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Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists

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World Journal of Gastroenterology 2011年第21期17卷 2602-2610页

作者： Joon Mee Kim Mee-Yon Cho Jin Hee Sohn dae young kang Cheol Keun Park Woo Ho Kim So-young Jin Kyoung Mee Kim Hee Kyung Chang Eunsil Yu Eun Sun Jung Mee Soo Chang Jong Eun Joo Mee Joo Youn Wha Kim Do Youn Park Yun Kyung kang Sun Hoo Park Hye Seung Han young Bae Kim Ho Sung Park Yang Seok Chae Kye Won Kwon Hee Jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists Department of Pathology Inha University Hospital Department of Pathology Yonsei University Wonju College of Medicine Wonju Christian Hospital Department of Pathology Sungkyunkwan University School of MedicineKangbuk Samsung Medical Center Department of Pathology Chungnam National University College of Medicine Department of Pathology Sungkyunkwan University School of MedicineSamsung Medical Center Department of Pathology Seoul National University College of Medicine Department of Pathology Soonchunhyang University Hospital Department of Pathology Kosin University College of Medicine Department of Pathology University of Ulsan College of MedicineAsan Medical Center Department of Pathology The Catholic University of KoreaSeoul St.Mary's Hospital Department of Pathology Seoul National University Boramae Hospital Department of Pathology Eulji General Hospital Department of Pathology Inje University Ilsan Paik Hospital Department of Pathology Kyunghee University College of Medicine Department of Pathology Pusan National University College of Medicine Department of Pathology Inje University Seoul Paik Hospital Department of Pathology Korea Cancer Center Hospital Department of Pathology Konkuk University Medical Center Department of Pathology Ajou University School of Medicine Department of Pathology Chonbuk National University Medical School Department of Pathology Korea University College of Medicine Department of Pathology Bundang Jesaeng Hospital Department of Pathology National Cancer Center The Korean Society of Pathologists 4FThe Korean Medical Association BuildingSeoul 140-721South Korea

The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of *** the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic *** pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western *** is geographically close to Korea,and academic exchanges are ***,Korean doctors are familiar with Western style medical *** a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in *** solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss

关键词： Intraepithelial neoplasia Stomach Dysplasia Adenoma Carcinoma Japanese Western Consensus Vienna

Network-Aided Intelligent Traffic Steering in 5G Mobile Networks

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Computers, Materials & Continua 2020年第10期65卷 243-261页

作者： dae-young Kim Seokhoon Kim School of Computer Software Daegu Catholic UniversityGeyongsan38430Korea Department of Computer Software Engineering Soonchunhyang UniversityAsan31538Korea

Recently,the fifth generation(5G)of mobile networks has been deployed and various ranges of mobile services have been *** 5G mobile network supports improved mobile broadband,ultra-low latency and densely deployed massive *** allows multiple radio access technologies and interworks them for services.5G mobile systems employ traffic steering techniques to efficiently use multiple radio access ***,conventional traffic steering techniques do not consider dynamic network conditions *** this paper,we propose a network aided traffic steering technique in 5G mobile network architecture.5G mobile systems monitor network conditions and learn with network *** a machine learning algorithm such as a feed-forward neural network,it recognizes dynamic network conditions and then performs traffic *** proposed scheme controls traffic for multiple radio access according to the ratio of measured ***,it can be expected to improve traffic steering *** performance of the proposed traffic steering scheme is evaluated using extensive computer simulations.

