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Long Short-Term Memory Recurrent Neural Network-Based Acoustic Model Using Connectionist Temporal Classification on a Large-Scale Training Corpus

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China Communications 2017年第9期14卷 23-31页

作者： Donghyun lee Minkyu Lim Hosung Park Yoseb Kang Jeong-Sik Park Gil-Jin Jang Ji-Hwan Kim Department of Computer Science and Engineering Sogang University Department of Information and Communication Engineering Yeungnam University School of Electronics Engineering Kyungpook National University

A Long Short-Term Memory(LSTM) Recurrent Neural Network(RNN) has driven tremendous improvements on an acoustic model based on Gaussian Mixture Model(GMM). However, these models based on a hybrid method require a forced aligned Hidden Markov Model(HMM) state sequence obtained from the GMM-based acoustic model. Therefore, it requires a long computation time for training both the GMM-based acoustic model and a deep learning-based acoustic model. In order to solve this problem, an acoustic model using CTC algorithm is proposed. CTC algorithm does not require the GMM-based acoustic model because it does not use the forced aligned HMM state sequence. However, previous works on a LSTM RNN-based acoustic model using CTC used a small-scale training corpus. In this paper, the LSTM RNN-based acoustic model using CTC is trained on a large-scale training corpus and its performance is evaluated. The implemented acoustic model has a performance of 6.18% and 15.01% in terms of Word Error Rate(WER) for clean speech and noisy speech, respectively. This is similar to a performance of the acoustic model based on the hybrid method.

关键词： acoustic model connectionisttemporal classification large-scale trainingcorpus long short-term memory recurrentneural network

Cirsium japonicum mitigates allergic nasal inflammation by regulating NRF2-mediated mucin production: Systematic transcriptome and molecular docking analyses

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Journal of Pharmaceutical Analysis 2024年第10期14卷 1527-1530页

作者： Bo-Jeong Pyun Su-Jin Baek Kyuhyung Jo Ik Soo lee Musun Park Hye Jin Kim Joo Young lee Susanna Choi Yun Hee Kim Taesoo Kim KM Convergence Research Division Korea Institute of Oriental Medicine1672 Yuseong-daero Yuseong-guDaejeon 34054Republic of Korea KM Data Division Korea Institute of Oriental Medicine1672 Yuseong-daeroYuseong-guDaejeon 34054Republic of Korea

Allergic rhinitis(AR)is an immunoglobulin(Ig)E-mediated allergic disease frequently recurring following seasonal changes and significantly impacting quality of life[1].Worsening AR symptoms can lead to more severe *** japonicum(CSJ,milk thistle)is an edible and medicinal plant with anti-oxidant,anti-inflammatory,and hepatoprotective properties;however,its effects and mechanisms of action in AR remain ***,we investigated the CSJ targets in AR and the underlying mechanisms in an ovalbumin(OVA)-induced AR mouse model.

关键词： allergic inflammation protective

Improved cell performance and sulphur tolerance using A-site substituted Sr_(2)Fe_(1.4)Ni_(0.1)Mo_(0.5)O_(6-δ)anodes for solid-oxide fuel cells

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Clean Energy 2023年第1期7卷 70-83页

作者： Haixia Li Wanhua Wang Jie Lin Ka-Young Park Taehee lee Andreas Heyden Dong Ding Fanglin Chen Department of Mechanical Engineering University of South CarolinaColumbiaSC29208USA Department of Chemical Engineering University of South CarolinaColumbiaSC29208USA Energy&Environmental Science and Technology Idaho National LaboratoryIdaho FallsID83401USA

Solid-oxide fuel cells(SOFCs)offer great promise for producing electricity using a wide variety of fuels such as natural gas,coal gas and gasified carbonaceous solids;however,conventional nickel-based anodes face great challenges due to contaminants in readily available fuels,especially sulphur-containing ***,the development of new anode materials that can suppress sulphur poisoning is crucial to the realization of fuel-flexible and cost-effective *** this work,La_(0.1)Sr_(1.9)Fe_(1.4)Ni_(0.1)Mo_(0.5)O_(6-δ)(LSFNM)and Pr_(0.1)Sr_(1.9)Fe_(1.4)Ni_(0.1)Mo_(0.5)O_(6-δ)(PSFNM)materials have been synthesized using a sol-gel method in air and investigated as anode mater-ials for *** nanoparticle-decorated ceramic anodes were obtained by the reduction of LSFNM and PSFNM in H_(2)at 850℃,forming a Ruddlesden-Popper oxide with exsolved FeNi3 bimetallic *** electrochemical performance of the Sr_(2)Fe_(1.4)Ni_(0.1)Mo_(0.5)O_(6-δ)ceramic anode was greatly enhanced by La doping of A-sites,resulting in a 44%decrease in the polarization resistance in reducing *** maximum power densities of Sr-and Mg-doped LaGaO_(3)(LSGM)(300μm)electrolyte-supported single cells with LSFNM as the anode reached 1.371 W cm^(-2)in H_(2)and 1.306 W cm^(-2)in 50 ppm H_(2)S-H_(2)at 850℃.Meanwhile,PSFNM showed improved sulphur tolerance,which could be fully recovered after six cycles from H_(2)to 50 ppm H_(2)S-H_(2)*** study indicates that LSFNM and PSFNM are promising high-performance anodes for SOFCs.

