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Rare Metals 2024年第1期43卷 280-288页

作者： Kyoung-Joung Yoo dae-yun Kang Nahyun Kim Ho-jin Lee Ta-Hyeong Kim Taeho Kim Tae Geun Kim School of Electrical Engineering Korea UniversitySeoul 02841Republic of Korea

The use of electrochemical-metallization-based volatile threshold switching selectors in cross-point arrays has been widely explored owing to their high on-off ratios and simple ***,these devices are unsuitable for cross-point architectures because of the difficulty in controlling the random filament formation that results in large fluctuations in the threshold voltage during *** this study,we investigated the unidirectional threshold transition characteristics associated with an Ag/GST/HfO_(x)/Pt-based bilayer selector and demonstrated the occurrence of a low leakage current(<1×10^(-11) A) and low distribution of the threshold voltage(Δ0.11 V).The bilayer structure could control the filament formation in the intermediate state through the insertion of an HfO_(x) tunneling *** stacking a bilayer selector with NiO_(x)based resistive random-access memory,the leakage and programming currents of the device could be significantly *** the crossbar array configuration,we performed equivalent circuit analysis of a one-selector oneresistor(1S1R) devices and estimated the optimal array size to demonstrate the applicability of the proposed *** maximum acceptable crossbar array size of the 1S1R device with the Ag/GST/HfO_(x)/Pt/Ti/NiO_(x)/Pt structure was 5.29×10^(14)(N^(2),N=2.3×10^(7)).

关键词： Selector device Tunneling barrier Threshold switching Sputtering 1S1R Cross-point array

DIRECT ITERATIVE METHODS FOR RANK DEFICIENT GENERALIZED LEAST SQUARES PROBLEMS

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Journal of Computational Mathematics 2000年第4期18卷 439-448页

作者： jin-yun Yuan Xiao-qing jin Departamento de Matematica Universidade Federal do ParanaCuritibaBrazil Faculty of Science and Technology University of MacaoMacaoChina

The generalized least squares (LS) problem ... (Ax - b)[sup TW[sup -1](Ax - b) appears in, many application areas. Here W is an m × m symmetric positive definite matrix and A is an m × n matrix with m ≥ n. Since the problem has many solutions in rank deficient case, some special preconditioned techniques are adapted to obtain the minimum 2-norm solution. A block SOR method and the preconditioned conjugate gradient (PCG) method are proposed here. Convergence and optimal relaxation parameter for the block SOR method are studied. An error bound for the PCG method is given. The comparison of these methods is investigated. Some remarks on the implementation of the methods and the operation cost are given as well. [ABSTRACT FROM AUTHOR]

关键词： rank deficient generalized LS problem block SOR method PCG method convergence optimal parameter

Generalized P(N)-graded Lie superalgebras

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Frontiers of Mathematics in China 2021年第3期16卷 647-687页

作者： jin CHENG yun GAO School of Mathematics and Statistics Shandong Normal UniversityJinan250014China Department of Mathematics and Statistics York UniversityTorontoONM3J 1P3Canada

We generalize the P(N)-graded Lie superalgebras of *** generalization is not so restrictive but sufficient enough so that we are able to have a classification for this generalized P(N)-graded Lie *** result is that the generalized P(N)-graded Lie superalgebra L is centrally isogenous to a matrix Lie superalgebra coordinated by an associative superalgebra with a ***,L is P(N)-graded if and only if the coordinate algebra R is commutative and the super-involution is *** recovers Martinez-Zelmanov’s theorem for type P(N).We also obtain a generalization of Kac’s coordinatization via Tits-Kantor-Koecher ***,the motivation of this generalization comes from the Fermionic-Bosonic module construction.

