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World Journal of Clinical Cases 2022年第7期10卷 2053-2062页

作者： dagmar Steinmair Henriette Löffler-Stastka Department of Psychoanalysis and Psychotherapy Medical University ViennaWien 1090ÖsterreichAustria

A recent meta-analysis revealed that mental health and baseline psychological impairment affect the quality of life and outcomes in different chronic *** mental health care in physical care services is still ***,interdisciplinary communication across treatment providers is *** standardized language provided by the diagnostic statistical manual favors a clear ***,this approach might not focus on the individual,as thinking in categories might impede recognizing the continuum from healthy to *** theory is concerned with an individual’s unconscious conflictual wishes and motivations,manifested through enactments like psychic symptoms or(maladaptive)behavior with long-term consequences if not *** modifiable internal and external factors often are inadequately ***,together with the physical chronic condition constraints,these factors determine degrees of freedom for a self-determined *** effect of therapeutic interventions,and especially therapy adherence,relies on a solid therapeutic *** and process research still investigates the mechanism of change in psychotherapeutic treatments with psychanalysis’s focus on attachment *** article examines existing knowledge about the mechanism of change in psychoanalysis under the consideration of current trends emerging from psychotherapy research.A clinical example is ***,further directions for research are *** theoretical frame in psychoanalytic therapies is the affect-cognitive *** affect-perception is enabled via awareness of subjective meanings in oneself and the other;shaping this awareness is the main intervention *** interactional ingredients,the patient’s inherent bioenvironmental history meeting the clinician,are relevant *** intrinsic,subliminal parameters relevant for changing behavior are *** inter

关键词： Chronic disease Psychological impairment Psychoanalysis Facial microexpressions Memory reconsolidation Reflection Relationship Resilience

Importance of communication in medical practice and medical education:An emphasis on empathy and attitudes and their possible influences

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World Journal of Psychiatry 2022年第2期12卷 323-337页

作者： dagmar Steinmair Katharina Zervos Guoruey Wong Henriette Löffler-Stastka Department of Psychoanalysis and Psychotherapy Medical University of ViennaVienna 1090Austria Karl Landsteiner University of Health Sciences Krems 3500Austria Department of Ophtalmology University Hospital St.PöltenSt.Pölten 3100Austria Department of Internal Medicine I KRH Klinikum Robert-Koch-GehrdenGehrden 30989Germany Faculty of Medicine University of MontréalMontréal 2900QuébecCanada

BACKGROUND Healthcare professionals need to be prepared to promote healthy lifestyles and care for *** focusing on what students should be able to perform one day as clinicians,we can bridge the gap between mere theoretical knowledge and its practical *** aspects in clinical medicine also have to be considered when speaking of personalized medicine and learning *** To determine sets of intellectual,personal,social,and emotional abilities that comprise core qualifications in medicine for performing well in anamnesis-taking,in order to identify training *** An analysis of training clinicians’conceptions with respect to optimal medical history taking was *** chosen study design also aimed to assess gender *** interviews with supervising clinicians were carried out in a descriptive study at the Medical University of *** were analyzed by conducting a qualitative computer-assisted content analysis of the *** category formation was *** main questions posed to the supervisors dealt with(1)Observed competencies of students in medical history taking;and(2)The supervisor’s own conceptions of"ideal medical history taking".RESULTS A total of 33 training clinicians(n=33),engaged in supervising medical students according to the MedUni Vienna’s curriculum standards,agreed to be enrolled in the study and met inclusion *** qualitative content analysis revealed the following themes relevant to taking an anamnesis:(1)Knowledge;(2)Soft skills(relationship-building abilities,trust,and attitude);(3)Methodical skills(structuring,precision,and completeness of information gathering);and(4)Environmental/contextual factors(language barrier,time pressure,interruptions).Overall,health care professionals consider empathy and attitude as critical features concerning the quality of medical history *** looking at physicians’theoretical conceptions,more general practitioners and ps

关键词： Medical history taking Attitude Empathy Training Physicians’view

Biotechnological preparation of chicken skin gelatine using factorial design of experiments

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Food Bioscience 2022年第3期47卷 898-907页

作者： Petr Mrázek Robert Gál Pavel Mokrejš Jana Orsavová dagmar Janáčová Tomas Bata University in Zlín Department of Polymer EngineeringVavrečkova 275760 01ZlínCzech Republic Tomas Bata University in Zlín Department of Food TechnologyMostní 5139760 01ZlínCzech Republic Tomas Bata University in Zlín Language CentreŠtefánikova 5670760 01ZlínCzech Republic Tomas Bata University in Zlín Department of Automation and Control EngineeringNad Stráněmi 4511760 01ZlínCzech Republic