关键词： Mobile network 5G traffic steering machine learning MEC

Adaptive Data Transmission Method According to Wireless State in Long Range Wide Area Networks

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Computers, Materials & Continua 2020年第7期64卷 1-15页

作者： Seokhoon Kim dae-young Kim Department of Computer Software Engineering Soonchunhyang UniversityAsan-si31538Korea School of Computer Software Daegu Catholic UniversityGyeongsan-si38430Korea

The Internet of Things(IoT)has enabled various intelligent services,and IoT service range has been steadily extended through long range wide area communication technologies,which enable very long distance wireless data ***-nodes are connected to a gateway with a single *** consume very low-power,using very low data rate to deliver *** long transmission time is consequently needed for each data packet transmission in long range wide area networks,data transmission should be efficiently ***,this paper proposes a multicast uplink data transmission mechanism particularly for bad network *** delay will be increased if only retransmissions are used under bad network ***,employing multicast techniques in bad network conditions can significantly increase packet delivery ***,retransmission can be reduced and hence transmission efficiency ***,the proposed method adopts multicast uplink after network condition *** predict network conditions,the proposed method uses a deep neural network *** proposed method performance was verified by comparison with uplink unicast transmission only,confirming significantly improved performance.

关键词： IoT wide area communication machine learning uplink transmission.

A Data Download Method from RSUs Using Fog Computing in Connected Vehicles

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Computers, Materials & Continua 2019年第5期59卷 375-387页

作者： dae-young Kim Seokhoon Kim School of Information Technology Daegu Catholic UniversityGyeongsan-si 38430Republic of Korea Department of Computer Software Engineering Soonchunhyang UniversityAsan-si 31538Republic of Korea

Communication is important for providing intelligent services in connected *** must be able to communicate with different places and exchange information while *** service operation,connected vehicles frequently attempt to download large amounts of *** can request data downloading to a road side unit(RSU),which provides infrastructure for connected *** RSU is a data bottleneck in a transportation system because data traffic is concentrated on the ***,it is not appropriate for a connected vehicle to always attempt a high speed download from the *** the mobile network between a connected vehicle and an RSU has poor connection quality,the efficiency and speed of the data download from the RSU is *** problem affects the quality of the user ***,it is important for a connected vehicle to connect to an RSU with consideration of the network conditions in order to try to maximize download *** proposed method maximizes download speed from an RSU using a machine learning *** collect and learn from network data,fog computing is used.A fog server is integrated with the RSU to perform *** the algorithm recognizes that conditions are not good for mass data download,it will not attempt to download at high ***,the proposed method can improve the efficiency of high speed *** conclusion was validated using extensive computer simulations.

关键词： Connected car fog computing data download DSRC machine learning

Evaluation of ring surfaces with several coatings for friction,wear and scuffing life

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中国有色金属学会会刊：英文版 2009年第4期19卷 992-996页

作者： dae-Hyun CHO young-Ze LEE School of Mechanical Engineering Sungkyunkwan University

Friction and wear of the sliding components in an automobile cause an increase in both fuel consumption and *** engine components involved with sliding contact are all susceptible to scuffing failure at some points during their operating ***,it is important to evaluate the effects of various surface coatings on the tribological characteristics of the piston ring and cylinder block surface of a diesel *** and scuffing tests were conducted using a friction and wear measurement of the piston ring and cylinder block in a low friction diesel *** frictional forces,wear amounts and cycles to scuffing in the boundary lubricated sliding condition were measured using the reciprocating wear *** tester used a piece of the cylinder block as the reciprocating specimen and a segment of the piston ring material as the fixed *** coatings on the ring specimen were used,such as DLC,TiN,Cr-ceramic and TiAlN,in order to improve the tribological characteristics of the *** coefficients of friction were monitored during the tests,and the wear volumes of the piston ring surfaces with various coatings were *** results show that the DLC coating exhibits better tribological properties than the other *** graphite structure of this coating is responsible for the low friction and wear of the DLC *** TiN and DLC coatings show better scuffing resistance than the other *** TiN and Cr-ceramic coated rings show good wear resistance and high friction.

