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How to perform gastrointestinal ultrasound: anatomy and normal findings

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World Journal of Gastroenterology 2017年第38期23卷 6931-6941页

作者： Nathan s s Atkinson Robert V Bryant Yi Dong Christian Maaser Torsten Kucharzik Giovanni Maconi Anil K Asthana Michael Blaivas Adrian Goudie Odd Helge Gilja Dieter Nuernberg dagmar s.hreiber-dietrich Christoph F dietrich Translational Gastroenterology Unit Oxford University Hospitals NHS Foundation Trust school of Medicine University of Adelaide Department of Gastroenterology and Hepatology Royal Adelaide Hospital Department of Ultrasound Zhongshan Hospital Fudan University Ambulanzzentrum Gastroenterologie Klinikum Lüneburg Department of Gastroenterology Stadtisches Klinikum Luneburg gGmbH Gastrointestinal Unit Department of Biomedical and Clinical Sciences 'L.Sacco' University Hospital Department of Gastroenterology and Hepato-logy The Alfred Hospital Monash University Piedmont Hospital Department of Emergency Medicine Fremantle Hospital and Health service Emergency Department National Centre for Ultrasound in Gastro- enterology Haukeland University Hospital Department of Clinical Medicine University of Bergen Department of Gastroenterology Brandenburg Medical School Med. Klinik 2 Caritas-Krankenhaus Bad Mergentheim

Gastrointestinal ultrasound is a practical, safe, cheap and reproducible diagnostic tool in inflammatorybowel disease gaining global prominence amongst clinicians. Understanding the embryological processes of the intestinal tract assists in the interpretation of abnormal sonographic findings. In general terms, the examination principally comprises interrogation of the colon, mesentery and small intestine using both lowfrequency and high-frequency probes. Interpretation of findings on GIUs includes assessment of bowel wall thickness, symmetry of this thickness, evidence of transmural changes, assessment of vascularity using Doppler imaging and assessment of other specific features including lymph nodes, mesentery and luminal motility. In addition to B-mode imaging, transperineal ultrasonography, elastography and contrast-enhanced ultrasonography are useful adjuncts. This supplement expands upon these features in more depth.

关键词： Ultrasound Intestinal Inflammatory bowel disease Guidelines Teaching

Abnormal metal homeostasis as a common drug target to combat neurodegenerative diseases

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Neural Regeneration Research 2021年第12期16卷 2388-2389页

作者： dagmar Pretsch Oxford Antibiotic Group GmbH Konrad-Lorenz-StraβeTullnAustria Department of PharmacognosyUniversity of ViennaAlthanstrasseViennaAustria

As life expectancy increases,the prevalence of age-related diseases will also *** has been an estimation that 50 million individuals are living with dementia in *** number will increase to 75 million in 2030 and 131.5 million by 2050(McGill-Carter,2020).Neurodegenerative diseases such as Alzheimer’s disease(AD),Parkinson´s disease(PD)and Huntington disease(HD)disproportionately affect older adult populations,inflicting a considerable physical,emotional,and economic burden.

关键词： diseases Huntington degenerative

Treating amyotrophic lateral sclerosis with allogeneic schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton dietrich Allan D.Levi James D.Guest Miller school of Medicine University of MiamiMiamiFLUSA stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,schwann cell function may also be ***,important signaling and potential trophic activities of schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic schwann cell-derived exosomal vesicles to potentially restore impaired schwann cell and motor neuron *** confirmed that cultured schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s schwann cells to allogeneic schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction schwann cell

Personalized treatment-which interaction ingredients should be focused to capture the unconscious

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World Journal of Clinical Cases 2022年第7期10卷 2053-2062页

作者： dagmar steinmair Henriette Löffler-stastka Department of Psychoanalysis and Psychotherapy Medical University ViennaWien 1090ÖsterreichAustria

A recent meta-analysis revealed that mental health and baseline psychological impairment affect the quality of life and outcomes in different chronic *** mental health care in physical care services is still ***,interdisciplinary communication across treatment providers is *** standardized language provided by the diagnostic statistical manual favors a clear ***,this approach might not focus on the individual,as thinking in categories might impede recognizing the continuum from healthy to *** theory is concerned with an individual’s unconscious conflictual wishes and motivations,manifested through enactments like psychic symptoms or(maladaptive)behavior with long-term consequences if not *** modifiable internal and external factors often are inadequately ***,together with the physical chronic condition constraints,these factors determine degrees of freedom for a self-determined *** effect of therapeutic interventions,and especially therapy adherence,relies on a solid therapeutic *** and process research still investigates the mechanism of change in psychotherapeutic treatments with psychanalysis’s focus on attachment *** article examines existing knowledge about the mechanism of change in psychoanalysis under the consideration of current trends emerging from psychotherapy research.A clinical example is ***,further directions for research are *** theoretical frame in psychoanalytic therapies is the affect-cognitive *** affect-perception is enabled via awareness of subjective meanings in oneself and the other;shaping this awareness is the main intervention *** interactional ingredients,the patient’s inherent bioenvironmental history meeting the clinician,are relevant *** intrinsic,subliminal parameters relevant for changing behavior are *** inter