Poultry meat production steadily increases and its by-products including legs or skins may be further utilized to prepare gelatine,generally by using alkali or acid *** they are toxic,different methods are desirable,*** proteolytic *** enzymes is beneficial as they shorten processing time and reduce the required water *** conditions(the enzyme amount during the pre-treatment,first and second extraction temperature and time)of the process may influence gelatine quality and its *** this study,gelatines were prepared from chicken skin at different conditions in the series of combined factorial design of *** significance of the influence of the conditions on the quality(gel strength,viscosity,melting and gelling point)and yield of chicken skin gelatine(CSG)was *** highest yield(31.5%)was obtained at the conditions of the enzyme amount of 0.8%,first extraction temperature 80℃ and time 30 min,second extraction temperature 90℃ and time 60 ***,the highest CSG quality of gel strength(190 Bloom),viscosity(4.06 mPas),melting point(38.3℃)and gelling point(20.5℃)was obtained at the conditions of 0.2%/50℃/30 min in the first extraction.

关键词： Collagen Chicken skin Enzyme pre-treatment Gelatine Gelling properties

Abnormal metal homeostasis as a common drug target to combat neurodegenerative diseases

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Neural Regeneration Research 2021年第12期16卷 2388-2389页

作者： dagmar Pretsch Oxford Antibiotic Group GmbH Konrad-Lorenz-StraβeTullnAustria Department of PharmacognosyUniversity of ViennaAlthanstrasseViennaAustria

As life expectancy increases,the prevalence of age-related diseases will also *** has been an estimation that 50 million individuals are living with dementia in *** number will increase to 75 million in 2030 and 131.5 million by 2050(McGill-Carter,2020).Neurodegenerative diseases such as Alzheimer’s disease(AD),Parkinson´s disease(PD)and Huntington disease(HD)disproportionately affect older adult populations,inflicting a considerable physical,emotional,and economic burden.

关键词： diseases Huntington degenerative

Three-dimensional printing in paediatric orthopaedic surgery

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World Journal of Orthopedics 2022年第1期13卷 1-10页

作者： Sven Goetstouwers dagmar Kempink Bertram The Denise Eygendaal Bart van Oirschot Christiaan JA van Bergen Department of Orthopaedic Surgery and Sports Medicine Erasmus Medical Centre/Sophia Children's HospitalRotterdam 3015GDSouth-HollandNetherlands Department of Orthopaedic Surgery Amphia HospitalBreda 4818CKNorth-BrabantNetherlands D Lab Amphia HospitalBreda 4818CKNorth-BrabantNetherlands

Three-dimensional(3D)printing is a rapidly evolving and promising field to improve outcomes of orthopaedic *** use of patient-specific 3D-printed models is specifically interesting in paediatric orthopaedic surgery,as limb deformity corrections often require an individual 3D *** this editorial,various operative applications of 3D printing in paediatric orthopaedic surgery are *** technical aspects and the imaging acquisition with computed tomography and magnetic resonance imaging are ***,there is a focus on the intraoperative applications of 3D printing during paediatric orthopaedic surgical *** overview of various upper and lower limb deformities in paediatrics is given,in which 3D printing is already implemented,including posttraumatic forearm corrections and proximal femoral *** use of patient-specific instrumentation(PSI)or guiding templates during the surgical procedure shows to be promising in reducing operation time,intraoperative haemorrhage and radiation ***,3D-printed models for the use of PSI or patient-specific navigation templates are promising in improving the accuracy of complex limb deformity surgery in ***,the future of 3D printing in paediatric orthopaedics extends beyond the intraoperative applications;various other medical applications include 3D casting and prosthetic limb *** conclusion,3D printing opportunities are numerous,and the fast developments are exciting,but more evidence is required to prove its superiority over conventional paediatric orthopaedic surgery.

关键词： Three-dimensional printing Paediatric Orthopaedic surgery Intraoperative Patient-specific instrumentation Guiding

Integrative techniques using acupuncture,Chinese herbal medicine,diet,and supplements for polycystic ovary syndrome:a case report

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Journal of Integrative Medicine 2013年第6期11卷 422-427页

作者： dagmar Ehling Oriental Health Solutions LLC.

Patients with a diagnosis of polycystic ovary syndrome （PCOS） are on the rise. About 4%-12% of women are currently estimated to have this condition. It is hypothesized that PCOS appears in women who have long-standing insulin resistance （1R）, which leads to high androgen and testosterone levels; this ultimately disrupts their menstrual cycles. Some researchers attribute IR to genetic factors, although there have been only minute changes in the human genome in the past 20 000 years. However, even with a stable gene pool, genes can be turned on and offby the environment, food and air quality and toxin exposure.