关键词：涂层表面摩擦评价生活划伤磨损

Superior electrocatalytic negative electrode with tailored nitrogen functional group for vanadium redox flow battery

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Journal of Energy Chemistry 2023年第3期78卷 148-157,I0005页

作者： Min Gu kang Wook Ahn Joonhee kang Shin Ae Song Kiyoung Kim Ju young Woo Yong-Cheol Jeong Bonwook Koo dae Soo Jung Sung Nam Lim Micro/Nano Scale Manufacturing Group Korea Institute of Industrial Technology143 HanggaulroSangrok-guAnsan-siGyeonggi-do 15588Republic of Korea Department of Energy Systems Engineering Soonchunhyang University22 Soonchunhyang-roShinchang-myeonAsan-siChungcheongnam-do 31538Republic of Korea Department of Nanoenergy Engineering Pusan National UniversityBusan 46241Republic of Korea Department of Nano Fusion Technology Pusan National UniversityBusan 46241Republic of Korea Energy Storage Materials Center Energy&Environmental DivisionKorea Institute of Ceramic Engineering&Technology(KICET)101 Soho-roJinju-siGyeongsangnam-doRepublic of Korea

Development of electrodes with high electrocatalytic activity and stability is essential for solving problems that still restrict the extensive application of vanadium redox flow batteries(VRFBs).Here,we designed a novel negative electrode with superior electrocatalytic activity by tailoring nitrogen functional groups,such as newly formed nitro and pyridinic-N transformed to pyridonic-N,from the prenitrogen-doped *** was experimentally confirmed that an electrode with pyridonic-N and nitro fuctional groups(tailored nitrogen-doped graphite felt,TNGF) has superior electrocatalytic acivity with enhanced electron and mass *** functional theory calulations demonstrated the pyridonic-N and nitro functional groups promoted the adsorption,charge transfer,and bond formation with the vanadium species,which is consistent with expermental *** addition,the V2+/V3+redox reaction mechanism on pyridonic-N and nitro functional groups was estabilised based on density functional theory(DFT) *** TNGF was applied to a VRFB,it enabled enhanced-electrolyte utilization and energy efficiencies(EE) of 57.9% and 64.6%,respectively,at a current density of 250 mA cm^(-2).These results are 18.6% and 8.9% higher than those of VRFB with electrode containing graphitic-N and pyridinicN ***,TNGF-based VRFB still operated with an EE of 59% at a high current density of300 mA cm^(-2).The TNGF-based VRFB exhibited stable cycling performance without noticeable decay of EE over 450 charge-discharge cycles at a current density of 250 mA cm^(-2).The results of this study suggest that introducing pyridonic-N and nitro groups on the electrode is effective for improving the electrochemical performance of VRFBs.

关键词： Tailored nitrogen functional group Pyridonic-N Nitro Negative electrode Density functional theory Vanadium redoxﬂow batteries

Low temperature-mediated repression and far-red light-mediated induction determine morning FLOWERING LOCUS T expression levels

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Journal of Integrative Plant Biology 2024年第1期66卷 103-120页

作者： Hayeon Kim Hye Won kang dae Yeon Hwang Nayoung Lee Akane Kubota Takato Imaizumi young Hun Song Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Korea Department of Biology Ajou UniversitySuwon 16499Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Graduate School of Science and Technology Nara Institute of Science and TechnologyIkomaNara 630‐0192Japan Department of Biology University of WashingtonSeattleWA 98195USA Institute of Agricultural Life Sciences Seoul National UniversitySeoul 08826Korea

In order to flower in the appropriate season,plants monitor light and temperature changes and alter downstream pathways that regulate florigen genes such as Arabidopsis(Arabidopsis thaliana)FLOWERING LOCUS T(FT).In Arabidopsis,FT messenger RNA levels peak in the morning and evening under natural long-day conditions(LDs).However,the regulatory mechanisms governing morning FT induction remain poorly *** morning FT peak is absent in typical laboratory LDs characterized by high red:far-red light(R:FR)ratios and constant ***,we demonstrate that ZEITLUPE(ZTL)interacts with the FT repressors TARGET OF EATs(TOEs),thereby repressing morning FT expression in natural *** LDs with simulated sunlight(R:FR=1.0)and daily temperature cycles,which are natural LD-mimicking environmental conditions,FT transcript levels in the ztl mutant were high specifically in the morning,a pattern that was mirrored in the toe1 toe2 double *** night-to-morning temperatures increased the inhibitory effect of ZTL on morning FT expression by increasing ZTL protein levels early in the ***-red light counteracted ZTL activity by decreasing its abundance(possibly via phytochrome A(phyA))while increasing GIGANTEA(GI)levels and negatively affecting the formation of the ZTL-GI complex in the ***,the phyA-mediated high-irradiance response and GI play pivotal roles in morning FT *** findings suggest that the delicate balance between low temperature-mediated ZTL activity and the far-red light-mediated functions of phyA and GI offers plants flexibility in fine-tuning their flowering time by controlling FT expression in the morning.