关键词： Chronic disease Psychological impairment Psychoanalysis Facial microexpressions Memory reconsolidation Reflection Relationship Resilience

Future of processing and facilitating change and learning

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World Journal of Psychiatry 2021年第9期11卷 507-516页

作者： Henriette Loffler-stastka dagmar steinmair Department of Psychoanalysis and Psychotherapy Medical University of ViennaVienna 1090Austria

The field of the sciences of the mind is evolving *** the diversification of knowledge and accumulation of data,often lacking integration and reproducibility,questions *** role of critical thinking and research is *** the science of the unconscious,psychoanalysis provides a method and theory to understand human minds and mentalities,helping the patient know his mind and transform action into *** activities,including social skills,develop in the social context,depending on the social environment’s demands and resources put onto the *** emotional signals,markers of meaning for the individual,is ontogenetically necessary and has influences on memory *** theoretical understanding,implicit relational knowledge is actualized in the therapeutic *** a strong focus on experiencing emotional reconsolidation of memories,previous relationships’repercussions are enriched with broadening viewpoints in the analytic *** long-term effects of psychotherapeutic treatments have been examined.A sufficient explanation of the specific factors contributing to success or an answer when an impact is lacking is still under *** investigating subliminal and implicit mechanisms leading to memory reconsolidation and the formation of functional object relations and interaction patterns,the focus is set on affective interplay and processing prior/during and after social *** present paper discusses which parameters might contribute to the reshaping of memories and the linkage of memory with the emotional load of *** insights into such dynamic mental phenomena could enhance process research by investigating moment by moment interactions in psychoanalysis,treatment,and learning *** to the research subject’s complexity,different research methods and integration of associated research fields are required.

关键词： Psychoanalysis Hermeneutic circle Evidence-based medicine Bias Affective interplay Micro-process

Clinical significance and potential translation of neural regeneration and functional recovery in monkeys after spinal cord injury

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science China(Life sciences) 2018年第10期61卷 1291-1292页

作者： W.Dalton dietrich Leonard M.Miller school of Medicine University of MiamiMiami FL 33136 USA

The recent manuscript by Dr. Rao and colleagues （Rao et al., 2018） reports on a new combinational strategy that significantly promotes neural regeneration and improves motor and sensory function in nonhuman primates after severe spinal cord injury （sCI）. This acute reparative strategy that included the insertion of neurotrophin 3-loaded chitosan biodegradable material into a l-cm gap of the hemisectioned spinal cord had previously been tested in rodent models of sCI. In addition to showing that this reparative approach led to corticospinal tract axonal growth across the lesion area with extension into the distal spinal cord.

关键词：绳索新生神经翻译猴子临床最小公倍数感觉功能

Ultrasonographic imaging of inflammatory bowel disease in pediatric patients

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World Journal of Gastroenterology 2015年第17期21卷 5231-5241页

作者： Liliana Chiorean dagmar s.hreiber-dietrich Barbara Braden Xin-Wu Cui Reiner Buchhorn Jian-Min Chang Christoph F dietrich sino-German Research Center of Ultrasound in Medicine the First Affiliated Hospital of Zhengzhou University Department of Ultrasonography "Octavian Fodor" Institute of Gastroenterology and Hepatology400162 Cluj-NapocaRomania Medical Department 2 Caritas-KrankenhausD-97980 Bad MergentheimGermany Translational Gastroenterology Unit Oxford University HospitalsOX3 9DU OxfordUnited Kingdom Department of Pediatrics Caritas-KrankenhausD-97980 Bad MergentheimGermany

Inflammatory bowel disease(IBD) is one of the most common chronic gastrointestinal diseases in pediatric *** the optimal imaging modality for the assessment of gastrointestinal disease in pediatric patients can be *** invasiveness and patient acceptance,the radiation exposure and the quality performance of the diagnostic test need to be *** reviewing the literature regarding imaging in inflammatory bowel disease the value of ultrasound in the clinical management of pediatric patients is *** ultrasound is a useful,noninvasive method for the initial diagnosis of IBD in children;it also provides guidance for therapeutic decisions and helps to characterize and predict the course of the disease in individual *** techniques including color Doppler imaging and contrast-enhanced ultrasound are promising imaging tools to determine disease activity and *** studies between different imaging methods are needed.

