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Effect of vitamin D3 on production of progesterone in porcine granulosa cells by regulation of steroidogenic enzymes

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The Journal of Biomedical Research 2016年第3期30卷 203-208页

作者： So-Hye Hong Jae-Eon Lee Hong Sung Kim Young-Jin Jung daeyoun hwang Jae Ho Lee Seung Yun Yang Seung-Chul Kim Seong-Keun Cho Beum-Soo An Department of Biomaterials Science College of Natural Resources & Life Science Pusan National University Miryang 50463 Korea Department of Obstetrics and Gynecology Biomedical Research Institute Pusan National University School of Medicine Busan 46269 Korea Department of Animal Science College of Natural Resources & Life Science Pusan National UniversityMiryang 50463 Korea

1,25-dihydroxyvitamin D3 （VD3）, an active form of Vitamin D, is photosynthesized in the skin of vertebrates in response to solar ultraviolet B radiation （UV-B）. VD3 deficiency can cause health problems such as immune disease, metabolic disease, and bone disorders. It has also been demonstrated that VD3 is involved in reproductive functions. Female sex hormones such as estrogen and progesterone are biosynthesized mainly in ovarian granulosa cells as the ovarian follicle develops. The functions of sex hormones include regulation of the estrus cycle and puberty as well as maintenance of pregnancy in females. In this study, we isolated granulosa cells from porcine ovaries and cultured them for experiments. To examine the effects of VD3 on ovarian granulosa cells, the mRNA and protein levels of genes were analyzed by Real-time PCR and Western blotting assay. Production of progesterone from granulosa cells was also measured by ELISA assay. As a result, transcriptional and translational regulation of progesterone biosynthesis-related genes in granulosa cells was significantly altered by VD3. Furthermore, progesterone concen- trations in porcine granulosa cell-cultured media decreased in response to VD3. These results show that VD3 was a strong regulator of sex steroid hormone production in porcine granulosa cells, suggesting that vitamin D deficiency may result in inappropriate sexual development of industrial animals and eventually economic loss.

关键词： Vitamin D3 steroidogenesis progesterone granulosa cell pig

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Saccharomyces boulardii as a single trigger of food protein-induced enterocolitis syndrome: Seven case reports

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World Journal of Clinical Cases 2025年第6期13卷 35-40页

作者： Jin-Bok hwang Hyo-Jeong Jang Department of Pediatrics Keimyung University School of MedicineDongsan Medical CenterDaegu 42601South Korea

BACKGROUND Food protein-induced enterocolitis syndrome(FPIES)is the most serious type of non-immunoglobulin E(IgE)-mediated food allergic reaction manifesting as sepsis-like symptom,which can lead to *** boulardii(***),a probiotic prescribed frequently in clinical settings,has been reported to trigger FPIES in an infant with soy-triggered *** this report,we describe a new clinical FPIES in which *** was the sole triggering factor of acute FPIES adverse reaction in seven healthy *** SUMMARY Seven FPIES cases triggered by only *** were gathered from 2011 to the *** of the patients had previously experienced any allergic reaction to cow’s milk,soy,or complementary *** age of the patients was 4-10-months old,and the symptoms of FPIES developed after ingestion of ***,which is mostly prescribed for the treatment of gastroenteritis or antibiotic-associated *** patients experienced severe repetitive vomiting 1-3 hours after *** *** lethargy,marked pallor,and cyanosis were also *** IgE-mediated hypersensitivity developed in any *** was followed by initial intense vomiting in approximately 5-10 hours after *** ingestion,and only one case showed bloody,purulent,and foul-smelling *** patients stabilized quickly,mostly within 6 *** got all improved within 24 hours after discontinuation of *** *** can be the sole trigger of acute FPIES and be prescribed cautiously even in healthy children without FPIES.

关键词： Food protein-induced enterocolitis syndrome Food hypersensitivity Saccharomyces boulardii Probiotics Child Case report

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Exosomes as promising frontier approaches in future cancer therapy

