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Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice

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Journal of Integrative Medicine 2024年第5期22卷 600-613页

作者： Mijung Yeom Sora Ahn dae-Hyun Hahm Sun-Young Jang Se Hoon Jang Su-Yang Park Jae-Hwan Jang Jihan Park Ju-Young Oh In-Seon Lee Kyuseok Kim Soon-Kyeong Kwon Hi-Joon Park Acupuncture and Meridian Science Research Center College of Korean MedicineKyung Hee University Department of Physiology School of MedicineKyung Hee University BioNanocomposite Research Center Kyung Hee University Department of Science in Korean Medicine College of Korean MedicineGraduate SchoolKyung Hee University College of Korean Medicine Kyung Hee University Department of Ophthalmology Otorhinolaryngology and Dermatology of Korean MedicineCollege of Korean MedicineKyung Hee University Division of Applied Life Science (BK21) Gyeongsang National University Department of Anatomy & Information Sciences College of Korean MedicineKyung Hee University

Objective: Atopic dermatitis(AD) is a chronic inflammatory skin disease that may be linked to changes in the gut microbiome. Acupuncture has been proven to be effective in reducing AD symptoms without serious adverse events, but its underlying mechanism is not completely understood. The purpose of this study was to investigate whether the potential effect of acupuncture on AD is gut ***: AD-like skin lesions were induced by applying MC903 topically to the cheek of the *** was done at the Gok-Ji(LI11) acupoints. AD-like symptoms were assessed by lesion scores,scratching behavior, and histopathological changes; intestinal barrier function was measured by fecal output, serum lipopolysaccharide levels, histopathological changes, and mRNA expression of markers involved in intestinal permeability and inflammation. Gut microbiota was profiled using 16S rRNA gene sequencing from fecal ***: Acupuncture effectively improved chronic itch as well as the AD-like skin lesions with epidermal thickening, and also significantly altered gut microbiota structure as revealed by β-diversity indices and analysis of similarities. These beneficial effects were eliminated by antibiotic depletion of gut microbiota,but were reproduced in gut microbiota-depleted mice that received a fecal microbiota transplant from acupuncture-treated mice. Interestingly, AD mice had intestinal barrier dysfunction as indicated by increased intestinal permeability, atrophy of the mucosal structure(reduced villus height and crypt depth), decreased expression of tight junctions and mucus synthesis genes, and increased expression of inflammatory mediators in the ileum. Acupuncture attenuated these abnormalities, which was gut ***: Acupuncture ameliorates AD-like phenotypes in a gut microbiota-dependent manner and some of these positive benefits are explained by modulation of the intestinal barrier, providing new perspective for non-phar

关键词： Acupuncture Atopic dermatitis Gut microbiota Intestinal barrier function

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The effects of mixed prebiotics in aquaculture:A review

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Aquaculture and Fisheries 2024年第1期9卷 28-34页

作者： Wendy Wee Noor Khalidah Abdul Hamid Khairiyah Mat Raja Ili Airina Raja Khalif Nor Dini Rusli Mohammad Mijanur Rahman Muhammad Anamul Kabir Lee seong Wei Centre for Foundation and Continuing Education Universiti Malaysia Terengganu21030Kuala NerusTerengganuMalaysia School of Biological Sciences Universiti Sains Malaysia11800MindenPulau PinangMalaysia Department of Agricultural Sciences Faculty of Agro-Based IndustryUniversiti Malaysia KelantanJeli Campus17600JeliKelantanMalaysia Faculty of Fisheries Sylhet Agricultural UniversitySylhet3100Bangladesh

Aquaculture industry contributes significant aquaculture species production to meet fish protein demand from the *** industry is gearing towards intensification to increase more production in the near *** technologies and efforts were introduced into aquaculture industry to bring it up to the next higher ***,the development of aquaculture industry is hindered by disease *** a result,excessive use of antibiotics and chemicals were applied to reduce or minimize risk of disease outbreak in aquaculture farming ***,aquacultures products and environment were highly exposed to these antibiotics and *** resolve this issue,fish farmers were encouraged to utilize alternative method in aquaculture species health *** has become a new approach in aquaculture industry to maintain aquaculture species health and a good environment at the same time produce chemical and antibiotic-free aquaculture *** this review paper,we summarize and discuss the effects of prebiotic mixtures administration on growth performance,immune response,disease resistance,and tolerance against abiotic stressors of aquatic animals.

关键词： Growth performance Immunosaccharide Disease resistance Stress relieve

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Changes in microorganisms and metabolites during long-term fermentation of commercially manufactured anchovy sauce

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Food Science and Human Wellness 2024年

作者： daehyeon Kim seong-Eun Park Eun-Ju Kim Seung-Ho Seo Kwang-Moon Cho Sun Jae Kwon Hong-Seok Son Department of Biotechnology， College of Life Sciences and Biotechnology， Korea University Sonlab Inc. 3. AccuGene Inc.

