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Immortalization of epidural fat-derived mesenchymal stem cells: In vitro characterization and adipocyte differentiation potential

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World Journal of Stem Cells 2025年第1期17卷 40-52页

作者： Seoung-Woo Lee Young-Ju Lim Hee-Yeon Kim Wansoo Kim wook-Tae park Min-Jung Ma Junho Lee Min-Soo Seo Young In Kim Sangbum park Seong-Kyoon Choi Gun Woo Lee Core Protein Resources Center Daegu-Gyeongbuk Institute of Science and TechnologyDaegu 42988South Korea Department of Orthopedic Surgery Yeungnam University Medical CenterYeungnam University College of MedicineDaegu 42415South Korea Department of Veterinary Pathology College of Veterinary MedicineKyungpook National UniversityDaegu 41566South Korea School of Life Science BK21 FOUR KNU Creative BioResearch GroupKyungpook National UniversityDaegu 41566South Korea Laboratory of Veterinary Tissue Engineering College of Veterinary MedicineKyungpook National UniversityDaegu 41566South Korea College of Veterinary Medicine Kyungpook National UniversityDaegu 41566South Korea Department of Veterinary Tissue Engineering Kyungpook National UniversityDaegu 41566South Korea Cellexobio. Ltd.Daegu 42415South Korea Michigan State University Institute for Quantitative Health Science&EngineeringEast LansingMI 48824United States Department of Orthopedic Surgery Yeungnam University College of MedicineDaegu 42415South Korea

BACKGROUND Mesenchymal stem cells(MSCs)are promising candidates for regenerative therapy due to their self-renewal capability,multilineage differentiation potential,and immunomodulatory *** molecular characteristics of MSCs are influenced by their ***,epidural fat(EF)and EF-derived MSCs(EF-MSCs)have garnered attention due to their potential benefits to the spinal microenvironment and their high expression of neural SC ***,their clinical applications are limited due to cell senescence and limited accessibility of *** many studies have attempted to establish an immortalized,stable SC line,the characteristics of immortalized EF-MSCs remain to be *** To establish and analyze stable immortalized *** The phenotypes of EF-MSCs were analyzed using optical *** immortalization was performed using lentiviral *** biomolecular characteristics of the cells were analyzed by immunoblotting,quantitative PCR,and *** The immortalized EF-MSCs demonstrated a significantly extended lifespan compared to the control group,with well-preserved adipogenic potential and SC surface marker *** of human telomerase reverse transcriptase genes markedly increased the lifespan of *** analysis revealed substantial increase in the expression of DNA replication pathway components in immortalized *** Immortalized EF-MSCs exhibited significantly enhanced proliferative capacity,retained adipogenic potential,and upregulated the expression of DNA replication pathway components.

关键词： Immortalization Transfection Stem cell Epidural fat Proteomics

Novel transparent high-entropy sesquioxide ceramics with high physicochemical plasma etching resistance

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Journal of Advanced Ceramics 2025年第1期14卷 163-176页

作者： Yu-Bin Shin Su Been Ham Ha-Neul Kim Mi-Ju Kim Jae-Woong Ko Jae-wook Lee Young-Jo park Jung-Hyung Kim Hyo-Chang Lee Young Hwa Jung Jung Woo Lee Ho Jin Ma Nano Materials Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea Department of Materials Science and Engineering Pusan National UniversityPusan 46241Republic of Korea Semiconductor Integrated Metrology Team Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Department of semiconductor Science Engineering and TechnologyKorea Aerospace UniversityGoyang 10540Republic of Korea School of Electronics and Information Engineering Korea Aerospace UniversityGoyang 10540Republic of Korea PLS-II Beamline Division Pohang Accelerator LaboratoryPohang 37673Republic of Korea

High-entropy ceramics exhibit novel intrinsic ***,they have been explored for a wide range of applications ranging from thermal insulation and energy storage to advanced optical ***,the semiconductor industry has faced a demand for higher-performance chips,necessitating higher aspect ratios in wafer fabrication and further miniaturization of ***,novel materials with high plasma etching resistance and minimal contaminant generation are *** plasma-etching resistance displayed by high-entropy ceramics can be an innovative solution to this emerging *** this study,we successfully fabricated single-phase high-entropy sesquioxide ceramics with high optical transparency,dense microstructure,and minimal residual pores.A structural analysis of the fabricated samples revealed a single-phase structure with excellent phase *** evaluation of the plasma-etching resistance of high-entropy ceramics revealed for the first time a low etching rate of 8 nm/h compared with that of conventional plasma-resistant *** comprehensive characterizations of high-entropy ceramics indicate that they are promising candidates for significantly improving the production yield of semiconductors and for a wide range of potential applications,such as next-generation active optical ceramics.

