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The AD/HD Syndrome as a Group of Biological Disorders

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Open Journal of Pediatrics 2016年第1期6卷 22-28页

作者： Anders Ziegler Magne Nødland dag Tveiten Karl L. Reichelt Lab 1 No. 1337 Sandvika Norway Stavanger Norway University of Oslo Oslo Norway

Problem: There is a need to collect the many and varied data on AD/HD (Attention deficit hyper-activity disorder) into a meaningful overview. Method: Based on peer reviewed and published data as well as own research we try to make sense of the physiological mechanisms resulting in the relevant symptoms. Conclusion: AD/HD clearly has a genetic disposition, but as with many other genetic syndromes, the resulting proteomics must be stressed to become manifest as disease/ disorder. A common trait in the different etiologies is lower arousal.

关键词： AD/HD Arousal Genetics Peptides Diet PUFA (Poly Unsaturated Fatty Acids) Monamines

Fermentative Bioethanol Production Using Enzymatically Hydrolysed <i>Saccharina latissima</i>

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Advances in Microbiology 2018年第5期8卷 378-389页

作者： Jacob Joseph Lamb Shiplu Sarker dag Roar Hjelme Kristian Myklebust Lien Department of Electronic Systems & ENERSENSE NTNU Trondheim Norway Department of Energy and Process Engineering & ENERSENSE NTNU Trondheim Norway

The increased demand for machinery and transport has led to an overwhelming increase in the use of fossil fuels in the last century. Concerning the economic and environmental concern, macroalgae with high fermentable polysaccharide content (mainly mannitol, cellulose and laminarin), can serve as an excellent alternative to food crops for bioethanol production, a renewable liquid fuel. In this study, Saccharina latissima, a brown macroalgae readily available on the Norwegian coast was used as the carbohydrate source for the fermentative production of bioethanol. The macroalgae harvested was found to contain 31.31 ± 1.73 g of reducing sugars per 100 g of dry Saccharina latissima upon enzymatic hydrolysis. The subsequent fermentation with Saccharomyces cerevisiae produced an ethanol yield of 0.42 g of ethanol per g of reducing sugar, resulting in a fermentation efficiency of 84% as compared to the theoretical maximum. Using these results, an evaluation of the fermentation process has demonstrated that the brown macroalgae Saccharina latissima could become a viable bioethanol source in the future.

关键词： Macroalgae Saccharina latissimi Fermentation Hydrolysis Bioethanol

Prognostic Factors and Treatment Outcome in 178 Locally Advanced Cervical Cancer Patients

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Open Journal of Obstetrics and Gynecology 2018年第5期8卷 485-496页

作者： Ozlem Yetmen Dogan Makbule Dogan Eren Sedef Ozdemir dag Alparsalan Mayadagli Radiation Oncology Department Kartal Dr Lutfi Kirdar Training and Research Hospital Saglik Bilimleri University Istanbul Turkey Radiation Oncology Department Sisli Hamidiye Etfal Training and Research Hospital Istanbul Turkey Radiation Oncology Department Bezmialem Vakif University Istanbul Turkey

Background: To evaluate local control, survival, radiation side effects and treatment outcome in locally advanced cervical cancer patients. Materials and Methods: Among 2006-2011, 178 patients with locally advanced cervical cancer were treated with chemoradiotherapy +/-?radiotherapy and high dose rate (HDR) brachytherapy. Follow-up was complete for all patients. Concomitant chemotherapy was not administered in 44 patients due to renal impairments and ECOG of 2 - 3. Results: The median follow-up period was 34.5 months (range, 5 to 93) and 42 months (range, 14 to 93 months) for alive patients. Five years local-regional control, progression-free survival and overall survival rates were 87.8%, 58.9% and 67.3% in all patients, respectively. In this retrospective study young age, tumor diameter, stage, presence of residual tumor and administration of chemotherapy were effected in survival analysis. The parameters which affected the complete response of patients were defined as presence of concomitant chemotherapy and number of courses <5. Central region recurrence rate was defined higher in the group with treatment duration of 9 weeks and higher (p = 0.044). Conclusion: Primary chemoradiotherapy +/-?radiotherapy achieved a satisfactory rate of local control and survival rates with acceptable complications in locally advanced cervical cancer. Concomitant chemotherapy and treatment duration were the important prognostic factors for completed response locally advanced cervical cancers.

