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The Ulva prolifera genome reveals the mechanism of green tides

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Journal of Oceanology and Limnology 2021年第4期39卷 1458-1470页

作者： yuan HE Songdong SHEN dachun yu Yehua WANG Jiao YIN Zongling WANG yuantu YE Institute of Aquaculture College of Biology and Basic Medical SciencesSoochow UniversitySuzhou 215123China First Institute of Oceanography(FIO) Ministry of Natural Resources(MNR)Qingdao 266100China

The genome of green microalgae has rarely been *** prolifera is a green microalga that has received much *** research articles about *** in recent years,we know very little about its ***,the 87.9-Mb haploid genome(containing 10311 protein-coding genes)of *** was studied,and the genome was compared with that of ***,which is the only published Ulva *** showed that the two species are closely related.A phylogenetic tree was constructed among *** and other green algae available in GenBank,revealing the evolutionary status of *** in *** understand why *** could grow rapidly,we identified some genes related to growth,such as those involved in cell division,phosphorylation,and cell *** addition,genes related to stress resistance were found,which supports the notion that *** grows vigorously in *** results help to characterize green tides from a new perspective and reveal some important insight into the biology of ***.

关键词： Ulva prolifera genome fast grow evolution

RESONANT INTERACTIONS OF TOLLMIEN-SCHLICHTING WAVES IN THE BOUNDARY LAYER ON A FLAT PLATE

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Acta Mechanica Sinica 1988年第4期4卷 305-310页

作者： Yan dachun Zhu Qiankan yu Dacheng Niu Zhennan (Department of Mechanics,Peking University)Sun Weixin Tong Chenkuan (Institute of Antichemical Welfare) (Luoyan Tractor Research Institute)Jiang Minjian (Chengdu University of Science and Technology) Department of Mechanics Peking University Beijing China Chengdu University of Science and Technology Chengdu China

Resonant interaction phenomena of Tollmien-Schlichting waves(T.-***)areexamined experimentally by spectral analysis *** demonstrate that,in the spectrameasured in the vicinity of the critical layer of the unstable boundary layer,the energy of T.-*** in a narrow band of frequency with one to three peaks in the power spectra correspondingto the eigenfrequencies of T.-*** and the frequency with maximum growth rate located betweenthe upper and lower branches of the neutral *** resonant interactions,transfer the energy ofthese eigencomponents to their subsequent subharmonics in a range of R_δ~* where their growth ratesincrease from zero to a maximum value,and the boundary layer becomes turbulent after the thirdresonant interaction.

关键词： Tollmien-Schlichting wave neutral curve critical layer eigenfrequency

Iron metabolism and arthritis: Exploring connections and therapeutic avenues

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中华医学杂志(英文版) 2024年第14期137卷 2024 Jun 12页

作者： Zhuo dachun Xiao Wenze Tang yulong Jiang Shuai Geng Chengchun Xie Jiangnan Ma Xiaobei Zhang Qing Tang Kunhai yu yuexin Bai Lu Zou Hejian Liu Jing Wang Jiucun Department of Rheumatology Shanghai Pudong Hospital Human Phenome Institute Zhangjiang Fudan International Innovation Center Fudan University Shanghai China State Key Laboratory of Genetic Engineering School of Life Science Fudan University Shanghai China Department of Vascular Surgery Shanghai Pudong Hospital Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling Fudan University Pudong Medical Center Shanghai China Department of Anthropology and Human Genetics School of Life Sciences Ministry of Education Key Laboratory of Contemporary Anthropology Fudan University Shanghai China Division of Rheumatology Huashan Hospital State Key Laboratory of Genetic Engineering School of Life Science Fudan University Shanghai China Institute of Rheumatology Immunology and Allergy Allergy and Disease Research Center Fudan University Shanghai China Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058) Chinese Academy of Medical Sciences Beijing China

Iron is indispensable for the viablility of nearly all living organisms, and it is imperative for cells, tissues, and organisms to acquire this essential metal sufficiently and maintain its metabolic stability for survival. Disruption of iron homeostasis can lead to the development of various diseases. There is a robust connection between iron metabolism and infection, immunity, inflammation, and aging, suggesting that disorders in iron metabolism may contribute to the pathogenesis of arthritis. Numerous studies have focused on the significant role of iron metabolism in the development of arthritis and its potential for targeted drug therapy. Targeting iron metabolism offers a promising approach for individualized treatment of arthritis. Therefore, this review aimed to investigate the mechanisms by which the body maintains iron metabolism and the impacts of iron and iron metabolism disorders on arthritis. Furthermore, this review aimed to identify potential therapeutic targets and active substances related to iron metabolism, which could provide promising research directions in this field.

关键词： Iron metabolism Arthritis Inflammation Immunity Rheumatoid arthritis Psoriatic arthritis Gouty arthritis

浅论金寨县生态环境建设的重要性及可持续发展对策

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安徽林业科技 2014年第5期40卷 57-59页

作者：余大春金寨县林业局安徽六安237300

保护与建设好生态环境,促进人与自然的和谐发展,是人类社会文明进步的重要标志和必然要求。本文从阐述生态环境保护与建设的重要性入手,结合当地实际情况,认真剖析了加大保护生态环境和园林绿化力度,对改善人居环境,提高生活质量,促进... 详细信息

保护与建设好生态环境,促进人与自然的和谐发展,是人类社会文明进步的重要标志和必然要求。本文从阐述生态环境保护与建设的重要性入手,结合当地实际情况,认真剖析了加大保护生态环境和园林绿化力度,对改善人居环境,提高生活质量,促进经济发展的积极作用与意义。

