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复合菌培养物对奶牛生产性能、非特异性免疫功能及抗氧化能力的影响

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动物营养学报 2024年第4期36卷 2416-2424页

作者：李薛强王岩刘世雄李松建杨岚胡红莲高民陈灰刘大程内蒙古农业大学兽医学院呼和浩特010018 农业农村部动物疾病临床诊疗技术重点实验室呼和浩特010018 内蒙古农牧业科学院动物营养与饲料研究所呼和浩特010031

本试验旨在研究复合菌培养物对奶牛生产性能、非特异性免疫功能及抗氧化能力的影响。试验选择2胎次以及泌乳天数[(92.1±25.6)d]、产奶量[(36.8±4.6)kg/d]和乳蛋白质含量[(2.98±0.48)%]相近的健康荷斯坦奶牛40头,随机分为2组,每组20... 详细信息

本试验旨在研究复合菌培养物对奶牛生产性能、非特异性免疫功能及抗氧化能力的影响。试验选择2胎次以及泌乳天数[(92.1±25.6)d]、产奶量[(36.8±4.6)kg/d]和乳蛋白质含量[(2.98±0.48)%]相近的健康荷斯坦奶牛40头,随机分为2组,每组20头。对照组饲喂基础饲粮,试验组在基础饲粮中添加0.23 kg/d的复合菌培养物。预试期7 d,正试期60 d。试验期间每日记录奶牛采食量和产奶量;每20 d采集1次牛奶测定乳成分;正试期开始和结束当天采集奶牛血液,测定乳成分以及免疫和抗氧化指标。结果表明:1)试验第41~60天,对照组奶牛平均日采食量比试验第1~20天降低了2.92%,而试验组提高了3.12%。试验第21~40天和第41~60天,试验组奶牛产奶量分别比对照组提高了2.17(P0.05)。2)试验第60天,试验组奶牛血清溶菌酶(LZM)含量、酸性磷酸酶(ACP)活性、淋巴细胞增殖能力和中性粒细胞吞噬能力均显著高于对照组(P<0.05),并且试验组奶牛血清总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性分别比对照组显著提高了11.54%、22.09%和17.18%(P<0.05),血清丙二醛(MDA)含量比对照组显著降低了35.38%(P<0.05)。结果提示,复合菌培养物能够显著提高奶牛采食量和产奶量,改善奶牛非特异性免疫功能,增强机体抗氧化能力。

关键词：复合菌培养物奶牛生产性能非特异性免疫功能抗氧化能力

A Reference Framework for Concurrent Engineering

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High Technology Letters 2001年第1期7卷 47-50页

作者：唐敦兵 Zheng Li Li Zhizhong liu dacheng Institute of Manufacturing Engineering Department of Precision Instruments and Mechanology Tsinghua University

Considering the diversity of methods and tools offered to concurrent engineering, the aspects playing important roles in the concurrent engineering context have been pinpointed as being four core elements which are Activity, Method, Object and Information. Based on these four elements, a reference framework called AMOI is proposed to be the guideline for the systematic concurrent product design. Using the AMOI reference framework, concurrent product development system can be structured into four function models (including the activity model, method model, object model and information model) which are interconnected with each other.

关键词： Concurrent engineering Concurrent product design Reference framework

siRNA干扰TLR4影响两种酵母多糖处理RAW264.7细胞NF-κB/MAPK信号通路的激活

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中国兽医科学 2024年第7期54卷 974-981页

作者：杜蕊陈灰张宇飞李松建刘世雄李薛强徐子萱薛晨刘大程内蒙古农业大学兽医学院内蒙古呼和浩特010018 农业农村部动物疾病临床诊疗技术重点实验室内蒙古呼和浩特010018 包头市固阳县畜牧业技术服务中心内蒙古包头014200

为了探究Toll样受体4(TLR4)在两种酵母多糖激活NF-κB/MAPK信号通路中发挥的作用,本研究利用CCK8法检测酵母β-葡聚糖和甘露聚糖的细胞毒性,并利用多种方法筛选效果最佳的TLR4 siRNA,然后利用ELISA、RT-qPCR方法检测相关炎症因子的分泌... 详细信息

为了探究Toll样受体4(TLR4)在两种酵母多糖激活NF-κB/MAPK信号通路中发挥的作用,本研究利用CCK8法检测酵母β-葡聚糖和甘露聚糖的细胞毒性,并利用多种方法筛选效果最佳的TLR4 siRNA,然后利用ELISA、RT-qPCR方法检测相关炎症因子的分泌量及其m RNA表达量的变化,最后通过Western-blot检测NF-κB/MAPK信号通路关键蛋白磷酸化水平。结果显示,2.5~20μg/m Lβ-葡聚糖及2.5~50μg/m L甘露聚糖对RAW264.7细胞的活力没有影响;TLR4 siRNA-2可以高效敲低TLR4 m RNA和蛋白表达水平;两种酵母多糖处理敲低TLR4的细胞后,IL-6、IL-12、IL-1β、TNF-α、NO分泌量及IL-6、IL-12、IL-1β、TNF-α、i NOSm RNA表达水平显著下降,NF-κB/MAPK信号通路关键蛋白p-P65、p-P38、p-ERK1/2、p-JNK和p-IκB水平显著降低。结果表明,两种酵母多糖可以通过TLR4调控NF-κB/MAPK信号通路及相关细胞因子的分泌,最终确定TLR4是两种酵母多糖发挥免疫调节作用的重要受体。

