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Effects of solid-state fermentation using R. oligosporus on the phytochemical composition of wild-simulated ginseng leaf and its biological properties

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Food Bioscience 2023年第2期52卷 532-540页

作者： Juho Lim Hayeong kim Sung Bae Park Kunal Pal Seung wook kim Doman kim Graduate School of International Agricultural Technology Seoul National UniversityGangwon-do25354Republic of Korea Institute of Food Industrialization Institutes of Green Bioscience and TechnologySeoul National UniversityGangwon-do25354Republic of Korea Biseondong Wild Ginseng Company Hongcheon-gunGangwon-do25162Republic of Korea Department of Biotechnology and Medical Engineering National Institute of TechnologyRourkela769008India Ottogi Corporation Anyang-siGyeonggi-do14060Republic of Korea Fervere Campus Corporation Gangwon-do25354Republic of Korea

Wild-simulated ginseng(WSG)grown in the mountains without specific facilities is widely used as functional foods in Asian countries due to its bioactive compounds,such as ***,long-time cultivation,lower survival rate,and small size of WSG limit its use in the food *** this study,WSG leaves,which can be harvested annually,were fermented using *** for 0-10 *** phytochemical compounds of fermented WSG leaves,including squalene,phenols,saponins,and most ginsenosides(except for Rb1),were increased.L-carnitine was newly synthesized in WSG leaves,with a content of 165.1μg/g measured after 10 days of ***,the minor ginsenosides Rg2,Rg3,Rh1,F1,F2,and CK increased by 1.32-,1.58-,1.42-,1.91-,1.49-,and 4.43-fold compared to non-fermented WSG *** highest antioxidant activities,as measured by FRAP and ORAC assays of WSG leaves,were obtained after 3 days of ***,the suppression of NO release in LPS-stimulated RAW264.7 cells and lipid accumulation in mouse 3T3-L1 cells of fermented WSG leaves was greater than in WSG *** these results,fermented WSG leaves have potential applications as functional materials in the food industry.

关键词： Wild-simulated ginseng leaf L-carnitine Solid-state fermentation R.oligosporus Ginsenosides Anti-inflammation Anti-lipid accumulation

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Prospects for nucleic acid-based therapeutics against hepatitis C virus

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World Journal of Gastroenterology 2013年第47期19卷 8949-8962页

作者： Chang Ho Lee Ji Hyun kim Seong-wook Lee Department of Molecular Biology Institute of Nanosensor and BiotechnologyDankook UniversityYongin 448-701South Korea

In this review,we discuss recent advances in nucleic acid-based therapeutic technologies that target hepatitis C virus(HCV)*** the HCV genome is present exclusively in RNA form during replication,various nucleic acid-based therapeutic approaches targeting the HCV genome,such as ribozymes,aptamers,siRNAs,and antisense oligonucleotides,have been suggested as potential tools against *** acids are potentially immunogenic and typically require a delivery tool to be utilized as *** limitations have hampered the clinical development of nucleic acid-based ***,despite these limitations,nucleic acid-based therapeutics has clinical value due to their great specificity,easy and large-scale synthesis with chemical methods,and pharmaceutical ***,nucleic acid therapeutics are expected to broaden the range of targetable molecules essential for the HCV replication cycle,and therefore they may prove to be more effective than existing therapeutics,such as interferon-αand ribavirin combination *** review focuses on the current status and future prospects of ribozymes,aptamers,siRNAs,and antisense oligonucleotides as therapeutic reagents against HCV.

关键词： Hepatitis C virus Nucleic acid-based therapeutics Ribozyme Aptamer siRNA Antisense oligonucleotide

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Clinical performance of presbyopia correction with a multifocal corneoscleral lens

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 529-535页

作者： Woo Chan Park Chae Hoon kim Sang wook Jin Department of Ophthalmology Dong-A University College of MedicineBusan 49201Republic of Korea

AIM:To assess the clinical performance of a multifocal corneoscleral lens for the presbyopia ***:A prospective clinical trial of the OnefitTM A multifocal corneoscleral lens was conducted with 40 participants with *** 4 wk of continuous wear of the corneoscleral lens,changes in the distance,intermediate,and near visual acuity(VA)were *** safety of the corneoscleral lens,central corneal thickness(CCT),corneal endothelial cell count,binocular stereopsis,tear film break-up time(BUT),corneal staining,corneal edema,corneal neovascularization(NV),and conjunctival hyperemia were *** addition,a subjective questionnaire addressing satisfaction(rated from 1 to 5 points)and discomfort(rated from 1 to 5 points)was ***:Forty participants were enrolled in this *** participants were excluded because of poor compliance with lens fitting(n=2)and loss to follow-up(n=4).The mean age of the participants was 53.0±4.9 *** 4 wk of continuous wear of the corneoscleral lens,the best corrected far,intermediate,and near VA was 0.08±0.11,0.10±0.12,and 0.10±0.12 log MAR,*** results were significant improvements over the baseline uncorrected VA(far:P=0.004;intermediate:P=0.004;near:P=0.002).CCT,corneal endothelial cell count,binocular stereopsis,BUT,corneal staining,corneal edema,corneal NV,and conjunctival hyperemia were not significantly different between baseline and after corneoscleral lens *** average satisfaction scores for fit sensation;corrected far,intermediate,and near VA;and ease of handling were 4.1,3.4,3.6,3.5,and 3.4,*** average discomfort scores for dryness,irritation,foreign body sensation,redness,fogging,and halo were 1.7,1.8,1.5,1.7,1.7,and 1.3,***:Far,intermediate,and near VA are improved in presbyopic patients with the multifocal corneoscleral lens compared to uncorrected baseline VA,without adverse ocular *** evidence supports the safety and effecti