关键词： Locally Advanced Cervix Cancer Chemo-Radiotherapy Cervix Cancer

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World Journal of Gastroenterology 2014年第14期20卷 3986-4000页

作者： Bjarte Fosby Sigrid Nss Johannes R Hov James Traherne Kirsten M Boberg John Trowsdale Aksel Foss Pl-dag Line Andre Franke Espen Melum Helge Scott Tom H Karlsen Norwegian PSC Research Center Division of CancerSurgery and TransplantationOslo University Hospital Institute of Clinical Medicine Faculty of MedicineUniversity of Oslo KG Jebsen Inflammation Research Centre Research Institute of Internal MedicineOslo University Hospital Department of Transplantation Medicine Division of CancerSurgery and TransplantationOslo University Hospital Division of Immunology Department of PathologyUniversity of Cambridge and Cambridge Institute for Medical ResearchUniversity of Cambridge Institute of Clinical Molecular Biology Christian-Albrechts-University Department of Pathology Divisoin of Diagnostics and InterventionInstitute of PathologyOslo University Hospital

AIM: To investigate influence of human leukocyte antigen (HLA) and killer immunoglobuline-like receptor (KIR) genotypes on risks of acute rejection (AR) after liver transplantation (LTX).

关键词： Liver transplantation Primary sclerosing cholangitis Acute rejection Human leukocyte antigen Killer immunoglobulin-like receptor

Fore-Body Side Vortex of KVLCC2 at 30°Drift: A Trailing Vortex Resolved with DES and Compared to PIV Data

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Open Journal of Fluid Dynamics 2019年第4期9卷 303-325页

作者： dag-Frederik Feder Ivan Shevchuk Ahmed Sahab Lukas Gerwers Moustafa Abdel-Maksoud FDS/TUHH Hamburg Germany

A hybrid RANS-LES approach is used to resolve the Fore-body Side Vortex (FSV) separating from the KVLCC2 hull at 30° drift angle and Reynolds number ReLoa ≈ 2.56e6. The performance of the DES approach is evaluated using a proper grid study. Besides, the following aspects of the CFD results are investigated: the resolution of turbulent energy, the prediction of instantaneous and time-averaged vortical structures, local flow features, the limiting streamlines and the evolution of the vortex core flow. New PIV data from wind tunnel experiments is compared to the latter. The results form a basis for future investigations in particular on the vortex interaction further downstream and the applicability of different kinds of turbulence models to trailing vortices like the FSV. Turbulence modelling is realised with the k-ω-SST-IDDES model presented in [1], the grids’ cell count is 6.4 M, 10.5 M and 17.5 M. Grid convergence of the time-averaged vortex core flow is observed. OpenFOAM version 1806 is used to carry out the simulations and snappyHexMesh to build the mesh.

关键词： KVLCC2 DES Hybrid RANS-LES PIV Trailing Vortex Drift

Carbohydrate Yield and Biomethane Potential from Enzymatically Hydrolysed <i>Saccharina latissima</i>and Its Industrial Potential

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Advances in Microbiology 2019年第4期9卷 359-371页

作者： Jacob J. Lamb dag R. Hjelme Kristian M. Lien Department of Electronic Systems & Enersense NTNU Trondheim Norway Department of Energy and Process Engineering & Enersense NTNU Trondheim Norway

The demand for fuel for utilisation of machinery and transport has culminated in large amounts of fossil fuel usage in the last century. The environmental dangers attached with the usage of fossil fuels have created a large demand for alternative sources of fuels. There is an array of polysaccharides contained within macroalgae, such as mannitol, cellulose and laminarin. These polysaccharides have potential for production of alternative biofuels;however, they are not easily accessible for biological digestion. By pretreatment of macroalgae with enzymes, these polysaccharides may be easier to access by microbes, allowing effective utilization in anaerobic digestion. Saccharina latissima, available in abundance on the Norwegian coast line, is a brown macroalgae with a high level of carbohydrates. This study assesses the ability for utilisation of enzymatically pre-treated Saccharina latissima for production of biogas through anaerobic digestion. The harvested Saccharina latissima was analysed to contain 30.11 ± 2.30 g of reducing sugars per 100 g of dry sample upon enzymatic hydrolysis. This was able to yield 459 ± 30 mL per gVS of biogas through anaerobic digestion, with a methane content of 56%. This suggests a biomethane potential of 1760 m3 per ha of productive sea floor growing Saccharina latissima. An evaluation of this process has been performed to demonstrate the industrial potential of Saccharina latissima in biogas production.

