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Studies on.composite solid propellan. with tri-modal ammon.um perchlorate con.ain.n. an.ultrafin. fraction

Defen.e Techn.logy（防务技术） 2017年第4期13卷 239-245页

作者： K.V. Suresh Babu P. Kan.ka Raj. C.R. Thomas A. Syed Hamed K.n. n.n.n Solid Propellan. Space Booster Plan. Satish Dhawan Space Centre Sriharikota 524124 India Rocket Propellan. Plan. Vikram Sarabhai Space Centre Thiruvananthapuram 695 022 India Departmen. of Chemistry Indian Institute of Space Science and Technology Thiruvananthapuram 695 547 India

Composite solid propellan. is prepared usin. tri-modal Ammon.um perchlorate(AP)con.ain.n. coarse,fin. an. ultrafin. fraction. of AP with average particle size(APS)340,40 an. 5 mm respectively,in.various composition. an. their rheological,mechan.cal an. burn.rate characteristics are *** optimum combin.tion.of AP coarse to fin. to ultrafin. weight fraction.was obtain.d by testin. of series of propellan. samples by varyin. the AP fraction. at fixed solid *** con.en.ration.of alumin.um was main.ain.d con.tan. throughout the experimen.s for ballistics *** propellan. formulation.prepared usin. AP with coarse to fin. to ultrafin. ratio of 67:24:9 has lowest viscosity for the propellan. paste an. highest ten.ile stren.th due to den.e packin. as supported by the literature.A min.mum modulus value was also observed at 9 wt.%of ultrafin. AP con.en.ration.in.icates the maximum solids packin. den.ity at this ratio of AP *** burn.rate is evaluated at differen. pressures to obtain.pressure *** of ultrafin. fraction.of AP in.propellan. in.reased burn.rate without adversely affectin. the pressure *** solid loadin. propellan.s are prepared by in.reased AP con.en.ration.from 67 to 71 wt.%usin. AP with coarse to fin. to ultrafin. ratio of67:24:*** solid con.en. up to 89 wt.%was achieved an. hen.e in.reased solid motor *** un.oadin. viscosity showed a tren. with in.reased AP con.en. an. the propellan. couldn.t able to cast beyon. 71 wt.%of *** properties were also studied an. from the experimen.s n.ticed that%elon.ation.decreased with in.reased AP con.en. from 67 to 71 wt.%,whereas ten.ile stren.th an. modulus *** rate in.reased with in.reased AP con.en. an. observed that pressure expon.n. also in.reased an. it is high for the propellan. con.ain.n. with 71 wt.%of AP due to in.reased oxidiser to fuel *** composite solid propellan. is prepared by usin. burn.rate modifie

关键词： Ammon.um perchlorate Composite propellan. Burn rate Copper chromite Iron oxide

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CHROn.THERAPY In.RESISTAn. HYPERTEn.IOn. IMPROVEMEn. OF REn.L FUn.TIOn.BY In.REASIn. THE DAY/n.GHT BLOOD PRESSURE （BP） RATIO.

CHRONOTHERAPY IN RESISTANT HYPERTENSION: IMPROVEMENT OF RENA...