关键词：生态环境科学治理合理开发可持续发展

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油田钻井队开展清洁生产审核的重点和方法

江苏科技信息 2015年第10期32卷 55-58页

作者：俞大春中石化华东石油工程有限公司六普钻井分公司江苏镇江212003

清洁生产是预防污染、保护环境的有效途径,文章根据清洁生产审核的步骤,结合实际审核经验,介绍油田钻井队开展清洁生产的重点、难点和方法,也可供其他领域基层队伍开展清洁生产审核借鉴。

关键词：石油工程钻井队清洁生产重点方法

和厚朴酚逆转非小细胞肺癌紫杉醇耐药的作用及机制

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西南医科大学学报 2024年第4期47卷 316-320页

作者：戴曦唐大春袁竞余文静西南医科大学附属医院呼吸与危重症医学科泸州646000 泸县人民医院呼吸内科泸州646000 泸州市人民医院检验科泸州646000 西南医科大学基础医学院泸州646000

目的探讨中药厚朴的有效单体成分和厚朴酚对非小细胞肺癌紫杉醇(paclitaxel,PTX)耐药性的逆转作用及可能机制。方法以非小细胞肺癌细胞株A549和PTX耐药细胞株A549T作为研究对象,分为空白对照组、和厚朴酚组、紫杉醇组、和厚朴酚+紫杉醇... 详细信息

目的探讨中药厚朴的有效单体成分和厚朴酚对非小细胞肺癌紫杉醇(paclitaxel,PTX)耐药性的逆转作用及可能机制。方法以非小细胞肺癌细胞株A549和PTX耐药细胞株A549T作为研究对象,分为空白对照组、和厚朴酚组、紫杉醇组、和厚朴酚+紫杉醇组,和厚朴酚组、紫杉醇组分别使用一定浓度的药物干预细胞,和厚朴酚+紫杉醇组使用两种药物联合干预细胞,空白对照组不干预。通过MTT实验、流式细胞术、细胞免疫荧光实验及Western Blot免疫印迹实验,观察和厚朴酚对A549T细胞株紫杉醇耐药性的影响。结果和厚朴酚联合紫杉醇干预体外培养的A549T细胞时,细胞存活率较对照组显著降低;和厚朴酚干预体外培养的A549T后,与对照组相比,G2/M期细胞数量增加,细胞P-糖蛋白(P-glycoprotein,P-gp)表达水平降低。结论和厚朴酚能逆转体外培养的A549T细胞的紫杉醇耐药性,其机制与抑制P-gp蛋白的表达,减少药物外排有关。

关键词：和厚朴酚非小细胞肺癌紫杉醇多药耐药 P-糖蛋白

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朱红竹荪形态及生态习性研究初报

食用菌学报 1997年第3期4卷 55-58页

作者：吴大椿余知和湖北农学院农学系荆州434103

本文首次报道湖北省荆州市发现的朱红竹荪（Dictyophora cinnabarina Lee）,并对其形态和生态习性进行了初步研究,为进一步开发出北省的竹荪资源提供了新的依据。

关键词：朱红竹荪形态生态习性

官本位意识的立与破——基于儒家思想和人本主义的双重审视

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黑龙江工程学院学报 2016年第6期30卷 61-64页

作者：王大春丁丽于红丽李庆云黑龙江工程学院思想政治理论教研部黑龙江哈尔滨150050 黑龙江工程学院测绘工程学院黑龙江哈尔滨150050

世界是矛盾的统一体,官本位意识的形成过程也是这样。促使官本位意识形成的因素本身就蕴含着破除官本位的内在逻辑,只不过这种破坏性在现实演绎中逐渐丧失了,但并不能因此否认这些因素本身所具备的这种二律背反现象,这在传统儒家思想和... 详细信息

世界是矛盾的统一体,官本位意识的形成过程也是这样。促使官本位意识形成的因素本身就蕴含着破除官本位的内在逻辑,只不过这种破坏性在现实演绎中逐渐丧失了,但并不能因此否认这些因素本身所具备的这种二律背反现象,这在传统儒家思想和当代人本主义理论审视官本位意识产生的过程中体现的尤为明显。

关键词：官本位儒家人本主义二律背反

融入与建构:工匠精神赋能“大思政”育人体系

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延边大学学报（社会科学版） 2023年第4期56卷 124-132页

作者：于红丽娄成彬王大春黑龙江工程学院马克思主义学院哈尔滨150006 吉林大学行政学院长春130015 黑龙江工程学院学工部哈尔滨150006

工匠精神是中国共产党精神谱系的重要组成部分,具有重要的时代价值与教育意义。工匠精神融入“大思政”育人体系,将有效提高思政育人的实效,优化思政的育人功能。工匠精神融入“大思政”育人体系存在可行性和合理性,二者在价值上存在着... 详细信息

工匠精神是中国共产党精神谱系的重要组成部分,具有重要的时代价值与教育意义。工匠精神融入“大思政”育人体系,将有效提高思政育人的实效,优化思政的育人功能。工匠精神融入“大思政”育人体系存在可行性和合理性,二者在价值上存在着契合性。一是工匠精神与“大思政”育人目标具有统一性。价值目标中,工匠精神与社会主义核心价值观相契合;教育目标中,工匠精神与应用型人才的培养目标相契合;实践目标中,工匠精神与产业转型升级的内在要求相契合。二是工匠精神与“大思政”育人基因相同。同时,工匠精神与“大思政”课程育人的理路融合可以分为“三维两课”,即从国家观维度、公民维度、价值维度总体设计,具体将工匠精神融入思政课和课程思政之中。工匠精神赋能“大思政”育人体系需要建构新的融合体,可以通过厚植富有工匠特色的校园文化,打造具有“匠心”的教师团队,完成建构共同体的任务,最终实现立德树人根本任务。

关键词：融入建构工匠精神 “大思政”育人