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Haemostatic therapy in spontaneous intracerebral haemorrhage patients with high-risk of haematoma expansion by CT marker: a systematic review and meta- analysis of randomised trials

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Stroke & Vascular Neurology 2021年第2期6卷 170-179页

作者： Ximing Nie Jingyi liu dacheng liu Qi Zhou Wanying Duan Yuehua Pu Zhonghua Yang Miao Wen Haixin Sun Wenzhi Wang Shengjun Sun Hongqiu Gu Liping liu Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Neurosurgical Institute Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose Current randomised controlled trials(RCTs)showed an uncertain benefit of haemostatic therapy on preventing haematoma expansion and improving the outcome in patients with intracerebral haemorrhage(ICH).This meta-analysis aims to systematically evaluate the effect of haemostatic agents on the prevention of haemorrhage growth in patients with high-risk spontaneous ICH predicted by CT signs in *** A comprehensive search of PubMed,EMBASE and Cochrane library from 1 January 2005 to 30 June 2021 was *** that compared haemostatic agents with placebo for the treatment of spontaneous patients with ICH with high-risk haemorrhage growth were *** primary endpoint was haematoma expansion at 24 *** major endpoints of interest included 90-day functional outcome and *** The meta-analysis included four RCTs that randomised 2666 patients with ICH with high-risk haemorrhage *** therapy reduced the rate of haematoma expansion at a marginally statistically significant level when compared with placebo(OR 0.84;95% CI 0.70 to 1.00;p=0.051).Subgroup analysis for patients with black hole sign on CT revealed a significant reduction of haematoma expansion with haemostatic therapy(OR 0.61;95% CI 0.39 to 0.94;p=0.03).However,both the primary analysis and subgroup analyses showed that haemostatic therapy could not reduce the rate of poor functional outcome(modified Rankin Scale>3)or *** Haemostatic therapy showed a marginally significant benefit in reducing early haematoma expansion in patients with high-risk spontaneous ICH predicted by markers on CT ***,no significant improvement in functional outcome or reduction of mortality was observed.

关键词： patients prevention expansion

基于视网膜中央凹视觉的生产监控图像处理方法

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清华大学学报（自然科学版） 2005年第2期45卷 258-261页

作者：郑勇刘大成清华大学工业工程系北京100084

在面向生产现场的远程视频监控系统中,视频图像的庞大数据量与系统的处理能力和网络带宽条件往往容易形成冲突,而繁杂冗余的现场视觉信息也难以符合生产监控的需求。该文提出了一种基于视网膜中央凹视觉的生产监控图像处理方法,从生产... 详细信息

在面向生产现场的远程视频监控系统中,视频图像的庞大数据量与系统的处理能力和网络带宽条件往往容易形成冲突,而繁杂冗余的现场视觉信息也难以符合生产监控的需求。该文提出了一种基于视网膜中央凹视觉的生产监控图像处理方法,从生产监控的特点和需求出发,模仿人眼的视觉感知特性对视频图像进行空间变分辨率转换,从而降低数据量并实现对监控效用信息(MEI)的筛选。实验结果表明,该方法能够帮助远程视频监控系统有效降低视频传输码率,在保证系统实时性的同时提高了生产监控的效率。

关键词：生产监控远程视频监控系统监控效用信息视网膜中央凹视觉空间变分辨率转换

Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion

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Stroke & Vascular Neurology 2022年第3期7卷 190-199页

作者： Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin liu Lina Zheng Jingyi liu Xinxuan Yang Yarong Ding dacheng liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping liu Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Neurovascular Division Department of NeurologyBarrow Neurological InstitutePhoenixArizonaUSA Department of Medicine and Therapeutics Prince of Wales HospitalHong KongChina Department of Radiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Interventional Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to *** Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct *** primary outcome was 90-day functional *** outcomes were assessed with adjusted OR(aOR)from the multivariable logistic *** addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with *** Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+*** EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of *** meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO.