关键词： polycystic ovary syndrome infertility Hashimoto disease acupuncture therapy medicine, Chinese traditional medicine, herbal diet dietary supplements case reports

On the laboratory rearing of green dock leaf beetles Gastrophysa viridula （Coleoptera： Chrysomelidae）

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Insect Science 2011年第3期18卷 379-384页

作者： dagmar Voigt Naoe Hosoda Jan Schuppert Stanislav Gorb Evolutionary Biomaterials Group Department of Thin-Films and Biological Systems Max Planck Institute for Metals Research Stuttgart Department of Functional Morphology and Biomechanics Zoological Institute Christian Albrechts University of Kiel Kiel Germany Advanced Nano Materials Laboratory Interconnect Design Group National Institute for Materials Tsukuba Ibaraki Japan

Leaf beetles Gastrophysa viridula have attracted recently increased research interest from various points of view, since they are：（i） pest insects in rhubarb crops; （ii） potential biocontrol agents of dock plants Rumex spp. in grasslands; and （iii） a model species in ecological studies on insect population dynamics, biochemistry, behavior, biomechanics and biomimetics. The continuous rearing of beetles at standardized conditions may help to unify the fitness state of different individuals, allowing a better comparison of experimental results. The present communication suggests a modular space- and time-saving rearing method ofG. viridula in stackable faunariums under laboratory conditions, which has been successfully established and continuously used over the last 5 years. Several developmental stages were kept in separate boxes, and multiple generations were kept simultaneously, depending on the required number of beetles.

关键词： Chrysomelidae standardisation Rumex obtusifolius

Future of processing and facilitating change and learning

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World Journal of Psychiatry 2021年第9期11卷 507-516页

作者： Henriette Loffler-Stastka dagmar Steinmair Department of Psychoanalysis and Psychotherapy Medical University of ViennaVienna 1090Austria

The field of the sciences of the mind is evolving *** the diversification of knowledge and accumulation of data,often lacking integration and reproducibility,questions *** role of critical thinking and research is *** the science of the unconscious,psychoanalysis provides a method and theory to understand human minds and mentalities,helping the patient know his mind and transform action into *** activities,including social skills,develop in the social context,depending on the social environment’s demands and resources put onto the *** emotional signals,markers of meaning for the individual,is ontogenetically necessary and has influences on memory *** theoretical understanding,implicit relational knowledge is actualized in the therapeutic *** a strong focus on experiencing emotional reconsolidation of memories,previous relationships’repercussions are enriched with broadening viewpoints in the analytic *** long-term effects of psychotherapeutic treatments have been examined.A sufficient explanation of the specific factors contributing to success or an answer when an impact is lacking is still under *** investigating subliminal and implicit mechanisms leading to memory reconsolidation and the formation of functional object relations and interaction patterns,the focus is set on affective interplay and processing prior/during and after social *** present paper discusses which parameters might contribute to the reshaping of memories and the linkage of memory with the emotional load of *** insights into such dynamic mental phenomena could enhance process research by investigating moment by moment interactions in psychoanalysis,treatment,and learning *** to the research subject’s complexity,different research methods and integration of associated research fields are required.

关键词： Psychoanalysis Hermeneutic circle Evidence-based medicine Bias Affective interplay Micro-process

Epigenetic modulations rendering cell-to-cell variability and phenotypic metastability

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Journal of Genetics and Genomics 2016年第8期43卷 503-511页

作者： Shawal Spencer Agustina Gugliotta Natascha Godecke Hansjorg Hauser dagmar Wirth Model Systems for Infection and Immunity Helmholtz Centre for Infection ResearchBraunschweig 38124Germany Experimental Hematology Hannover Medical SchoolHannover 30625Germany cell culture laboratory faculty of biochemistry and biological sciencesnational university of the littoralSanta Fe 3000Argentina

Tumor cells display phenotypic plasticity and heterogeneity due to genetic and epigenetic variations which limit the predictability of therapeutic interventions. Chromatin modifications can arise stochas- tically but can also be a consequence of environmental influences such as the microenvironment of cancer cells. A better understanding of the impact and dynamics of epigenetic modulation at defined chromosomal sites is required to get access to the underlying mechanisms. We investigated the epige- netic modulations leading to cell-to-cell heterogeneity in a tumor cell line model. To this end, we analyzed expression variance in 80 genetically uniform cell populations having a single-copy reporter randomly integrated in the genorne. Single-cell analysis showed high intraclonal heterogeneity. Epige- netic characterization revealed that expression heterogeneity was accompanied by differential histone marks whereas contribution of DNA methylation could be excluded. Strikingly, some clones revealed a highly dynamic, stochastically altered chromatin state of the transgene cassette which was accompanied with a metastable expression pattern. In contrast, other clones represented a robust chromatin state of the transgene cassette with a stable expression pattern. Together, these results elucidate locus-specific epigenetic modulation in gene expression that contributes to phenotypic heterogeneity of cells and might account for cellular plasticity.

关键词： lntraclonal heterogeneityEpigenetic regulationDNA methylationDifferential histone marksMetastable expression