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 28-33页

作者： Fatt-Yang Chew Chin-Hung Tsai Kuang-Hsi Chang Yu-Kang Chang Ruey-hwang Chou Yi-Jui Liu Department of Medical Imaging China Medical University HospitalTaichung 404TaiwanChina Department of Radiology School of MedicineChina Medical UniversityTaichung 404TaiwanChina Department of Cancer Center Tungs’Taichung MetroHarbor HospitalTaichung 435TaiwanChina Department of Chest Medicine Tungs’Taichung MetroHarbor HospitalTaichung 435TaiwanChina Department of Post-Baccalaureate Medicine College of MedicineNational Chung Hsing UniversityTaichung 402TaiwanChina Department of Medical Research Tungs’Taichung MetroHarbor HospitalTaichung 435TaiwanChina Center for General Education China Medical UniversityTaichung 404TaiwanChina General Education Center Jen-Teh Junior College of MedicineNursing and ManagementMiaoli 356TaiwanChina Department of Nursing Jen-Teh Junior College of MedicineNursing and ManagementMiaoli 356TaiwanChina Graduate Institute of Biomedical Sciences China Medical UniversityTaichung 404TaiwanChina Center for Molecular Medicine China Medical University HospitalTaichung 404TaiwanChina Department of Medical Laboratory and Biotechnology Asia UniversityTaichung 413TaiwanChina Department of Automatic Control Engineering Feng Chia UniversityTaichung 407TaiwanChina

In this editorial,we will discuss the article by Tang et al published in the recent issue of the World Journal of Gastrointestinal *** explored an innovative approach to enhancing gemcitabine(GEM)delivery and efficacy using human bone marrow mesenchymal stem cells(HU-BMSCs)-derived *** manufacture of GEM-loaded HU-BMSCs-derived exosomes(Exo-GEM)has been *** Tang et al’s study demonstrated that Exo-GEM exhibits enhanced cytotoxicity and apoptosis-inducing effects compared to free GEM,highlighting the potential of exosome-based drug delivery systems as a more effective and targeted approach to chemotherapy in pancreatic *** in vivo studies are required to confirm the safety and effectiveness of Exo-GEM before it can be considered for clinical use.

关键词： Mesenchymal stem cells Exosomes Gemcitabine Pancreatic cancer Apoptosis

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Aligned Ion Conduction Pathway of Polyrotaxane‑Based Electrolyte with Dispersed Hydrophobic Chains for Solid‑State Lithium–Oxygen Batteries

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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang Sung Gwang‑Hee Lee Byoungjoon hwang Sojung Seo Ji‑Hun Seo Dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo hwang Seunghwan Choi Soo-Ho Choi Keun-Young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

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Strain hardening rate dependency of deformation shape,strain distribution,and contact pressure during wire flat rolling

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Journal of Iron and Steel Research International 2023年第3期30卷 475-486页

作者： Joong-Ki hwang School of Mechatronics Engineering Korea University of Technology and EducationCheonan 31253Republic of Korea

The effect of the strain hardening exponent(n)of a material on the changes in shape,strain inhomogeneity,and contact pressure was investigated during wire flat rolling to understand its effect on the deformation behavior of a flat-rolled wire and to determine the optimal working conditions with *** deformation behaviors of wires with various n values were systematically compared using finite element *** shape of the deformed wire was found to depend on the n value of the *** the contact width and lateral spreading of the wire decrease with increasing n,resulting in a large reduction in area with the n *** strain homogeneity of the wire increases with the n value of the *** improvement in the strain homogeneity with the n value is attributable to two factors:a lower strain concentration in the central region and a higher overall elongation as n *** addition,the average effective strain of the wire cross section decreases with the n value of a material during wire flat *** contact pressure distribution on the surface of the wire differs significantly depending on the n *** materials with a low n value,the contact pressure exhibits a higher value at the entry and edge zones of the contact *** contrast,materials with high n values exhibit a higher contact pressure at the exit *** behavior can be explained by the strain hardening behavior of the material during wire flat rolling.

关键词： Strain hardening exponent Wire flat rolling Shape change Strain inhomogeneity Contact pressure

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Effect of drawing speed on microstructure distribution and drawability in twinning-induced plasticity steel during wire drawing

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Journal of Iron and Steel Research International 2020年第5期27卷 577-587页

作者： Joong-ki hwang School of Mechanical Engineering Tongmyong UniversityBusan 48520Republic of Korea

The effect of drawing speed on temperature rise and microstructure distribution in twinning-induced plasticity(TWIP)steel during wire drawing has been investigated to improve drawability for wire rod *** wire drawing process is performed at room temperature,heat is generated due to the plastic deformation and friction at the wire-die *** steel wires subjected to the low drawing speed(LD)of 0.5 m/min and the high drawing speed(HD)of 5.0 m/min were analyzed using the numerical simulation and electron backscatter diffraction ***,the specimens subjected to the HD had a higher drawability by about 18%compared to the LD,which is totally different from the general behavior of plain carbon pearlitic *** LD wire had uniform temperature distribution along the radial direction during wire *** contrast,the HD wire had a temperature gradient along the radial direction due to the higher frictional effect at surface:the minimum temperature of 58℃ at center area and the maximum temperature of 143 C at surface *** higher stacking fault energy of HD wire at the surface area due to the high temperature rise retarded twinning rate,resulting in the prevention of fast exhaustion in ductility in comparison with the LD wires since the earlier depletion of twins at surface area is known as the main reason for the fracture of TWIP steel during wire ***,HD process delayed the fracture strain of wire and increased the uniformity of microstructure and mechanical properties along the radial direction.