关键词： high-entropy ceramics plasma etching resistance transparent ceramics sintering semiconductor manufacturing

Robotic versus laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: A propensity score-matched analysis

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 154-159页

作者： Dakyum Shin Jaewoo Kwon Jae Hoon Lee Seo Young park Yejong park Woohyung Lee Ki Byung Song dae wook Hwang Song Cheol Kim Division of Hepato-Biliary and Pancreatic Surgery Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine88 Olympic-ro 43-gilSongpa-guSeoul 05505Korea Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of Medicine29 Saemunan-roJongno-guSeoul 03181Korea Department of Statistics and Data Science Korea National Open University86 Daehak-roJongno-guSeoul 03087Korea

Background: Minimally invasive surgery is becoming increasingly popular in the field of pancreatic surgery. However, there are few studies of robotic distal pancreatectomy(RDP) for pancreatic ductal adenocarcinoma(PDAC). This study aimed to investigate the efficacy and feasibility of RDP for PDAC. Methods: Patients who underwent RDP or laparoscopic distal pancreatectomy(LDP) for PDAC between January 2015 and September 2020 were reviewed. Propensity score matching analyses were performed. Results: Of the 335 patients included in the study, 24 underwent RDP and 311 underwent LDP. A total of 21 RDP patients were matched 1:1 with LDP patients. RDP was associated with longer operative time(209.7 vs. 163.2 min;P = 0.003), lower open conversion rate(0% vs. 4.8%;P < 0.001), higher cost(15 722 vs. 12 699 dollars;P = 0.003), and a higher rate of achievement of an R0 resection margin(90.5% vs. 61.9%;P = 0.042). However, postoperative pancreatic fistula grade B or C showed no significant intergroup difference(9.5% vs. 9.5%). The median disease-free survival(34.5 vs. 17.3 months;P = 0.588) and overall survival(37.7 vs. 21.9 months;P = 0.171) were comparable between the groups. Conclusions: RDP is associated with longer operative time, a higher cost of surgery, and a higher likelihood of achieving R0 margins than LDP.

关键词： Minimally invasive surgery Robotic distal pancreatectomy Laparoscopic distal pancreatectomy Pancreatic ductal adenocarcinoma Propensity score matching

Assessment of disease activity by fecal immunochemical test in ulcerative colitis

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World Journal of Gastroenterology 2016年第48期22卷 10617-10624页

作者： dae Gon Ryu Hyung wook Kim Su Bum park dae Hwan Kang Cheol Woong Choi Su Jin Kim Hyeong Seok Nam Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital

AIM To evaluate the efficacy of quantitative fecal immunochemical test(FIT) as biomarker of disease activity in ulcerative colitis(UC).METHODS Between February 2013 and November 2014, a total of 82 FIT results, obtained in conjunction with colonoscopies, were retrospectivelyevaluated for 63 patients with UC. The efficacy of FIT for evaluation of disease activity was compared to colonoscopic findings. Quantitative fecal blood with automated equipment examined from collected feces. Endoscopic disease severity were assessed using the Mayo endoscopic subscore(MES) classification. The extent of disease were classified by proctitis(E1), left sided colitis(E2), and extensive colitis(E3). Clinical activity were subgrouped by remission or *** All of 21 patients with MES 0 had negative FIT( 134.89 ng/m L. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and accuracy of negative FIT about mucosal healing were 73.33%, 81.82%, 91.49%, 51.43% and 73.17%, respectively. The sensitivity, specificity, PPV, NPV and accuracy of predictive value of positive FIT(cutoff value > 100 ng/mL) about active disease status were 45.45%, 93.33%, 71.43%, 82.35%and 26.83%, respectively. Among patients with clinical remission, FIT was negative in 31(81.6%) of 38 cases, with a mean fecal hemoglobin concentration of 6.12 ng/mL(range, negative to 80.9 ng/mL) for this group of patients. Among patients with clinical active disease, FIT was negative in 16(36.4%) out of 44 cases, with a mean fecal hemoglobin concentration > 167.4 ng/mL for this group of patients. FIT was positively correlated with endoscopic activity(r = 0.626, P < 0.01) and clinical activity(r = 0.496, P < 0.01). But, FIT did not correlate with the extent of disease(r =-0.047, P = 0.676)CONCLUSION Quantitative FIT can be a non-invasive and effective biomarker for evaluation of clinical and endoscopic activity in UC, but not

关键词： Ulcerative colitis Fecal immunochemical test Mayo endoscopic subscore Biomarker Disease activity

Efficacy and safety of limited endoscopic sphincterotomy before self-expandable metal stent insertion for malignant biliary obstruction

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World Journal of Gastroenterology 2017年第9期23卷 1627-1636页