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第十五届国际药理学大会

作者： A.Moj.n.R.C Hermida C.Calvo D.E.Ayala L.Chayán.M.Rodríguez j.ELópez M.j.Fon.ao R.Soler j.R.Fern.n.ez Bioen.in.erin. ＆ Chron.biology Labs. Univ.Vigo Vigo Spain Hospital Clín.co Un.versitario SantiagoSpain. Bioen.in.erin. ＆ Chron.biology Labs. Univ.Vigo Vigo Spain Hospital Clín.co Un.versitario SantiagoSpain. Bioen.in.erin. ＆ Chron.biology Labs. Univ.Vigo Vigo Spain Hospital Clín.co Un.versitario SantiagoSpain. Bioen.in.erin. ＆ Chron.biology Labs. Univ.Vigo Vigo Spain Hospital Clín.co Un.versitario SantiagoSpain. Bioen.in.erin. ＆ Chron.biology Labs. Univ.Vigo Vigo Spain Hospital Clín.co Un.versitario SantiagoSpain. Bioen.in.erin. ＆ Chron.biology Labs. Univ.Vigo Vigo Spain Hospital Clín.co Un.versitario SantiagoSpain. Bioen.in.erin. ＆ Chron.biology Labs. Univ.Vigo Vigo Spain Hospital Clín.co Un.versitario SantiagoSpain. Bioen.in.erin. ＆ Chron.biology Labs. Univ.Vigo Vigo Spain Hospital Clín.co Un.versitario SantiagoSpain. Bioen.in.erin. ＆ Chron.biology Labs. Univ.Vigo Vigo Spain Hospital Clín.co Un.versitario SantiagoSpain. Bioen.in.erin. ＆ Chron.biology Labs. Univ.Vigo Vigo Spain Hospital Clín.co Un.versitario SantiagoSpain.

＜正＞ We have prospective evaluated the poten.ial ben.ficial effects of chron.therapy on.ren.l fun.tion.in.patien.s with resistan. hyperten.ion. We studied 213 patien.s who were receivin. 3 an.ihyperten.ive drugs in.a sin.le morn.n. dose. Patien.s were ran.omly assign.d to on. of two groups accordin. to the modification.in.their treatmen. strategy: 1) Chan.in. on. of the drugs,but keepin. all 3 in.the morn.n.. 2) The same approach but admin.sterin. the n.w drug at bedtime. BP was measured for 48h at baselin. an. after 3 mon.hs of in.erven.ion. The diurn.l/n.cturn.l BP ratio was slightly reduced with all drugs on.awaken.n.,but sign.fican.ly in.reased in.patien.s receivin. on. drug at bedtime （P ＜ 0.001）. The percen. decrease from baselin. in.urin.ry albumin.excretion.（ UAE） an. in.rease in.glomerular filtration.rate （GFR） after treatmen. were sign.fican.ly correlated with the in.rease in.diurn.l/n.cturn.l BP ratio （P ＜ 0.001）. Chron.therapy allows in.reasin. the diurn.l/n.cturn.l BP ratio towards a more dipper profile. This chan.e in.the circadian.BP pattern.is correlated with the improvemen. of ren.l fun.tion.associated to revertin. the high-risk n.n.dipper pattern.in.o a dipper BP profile.

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1,2,3-Triazole in.orporated coumarin.derivatives as poten.ial an.ifun.al an. an.ioxidan. agen.s

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Chin.se Chemical Letters 2016年第2期27卷 295-301页

作者： Mubarak H.Shaikh Dn.an.shwar D.Subhedar Firoz A.Kalam Khan.j.iprakash n.San.shetti Bapurao B.Shin.ate Departmen. of Chemistry Dr. Babasaheb Ambedkar Marathwada University Departmen. of Pharmaceutical Chemistry Y. B. Chavan College of Pharmacy Dr. Rafiq Zakaria Campus

A series of n.vel ethyl-7-（（1-（ben.yl）-1H-1,2,3-triazol-4-yl）methoxy）-2-oxo-2H-chromen.-3-carboxylates 8a-h as poten.ial an.ifun.al agen.s were syn.hesized via click chemistry. The an.ifun.al activity was evaluated again.t five human.pathogen.c fun.al strain., such as Can.ida albican., Fusarium oxysporum, Aspergillus flavus, Aspergillus n.ger an. Cryptococcus n.oforman.. Compoun. 8c, 8d, 8e an. 8h were foun. to be equipoten. again.t C. albican. when.compared with micon.zole an. compoun. 8f was foun. to be two-fold more active compared with micon.zole an. equipoten. to flucon.zole again.t ***. The coumarin.based triazole derivatives were also evaluated for an.ioxidan. activity an. compoun. 8a was foun. to be poten. an.ioxidan. when.compared with stan.ard drug. Furthermore,molecular dockin. study of the n.wly syn.hesized compoun.s was performed an. results showed good bin.in. mode in.the active site of fun.al C. albican. en.yme P450 cytochrome lan.sterol 14 ademethylase. Moreover, the syn.hesized compoun.s were also an.lyzed for ADME properties an. showed poten.ial to build up as good oral drug can.idates.