关键词： presbyopia multifocal lens corneoscleral lens

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Anomaly Detection Based on Discrete Wavelet Transformation for Insider Threat Classification

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Computer Systems Science & Engineering 2023年第7期46卷 153-164页

作者： Dong-wook kim Gun-Yoon Shin Myung-Mook Han Department of Computer Engineering Gachon UniversitySeongnam-si13120Korea Department of AI Software Gachon UniversitySeongnam-si13120Korea

Unlike external attacks,insider threats arise from legitimate users who belong to the *** individuals may be a potential threat for hostile behavior depending on their *** insider detection,many intrusion detection systems learn and prevent known scenarios,but because malicious behavior has similar patterns to normal behavior,in reality,these systems can be ***,because insider threats share a feature space similar to normal behavior,identifying them by detecting anomalies has *** study proposes an improved anomaly detection methodology for insider threats that occur in cybersecurity in which a discrete wavelet transformation technique is applied to classify normal *** *** discrete wavelet transformation technique easily discovers new patterns or decomposes synthesized data,making it possible to distinguish between shared *** verify the efficacy of the proposed methodology,experiments were conducted in which normal users and malicious users were classified based on insider threat scenarios provided in Carnegie Mellon University’s Computer Emergency Response Team(CERT)*** experimental results indicate that the proposed methodology with discrete wavelet transformation reduced the false-positive rate by 82%to 98%compared to the case with no wavelet ***,the proposed methodology has high potential for application to similar feature spaces.

关键词： Anomaly detection cybersecurity discrete wavelet transformation insider threat classification

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Impact of supercritical carbon dioxide on the frictional strength of and the transport through thin cracks in shale

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第12期16卷 4990-5003页

作者： Talal Al Shafloot Arjun Kohli Tae wook kim Anthony R.Kovscek College of Petroleum Engineering and Geosciences King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Energy Science&Engineering Stanford UniversityStanfordCAUSA

Understanding the mechanical and transport behavior of thin(*** aperture)cracks slipping under supercritical carbon dioxide(sc-CO_(2))conditions is essential to evaluate the integrity of sealing formations with buoyant sc-CO_(2)below and the success of waterless *** two major items of interest in this work are frictional strength and permeability change of the *** used a triaxial cell that permits in situ visualization to conduct and monitor slippage along the faces of narrow cracks subjected to triaxial *** cracks are analogs to small geological *** tested carbonate-rich,1-inch diameter Wolfcamp shale samples that are saw cut 30to vertical to create a thin *** coefficients ranged from about 0.6 to 0.8 consistent with expectations for brittle *** sc-CO_(2)generally did not alter friction coefficient over the time scale of *** a transport perspective,saturating cracks with sc-CO_(2)substantially decreased permeability of the crack by 26%e52%,while slip resulted in a variety of permeability ***,the combined impact of sc-CO_(2)saturation and slip reduced fault permeability for all *** observations support the notion that the sealing capacity of some caprocks improves when saturated with sc-CO_(2)and that some slip of small fractures is not necessarily detrimental to caprock integrity.

关键词： Supercritical carbon dioxide(sc-CO_(2)) storage Caprock Fracture permeability Friction coefficient

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Fabrication of SiC_p/AA5083 composite via friction stir welding

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中国有色金属学会会刊：英文版 2012年第S3期22卷 634-638页

作者： Byung-wook AHN Don-Hyun CHOI Yong-Hwan kim Seung-Boo JUNG School of Advanced Materials Science and Engineering Sungkyunkwan University

Microstructure and mechanical properties of SiCp /AA5083 composite fabricated by friction stir welding (FSW) were *** influence of the number of FSW passes on the distribution of SiC particles and mechanical properties in the joint was *** one pass,the SiC particles were entangled in the upper side of the stir zone (SZ).However,the particle distribution became more uniform after two passes due to the repeated stirring of the *** the SiC particles facilitate the grain refinement in the SZ by the pinning effect,the particle including region has much smaller grain size than the SZ without SiC *** SiCp /AA5083 composite region exhibits a Vickers hardness of HV90,which is much higher than the value of HV80 in the SZ produced by FSW without SiC particles.