关键词： Root system graded Lie superalgebras associative superalgebra quantum tori representations

Assessment of risk of complications in cirrhosis using portal thallium scans

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World Journal of Gastroenterology 2014年第1期20卷 228-234页

作者： Hye-jin Tae dae-Won Jun yun-Young Choi Min-Jung Kwak Min-Ho Lee Department of Internal Medicine Hanyang University School of MedicineSeoul 133-792South Korea Department of Nuclear Medicine Hanyang University College of MedicineSeoul 133-792South Korea Department of Computer Science and Statistics Pyongtaek UniversityPyongtaek 450-701South Korea

AIM:To investigate the usefulness of a novel thallium scan shunt index for assessing portosystemic shuntrelated cirrhotic ***:We enrolled 209 chronic hepatitis B-related cirrhosis *** rectal thallium instillation,radioactive isotope activity in the heart and liver was *** ratio of radiation uptake between the heart and the liver was calculated(the shunt index).This value indicates the degree of portosystemic circulation *** tests,serum biochemistry tests,abdominal ultrasonography,gastroscopy and examination of clinical features such as the occurrence of varices,bleeding and hepatic encephalopathy were *** analysis was used to identify independent risk factors for *** compared the cumulative incidence rates of complications during the follow-up ***:The thallium scan shunt index was significantly higher in the decompensated liver cirrhosis group than in the compensated liver cirrhosis group(0.91±0.39 vs 0.39±0.32,P<0.001).It was also higher in the varices group,the hepatic encephalopathy group,and the variceal bleeding group than in the control group(P<0.001).Multivariate analysis showed that the index was an independent risk factor for predicting decompensated liver *** the cut-off value was 0.75,the shunt index had a sensitivity of 82.6%,a specificity of 84%,a positive predictive value of 61.5%,and a negative predictive value of 94.4%in diagnosing decompensated *** the shunt index was greater than 0.75,there was a significant increase in the number of decompensated ***:The thallium shunt index is a good predictor of cirrhosis-related complications.

关键词： Liver cirrhosis Portosystemic shunt Decompensation

Current opinion and mechanistic interpretation of combination therapy for castration-resistant prostate cancer

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Asian Journal of Andrology 2019年第3期21卷 270-278页

作者： jin Xu yun Qiu Department of Pharmacology University of Maryland School of Medicine Baltimore MD 21201 USA

Recent advances in genomics technology have led to the massive discovery of new drug targets for prostate cancer;however, none of the currently available therapeutics is curative. One of the greatest challenges is drug resistance. Combinations of therapies with distinct mechanisms of action represent a promising strategy that has received renewed attention in recent years. Combination therapies exert cancer killing functions through either concomitant targeting of multiple pro-cancer factors or more effective inhibition of a single pathway. Theoretically, the combination therapy can improve efficacy and efficiency compared with monotherapy. Although increasing numbers of drug combinations are currently being tested in clinical trials, the mechanisms by which these combinations can overcome drug resistance have yet to be fully understood. The purpose of this review is to summarize recent work on therapeutic combinations in the treatment of castration-resistant prostate cancer and discuss emerging mechanisms underlying drug resistance. In addition, we provide an overview of the current preclinical mechanistic studies on potential therapeutic combinations to overcome drug resistance.

关键词： combination therapy drug resistance prostate cancer

A study of influence of gravity on bulk behaviour of particulate solid

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Particuology 2008年第6期6卷 467-474页

作者： yun-Chi Chung jin Yeam Ooi Department of Civil and Environmental Engineering Nanya Institute of Technology Institute for Infrastructure & Environment School of Engineering & Electronics University of Edinburgh

This paper examines the influence of gravity on the bulk responses of a granular solid. The loading scenarios in this study include confined compression, rod penetration into a granular medium and discharging through an orifice. Similar loading and flow conditions are likely to be encountered in the stress and deformation regimes that regoliths are subjected to in extraterrestrial exploration activities including in situ resource utilisation processes. Both spherical and non-spherical particles were studied using the discrete element method （DEM）. Whilst DEM is increasingly used to model granular solids, careful validations of the simulation outcomes are rather rare. Thus in addition to exploring the effect of gravity, this paper also compares DEM simulations with experiments under terrestrial condition to verify whether DEM can produce satisfactory predictions. The terrestrial experiments were conducted with great care and simulated closely using DEM. The key mechanical and geometrical properties for the particles were measured in laboratory tests for use in the DEM simulations. A series of DEM computations were then performed under reduced gravity to simulate these experiments under extraterrestrial environment. It was found that gravity has no noticeable effect on the force transmission in the confined compression case; the loading gradient in the rod penetration is linearly proportional to the gravity; the mass flow rate in silo discharge is proportional to square root of the gravity and the angle of repose increases with reducing gravity. These findings are in agreement with expectation and existing scientific evidence.