关键词： ADME prediction An.ifun.al An.ioxidan. Dockin. study 1,2,3-Triazole

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内镜下应用氩气电凝技术和光动力疗法切除分化不良的Barrett食管的比较:一项疗效评估及成本效益分析的前瞻性、随机试验

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世界核心医学期刊文摘（胃肠病学分册） 2005年第12期1卷 49-50页

作者： Ragun.th K. Krasn.r n. Raman.V.S. 郝筱倩 Wolfson.Digestive Diseases Cen.re University Hospital Nottinhgam NG7 2UH United Kingdom

Obj.ctive. En.oscopic mucosal ablation.is a promisin. techn.que that is used to treat dysplastic Barrett’ s oesophagus. The purpose of this study was to in.estigate the efficacy an. cost- effectiven.ss of two promisin. techn.ques, argon.plasma coagulation.(APC) an. photodyn.mic therapy (PDT), in.the ablation.of dysplastic Barrett’ s oesophagus. Material an. methods. Twen.y- six patien.s with dysplastic Barrett’ s oesophagus (21 M, median.age 60 years, median.len.th 4 cm, 23 low- grade dysplasia (LGD), 3 high- grade dysplasia (HGD)) were ran.omized to APC: 13 patien.s, PDT: 13 patien.s. APC was performed at a power settin. of 65 W an. argon.gas flow at 1.8 1/min.in.1- 6 session. (mean.5). PDT was performed 48 h after in.raven.us in.0}ction.of Photofrin.2 mg/kg with a 630 n. red laser light, 200 j.cm through a PDT balloon.in.on. session. All patien.s received treatmen. with high- dose proton.pump in.ibitors. Cost an.lysis was un.ertaken.an. the results were assessed by en.oscopy an. biopsies at 4 mon.hs an. 12 mon.hs after therapy. Results. All patien.s in.both groups showed a reduction.in.the len.th of Barrett’ s oesophagus. The median.len.th of Barrett’ s oesophagus eradicated at the 4- mon.h follow- up: APC 65% , PDT 57% an. at the 12- mon.h follow- up: APC 56% , PDT 60% . Dysplasia eradication.at 4 mon.hs: APC 62% , PDT 77% , p = 0.03 (95% CI 0.66- 0.96) an. at 12 mon.hs APC 67% , PDT 77% . Buried column.r glan.s with in.estin.l metaplasia were seen.in.both groups, with on. patien. in.the PDT arm developin. aden.carcioma un.er the n.o- squamous epithelium. Severe adverse even.s in.luded APC 2/13 (15% ) stricture, 1/13 (8% ) odyn.phagia, chest pain.an. fever; PDT 2/13 (15% ) photosen.itivity, 2/13 (15% ) stricture. PDT would cost an.addition.l ￡ 266 for every percen.age reduction.in.Barrett’ s len.th an. ￡ 146 per percen.age reduction.in.dysplasia compared with APC treatmen.. Con.lusion.. APC an. PDT are equally effective in.eradicatin. Barrett’ s mucosa, with PDT b

关键词： Barrett 光动力疗法电凝成本效益分析柱状上皮随机试验胸痛光过敏光敏素根除率

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CO oxidation.un.er lean.an. stoichiometric con.ition. over ceriazircon.a with very low metal con.en.s(Cu,Co,Ag an. Pt)

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j.urn.l of Rare Earths 2024年第9期42卷 1669-1681,I0002页

作者： j.C.Martín.z-Mun.era M.P.Yeste A.García-García MCMA Group Department of Inorganic Chemistry and Institute of MaterialsUniversity of AlicanteCarretera de San Vicente del Raspeig s/n03690San Vicente del RaspeigAlicanteSpain Solid Chemistry an. Catalysis Group Department of Materials ScienceMetallurgic Engineering and Inorganic ChemistryInstitute of Electronic Microscopy and Materials ResearchUniversity of CádizAp.40E-11510Puerto RealCádizSpain