作者： Hyeong Seok Nam dae Hwan Kang Hyung wook Kim Cheol Woong Choi Su Bum park Su Jin Kim dae Gon Ryu Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsan-siGyeongsangnam-do 50612South Korea

To evaluate the safety and efficacy of limited endoscopic sphincterotomy (ES) before placement of self-expandable metal stent (SEMS).METHODSThis was a retrospective analysis of 244 consecutive patients with unresectable malignant biliary obstruction, who underwent placement of SEMSs following limited ES from December 2008 to February 2015. The diagnosis of malignant biliary obstruction and assessment of patient eligibility for the study was established by a combination of clinical findings, laboratory investigations, imaging and pathological results. All patients were monitored in the hospital for at least 24 h following endoscopic retrograde cholangio pancreatography (ERCP). The incidence of immediate or early post-ERCP complications such as post-ERCP pancreatitis (PEP) and bleeding related to limited ES were considered as primary outcomes. Also, characteristics and complications according to the cancer type were *** the 244 patients included, the underlying diagnosis was cholangiocarcinoma in 118 patients, pancreatic cancer in 79, and non-pancreatic or non-biliary malignancies in the remaining 47 patients. Early post-ERCP complications occurred in 9 patients (3.7%), with PEP in 7 patients (2.9%; mild, 6; moderate, 1) and mild bleeding in 2 patients (0.8%). There was no significant association between the incidence of post-ERCP complications and the type of malignancy (cholangiocarcinoma vs pancreatic cancer vs others, P = 0.696) or the type of SEMS used (uncovered vs covered, P = 1.000). Patients who had more than one SEMS placed at the first instance were at a significantly higher risk of post-ERCP complications (one SEMS vs two SEMS, P = 0.031). No other factors were predictive of post-ERCP *** ES is feasible and safe, and effectively facilitates the placement of SEMS, without any significant risk of PEP or severe bleeding.

关键词： Endoscopic sphincterotomy Endoscopic retrograde cholangio pancreatography Complications Pancreatitis Bleeding Cholestasis Self-expandable metal stent

Simple reactor for the synthesis of silver nanoparticles with the assistance of ethanol by gas-liquid discharge plasma

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Plasma Science and Technology 2019年第4期21卷 34-43页

作者： Pan LU Dong-wook KIM Dong-Wha park Department of Chemistry and Chemical Engineering Inha University100 Inha-Ro.Michuhol-guIncheon 22212Republic of Korea Regional Innovation Center for Environmental Technology of Thermal Plasma(RIC-ETTP: Inha University100 Inha-RoMichuhol-gu.Incheon 22212.Republic of Korea

Atmospheric pressure plasma technology is gaining increasing importance because it is a simple and tunable synthesis process for the production of metallic *** addition to the development of the power supply,improving the reactor is also one of the main strategies to enhanee the *** this study,a simple reactor for the gas-liquid discharge plasma induced by argon gas was applied to synthesize silver nanopailicles from silver nitrate(AgNO3)in *** AC power supply with a peak voltage of 3.5 kV was *** frequency and on-time were set to 50 kHz and 2.5“s,*** oscilloscope showed that the rising time was approximately 2“*** ethanol was used as the source for the reactive reducing *** more additional comp on ents existed in the solution during the discharge and neither of the electrodes was in contact with the treated *** temperature in creased by 10°C within 1 min without a cooling *** was the main impurity and was expected to be produced from the decomposition of the organics under the *** elevated temperature decreased the organic by-products by evaporation and could also decrease the production of *** electron microscopy showed that the spherical silver nanoparticles with a size of approximately 10 nm were synthesized with a crystal structure and that a low concentration of ethanol prefers the production of the mono-dispersed colloid.

关键词： silver nanoparticles synthesis nonthermal plasma ethanol reduction gas-liquid discharge

Improved corrosion resistance of Mg alloy AZ31B induced by selective evaporation of Mg using large pulsed electron beam irradiation

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Journal of Materials Science & Technology 2019年第5期35卷 891-901页

作者： Woo Jin Lee Jisoo Kim Hyung wook park Department of Mechanical Aerospace and Nuclear Engineering Ulsan National Institute of Science and Technology

Large pulsed electron beam(LPEB) irradiation was employed as a surface treatment of magnesium(Mg)alloy AZ31B to enhance its corrosion and wear resistance. Selective evaporation of Mg induced by LPEB irradiation at an energy density of 5J/cm^2 for 40 cycles has led to the formation of an Al-enriched resolidified layer with nano-grained structure consisting of Mg3.1 Al0.9 metastable phase. The formation of such a re-solidified layer after LPEB irradiation has enabled a decrease in corrosion rate of Mg alloy AZ31B in 3.5% NaCl solution. Different equivalent electrical circuit models were proposed to account for the corrosion behavior of untreated Mg alloy AZ31B and those subjected to LPEB irradiation. A decrease in wear depth when compared to that of the untreated alloy suggests an increase in wear resistance of LPEB-irradiated Mg alloy AZ31B. Adhesive wear is the predominant mechanism of untreated Mg alloy AZ31B while abrasive wear mechanism dominates for LPEB-irradiated Mg alloy AZ31B.