关键词： metal matrix composite SiC particle friction stir welding mechanical property

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Understanding protein translocation across chloroplast membranes:Translocons and motor proteins

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Journal of Integrative Plant Biology 2023年第2期65卷 408-416页

作者： Da Been kim Changhee Na Inhwan Hwang Dong wook Lee Department of Integrative Food Bioscience and BiotechnologyChonnam National UniversityGwangju 61186Korea Department of Life Sciences Pohang University of Science and TechnologyPohang 37673Korea Department of Bioenergy Science and Technology Chonnam National UniversityGwangju 61186Korea Kumho Life Science Laboratory Chonnam National UniversityGwangju 61186Korea

Subcellular organelles in eukaryotes are surrounded by lipid *** an endomembrane system,vesicle trafficking is the primary mechanism for the delivery of organellar proteins to specific ***,organellar proteins for chloroplasts,mitochondria,the nucleus,and peroxisomes that are translated in the cytosol are directly imported into their target *** are a plant-specific organelle with outer and inner envelope membranes,a dual-membrane structure that is similar to *** chloroplast proteins translated by cytosolic ribosomes are thus translocated through TOC and TIC complexes(translocons in the outer and inner envelope of chloroplasts,respectively),with stromal ATPase motor proteins playing a critical role in pulling pre-proteins through these import *** the last three decades,the identity and function of TOC/TIC components and stromal motor proteins have been actively investigated,which has shed light on the action mechanisms at a molecular ***,there remains some disagreement over the exact composition of TIC complexes and genuine stromal motor *** this review,we discuss recent findings on the mechanisms by which proteins are translocated through TOC/TIC complexes and discuss future prospects for this field of research.

关键词： ATPase motor protein chloroplast molecular chaperone protein translocation TOC/TIC translocon

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Intracellular zinc signaling via Kruppel-like transcription factor 6 promotes HuD expression in pancreatic β cell

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Genes & Diseases 2024年第4期11卷 24-27页

作者： Seongho Cha Chongtae kim Myeongwoo Jung Seungyeon Ryu Sukyoung Han wook kim Eun Kyung Lee Department of Biochemistry Department of Biomedicine&Health SciencesCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea Catholic Institute for Visual Science College of MedicineThe Catholic University of KoreaSeoul 06591South Korea Department of Molecular Science&Technology Ajou UniversitySuwon 16499South Korea

Dysfunction of pancreaticβcells caused by zinc deficiency is related to the pathogenesis of diabetes.1 Impaired zinc homeostasis in diabetes is associated with reduced zinc transporters.2 Down-regulation of HuD,an es... 详细信息

关键词： βcell homeostasis zinc

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Simultaneous robot-assisted approach in a super-elderly patient with urothelial carcinoma and synchronous contralateral renal cell carcinoma:A case report

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World Journal of Clinical Cases 2022年第20期10卷 7153-7162页

作者： Ji Kang Yun Si Hyun kim Woong Bin kim Hee Kyung kim Sang wook Lee Department of Urology Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584South Korea Department of Urology Soonchunhyang University Cheonan HospitalSoonchunhyang University College of MedicineCheonan 31151South Korea Department of Pathology Soonchunhyang University Bucheon HospitalSoonchunhyang University College of MedicineBucheon 14584South Korea

BACKGROUND It is rare for urothelial and renal cell carcinomas to coexist in the same patient,and even rarer for them to be detected *** of this rarity,a standard treatment has not been established and studies about overall survival are ***,physicians must modify treatments according to the individual’s situation and the stage of each *** recent years,with advances in the instruments and techniques,minimal invasive robotic surgeries have become available for advanced-stage or high-risk *** SUMMARY An 85-year-old woman with a medical history of hypertension and hyperlipidemia visited our *** had visited her local hospital complaining of intermittent,painless,gross hematuria that had started 3 mo *** computed tomography,a right renal mass and left proximal ureteral mass with hydronephrosis were found *** decided to perform robot-assisted surgery on both sides during one *** renal function and kidney loading,right partial nephrectomy was performed first,followed by left nephroureterectomy with bladder cuff *** the 6-mo follow-up,no specific symptoms were reported and dialysis was not *** were no unusual findings in the imaging study,and regular follow-up and imaging studies are *** This case report assessed the feasibility of simultaneous minimal invasive robotic surgery as an alternative to conventional open or laparoscopic surgery.

关键词： Robot surgical procedure Renal cell carcinoma Transitional cell carcinoma Minimally invasive surgical procedures Case report

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Living donor liver transplantation for an adult patient with situs inversus totalis

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World Journal of Gastroenterology 2010年第18期16卷 2311-2313页

作者： Bong-Wan kim Byong-Ku Bae Weiguang Xu Hee-Jung Wang Myung-wook kim Center for Liver Transplantation and Hepatobiliary Surgery Ajou University Hospital Ajou University School of Medicine

This recipient with situs inversus totalis(SIT) was a 60-year-old female who had hepatitis B-related endstage liver *** donor evaluation showed that the right posterior section satisfied graft volume and was space-fitting in the recipient hepatic fossa when it was rotated 180 *** operation and postoperative course progressed *** weeks after living donor liver transplantation(LDLT),the graft function was disturbed by compression of bottom-placed right hepatic *** was treated with a vascular stent and subsequently the graft function was *** present case shows that LDLT for patients with SIT using a right posterior section graft is feasible.

关键词： Living donor liver transplantation Situs inversus totalis Right posterior section graft

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