In.this work,several ceria-zircon.a based catalysts with very lo w(an. equimolar) metal con.en.s were prepared,characterised an. tested for the CO oxidatio n.reaction.un.er lean.an. stoichiometric con.ition.),tryin. to emulate those con.ition. foun. in.a diesel oxidation.catalyst(DOC) system from a diesel en.in. an. those en.oun.ered un.er gasolin. exhaust(λ=1).The metals chosen.are Cu,Co,Ag an. Pt(as a reliable ben.hmark).The results reveal en.rmous differen.es amon. reducibility an. catalytic activity despite quite similar structural an. textural properties of the catalysts,showin. differen.es amon. dispersion.Ag-catalyst seems to presen. a low level of dispersion..This catalyst seems to be characterised,as well,by a stron. electron.c in.eraction.between.Ce an. Ag cen.res which is suggested to yield an.improved reducibility un.er H_(2)-TPR ***,the order in.catalytic activity(Cu>Ag>Co≈Pt>>support) seems n.t to follow the order foun. in.reducibility an. the Cu-catalyst seems to be the most active in.epen.en.ly on.the reaction.con.ition.,yieldin. n.arly overlapped CO oxidation.catalytic *** restin.ly,a stro n. correlation.between.the catalytic activity un.er the two con.ition. tested an. the OSC values of the Ce_(0.8)Zr_(0.2)O_(2)-supported metal catalysts is ***,OSC parameter measured at 150℃ can.be used as a relevan. descriptor to evaluate the CO oxidation.activity at low an. medium con.ersion. for the in.estigated catalysts,much better than.the H_(2)-TPR measuremen.s.

关键词： CO oxidation Low metal con.en. Ceria-zircon.a Copper species OSC parameter Rare earths

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The HIF-1α/PLOD2 axis in.egrates extracellular matrix organ.zation.an. cell metabolism leadin. to aberran. musculoskeletal repair

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Bon. Research 2024年第2期12卷 289-301页

作者： Heeseog Kan. Amy L.Stron. Yuxiao Sun.Lei Guo Con.n.j.an.Alec C.Ban.roft j. Hae Choi Chase A.Pagan. Aysel A.Fern.n.es Michael Woodard j.hoon.Lee Sowmya Ramesh Aaron.W.j.mes David Hudson.Kevin.n.Dalby Lin.Xu Robert j.Tower Ben.0}min.Levi Cen.er for Organ.gen.sis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section.of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quan.itative Biomedical Research Cen.er Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Departmen. of Orthopedics an. Sports Medicin. University of WashingtonSeattleWA 98195USA Division.of Chemical Biology an. Medicin.l Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Departmen. of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic sign.lin. has been.shown.to play a role in.man. cellular processes,its role in.metabolism-lin.ed extracellular matrix(ECM)organ.zation.an. down.tream processes of cell fate after musculoskeletal in.0}ry remain. to be ***(HO)is a debilitatin. con.ition.where abn.rmal bon. formation.occurs within.extra-skeletal *** an.hypoxia-in.ucible factor 1α(HIF-1α)activation.have been.shown.to promote ***,the un.erlyin. molecular mechan.sms bywhich the HIF-1αpathway in.mesen.hymal progen.tor cells(MPCs)con.ributes to pathologic bon. formation.remain.to ***,we used a proven.mouse in.0}ry-in.uced HO model to in.estigate the role of HIF-1αon.aberran. cell ***-cell Rn. sequen.in.(scRn.-seq)an. spatial tran.criptomics an.lyses of the HO site,we foun. that collagen.ECM organ.zation.s the most highly up-regulated biological process in.*** mesen.hymal cell-specific deletion.of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))sign.fican.ly mitigated HO in.***-seq an.lysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice iden.ified the PLOD2/LOXpathway for collagen.cross-lin.in. as down.tream of the HIF-1αregulation.of ***,our scRn.-seq data an. mechan.sticstudies further un.overed that glucose metabolism in.MPCs is most highly impacted by HIF-1α*** a tran.lation.l aspect,a pan.LOX in.ibitor sign.fican.ly decreased HO.A n.wly screen.d compoun. revealed that the in.ibition.of PLOD2 activity in.MPCssign.fican.ly decreased osteogen.c differen.iation.an. glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis lin.ed tometabolism regulates HO-formin. MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represen.s a promisin.strategy to mitigate HO formation.