关键词： Twinning-induced plasticity steel Wire drawing Deformation twin Drawing speed Temperature rise

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Analysis on motion of Earth’s center of mass observed with CHAMP mission

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Science China(Physics,Mechanics & Astronomy) 2008年第10期51卷 1597-1606页

作者： hwang CheinWay National Astronomical Observatories Chinese Academy of Sciences Department of Civil Engineering Chiao Tung University

Geocenter motion (GCM) is one important topic for constructing and maintaining the terrestrial reference frame and its applications. GCM is studied from CHAMP with the multi-step approach in this paper. Geometric orbits of CHAMP in 2001-2006 are precisely determined with the kinematic method only from the satel-lite-borne GPS zero-difference data. Then a GCM time series is estimated from the precise kinematic orbits based on the theory of satellite dynamics to fit the CHAMP’s real geometric orbits. We compare the series with the geocenter series used in ITRF2005. Then the GCM series are analyzed with Fourier transform and wavelet transformation. The mean motions within 6 years in TX, TY and TZ direc-tions are respectively 0.8 mm, 2.2 mm, and 7.9 mm. The trends of GCM in the three directions are 0.495 mm/a, -0.004 mm/a, and 1.309 mm/a, respectively. The long-term movement (2001-2006) indicates that the crustal figure is changing. The seasonal variations are the main component which may be excitated by the mass redistribution of Earth’s fluid layer, e.g. ocean, atmosphere and continental water. The inter-annual variations are also found in the GCM series measured with CHAMP.

关键词： geocenter motion CHAMP power spectral analysis wavelet transformation

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Cartan-Fubini type extension of holomorphic maps respecting varieties of minimal rational tangents

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Science China Mathematics 2015年第3期58卷 513-518页

作者： hwang JunMuk Korea Institute for Advanced Study

A fundamental result in the theory of minimal rational curves on projective manifolds is Cartan- Fubini extension theorem proved by hwang and Mok, which describes the extensibility of biholomorphisms between connected open subsets of two Fano manifolds of Picard number 1 which preserve varieties of minimal rational tangents （VMRT）, under a mild geometric assumption on the second fundamental forms of VMRT＇s. Hong and Mok have developed Cartan-Fubini extension for non-equidimensional holomorphic immersions from a connected open subset of a Pano manifold of Picard number 1 into a uniruled projective manifold, under the assumptions that the map sends VMRT＇s onto linear sections of VMRT＇s and it satisfies a mild geometric condition formulated in terms of second fundamental forms on VMRT＇s. In the current paper, we give a generalization of Hong and Mok＇s result, under the same condition on second fundamental forms, assuming only that the holomorphic immersions send VMRT＇s to VMRT＇s. Our argument is different from Hong and Mok＇s and is based on the study of natural foliations on the total family of VMRT＇s. This gives a substantially simpler proof than Hong and Mok＇s argument.

关键词： varieties of minimal rational tangents extension of holomorphic maps

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A multi-subwaveform parametric retracker of the radar satellite altimetric waveform and recovery of gravity anomalies over coastal oceans

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Science China Earth Sciences 2010年第4期53卷 610-616页

作者： hwang CheinWay Department of Civil Engineering Chiao Tung University

The quality of satellite radar altimetric data is very important in studies of geodesy,geophysics,and *** coastal oceans,altimeter waveforms are contaminated by the terrain and physical environments so that the accuracy of altimeter data is lower than that over open *** we develop a new multi-subwaveform parametric retracker(MSPR) to improve the quality of altimeter data for the recovery of gravity anomaly in coastal *** least squares collocation method is used to recover the residual gravity anomaly over the coastal water from altimetric *** waveform data records from Geosat/GM around Taiwan Island are practically retracked with *** compared with the Taiwan geoid height,the results retracked by MSPR are more accurate than those retracked by the well-known β-5-parmeter method and from the geophysical data records(GDRs).The gravity anomalies over Taiwan coastal waters are calculated from the retracked altimeter data with the least squares *** we compared gravity anomalies computed using altimeter GDRs with the ship-borne gravity data over Taiwan coastal ocean,we found that the results from retracked data are more accurate than those from GDRs.

关键词： multi-subwaveform parametric retracker waveform retracking for radar satellite altimetry gravity anomaly least squares collocation Geosat/GM

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