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World Journal of Clinical Cases 2022年第4期10卷 1349-1356页

作者： dae hun yun Eun Ha Suk Wan Ju Eun Hyoung Seo Hyun Kang Department of Anesthesiology and Pain Medicine Kwangju Christian HospitalGwangju 61661South Korea

BACKGROUND Rhabdomyolysis develops as a result of skeletal muscle cell collapse from leakage of the intracellular contents into *** severe cases,it can be associated with acute kidney injury and disseminated intravascular coagulation,leading to life threatening *** can occur in the perioperative period from various etiologies but is rarely induced by tourniquet use during orthopedic *** SUMMARY A 77-year-old male underwent right total knee arthroplasty using a tourniquet under spinal *** 24 h after surgery,he was found in a drowsy mental state and manifested features of severe rhabdomyolysis,including fever,hypotension,oliguria,high creatine kinase,myoglobinuria,and disseminated intravascular *** supportive care,cardiac arrest developed abruptly,and the patient was not able to be *** Severe rhabdomyolysis and disseminated intravascular coagulation can develop from surgical tourniquet,requiring prompt,aggressive treatments to save the patient.

关键词： Rhabdomyolysis Total knee arthroplasty Tourniquet Disseminated intravascular coagulation Case report

Redox sensor QSOX1 regulates plant immunity by targeting GSNOR to modulate ROS generation

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Molecular Plant 2021年第8期14卷 1312-1327页

作者： Ho Byoung Chae Min Gab Kim Chang Ho Kang Joung hun Park Eun Seon Lee Sang-Uk Lee Yong hun Chi Seol Ki Paeng Su Bin Bae Seong Dong Wi Byung-Wook yun Woe-Yeon Kim dae-Jin yun David Mackey Sang Yeol Lee Division of Applied Life Sciences(BK21)and PMBBRC Gyeongsang National UniversityJinju 52828Korea College of Pharmacy Research Institute of Pharmaceutical ScienceGyeongsang National UniversityJinju 52828Korea School of Applied Biosciences College of Agriculture and Life SciencesKyungpook National UniversityDaegu 41566Korea Department of Biomedical Science and Engineering Konkuk UniversitySeoul 05029Korea Department of Horticulture and Crop Science Department of Molecular Geneticsand Center for Applied Plant SciencesThe Ohio State UniversityColumbusOH 43210USA College of Life Sciences Qingdao Agricultural UniversityQingdao 266109P.R.China Plant Propagation Team Plant Production DivisionSejong National ArboretumSejong 30106Korea

Reactive oxygen signaling regulates numerous biological processes,including stress responses in *** sensors transduce reactive oxygen signals into cellular ***,we present biochemical evidence that a plant quiescin sulfhydryl oxidase homolog(QSOX1)is a redox sensor that negatively regulates plant immunity against a bacterial *** expression level of QSOX1 is inversely correlated with pathogen-induced reactive oxygen species(ROS)***,QSOX1 both senses and regulates ROS levels by interactingn with and mediating redox regulation of S-nitrosoglutathione reductase,which,consistent with previous findings,influences reactive nitrogen-mediated regulation of ROS ***,our data indicate that QSOX1 is a redox sensorthat negatively regulates plant immunity by linking reactive oxygen and reactive nitrogen signaling to limit ROS production.

关键词： redox sensor plant immu nity QSOX1 GSNOR reactive oxygen species(ROS) reactive nitrogen species(RNS)

Electrical and Corrosion Properties of Titanium Aluminum Nitride Thin Films Prepared by Plasma-Enhanced Atomic Layer Deposition

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Journal of Materials Science & Technology 2017年第3期33卷 295-299页

作者： Eun-Young yun Woo-Jae Lee Qi Min Wang Se-hun Kwon School of Materials Science and Engineering Pusan National University School of Electromechanical Engineering Guangdong University of Technology

Titanium-aluminum-nitride（TiAlN） films were grown by plasma-enhanced atomic layer deposition（PEALD）on 316 L stainless steel at a deposition temperature of 200 °C. A supercycle, consisting of one AlN and ten TiN subcycles, was used to prepare TiAlN films with a chemical composition of Ti（0.25）Al（0.25）N（0.50）. The addition of AlN to TiN resulted in an increased electrical resistivity of TiAlN films of 2800 μΩ cm, compared with 475 μΩ cm of TiN films, mainly due to the high electrical resistivity of AlN and the amorphous structure of TiAlN. However, potentiostatic polarization measurements showed that amorphous TiAlN films exhibited excellent corrosion resistance with a corrosion current density of 0.12 μA/cm^2, about three times higher than that of TiN films, and about 12.5 times higher than that of 316 L stainless steel.