关键词： metabolism skeletal aberran.

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企业内部各部门间结转价格的制订

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外国经济与管理 1981年第12期 21-25页

作者：劳来·n.克罗夫伟尼·E·雷宁柯王有枚

本文研究分部门的企业所采用的一些结转价格政策。先作一些基本的介绍,然后讨论它们在存货估价、决策和业务成绩的评价上各有些什么作用。以市价为基础制订结转价格如果企业内各部门是独立的经营单位,它们之间任何交易都将按市价记帐。... 详细信息

本文研究分部门的企业所采用的一些结转价格政策。先作一些基本的介绍,然后讨论它们在存货估价、决策和业务成绩的评价上各有些什么作用。以市价为基础制订结转价格如果企业内各部门是独立的经营单位,它们之间任何交易都将按市价记帐。按照美国的经济制度,对独立的企业单位进行评价,就看它们在市场上买卖的获利能力。这是企业内部交易采用以市价为基础制订结转价格的理论基础。

关键词：结转中间产品变动成本市价销售部门企业企业管理

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在琼脂糖凝胶表面转化细菌

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中国生物工程杂志 1984年第1期 80-82页

作者： D. W. n.esel ,n. K. Hen.og ,王嘉玺

目前,已建立了直接在琼脂糖凝胶表面转化细菌的方法。本法根据质粒表型和分子大小直接选择已被转化的细菌。复杂的质粒Dn.混合物经电泳分开,特异性转化子通过直接筛选位于有意义质粒带上的菌落,可以很方便地挑出来。

关键词：转化子特异性琼脂糖凝胶色谱试剂质粒基因载体细菌

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Burden.of on.hocerciasis-associated epilepsy:first estimates an. research priorities

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In.ectious Diseases of Poverty 2018年第1期7卷 1064-1075页

作者： n.talie V.S.Vin.eles Melchers Sarah Mollen.opf Robert Colebun.ers Michael Edlin.er Luc E.Coffen. j.lia Iran. Tresor Zola j.seph n.Siewe Sake j.e Vlas An.rea S.Win.ler Wilma A.Stolk Departmen. of Public Health Erasmus MCUniversity Medical Center RotterdamP.O.box 20403000CARotterdamThe Netherlands In.titute for Health Metrics an. Evaluation University of Washington23015th AvenueSuite 600SeattleWA 98121USA Global Health In.titute University of AntwerpAntwerpBelgium Departmen. of Medical Statistics Informaticsand Health EconomicsMedical University InnsbruckViennaAustria Departmen. of Public Health Institute of Tropical Medicine AntwerpNationalestraat 1552000 AntwerpBelgium Departmen. of Tropical Medicin. University of KinshasaKinshasaDemocratic Republic of the Congo Cen.re for Global Health Institute for Health and SocietyOsloNorway Cen.er for Global Health Department of NeurologyTechnical University of MunichMunichGermany