关键词： acute intravenous occlusion

China Antihypertensive Trial in Acute Ischemic Stroke II (CATIS-2): rationale and design

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Stroke & Vascular Neurology 2021年第2期6卷 286-290页

作者： Liping liu Yilong Wang Xuewei Xie dacheng liu Aili Wang Penglian Wang Suwen Shen Chongke Zhong Yufei Wei Tan Xu Yuesong Pan Yong Jiang Xia Meng David Wang Yonghong Zhang Jiang He Yongjun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Epidemiology School of Public HealthMedical College of Soochow UniversitySuzhouChina Neurovascular Division Department of NeurologyBarrow Neurological InstituteSt Joseph's Hospital and Medical CenterPhoenixArizonaUSA Department of Epidemiology Tulane University School of Public Health and Tropical MedicineNew OrleansLouisianaUSA

Backgrounds Increased blood pressure(BP)for patients who had an acute ischaemic stroke is associated with poor functional outcome,however the optimal timing of antihypertensive therapy is *** We aim to compare early antihypertensive treatment to delayed antihypertensive treatment for reducing the risk of composite major disability and mortality at 3 months in acute ischaemic *** The China Antihypertensive Trial in Acute Ischemic Stroke II(CATIS-2)trial is a multicentre,randomised,open-label,blinded-endpoints trial that will be conducted in 100 hospitals in *** primary outcome is the composite of death and major disability(modified Rankin Scale score≥3)at 3 months of *** treatment will be received immediately after randomisation in the early treatment group,aimed at average systolic BP by 10%-20%reduction within the first 24 hours,and achieving an average BP level of<140/90 mm Hg within 5 *** in the delayed treatment group will discontinue any antihypertension medications for the first 7 days of randomisation,and will receive antihypertensive therapy achieving a BP goal of<140/90 mm Hg after 7 *** The CATIS-2 trial will be testing the hypotheses that early BP lowering leads to improved functional outcome without any other harms,and developing clinical guidelines of the BP management for patients who had an acute ischaemic stroke.

关键词： hypertensive acute mortality

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欧盟法院影响共同商业政策的司法途径探析

学术前沿 2020年第5期 112-115页

作者：刘大成北京大学法学院

自《罗马条约》颁布以来,欧盟的内涵不断被扩充。欧盟法的内容主要涉及经济和社会领域,共同商业政策在经济领域中具有决定性的作用。因而,该政策随着发展形势的变化而不断产生相应变化。面对不断涌现的新问题,具有针对性的制度与政策应... 详细信息

自《罗马条约》颁布以来,欧盟的内涵不断被扩充。欧盟法的内容主要涉及经济和社会领域,共同商业政策在经济领域中具有决定性的作用。因而,该政策随着发展形势的变化而不断产生相应变化。面对不断涌现的新问题,具有针对性的制度与政策应运而生。欧盟法院力排众议,给予了司法机构足够的机动性,以面对实时的社会需求与法律漏洞,此举对于共同商业政策而言是极大的鼓舞与支撑,同时有助于补充与完善以往的法律政策。

关键词：欧盟法院共同商业政策司法途径

Tranexamic acid for acute intracerebral haemorrhage growth based on imaging assessment (TRAIGE): a multicentre, randomised, placebo- controlled trial

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Stroke & Vascular Neurology 2021年第2期6卷 160-169页