关键词： Titanium-aluminum nitride Plasma-enhanced atomic layer deposition Corrosion protection Ternary transition metal nitrides

Challenges for clinicians treating autoimmune pancreatitis:Current perspectives

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World Journal of Clinical Cases 2023年第1期11卷 30-46页

作者： Seong-hun Kim yun Chae Lee Hyung Ku Chon Division of Gastroenterology Department of Internal MedicineJeonbuk National University Medical SchoolJeonju 54907South Korea Department of Internal Medicine Institution of Wonkwang Medical ScienceWonkwang University School of Medicine and HospitalIksan 54538South Korea

Autoimmune pancreatitis(AIP)is a rare disease clinically characterized by obstructive jaundice,unintentional weight loss,acute pancreatitis,focal pancreatic mass,and *** is classified into two subtypes-type 1 and type 2-according to pathological findings,clinical features,and serology test results,but some cases may be defined as type not otherwise in the absence of pathological findings and inflammatory bowel *** address the differences in diagnostic criteria by country,standard diagnostic criteria for AIP were proposed in 2011 by an international consensus of expert *** diagnosis of AIP from pancreatic ductal adenocarcinoma is important but remains challenging for ***,all subtypes of AIP show dramatic response to steroid *** review discusses the current perspectives on the diagnosis and management of AIP in clinical practice.

关键词： Autoimmune pancreatitis Pancreatic cancer International consensus diagnostic criteria Steroid

Relief of YAP-mediated inhibition by IKKε promotes innate antiviral immunity

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Cellular & Molecular Immunology 2018年第6期15卷 642-644页

作者： Nayoung Kim yun-Yong Park Chul Hyun Joo hun Sik Kim Department of Convergence Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea Department of Microbiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea Department of Biomedical Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505Korea

The innate immune response to invading viruses is critical for the mounting of protective immunity,in which type I interferons(IFN),for example,IFN-αandβ,are potent effector molecules.1 Most cell types,particularly fibroblasts and epithelial cells,produce IFN-β,whereas hematopoietic cells,notably plasmacytoid dendritic cells,are the predominant sources of IFN-α.IFNs potently stimulate a variety of innate and adaptive immune cells,including macrophages,NK cells and T *** binding of type I IFN to its cognate receptor triggers the activation of the Janus kinase signal transducer and activator of transcription pathway,which results in the transcription of IFNstimulated genes that play key roles in host resistance to viral infections.

关键词： immunity protective mount

Variability of the Dokdo Abyssal Current observed in the Ulleung Interplain Gap of the East/Japan Sea

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Acta Oceanologica Sinica 2013年第1期32卷 12-23页

作者： KIM yun-Bae CHANG Kyung-Il PARK Jae-hun PARK Jong Jin East Sea Research Institute Korea Institute of Ocean Science and Technology Research Institute of Oceanography School of Earth and Environmental Sciences Seoul National University Ocean Science Research Department Korea Institute of Ocean Science and Technology Department of Oceanography Kyungpook National University

Subinertial fluctuation of a strong northward deep current, which is referred to the Dokdo Abyssal Current （DAC） by Chang et al. （2009）, is investigated from current records for about 16.5 and 8.0 months in the Ulle- ung Interplain Gap of the East/lapan Sea. The current below 300 m is bottom-intensified and has nearly depth-independent flow. Near bottom, the spectral peaks of the current were found near 10, 20, and 60 d. The DAC variability near 10 d and 20 d is reasonably consistent with the linear theory of topographic Rossby waves （TRWs） in the following aspects：（1） The motion is columnar and bottom-intensified; （2） the theo- retical cutoff frequency is similar to the observation; （3） The observation-based angles of the wavenumber vector are in good agreement with the theoretical ones. The wavelengths of the TRWs with periods of near 10 d and 20 d near Dokdo are significantly shorter than those with similar timescales in the open oceans （100-250 km）. It is primarily due to the weak stratification below 300 m in the East Sea. The deep cur- rent fluctuations with periods of near 10 d and 20 d were accompanied by warm events in the upper layer resulting from eddying processes and/or meandering of the Tsushima Warm Current.

关键词： East/Iapan Sea Ulleung Interplain Gap Deep currents Topographic Ressby waves

Structural Resistance of SRC Column-Steel Beam Joint Developed for Innovative Construction of Buildings

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Journal of Iron and Steel Research International 2011年第S1期18卷 924-928页

作者： Seo Soo-yeon yun Hyun-Do Kim Seung-hun Dept.of Architectural Engineering Chungju National UniversityChungjuKorea Dept.of Architectural Engineering Chungnam National UniversityDaejeonKorea Dept.of Architectural Engineering Hanbat National UniversityDaejeonKorea

This paper presents an experimental study investigating factors influencing the effective width of steel reinforced concrete (SRC) column-steel beam joints of building in order to calculate its resisting *** 1/2 scaled interior SRC column-steel beam joint specimens were made with considering parameters such as beam flange width,beam depth and SRC column *** directional increasing moment was applied to the joint by acting forces to each ends of beam and the structural behavior of joint was *** previous design method suggested by Deierlein was reviewed and a modified equation was proposed from the analysis of test *** result indicated that the equation to calculate the effective width in Deierlein’s design method didn’t consider effectively the influence caused by the variation of beam depth so that a modified equation was suggested and the validation of it was confirmed in this paper.