关键词： A-site doping perovskite Ruddlesden-Popper structure alloy nanoparticles polarization resistance solid oxide fuel cells

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Neighbors of War

Beijing Review 2015年第46期58卷 26-27页

作者： Kathryn lee Mara lee Durrell public health at Johns Hopkins University

As the world＇s attention shifted from the impact of the Syrian refugee crisis in the Middle East itself to its effects on Europe,those countries that continue to bear the brunt of supporting refugees have largely been left to do so without adequate funding. With the world＇s attention went resources, resulting in dire situations for both refugees and their hosts as they struggle to keep their economies afloat citizens healthy and conflict at bay.

关键词：战争邻国海湾地区注意力难民叙利亚世界

Growth and photosynthesis of Chlorella strains from polar,temperate and tropical freshwater environments under temperature stress

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Journal of Oceanology and Limnology 2018年第4期36卷 1266-1279页

作者： Kok-Keong lee Phaik-Eem LIM Sze-Wan POONG Chiew-Yen WONG Siew-Moi PHANG John BEARDALL Institute of Ocean and Earth Sciences University of Malaya Institute of Graduate Studies University of Malaya School of Health Sciences International Medical University National Antarctic Research Centre University of Malaya Institute of Biological Sciences University of Malaya School of Biological Sciences Monash University

Elevated temperatures as a consequence of global warming have significant impacts on the adaptation and survival of microalgae which are important primary producers in many ecosystems. The impact of temperature on the photosynthesis of microalgae is of great interest as the primary production of algal biomass is strongly dependent on the photosynthetic rates in a dynamic environment. Here, we examine the effects of elevated temperature on Chlorella strains originating from different latitudes, namely Antarctic, Arctic, temperate and tropical regions. Chlorophyll fluorescence was used to assess the photosynthetic responses of the microalgae. Rapid light curves(RLCs) and maximum quantum yield( F_v/F_m) were recorded. The results showed that Chlorella originating from different latitudes portrayed different growth trends and photosynthetic performance. The Chlorella genus is eurythermal, with a broad temperature tolerance range, but with strain-specific characteristics. However, there was a large overlap between the tolerance range of the four strains due to their "eurythermal adaptivity". Changes in the photosynthetic parameters indicated temperature stress. The ability of the four strains to reactivate photosynthesis after inhibition of photosynthesis under high temperatures was also studied. The Chlorella strains were shown to recover in terms of photosynthesis and growth(measured as Chl a) when they were returned to their ambient temperatures. Polar strains showed faster recovery in their optimal temperature compared to that under the ambient temperature from which they were isolated.

关键词： Antarctic Arctic Fv/Fm microalgae pigments recovery

丹参提取物对皮肤表皮分化和水合促进作用的研究

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丹参提取物对皮肤表皮分化和水合促进作用的研究

Mesenchymal stem cells ameliorate B-cell-mediated immune responses and increase IL-10-expressing regulatory B cells in an EBI3-dependent manner

第九届中国化妆品学术研讨会

作者： lee Jin Young KIM Han Byul lee Sung Hoon lee Ok Chan BAE Ji hyun lee Hae Kwang Amorepacific Corporation R&D Center

表皮分化在皮肤老化和水合过程中可能发挥关键作用。特别是丝聚蛋白的表达直接参与了皮肤的屏障功能和表皮天然保湿因子(NMFS)的合成。丹参(Salvia miltiorrhiza)是一味常见中药,在中国已经有数百年的使用历史,但其对皮肤的影响尚未得... 详细信息

表皮分化在皮肤老化和水合过程中可能发挥关键作用。特别是丝聚蛋白的表达直接参与了皮肤的屏障功能和表皮天然保湿因子(NMFS)的合成。丹参(Salvia miltiorrhiza)是一味常见中药,在中国已经有数百年的使用历史,但其对皮肤的影响尚未得到评估。在本研究中,我们发现丹参提取物(ESM)可以刺激正常人角质细胞和Amo Re Skin(本实验室建立的重建人类皮肤模型)中丝聚蛋白的表达。实时定量PCR试验证实了这一结论,丹参提取物(ESM)干预能够上调角质细胞中丝聚蛋白m RNA的表达。免疫染色试验证实丹参提取物(ESM)干预后Amo Re Skin中丝聚蛋白的表达增加。此外,实时定量PCR试验也证实角质细胞中表皮分化的标志物角蛋白1 m RNA的量增多。这些结果表明,丹参提取物(ESM)可以增强表皮分化和水合的活性,可能会增强表皮对抗皮肤老化的功能。

关键词：丹参丝聚合蛋白表皮分化

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Cellular & Molecular Immunology 2017年第11期14卷 895-908页