This study was performed to investigate the changes in microbial communities and metabolites during the long-term fermentation of commercially manufactured anchovy sauce. Samples of commercial anchovy sauce were collected from large-scale fermentation tanks with fermentation periods of up to 7.87 years. The complex bacterial community was simplified to two genera， Tetragenococcus and Halanaerobium， after approximately 0.55 years of fermentation. Although genera， such as Saccharomyces， Cladosporium， Candida， and Aspergillus， were relatively dominant， no clear pattern was identified in fungal community analysis. The longitudinal metabolite profile demonstrated that approximately half (55.8%) of the metabolites present in anchovy sauce were produced within a year of fermentation due to rapid fermentation. Despite the static microbial community， the contents of several metabolites including amino acids and biogenic amines changed continuously during the long-term fermentation of anchovy sauce. This study provides novel insights into the changes in microbiota and metabolites in fish sauce produced without any starter inoculation.

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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku Gun Young Yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim Yoon-Sun Yi Sangmi Jun Bum-Tae Kim Jong-Won Oh Aleem Siddiqui seong-Jun Kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

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A Deep Learning Approach for Detecting Covid-19 Using the Chest X-Ray Images

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Computers, Materials & Continua 2023年第1期74卷 751-768页

作者： Fatemeh Sadeghi Omid Rostami myung-Kyu Yi seong Oun Hwang Department of Industrial Engineering Sharif University of TechnologyTehran14588-89694Iran Department of Industrial Engineering University of HoustonHoustonTX77204USA Department of Computer Engineering Gachon UniversitySeongnam13120Korea

Real-time detection of Covid-19 has definitely been the most widely-used world-wide classification problem since the start of the pandemic from 2020 until *** the meantime,airspace opacities spreads related to lung have been of the most challenging problems in this area.A common approach to do on that score has been using chest X-ray images to better diagnose positive Covid-19 *** to most other classification problems,machine learning-based approaches have been the first/most-used candidates in this *** schemes based on machine/deep learning have been proposed in recent years though increasing the performance and accuracy of the system has still remained an open *** this paper,we develop a novel deep learning architecture to better classify the Covid-19 X-ray *** do so,we first propose a novel multi-habitat migration artificial bee colony(MHMABC)algorithm to improve the exploitation/exploration of artificial bee colony(ABC)*** that,we optimally train the fully connected by using the proposed MHMABC algorithm to obtain better accuracy and convergence rate while reducing the execution *** experiment results on Covid-19 X-ray image dataset show that the proposed deep architecture has a great performance in different important optimization ***,it will be shown that the MHMABC algorithm outperforms the state-of-the-art algorithms by evaluating its performance using some wellknown benchmark datasets.

关键词： ChestX-ray image processing evolutionary deep learning covid-19

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Assembly of charged aerosols on non-conducting substrates via ion-assisted aerosol lithography （IAAL）

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Particuology 2017年第4期15卷 17-23页

作者： Seunghyon Kang Wooik Jung dae seong Kim Sei Jin Park Mansoo Choi School of Mechanical and Aerospace Engineering Seoul National University Seou 108826 Republic of Korea Global Frontier Center for Multiscale Energy Systems Seoul National University Seou108826 Republic of Korea

The development of ion-assisted aerosol lithography （IAAL） has enabled fabrication of complex three- dimensional nanoparticle （NP） structures on conducting substrates. In this work, the applicability of the IAAL technique was investigated on non-conducting substrates. The NP structure growth process on a non-conducting substrate was found to self-terminate and the structures subsequently repel incoming charged NPs and scatter them away. Electric field calculations supported the experimental findings and confirmed that the electric field distortions owing to charge build-up within the structures prevented additional NP deposition thereon. To regulate the charge build-up without compromising the number of NPs available for assembly, a corona discharger and an ion trap were implemented. By varying the number of ions available in the assembly process, an optimum level of ion injection was found that allowed for a prolonged （〉120 rain） assembly of NP structures on non-conducting substrates without the unwanted scattering of NPs.

关键词： Nanoparticle assembly Non-conducting substrate Ion-assisted aerosol lithography Ion trap

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Evaluation of particle growth systems for sampling and analysis of atmospheric fine particles

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Particuology 2011年第6期9卷 606-610页

作者： dae seong Kim Sang Bum Hong Jung-Taek Kwon Kihong Park Department of Environmental Science and Engineering Gwangju Institute of Science and Technology Korea Polar Research Institute Laboratory of Toxicology College of Veterinary Medicine Seoul National University

Three types of water-based condensational growth systems, which can enable particles to grow in size to facilitate sampling and subsequent chemical analysis, were evaluated. The first one is a mixing type growth system where aerosols are mixed with saturated water vapor, the second one is a thermal diffusive growth system where warm flow enters cold-walled tube, and the third one is a laminar flow type where cold flow enters a warm wet-wall tube. Hygroscopic sodium chloride （NaCl）, ammonium sulfate （（NH4）2SO4） and ammonium nitrate （NH4N03）, and non-hygroscopic polystyrene latex （PSL） particles, in the size range of 50-400 nm, were used to determine their growth factors through the growth systems. Our data showed that the third-type growth system could enable particles to grow most efficiently regardless of their hygroscopic property. Collection efficiency of particles in the size range of 0.05-2.5 μm, in a continuous aerosol sampler after they passed through the third-type growth system was about 100%, suggesting that the third-type growth system would he the most useful among the tested growth systems for sampling and subsequent chemical analysis of fine and ultrafine particles.