关键词： SRC column-steel beam joint effective width flange width beam depth

Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma

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World Journal of Gastroenterology 2012年第6期18卷 557-562页

作者： Hyung hun Kim You Sun Kim yun Kyung Kang Jeong Seop Moon Department of Internal Medicine Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea Department of Pathology Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea Hyung Hun Kim Department of Internal Medicine Kosin University College of MedicineBusan 602-702South Korea

AIM： To investigate the expressions of leptin and per- oxisome proliferator-activated receptor y （PPARG） in relation to body mass index （BMI）. METHODS： We evaluated leptin and PPARG expres- sion in 30 adenomas over 1 cm in size by immunohisto- chemical staining. In addition, clinicopathologic features including BMI were assessed. RESULTS： PPARG and leptin expression showed a strong positive correlation （P = 0.035）. The average BMI of the leptin-positive group was higher than that of the leptin-negative group （25.4 ＋ 3.4 kg/m2 vs 22.6 ＋ 2.4 kg/m2, P = 0.018）, and leptin expression was sig- nificantly correlated with high BMI （P = 0.024）. Leptinexpression was more frequently observed in intermedi- ate/high grade dysplasia than in low grade dysplasia （P = 0.030）. However, PPARG expression was not cor- related with BMI and grade of dysplasia. CONCLUSION： BMI has influenced on the leptin ex- pression of colorectal adenoma. The exact mechanism underlies the strong correlation between leptin and PPARG expression needs further study.

关键词： Leptin Peroxisome proliferator-activated re-ceptor y Obesity Body mass index Colorectal adenoma

Classification of hepatobiliary scintigraphy patterns in segmented gallbladder according to anatomical discordance

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World Journal of Clinical Cases 2023年第11期11卷 2423-2434页

作者： yun-Chae Lee Won-Sik Jung Chang-hun Lee Seong-hun Kim Seung-Ok Lee Division of Gastroenterology Department of Internal MedicineJeonbuk National University Medical SchoolJeonju 54907JeonbukSouth Korea Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital Jeonju 54907JeonbukSouth Korea

BACKGROUND Hepatobiliary scintigraphy(HBS)is a useful diagnostic imaging technique that uses radiotracers to evaluate the function of the gallbladder(GB)and biliary *** segmented GB,some HBS images reveal a discordant GB boundary as compared to anatomical *** To evaluate the characteristics of HBS in segmented GB and determine the clinical relevance according to HBS *** A total of 268 patients with chronic cholecystitis,gallstones,or biliary colic symptoms who underwent HBS between 2011 and 2020 were *** GB was defined as segmental luminal narrowing of the GB body on computed tomography(CT)or magnetic resonance(MR)images,and HBS was examined 1 mo before or after CT or *** GB was classified into 3 types based on the filling and emptying patterns of the proximal and distal segments according to the characteristics of HBS images,and GB ejection fraction(GBEF)was identified:Type 1 was defined as a normal filling and emptying pattern;Type 2 was defined as an emptying defect on the distal segment;and Type 3 was defined as a filling defect in the distal *** Segmented GB accounted for 63 cases(23.5%),including 36 patients(57.1%)with Type 1,18 patients(28.6%)with Type 2,and 9 patients(14.3%)with Type 3 emptying ***,approximately 43%of HBS images showed a discordant pattern as compared to anatomical imaging of segmented *** there were no significant differences in clinical symptoms,rate of cholecystectomy,or pathological findings based on the type,most gallstones occurred in the distal *** GBEF was 62.50%±24.79%for Type 1,75.89%±17.21%for Type 2,and 88.56%±7.20%for Type *** 1 showed no difference in reported GBEF compared to the non-segmented GB group(62.50%±24.79%vs 67.40%±21.78%).In contrast,the reported GBEF was higher in Types 2 and 3 with defective emptying and filling when compared to Type 1(80.11%±15.70%vs 62.57%±24.79%;P=0.001).CONCLUSION In segmented GB,discordance i

关键词： Gallbladder Segmented Gallbladder emptying Radionuclide imaging Misdiagnosis Cholecystitis

Transient severe mitral regurgitation after paroxysmal supraventricular tachycardia in patient with WPW syndrome

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Journal of Geriatric Cardiology 2017年第10期14卷 652-653页

作者： yun-Seok Song Sang-Hoon Seol Dong-Kie Kim Ki-hun Kim Doo-Il Kim Division of Cardiology Department of lnternal Medicine Inje University College of Medicine Haeundae Paik hospital Busan South Korea

A 65-year-old woman was presented with acute ab- dominal pain. The initial heart rate was 170 beats/min and the ECG showed supraventricular tachycardia （Figure IA）. After intra-venous adenosine administered, it recovered to sinus rhythm and the follow-up ECG showed WPW pattern （Figure 1B）. The echocardiography revealed mitral valve prolapse of mid portion of anteromedial valve leaflet （A2） with severe mitral regurgitation （MR）（Figure 2）.

关键词： Tachycardia Transient mitral regurgitation WPW syndrome