关键词： far-red light FLOWERING LOCUS T flowering time GIGANTEA low night-to-morning temperature natural long days phytochrome A red to far-red ratio ZEITLUPE

Data Aggregation-based Transmission Method in Ultra-Dense Wireless Networks

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Intelligent Automation & Soft Computing 2023年第1期35卷 727-737页

作者： dae-young Kim Seokhoon Kim Department of Computer Software Engineering Soonchunhyang UniversityAsan31538Korea

As the Internet of Things(IoT)advances,machine-type devices are densely deployed and massive networks such as ultra-dense networks(UDNs)are *** devices attend to the network to transmit data using machine-type communication(MTC),whereby numerous,various are *** devices generally have resource constraints and use wireless *** this kind of network,data aggregation is a key function to provide transmission *** can reduce the number of transmitted data in the network,and this leads to energy saving and reducing transmission *** order to effectively operate data aggregation in UDNs,it is important to select an aggregation point *** total number of transmitted data may vary,depending on the aggregation point to which the data are ***,in this paper,we propose a novel data aggregation scheme to select the appropriate aggregation point and describe the data transmission method applying the proposed aggregation *** addition,we evaluate the proposed scheme with extensive computer *** performances in the proposed scheme are achieved compared to the conventional approach.

关键词： Data aggregation data transmission ultra-dense network machine-type communication Internet of Things

Double layered self-expanding metal stents for malignant esophageal obstruction, especially across the gastroesophageal junction

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World Journal of Gastroenterology 2012年第28期18卷 3732-3737页

作者： Min dae Kim Su Bum Park dae Hwan kang Jae Hyung Lee Cheol Woong Choi Hyung Wook Kim Chung Uk Chung young Il Jeong Department of Internal Medicine Bongseng Memorial Hospital Busan 601-723 South Korea Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan 626-770 South Korea

AIM: To evaluate the clinical outcomes of double-layered self-expanding metal stents (SEMS) for treatment of malignant esophageal obstruction according to whether SEMS crosses the gastroesophageal junction (GEJ). METHODS: Forty eight patients who underwent the SEMS insertion for malignant esophageal obstruction were enrolled. Patients were classified as GEJ group (SEMS across GEJ, 18 patients) and non-GEJ group (SEMS above GEJ, 30 patients) according to SEMS position. Double layered (outer uncovered and inner covered stent) esophageal stents were placed. RESULTS: The SEMS insertion and the clinical improvement were achieved in all patients in both groups. Stent malfunction occurred in seven patients in the GEJ group and nine patients in the non-GEJ group. Tumor overgrowth occurred in five and eight patients, respectively, food impaction occurred in one patient in each group, and stent migration occurred in one and no patient, respectively. There were no significant differences between the two groups. Reflux esophagitis occurred more frequently in the GEJ group (eight vs five patients, P = 0.036) and was controlled by proton pump inhibitor. Aspiration pneumonia occurred in zero and five patients, respectively, and tracheoesophageal fistula occurred in zero and two patients, respectively. CONCLUSION: Double-layered SEMS are a feasible and effective treatment when placed across the GEJ for malignant esophageal obstruction. Double-layered SEMS provide acceptable complications, especially migration, although reflux esophagitis is more common in the GEJ group.

关键词： Metal stent Gastroesophageal junction Malignant esophageal obstruction