关键词： Magnesium alloys Electron beam treatment Corrosion resistance Microstructure Rapid re-solidification Wear resistance

Trifunctional robust electrocatalysts based on 3D Fe/N-doped carbon nanocubes encapsulating Co4N nanoparticles for efficient battery-powered water electrolyzers

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Carbon Energy 2024年第6期6卷 124-139页

作者： Hyung wook Choi Hongdae Lee Jun Lu Seok Bin Kwon Dong In Jeong Beum Jin park Jiwon Kim Bong Kyun Kang Gun Jang dae Ho Yoon Ho Seok park SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea School of Advanced Materials Science and Engineering Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Electronic Materials Devicesand Equipment EngineeringSoonchunhyang UniversityAsan CityChungnamRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwon-siGyeonggi-doRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

Herein,we have designed a highly active and robust trifunctional electrocatalyst derived from Prussian blue analogs,where Co_(4)N nanoparticles are encapsulated by Fe embedded in N-doped carbon nanocubes to synthesize hierarchically structured Co_(4)N@Fe/N-C for rechargeable zinc-air batteries and overall water-splitting *** confirmed by theoretical and experimental results,the high intrinsic oxygen reduction reaction,oxygen evolution reaction,and hydrogen evolution reaction activities of Co_(4)N@Fe/N-C were attributed to the formation of the heterointerface and the modulated local electronic ***,Co_(4)N@Fe/N-C induced improvement in these trifunctional electrocatalytic activities owing to the hierarchical hollow nanocube structure,uniform distribution of Co_(4)N,and conductive encapsulation by Fe/***,the rechargeable zinc-air battery with Co_(4)N@Fe/N-C delivers a high specific capacity of 789.9 mAh g^(-1) and stable voltage profiles over 500 ***,the overall water electrolyzer with Co_(4)N@Fe/N-C achieved better durability and rate performance than that with the Pt/C and IrO2 catalysts,delivering a high Faradaic efficiency of 96.4%.Along with the great potential of the integrated water electrolyzer powered by a zinc-air battery for practical applications,therefore,the mechanistic understanding and active site identification provide valuable insights into the rational design of advanced multifunctional electrocatalysts for energy storage and conversion.

关键词： battery-powered electrolyzers hierarchical structure Prussian blue analog trifunctional electrocatalyst zinc-air battery

Advantage of endoscopic mucosal resection with a cap for rectal neuroendocrine tumors

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World Journal of Gastroenterology 2015年第31期21卷 9387-9393页

作者： Su Bum park Hyung wook Kim dae Hwan Kang Cheol Woong Choi Su Jin Kim Hyeong Seok Nam Department of Internal Medicine Pusan National University School of Medicine Research institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital

AIM: To compare the outcomes of endoscopic mucosal resection with a cap(EMR-C) with those of endoscopic submucosal dissection(ESD) for the resection of rectal neuroendocrine ***: One hundred and sixteen lesions in 114 patients with rectal neuroendocrine tumor(NET) resected with EMR-C or ESD were included in the study. This study was performed at Pusan National University Yangsan Hospital between July 2009 and August 2014. We analyzed endoscopic complete resection rate,pathologic complete resection rate,procedure time,and adverse events in the EMR-C(n = 65) and ESD(n = 51) groups. We also performed a subgroup analysis by tumor ***: Mean tumor size was 4.62 ± 1.66 mm in the EMR-C group and 7.73 ± 3.14 mm in the ESD group(P < 0.001). Endoscopic complete resection rate was 100% in both groups. Histologic complete resection rate was significantly greater in the EMR-C group(92.3%) than in the ESD group(78.4%)(P = 0.042). Mean procedure time was significantly longer in the ESD group(14.43 ± 7.26 min) than in the EMR-C group(3.83 ± 1.17 min)(P < 0.001). Rates of histologic complete resection without complication were similar for tumor diameter ≤ 5 mm(EMR-C,96%; ESD,100%,P = 0.472) as well as in cases of 5 mm < tumor diameter ≤ 10 mm(EMR-C,80%; ESD,71.0%,P = 0.524).CONCLUSION: EMR-C may be simple,faster,and more effective than ESD in removing rectal NETs and may be preferable for resection of small rectal NETs.

关键词： Neuroendocrine tumor Endoscopic mucosal resection