关键词： Extraterrestrial Particulate assembly Confined compression Rod penetration Silo discharge Discrete element method Gravity effect

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-yun Zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Disjoint Cliques in Claw-free Graphs

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Acta Mathematicae Applicatae Sinica 2018年第1期34卷 19-34页

作者： Su-yun JIANG jin YAN School of Mathematics Shandong University

A graph is said to be claw-free if it does not contain an induced subgraph isomorphic to K_（1,3）. Let s and k be two integers with 0≤s≤k and let G be a claw-free graph of order n. In this paper, we investigate clique partition problems in claw-free graphs. It is proved that if n≥3 s ＋4（k-s） and d（x）＋ d（y）≥n-2 s ＋2 k ＋1 for any pair of non-adjacent vertices x, y of G, then G contains s disjoint K3 s and k-s disjoint K4 s such that all of them are disjoint. Moreover, the degree condition is sharp in some cases.

关键词： claw-free graphs disjoint clique degree condition

A Self-Learning Data-Driven Development of Failure Criteria of Unknown Anisotropic Ductile Materials with Deep Learning Neural Network

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Computers, Materials & Continua 2021年第2期66卷 1091-1120页

作者： Kyungsuk Jang Gun jin yun Department of Aerospace Engineering Seoul National UniversitySeoul088262South Korea Institute of Advanced Aerospace Technology Seoul National UniversitySeoul08826South Korea

This paper first proposes a new self-learning data-driven methodology that can develop the failure criteria of unknown anisotropic ductile materials from the minimal number of experimental *** failure criteria of anisotropic ductile materials requires time-consuming tests and manual data *** proposed method can overcome such practical *** methodology is formalized by combining four ideas:1)The deep learning neural network(DLNN)-based material constitutive model,2)Self-learning inverse finite element(SELIFE)simulation,3)Algorithmic identification of failure points from the selflearned stress-strain curves and 4)Derivation of the failure criteria through symbolic regression of the genetic *** update and the algorithmic tangent operator were formulated in terms of DLNN parameters for nonlinear finite element ***,the SELIFE simulation algorithm gradually makes the DLNN model learn highly complex multi-axial stress and strain relationships,being guided by the experimental boundary *** the failure point identification,a self-learning data-driven failure criteria are eventually developed with the help of a reliable symbolic regression *** methodology and the self-learning data-driven failure criteria were verified by comparing with a reference failure criteria and simulating with different materials orientations,respectively.

关键词： Data-driven modeling deep learning neural networks genetic programming anisotropic failure criterion

On Disjoint Cycles of the Same Length in Tournaments

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Acta Mathematicae Applicatae Sinica 2022年第2期38卷 271-281页

作者： yun WANG jin YAN SHUO ZHU School of Mathematics Shandong UniversityJinan 250100China

A tournament is an orientation of the complete *** form perhaps the most interesting class of digraphs and it has a great potential for *** provide a model of the statistical technique called the method of paired comparisons and they have also been studied in connection with sociometric relations in small *** this paper,we investigate disjoint cycles of the same length in *** 2010,Lichiardopol conjectured that for given integers l≥3 and k≥1,any tournament with minimum out-degree at least(l-1)k-1 contains k disjoint l-cycles,where an l-cycle is a cycle of order ***-Jensen et *** the conjecture for l=3 and Ma et *** that it also holds for l≥*** paper provides a proof of the conjecture for the case of 9≥l≥4.

关键词： tournaments minimum out-degree disjoint cycles