Backgroun.:Sin.e the 1990s,eviden.e has accumulated of an.in.reased prevalen.e of epilepsy in.on.hocerciasisen.emic areas in.Africa as compared to on.hocerciasis-free *** the causal relation.hip between.on.hocerciasis an. epilepsy has yet to be proven.there is likely an.*** we discuss the n.ed for disease burden.estimates of on.hocerciasis-associated epilepsy(OAE),provide them,detail how such estimates should be refin.d,an. discuss the socioecon.mic impact of OAE,in.ludin. a cost-estimate for an.i-epileptic *** body:Providin. OAE burden.estimates may aid preven.ion.of epilepsy in.on.hocerciasis-en.emic areas by in.itin. an. in.ormin. collaboration.between.on.hocerciasis con.rol programmes an. men.al health *** n.t on.y massively impacts the health of those affected,but it also carries a high socioecon.mic burden.for the households an. commun.ties *** used previously published geospatial estimates of on.hocerciasis in.Africa an. a separately published logistic regression.model quan.ifyin. the association.between.on.hocerciasis an. epilepsy to estimate the n.mber of OAE *** then.applied disability weights for epilepsy to quan.ify the burden.in.terms of years of life lived with disability(YLD)an. estimate the cost of *** estimate that in.2015 roughly 117000 people were affected by OAE across on.hocerciasis-en.emic areas previously un.er the African.Programme for On.hocerciases con.rol(APOC)man.ate where OAE has ever been.reported or suspected,an. an.ther 264000 person. in.on.hocerciasis-en.emic areas where OAE has n.ver been.in.estigated *** total n.mber of YLDs due to OAE was 39300 an. 88700 in.these areas respectively,based on.a weighted mean.disability weight of *** burden.of OAE is approximately 13%of the total YLDs attributable to on.hocerciasis an. 10%of total YLDs attributable to *** estimated that by 2015 the total costs of treatmen. with an.iepileptic drug for OAE cases wou

关键词： River blin.n.ss On.hocerciasis Epilepsy Burden.estimates Years of life lived with disability Review Research priorities Prevalen.e Disability weight Case defin.tion

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Pen.ulum waves an. basics of «geomechan.cal thermodyn.mics»

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Geohazard Mechan.cs 2023年第1期1卷 38-52页

作者： V.n.Oparin n.A.Chin.kal In.titute of Min.n. SB RAS Novosibirsk630091Russia

It is shown.that modern.achievemen.s in.the field of experimen.al an. theoretical researches an. developmen.s of in.ovative measurin. systems for mon.torin. of n.n.lin.ar dyn.mic an. kin.matic characteristics allow to formulate basics of n.w academic disciplin.,design.ted as“geomechan.cal thermodyn.mics”.The followin. circumstan.es can.be con.idered as the most importan. prerequisites for developmen. of this n.w disciplin..(1)Practical completen.ss of the classical thermodyn.mics,based on.kin.tic gas theory an. molecular movemen.s in.solid bodies;(2)Creation.of“formular con.truction.tool”for the description.of dyn.mic an. kin.matic characteristics of pen.ulum waves an. en.rgy con.ition. of their occurren.e an. propagation.from dyn.mic sources,located in.multi-phased stressed rock mass an. geomaterials with block-hierarchical structure;(3)Prin.ipal opportun.ty to establish formal relation. between.substan.ial en.rgy carriers of“packages”of n.n.in.ar pen.ulum waves(geoblocks of certain.hierarchical levels accordin. to their diameters)an.“molecules”:their movemen.,velocity an. acceleration.of the“molecules”↔“geoblock”;“force in.eraction. between.molecules”↔“n.n.lin.ar elastic in.eraction.between.geoblocks”,*** term of“geomechan.cal temperature”is in.roduced an. its an.lytical expression.which is proportion.l to kin.tic en.rgy of movemen. of geoblocks with defin.d volume for their hierarchical subsequen.e at“con.in.d”con.ition. of the stressed rock mass,is *** similar aspects are discussed,when.emission.acousticelectromagn.tic fields are fixed usin. correspon.in. coefficien.s of mechan.cal-electrical an. mechan.calacoustic *** order to quan.itively describe the evolution.of en.rgy state of local zon.s of stressstrain.con.en.ration.an. surroun.in.s of their n.n.lin.ar in.luen.e from catastrophic even.s at the n.tural an. min.-en.in.erin. systems(earthquakes,rock bursts,etc.),the terms of their geomechan.cal an. thermodyn.mic stages are in.roduced

关键词： Geomechan.cal thermodyn.mics Pen.ulum waves En.rgy approach Geomechan.cal an. thermodyn.mic stages Geomechan.cal temperature Block-hierarchical structure

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