作者： Kyung-Ah Cho Jun-Kyu lee Yu-Hee Kim Minhwa Park So-Youn Woo Kyung-Ha Ryu Department of Microbiology School of MedicineEwha Womans UniversitySeoul 07985Republic of Korea Department of Pediatrics School of MedicineEwha Womans UniversitySeoul 07985Republic of Korea

Effector B cells are central contributors to the development of autoimmune disease by activating autoreactive T cells,producing pro-inflammatory cytokines and organizing ectopic lymphoid ***,IL-10-producing regulatory B(Breg)cells have pivotal roles in maintaining immunological tolerance and restraining excessive inflammation in autoinflammatory ***,regulating the equilibrium between antibody-producing effector B cells and Breg cells is critical for the treatment of autoimmune *** this study,we investigated the effect of human palatine tonsil-derived mesenchymal stem cells(T-MSCs)on estradiol(E2)-induced B-cell responses in vivo and in *** of T-MSC into E2-treated mice alleviated B-cell-mediated immune responses and increased the population of IL-10-producing Breg cells.T-MSCs regulated the B-cell populations by producing Epstein–Barr virus(EBV)-induced 3(EBI3),one of the two subunits of IL-35 that is the well-known inducer of Breg *** demonstrate a critical role of EBI3(IL-35)in vitro by depleting EBI3 in T-MSCs and by adding exogenous IL-35 to the culture *** together,our data suggest that IL-35-secreting MSCs may become an attractive therapeutic to treat B-cell-mediated autoimmune diseases via expanding Breg cells.

关键词： autoimmune disease B cells IL-35 mesenchymal stem cells

Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection

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World Journal of Gastroenterology 2022年第15期28卷 1548-1562页

作者： Jiyoung Yoon Seung-Yeon Yoo Young Soo Park Kee Don Choi Beom Su Kim Moon-Won Yoo In Seob lee Jeong Hwan Yook Ga Hee Kim Hee Kyong Na Ji Yong Ahn Jeong Hoon lee Kee Wook Jung Do Hoon Kim Ho June Song Gin Hyug lee Hwoon-Yong Jung Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although the criteria for the indication of endoscopic submucosal dissection(ESD)for undifferentiated early gastric cancer(UD-EGC)have been recently proposed,accumulating reports on the non-negligible rate of lymph node metastasis(LNM)after indicated ESD raise questions on the reliability of the current *** To investigate the prevalence and risk factors of LNM in UD-EGC cases meeting the expanded indication for *** We retrospectively reviewed 4780 UD-EGC cases that underwent surgical resection between January 2008 and February 2019 at Asan Medical Center,a tertiary university hospital in *** identify the risk factors of LNM of UDEGC meeting the expanded criteria for ESD,we performed a case-control study by matching the cases with LNM to those without at a ratio of 1:*** reviewed the clinical,endoscopic,and histologic features of the cases to identify features with a significant difference according to the presence of *** and multivariate logistic regression analyses were performed to estimate the odds ratios(ORs).RESULTS Of the 4780 UD-EGC cases,1240(25.9%)were identified to meet the expanded indication for *** the 1240 cases,14(1.1%)cases had *** the various clinical,endoscopic,and histopathological features that were evaluated,mixed histology(tumors consisting of 10%-90%of signet ring cells)had a marginally significant association(P=0.059)with the risk of ***,diffuse blurring of the muscularis mucosae(MM)underneath the tumorous epithelium,a previously unrecognized histologic feature,had a significant association with the absence of LNM(P=0.028).Multivariate logistic regression analysis showed that the blurring of MM was the only explanatory variable significantly associated with a reduced risk of LNM(OR:0.12,95%CI:0.02-0.95;P=0.045).CONCLUSION The risk of LNM is higher than expected when using the current expanded indication for *** evaluation could provide useful clues for reducing the

关键词： Gastric cancer Undifferentiated carcinoma Endoscopic submucosal dissection Lymph node metastasis

Near-Net Shape Continuous Casting of Aluminum Alloy Billet Using Electromagnetic Field

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Journal of Iron and Steel Research International 2012年第S1期19卷 40-45页

作者： Joonpyo PARK Myounggyun KIM Jongho-KIM Gyuchang lee 32 Hyoja Research Institute of Industrial Science and TechnologyPohangKorea

The present study investigates on the continuous casting of near-net shape aluminum billet using electromagnetic casting and stirring *** machine for continuous casting process involves round, square and rectangular billets;therefore it requires additional multistep forging process to fabricate final products.A new process for the designed free-shaped billets offers some advantages:the process of extrusion and forging is simplified and the cost of plastic working can be greatly *** order to reduce the peculiar problems such as surface crack and internal defect due to inhomogeneous heat transfer through solidified billets,electromagnetic casting and stirring technique were *** the numerical computer simulation,we have calculated the slit design of the free-shaped *** free-shaped aluminum billet was continuously cast at the various casting speed and coil current of about 1,*** velocity and melt pool depth were *** and microstructure of the free-shape aluminum billet using EMC and EMS techniques were compared with those of the billet using the conventional DC casting.

关键词： continuous casting free-shaped aluminum billet EMC EMS