关键词： Macroalgae Hydrolysis Biogas Biomethane Enzymatic Hydrolysis

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完美日落

船舶工业技术经济信息 2005年第6期 14-19页

作者： dag Pike

最大的新型掠食者108游艇,同时具有大型游艇的尺寸和运动、巡航游艇的性能。用一个词来形容圣斯克的就是华丽。它的船体源自老式的108英尺游艇。但得益于他的三台发动机和ARNESON推进器,这种游艇能达到每小时50英里的速度。

关键词： 108型号游艇内部设计技术性能船体设计航海性能

A reasonable option in vitrectomized eyes: manual small incision cataract surgery

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 181-181页

作者： Hüseyin Bayramlar Remzi Karadag Bahri Aydin Yasar dag Department of Ophthalmology School of MedicineIstanbul Medeniyet University

Dear Sir,It is known that cataract surgery is challenging in vitrectomized *** surgeons may have encountered with posterior capsular complications and nucleus drop events even with minimal ocular manipulations and low irrigation bottle *** damage to the zonular fibers,posterior or peripheral lens capsule with ocutome or microvitreoretinal(MVR)blade in previous

关键词： manual small incision cataract surgery A reasonable option in vitrectomized eyes

Integrated lipidomics and proteomics network analysis highlights lipid and immunity pathways associated with Alzheimer's disease

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Translational Neurodegeneration 2020年第3期9卷 458-472页

作者： Jin Xu Giulia Bankov Min Kim Asger Wretlind Jodie Lord Rebecca Green Angela Hodges Abdul Hye dag Aarsland Latha Velayudhan Richard J.B.Dobson Petroula Proitsi Cristina Legido-Quigley on behalf of the AddNeuroMed Consortium Institute of Pharmaceutical Science King's College LondonLondonUK. Institute of Psychiatry Psychology&NeuroscienceKing's College LondonLondonUK. Steno Diabetes Center Copenhagen GentofteDenmark Center for Age Related Medicine Stavanger University HospitalStavangerNorway 不详

Background:There is an urgent need to understand the pathways and processes underlying Alzheimer's disease(AD)for early diagnosis and development of effective *** study was aimed to investigate Alzheimer's dementia using an unsupervised lipid,protein and gene multi-omics integrative ***:A lipidomics dataset comprising 185 AD patients,40 mild cognitive impairment(MCI)individuals and 185 controls,and two proteomics datasets(295 AD,159 MCI and 197 controls)were used for weighted gene CO-expression network analyses(WGCNA).Correlations of modules created within each modality with clinical AD diagnosis,brain atrophy measures and disease progression,as well as their correlations with each other,were *** ontology enrichment analysis was employed to examine the biological processes and molecular and cellular functions of protein modules associated with AD *** species were annotated in the lipid modules associated with AD *** associations between established AD risk loci and the lipid/protein modules that showed high correlation with AD phenotypes were also ***:Five of the 20 identified lipid modules and five of the 17 identified protein modules were correlated with clinical AD diagnosis,brain atrophy measures and disease *** lipid modules comprising phospholipids,triglycerides,sphingolipids and cholesterol esters were correlated with AD risk loci involved in immune response and lipid *** five protein modules involved in positive regulation of cytokine production,neutrophil-mediated immunity,and humoral immune responses were correlated with AD risk loci involved in immune and complement systems and in lipid metabolism(the APOE ε4 genotype).Conclusions:Modules of tightly regulated lipids and proteins,drivers in lipid homeostasis and innate immunity,are strongly associated with AD phenotypes.

关键词： Alzheimer's disease Dementia Brain atrophy sMRI Rate of cognitive decline Lipidomics Proteomics AD risk loci WGCNA