

Detailed mechanisms behind regeneration after nerve injury, in particular signal transduction and the fate of Schwann cells （SCs）, are poorly understood. Here, we investigated axotomy-induced activation of extracellular- signal-regulated kinase-1/2 （ERK1/2; important for proliferation） and m-calpain in vitro, and the relation to Ca2＋ deletion and Schwann cell proliferation and death after rat sciatic nerve axotomy. Nerve segments were cultured for up to 72 hours with and without ethylene glycol-bis（β-aminoethyl ether）- N,N,N＇,N＇-tetraacetic acid （EGTA）. In some experiments, 5-bromo-2′-deoxyuridine （BrdU） was added during the last 24 hours to detect proliferating cells and propidium iodide （PI） was added at the last hour to detect dead and/or dying cells. Immunohistochemistry of sections of the cultured nerve segments was performed to label m-calpain and the phosphorylated and activated form of ERK1/2. The experiments revealed that immunoreactivity for p-ERK1/2 increased with time in organotypically cultured SCs. p-ERK1/2 and m-calpain were also observed in axons. A significant increase in the number of dead or dying SCs was observed in nerve segments cultured for 24 hours. When deprived of Ca2＋, activation of axonal m-calpain was reduced, whereas p-ERK1/2 was increased in SCs. Ca2＋ deprivation also significantly reduced the number of proliferating SCs, and instead increased the number of dead or dying SCs. Ca2＋ seems to play an important role in activation of ERK1/2 in SCs and in SC survival and proliferation. In addition, extracellular Ca2＋ levels are also required for m-calpain activation and up-regulation in axons. Thus, regulation of Ca2＋ levels is likely to be a useful method to promote SC proliferation.

关键词： nerve regeneration p-ERK1/2 m-calpain nerve injury signal transduction cell proliferation cell death activation axotomy sciatic nerve neural regeneration

Direct synthesis of per(poly)fluoroalkylmethyl-substituted electrophilic cyclopropane derivatives

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Chinese Journal of Chemistry 1995年第4期13卷 368-379页

作者： CHEN, J HU, cm CHINESE ACAD SCI SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

A convenient and direct per(poly)fluoroalkylmethyl-introducing cyclopropanation reaction was described. In the presence of CrCl3/Fe, per(poly)fluoroalkyl iodides reacted with diethyl allylmalonate and its analogs to give per(poly)fluoroalkylmethyl-substituted electrophilic cyclopropane derivatives in high yields. This reaction was considered to proceed by two steps: radical addition followed by cyclopropanation.

关键词： FLUOROALKYL IODIDE DIETHYL ALLYLMALONATE CRCL3/FE REDOX SYSTEM ADDITION CYCLOPROPANATION

Addition of polyfluoropolyhaloethanes to alkenes

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Chinese Journal of Chemistry 1995年第3期13卷 273-279页

作者： CHEN, J HU, cm CHINESE ACAD SCI SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

In the presence of CrCl3/Fe redox system, polyfluoropolyhaloethanes readily added to electron-deficient or electron-rich alkenes, giving the corresponding 1:1 hydropolyfluoroalkylation product or 1:1 adduct in high yields. This reaction provided a simple and convenient method to synthesize building blocks containing a CF3 or CF2 moiety.

关键词： CRCL3/FE REDOX SYSTEM POLYFLUOROPOLYHALOETHANE ALKENE ADDITION ADDUCT

Heme oxygenase-1 system and gastrointestinal tumors

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World Journal of Gastroenterology 2010年第21期16卷 2633-2637页

作者： Marie cm Lin Hsiangfu Kung The Brain Tumor Center and Neurosurgery Division Prince of Wales HospitalThe Chinese University of Hong Kong Li Ka Shing Institute of Medical Sciences the Chinese University of Hong Kong

Heme oxygenase-1(HO-1) system catabolizes heme into three products:carbon monoxide,biliverdin/bilirubin and free *** is involved in many physiological and pathophysiological processes.A great deal of data has demonstrated the roles of HO-1 in the formation,growth and metastasis of *** interest in this system by investigators involved in gastrointestinal tumors is fairly recent,and few papers on HO-1 have touched upon this *** review focuses on the current understanding of the physiological significance of HO-1 induction and its possible roles in the gastrointestinal tumors studied to *** implications for possible therapeutic manipulation of HO-1 in gastrointestinal tumors are also discussed.

关键词： Heme oxygenase-1 Gastrointestinal tumors

DICE:An Effective Query Result Cache for Distributed Storage Systems

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Journal of Computer Science & Technology 2010年第5期25卷 933-944页

作者： Jun-Ki Min Member, A cm Mi-Young Lee School of Computer Science and Engineering Korea University of Technology and Education Byeongcheon-myeon Cheonan Chungnam 330-708 Korea Cloud Computing Research Department Electronics and Telecommunications Research Institute (ETRI) Daejeon 305-700 Korea

Due to the proliferation of Internet and Intranet,the distributed storage systems have received a lot of attention. These systems span a large number of machines and store huge amount of data for a lot of *** the distributed storage systems,a row can be directly accessed using a row *** concentrate on a problem of efficient processing of queries whose predicate is on a column but not a row *** this paper,we present a cache management technique,called DICE which maintains query results of range queries to support the next range *** accelerate the search time of the cached query results,we use modified Interval Ski *** addition,we devise a novel cache replacement policy since DICE maintains an interval rather than a data *** our cache replacement policy considers the properties of intervals,our proposed technique is more efficient than traditional buffer replacement *** experimental result demonstrates the efficiency of our proposed technique.

关键词： distributed system range query query caching Interval Skip List cache replacement

On bi-symmetric algebras

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Chinese Science Bulletin 1997年第21期42卷 1774-1778页

作者： Bai, cm Meng, DJ Nankai Univ Dept Math Tianjin 300071 Peoples R China

LEFT-symmetric algebra is a new kind of algebra system obtained from the studying of Lie al-gebra, Lie group and differential geometry. It is very useful for many topics in geometry andalgebra. In this note, we discus... 详细信息

关键词： bi-symmetric algebra anti-isomorphism transitive bi-symmetric algebra

SYNTHESIS OF 3-PER(POLY)FLUOROALKYLPYRAZOLES

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Chinese Chemical Letters 1995年第4期6卷 281-284页

作者： Tang, XQ Hu, cm Chinese Acad Sci Shanghai Inst Organ Chem Shanghai 200032 Peoples R China

The reaction of the adducts of per(poly)fluoroalkyl iodides and vinyl acetate with hydrazine monohydrate to give the corresponding 3-per(poly)fluoroalkylpyrazoles in excellent yields is described. The reaction might g... 详细信息

关键词： V

Synthesis of Pyridylazo-substituted Chromogenic Calix[4]arenes

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Chinese Chemical Letters 2001年第11期12卷 959-960页

作者： Jin, cm Lu, GY You, XZ Nanjing Univ State Key Lab Coordinat Chem Dept Chem Nanjing 210093 Peoples R China

This letter reports a novel method for preparing chromogenic calix[4]arenes, in which the 4-aminopyridine was diazotized with isoamyl nitrite in EtONa/EtOH, and mono(azo)-, bis(azo)- and tetra(azo)-substituted calix[4]arenes were obtained as main product respectively by diazo-coupling in different molar ratio to calix[4]arene in non-aqueous solution at 0-5 degrees.

关键词： chromogenic calixarene diazo-coupling isoamyl nitrite aminopyridine