关键词： Ultrasonography Guidelines Complication Intestine Pediatrics

simulating the mind and applications-a theory-based chance for understanding psychic transformations in somatic symptom disorders

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World Journal of Meta-Analysis 2021年第6期9卷 474-487页

作者： Henriette Löffler-stastka Dietmar dietrich Thilo sauter Martin Fittner dagmar steinmair Department of Psychoanalysis and Psychotherapy Medical University ViennaVienna 1090Austria Institute of Computer Technology TU WienVienna 1040Austria Center for Integrated sensor systems Danube University KremsWiener Neustadt 2700Austria University Hospital st.Pölten Karl Landsteiner University of Health SciencesSt.Pölten 3100Austria

With the new category of somatic symptom disorder/bodily distress disorder in ICD-11,research into pathogenetic and therapeutic pathways is *** turning away from the definition of somatoform disorders as“the lack of something physical explaining everything”,this new classification might offer a way to put the focus on the individual patient’s psychodynamic balance and conflicts and their condensation in the *** and simulation have a long history in science to gain insight also into complex *** the evolution of precision medicine many different parameters are meanwhile operationalised and ready for consequent process *** models have to fit to the complexity of this disorder *** an interdisciplinary discourse between computer and medical/psychoanalytic scientists a multilayer,fine grained calculation model is *** from a clinical case history,within iterative discussion,by acknowledging the demand for interdisciplinary synergy and cooperation in science,psychoanalytic theory served as the basis for computer-scientific information technique.A parallelisation with the Mealy model helped to establish a meaningful calculation possibility for further process *** psychic transformations can be understood properly in order to provide meaningful treatments,the respective training,and to conduct appropriate process-and outcome-research is established in simulating the mind and applications.

关键词： Psychic transformation Computer-technology simulation somatic symptom disorder Bodily distress disorder Mealy model

Methodological impact of starch determination on starch content and ileal digestibility of starch in grain legumes for growing pigs

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Journal of Animal science and Biotechnology 2017年第2期8卷 459-466页

作者： dagmar Jezierny Rainer Mosenthin Nadja sauer Klaus schwadorf Pia Rosenfelder-Kuon University of Hohenheim Institute of Animal ScienceEmil-Wolff-Strasse 1070599 StuttgartGermany Agricultural Analytic andResearch Institute speyer Obere Langgasse 4067346 SpeyerGermany University of Hohenheim Core Facility HohenheimEmil-Wolff-Strasse 1270599 StuttgartGermany

Background： Grain legumes represent a valuable energy source in pig diets due to their high starch content. The present study was conducted to determine the content and apparent ileal digestibility（AID） of starch in different grain legume cultivars for pigs by means of both a polarimetric and enzymatic method for starch ***： Three experiments were conducted with six barrows each which were fitted with ileal T-cannulas. In total, 18 diets including six different cultivars of faba beans（Vicia faba L.） and peas（Pisum sativum L.）, five different cultivars of lupins（Lupinus luteus L., Lupinus angustifolius L.）, and one diet with a soybean meal（sBM） were ***： The starch content of faba beans and peas was greater（P ＆lt; 0.05） when determined polarimetrically than enzymatically（438 vs. 345 g/kg dry matter（DM） in faba beans and 509 vs. 390 g/kg DM in peas, respectively）.Considerable lower starch contents were obtained in lupins and sBM, with 82 and 48 g/kg DM（analyzed polarimetrically） and ＆lt;1.1 and 3 g/kg DM（analyzed enzymatically）, respectively. Mean values for contents of neutral detergent fiber（NDF） and acid detergent fiber（ADF） in grain legumes ranged from 111 and 79 g/kg DM in peas to248 and 207 g/kg DM in lupins, respectively. Contents of condensed tannins in the colored flowered faba bean cultivars ranged from 2.1 to 7.4 g/kg DM. The AID of starch was greater（P ＆lt; 0.05） in pea than in faba bean cultivars,and using the polarimetric starch determination method resulted in greater（P ＆lt; 0.05） digestibility values than using enzymatic starch analysis（84 vs. 80% in faba beans and 86 vs. 83% in peas）. Moreover, AID of starch differed（P ＆lt; 0.05）within pea cultivars and starch digestibility in faba beans decreased linearly（P ＆lt; 0.05） as the content of condensed tannins increased. However, there was no relationship between contents of NDF and ADF and AID of starch in pea and faba bean ***： Both contents and AID of starch in

关键词： Grain legumes Growing pigs Ileal starch digestibility starch determination method