作者： Jingyi liu Ximing Nie Hongqiu Gu Qi Zhou Haixin Sun Ying Tan dacheng liu Lina Zheng Jiahui Zhao Yan Wang Yibin Cao Haomeng Zhu Yunpeng Zhang Lijin Yi Yuehua Pu Miao Wen Zhonghua Yang Shengjun Sun Wenzhi Wang Xingquan Zhao Liping liu Yongjun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Neurosurgical Institute Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Xi'an Jiaotong UniversityBeijingChina Department of Medicine and Therapeutics Prince of Wales HospitalShatinHong Kong Department of Neurology Tangshan People’s HospitalTangshanChina Department of Neurology Tangshan Gongren HospitalTangshanChina Department of Neurology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Pinggu HospitalBeijingChina Department of Neurology Liangxiang Hospital of Beijing Fangshan DistrictBeijingChina Department of Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background Studies show tranexamic acid can reduce the risk of death and early neurological deterioration after intracranial *** aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in intracerebral haemorrhage patients susceptible to haemorrhage *** We did a prospective,double-blind,randomised,placebo-controlled trial at 10 stroke centres in *** supratentorial intracerebral haemorrhage patients were eligible if they had indication of haemorrhage expansion on admission imaging(eg,spot sign,black hole sign or blend sign),and were treatable within 8 hours of symptom *** were randomly assigned(1:1)to receive either tranexamic acid or a matching *** primary outcome was intracerebral haematoma growth(>33% relative or>6 mL absolute)at 24 *** outcomes were assessed at 90 *** Of the 171 included patients,124(72.5%)were male,and the mean age was 55.9±11.6 years.89 patients received tranexamic acid and 82 received *** primary outcome did not differ significantly between the groups:36(40.4%)patients in the tranexamic acid group and 34(41.5%)patients in the placebo group had intracranial haemorrhage growth(OR 0.96,95% CI 0.52 to 1.77,p=0.89).The proportion of death was lower in the tranexamic acid treatment group than placebo group(8.1%vs 10.0%),but there were no significant differences in secondary outcomes including absolute intracranial haemorrhage growth,death and *** Among patients susceptible to haemorrhage expansion treated within 8 hours of stroke onset,tranexamic acid did not significantly prevent intracerebral haemorrhage *** studies are needed to assess safety and efficacy of tranexamic acid in intracerebral haemorrhage patients.

关键词： placebo centre absolute

打造壮乡民族文化精品填补影视族群志空白——评十二集壮族文化电视系列片《丽哉勐僚》

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民族艺术研究 2008年第4期21卷 64-69页

作者：刘达成云南省社科院

十二集壮族文化电视系列片《丽哉勐僚》是我国迄今为止,第一部运用文化人类学的观点,全面剖析壮族族群的电视纪录片,是一部填补中国少数民族影视族群志空白的人文大片。本文从六个方面的科学立论和学术观点,对此进行全面、深入的评鉴。

关键词：人文纪录片壮族文化丽哉勐僚

活性组分稀土氧化物对甲苯催化燃烧性能的影响

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环境工程学报 2016年第12期10卷 7317-7320页

作者：刘大成刘艳娟唐山学院环境与化学工程系唐山063000

以活性组分氧化铜、氧化锰为基础,加入活性组分稀土氧化物,研究对甲苯催化燃烧性能影响。研究结果表明,在所选稀土氧化物中,加入氧化铈时甲苯的起燃温度和完全燃烧温度最低;在一定的负载量下,Cu∶Mn∶Ce摩尔比为1∶2∶0.7时,制备的Cu Mn... 详细信息

以活性组分氧化铜、氧化锰为基础,加入活性组分稀土氧化物,研究对甲苯催化燃烧性能影响。研究结果表明,在所选稀土氧化物中,加入氧化铈时甲苯的起燃温度和完全燃烧温度最低;在一定的负载量下,Cu∶Mn∶Ce摩尔比为1∶2∶0.7时,制备的Cu Mn Ce/Zr O2整体催化剂甲苯完全燃烧温度最低;催化剂合理的焙烧温度为500℃,此时甲苯的起燃温度约200℃,完全燃烧温度为220℃;催化剂合理的焙烧时间为3 h。

关键词：稀土氧化物甲苯催化燃烧催化活性

LOCALIZED CORROSION OF MICROCRYSTALS OF 1Crl8Ni9Ti STAINLESS STEEL

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Acta Metallurgica Sinica(English Letters) 1989年第8期2卷 143-145页

作者： liu dacheng CAO Chunan WANG Fuhui LOU Hanyi ZHANG Lixin

The resistances against localized corrosion of 1Cr18Ni9Ti microcrystals with normal grain size and bcc structure obtained hy magnetron sputtering have been *** two kinds of microcrystals with (110) and (211) textures respectively were obtained under different sputtering *** microcrystals were found to have better resistance against local- ized corrosion than the crystal with normal *** microcrystal with (110) preferred orientation has larger resistance to localized corrosion than that with (211) preferred orientation.

关键词： microcrystal localized corrosion magnetron sputtering