关键词：酵母β-葡聚糖酵母甘露聚糖 Toll样受体4 RAW264.7细胞 NF-κB/MAPK信号通路

汽车保险与理赔领域中的信用建设与社会责任:课程思政的价值导向与实践路径

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时代汽车 2024年第15期 61-63页

作者：张倩然张翊刘大诚冯耀温杰江苏电子信息职业学院江苏淮安223001

本研究致力于论证在汽车保险及其理赔业务中诚信体系构建的关键性,并探讨如何借助课程思政的手段,将对社会负责的理念深植于这一领域之中。本文首先深入剖析了汽车保险理赔行业内信用体系的现有状况与面临的问题,接着强调了高校课程思... 详细信息

本研究致力于论证在汽车保险及其理赔业务中诚信体系构建的关键性,并探讨如何借助课程思政的手段,将对社会负责的理念深植于这一领域之中。本文首先深入剖析了汽车保险理赔行业内信用体系的现有状况与面临的问题,接着强调了高校课程思政在引导正确价值观中的作用,并以“汽车保险与理赔”这门课程为例,提出了具体的课程思政实施路径与策略,旨在为促进汽车保险市场的健康成长提供实践指引。

关键词：汽车保险理赔信用建设社会责任课程思政

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尿液检测仪器分代理论模型构建及评价

现代检验医学杂志 2024年第2期39卷 175-180页

作者：陆志方刘大成孟宪杰金雅康陈玉文广州华商学院健康医学院广州511300 清华大学工业工程系北京100084 易源易贝(北京)科技有限公司北京100176

随着信息技术和智能化技术的进步,尿液检测仪器的智能化发展面临新的机遇。运用疾病控制论理论模型对临床尿液检测的业务流程、现行尿液检测仪器等进行分析,构建了尿液检测仪器的分代理论模型,有利于指引尿液检测仪器的智能化发展方向... 详细信息

随着信息技术和智能化技术的进步,尿液检测仪器的智能化发展面临新的机遇。运用疾病控制论理论模型对临床尿液检测的业务流程、现行尿液检测仪器等进行分析,构建了尿液检测仪器的分代理论模型,有利于指引尿液检测仪器的智能化发展方向。研究将尿液检测仪器分为一到四代产品,其中一代产品为医生操作阶段;二代产品为现阶段的检验师借助各种尿液分析仪阶段;三代产品进一步优化检测流程和智能化,无需检验师操作;四代产品则实现无人操作、无须采样。可见随着科技的发展,尿液分析的确变得更为简便,但是毕竟各种仪器都有其局限性,应把建立尿液分析仪器分代理论模型,运用在临床尿液检验中,既能提高尿液分析的效率又能提高其质量。

关键词：尿液分析仪分代模型疾病控制论

Recent progress on rapid diagnosis of COVID-19 by point-of-care testing platforms

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Chinese Chemical Letters 2024年第3期35卷 66-75页

作者： Ya-Nan Tang Dingding Jiang Xuejun Wang Yunqi liu dacheng Wei State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular ScienceFudan UniversityShanghai 200433China Institute of Molecular Materials and Devices Fudan UniversityShanghai 200433China

The outbreak of COVID-19 has drawn great attention around the ***-CoV-2 is a highly infectious virus with occult transmission by many mutations and a long incubation *** particular,the emergence of asymptomatic infections has made the epidemic even more ***,early diagnosis and timely management of suspected cases are essential measures to control the spread of the *** simple,portable,and accurate diagnostic techniques for SARS-CoV-2 is the key to epidemic *** advantages of point-of-care testing technology make it play an increasingly important role in viral detection and *** review summarizes the point-of-care testing platforms developed by nucleic acid detection,immunological detection,and nanomaterial-based biosensors ***,this paper provides a prospect for designing future highly accurate,cheap,and convenient SARS-CoV-2 diagnostic technology.

关键词： COVID-19 Point-of-care testing platforms Nucleic acid detection Asymptomatic infection Biosensors

Haemostatic therapy in spontaneous intracerebral haemorrhage patients with high-risk of haematoma expansion by CT marker: a systematic review and meta- analysis of randomised trials

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Stroke & Vascular Neurology 2021年第2期6卷 170-179页