关键词： Particle growth chamber Condensational growth Particle sampler Hygroscopic particles

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Continuity control method of cutter posture vector for efficient five-axis machining

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Journal of Central South University 2011年第6期18卷 1969-1975页

作者： HWANG Jong-dae KIM Sang-myung JUNG Hyun-chul JUNG Yoon-gyo School of Mechatronics Changwon National University

During five-axis machining of impeller, the excessive local interference avoidance leads to inconsistency of cutter posture, low quality of machined surface and increase of processing time. Therefore, in order to improve the efficiency of five-axis machining of impellers, it is necessary to minimize the cutter posture changes and create a continuous tool path while avoiding interference. By using an MC-space algorithm for interference avoidance, an MB-spline algorithm for continuous control was intended to create a five-axis machining tool path with excellent surface quality and economic feasibility. A five-axis cutting experiment was performed to verify the effectiveness of the continuity control. The result shows that the surface shape with continuous method is greatly improved, and the surface roughness is generally favorable. Consequently, the effectiveness of the suggested method is verified by identifying the improvement of efficiency of five-axis machining of an impeller in aspects of surface quality and machining time.

关键词： five-axis control machining configuration-space B-spline continuity control method impeller interference

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Surface-phonon-polariton-enhanced photoinduced dipole force for nanoscale infrared imaging

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National Science Review 2024年第05期 227-235页

作者： Jian Li Junghoon Jahng Xuezhi Ma Jing Liang Xue Zhang Qianhao Min Xiao-Liang Wang Shuangjun Chen Eun seong Lee Xing-Hua Xia State Key Lab of Analytical Chemistry for Life Science School of Chemistry and Chemical Engineering Nanjing University Hyperspectral Nano-Imaging Team Korea Research Institute of Standards and Science Institute of Materials Research and Engineering Agency for ScienceTechnology and Research College of Materials Science and Engineering Nanjing Tech University

The photoinduced dipole force(Pi DF) is an attractive force arising from the Coulombic interaction between the light-induced dipoles on the illuminated tip and the sample. It shows extreme sample-tip distance and refractive index dependence, which is promising for nanoscale infrared(IR) imaging of ultrathin samples. However, the existence of Pi DF in the mid-IR region has not been experimentally demonstrated due to the coexistence of photoinduced thermal force(Pi TF), typically one to two orders of magnitude higher than Pi DF. In this study, we demonstrate that, with the assistance of surface phonon polaritons, the Pi DF of c-quartz can be enhanced to surpass its Pi TF, enabling a clear observation of Pi DF spectra reflecting the properties of the real part of permittivity. Leveraging the detection of the Pi DF of phonon polaritonic substrate, we propose a strategy to enhance the sensitivity and contrast of photoinduced force responses in transmission images, facilitating the precise differentiation of the heterogeneous distribution of ultrathin samples.

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韩国艺术歌曲《新阿里郎》与《同心草》作品与演唱分析

韩国艺术歌曲《新阿里郎》与《同心草》作品与演唱分析

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作者：明谞英（myung SEO YOUNG）上海音乐学院

学位级别：硕士

在1940年代,金东振和金圣泰创作了《新阿里郎》和《同心草》两首代表韩国特色的歌曲。本文通过分析这两首歌的曲式、节拍、旋律、和声及伴奏,揭示了它们的音乐结构和特点。两首歌均采用了韩国传统曲式,展现了韩国音乐的独特节奏和旋律... 详细信息

在1940年代,金东振和金圣泰创作了《新阿里郎》和《同心草》两首代表韩国特色的歌曲。本文通过分析这两首歌的曲式、节拍、旋律、和声及伴奏,揭示了它们的音乐结构和特点。两首歌均采用了韩国传统曲式,展现了韩国音乐的独特节奏和旋律线条。节拍方面,它们体现了韩国音乐的韵律美。旋律优美动听,和声与旋律和谐统一。此外,本文还探讨了外国人演唱韩国歌曲时的国际标准发音,以及根据韩语特性演唱韩国艺术歌曲时需要注意的方面。这些建议有助于外国人更好地理解和演绎韩国艺术歌曲。总的来说,这两首歌作为韩国音乐的代表,展现了其独特的价值。

关键词：韩国艺术歌曲《新阿里郎》《同心草》

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