作者： Ximing Nie Jingyi liu dacheng liu Qi Zhou Wanying Duan Yuehua Pu Zhonghua Yang Miao Wen Haixin Sun Wenzhi Wang Shengjun Sun Hongqiu Gu Liping liu Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Neurosurgical Institute Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose Current randomised controlled trials(RCTs)showed an uncertain benefit of haemostatic therapy on preventing haematoma expansion and improving the outcome in patients with intracerebral haemorrhage(ICH).This meta-analysis aims to systematically evaluate the effect of haemostatic agents on the prevention of haemorrhage growth in patients with high-risk spontaneous ICH predicted by CT signs in *** A comprehensive search of PubMed,EMBASE and Cochrane library from 1 January 2005 to 30 June 2021 was *** that compared haemostatic agents with placebo for the treatment of spontaneous patients with ICH with high-risk haemorrhage growth were *** primary endpoint was haematoma expansion at 24 *** major endpoints of interest included 90-day functional outcome and *** The meta-analysis included four RCTs that randomised 2666 patients with ICH with high-risk haemorrhage *** therapy reduced the rate of haematoma expansion at a marginally statistically significant level when compared with placebo(OR 0.84;95% CI 0.70 to 1.00;p=0.051).Subgroup analysis for patients with black hole sign on CT revealed a significant reduction of haematoma expansion with haemostatic therapy(OR 0.61;95% CI 0.39 to 0.94;p=0.03).However,both the primary analysis and subgroup analyses showed that haemostatic therapy could not reduce the rate of poor functional outcome(modified Rankin Scale>3)or *** Haemostatic therapy showed a marginally significant benefit in reducing early haematoma expansion in patients with high-risk spontaneous ICH predicted by markers on CT ***,no significant improvement in functional outcome or reduction of mortality was observed.

关键词： patients prevention expansion

Engineering S-scheme W_(18)O_(49)/ZnIn_(2)S_(4)heterojunction by Co_(x)P nanoclusters for enhanced charge transfer capability and solar hydrogen evolution

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Nano Research 2024年第9期17卷 8095-8103页

作者： Xiaojie liu Erkang liu Zixian Wang Wen Zhang Mingyu Dou Hua Yang Changhua An dacheng Li Jianmin Dou Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology School of Chemistry and Chemical EngineeringLiaocheng UniversityLiaocheng 252059China Tianjin Key Laboratory of Organic Solar Cell and Photochemical Conversion School of Chemistry and Chemical EngineeringTianjin Key Laboratory of Advanced Functional Porous MaterialsInstitute for New Energy Materials and Low-Carbon TechnologiesTianjin University of TechnologyTianjin 300384China Institute of Powder Metallurgy and Advanced Ceramics School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Enhancement of the light-absorption response and utilization of the photogenerated carriers represent a robust strategy for the design of high-performance *** this work,grafting Co_(x)P nanoclusters onto S-scheme heterojunction of W18O49/ZnIn2S4(WO/ZIS-CoxP)with strong response to the ultraviolet-visible-near infrared ray(UV-vis-NIR)region has been achieved,which possesses efficient electron-transfer-channel,and boosts charge-separation and transport *** as-prepared WO/ZIS-Co_(x)P yields an impressive solar-driven hydrogen production rate of 45 mmol·g^(-1)·h^(-1).The increased photocatalytic performance is attributed to the synergistic effect of the composite catalyst:(1)The local surface plasmon resonance-induced“hot electron”injection of W_(18)O_(49)significantly increases the electron density;(2)the engineered S-scheme directional electron transfer promotes charge separation and enhances the reducing capability of photoexcited electrons;and(3)Co_(x)P as electron-trap site for accelerating surface proton reduction *** work provides a platform to impart nonprecious co-catalyst for engineering S-scheme heterojunction,serving a class of efficient solar-driven photocatalyst towards hydrogen production.

关键词： hydrogen cocatalyst photocatalysis S-scheme hot electron

亚硫酸氢钠甲萘醌中间体2-甲基-1,4-萘醌的绿色合成

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云南化工 2024年第9期51卷 48-50页

作者：彭诗咏陈锦蕙吴银霞张秋瑜刘大成陈洪广东海洋大学广东湛江524088

以2-甲基萘为原料合成了亚硫酸氢钠甲萘醌的中间体2-甲基-1,4-萘醌。使用过硫酸钾为引发剂,过氧化氢为氧化剂,乙酸为溶剂,探究了过硫酸钾与2-甲基萘的质量比、过氧化氢用量、反应温度、时间等单因素对合成中间体2-甲基-1,4-萘醌产率的... 详细信息

以2-甲基萘为原料合成了亚硫酸氢钠甲萘醌的中间体2-甲基-1,4-萘醌。使用过硫酸钾为引发剂,过氧化氢为氧化剂,乙酸为溶剂,探究了过硫酸钾与2-甲基萘的质量比、过氧化氢用量、反应温度、时间等单因素对合成中间体2-甲基-1,4-萘醌产率的影响。在单因素实验的基础上,进行正交实验,得到最佳合成条件:2-甲基萘1.42 g(0.01 mol)、过硫酸钾与2-甲基萘的质量比为3%、过氧化氢9.3 mL[即n(过氧化氢)∶n(2-甲基萘)为12∶1]、乙酸9.5 mL[即n(乙酸)∶n(2-甲基萘)为15∶1]、反应温度为80℃、反应时间为3 h,其产率达到55.9%。在优化合成工艺的同时,达到了既绿色环保又高效合成的目的。

关键词： 2-甲基-1,4萘醌 2-甲基萘过硫酸钾绿色合成