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Liver Research 2021年第2期5卷 97-101页

作者： Zhishuo Mo Jian Tang Zeqian Wu dabiao chen Dongying Xie Peipei Wang Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Gastroenterology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Interferon(IFN)is a multifaceted immunomodulator that is effective against many diseases,including chronic hepatitis B and chronic hepatitis C *** defends against viral infection,but may also cause various side effects,such as ulcerative colitis(UC).Herein,we present a case of UC triggered by pegylated interferon alpha-2b(PEG-IFN-α-2b)therapy in a patient with concurrent chronic hepatitis B(CHB)*** diagnosis was based on typical clinical symptoms,colonoscopy findings,colonic mucosal biopsy,and ***,treatment with mesalazine was initiated without stopping PEG-IFN-α-***,UC relieved gradually without compromising the effects of ***,we conducted a literature review of previously published case reports on the side effect of UC in patients with underlying chronic *** reactions have been reported,including induction,exacerbation,and no *** is the first report of UC triggered by PEG-IFN-α-2b in a CHB *** recommend that physicians pay attention to the rare side effect of UC during administration of PEG-IFN-α-*** can relieve UC with sustained use of PEG-IFN-α-2b.

关键词： Interferon(IFN) Hepatitis Chronic hepatitis B(CHB) Chronic hepatitis C(CHC) Ulcerative colitis(UC)

Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19

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Synthetic and Systems Biotechnology 2021年第3期6卷 135-143页

作者： Jing Liu Sheng Liu Zhao Zhang Xuejun Lee Wenxuan Wu Zhanlian Huang Ziying Lei Wenxiong Xu dabiao chen Xing Wu Yang Guo Liang Peng Bingliang Lin Yutian Chong Xiangyu Mou Mang Shi Ping Lan Tao chen Wenjing Zhao Zhiliang Gao Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong510630China The Center for Infection and Immunity Study(CIIS) School of MedicineSun Yat-sen UniversityShenzhenChina Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSchool of MedicineSun Yat-sen UniversityGuangzhouChina South China Institute of Biomedicine GuangzhouGuangdong510535China

SARS-CoV-2,the causative agent for COVID-19,infect human mainly via respiratory tract,which is heavily inhabited by local ***,the interaction between SARS-CoV-2 and nasopharyngeal microbiota,and the association with metabolome has not been well ***,metabolomic analysis of blood,urine,and nasopharyngeal swabs from a group of COVID-19 and non-COVID-19 patients,and metagenomic analysis of pharyngeal samples were used to identify the key features of *** showed lactic acid,L-proline,and chlorogenic acid methyl ester(CME)were significantly reduced in the sera of COVID-19 patients compared with non-COVID-19 *** commensal bacteria including Gemella morbillorum,Gemella haemolysans and Leptotrichia hofstadii were notably depleted in the pharynges of COVID-19 patients,while Prevotella histicola,Streptococcus sanguinis,and Veillonella dispar were relatively *** abundance of *** and *** were significantly positively associated with serum CME,which might be an anti-SARS-CoV-2 bacterial *** study provides important information to explore the linkage between nasopharyngeal microbiota and disease *** findings were based on a very limited number of patients enrolled in this study;a larger size of cohort will be appreciated for further investigation.

关键词： Metabolome Nasopharyngeal microbiome COVID-19 SARS-CoV-2 Susceptibility

三种药物治疗方案治疗广泛性焦虑症的成本-效果分析

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中国现代医生 2014年第7期52卷 73-75页

作者：林雪菜陈达标浙江省台州市第二人民医院药剂科浙江台州317200

目的探讨三种药物治疗方案治疗广泛性焦虑症的成本-效果分析。方法对三种药物治疗方案治疗广泛性焦虑症进行成本-效果分析,并对可能影响因素做敏感性分析。结果阿普唑仑组不良反应总发生率明显高于曲唑酮和坦度螺酮两组(χ2=7.68和7.44,... 详细信息

目的探讨三种药物治疗方案治疗广泛性焦虑症的成本-效果分析。方法对三种药物治疗方案治疗广泛性焦虑症进行成本-效果分析,并对可能影响因素做敏感性分析。结果阿普唑仑组不良反应总发生率明显高于曲唑酮和坦度螺酮两组(χ2=7.68和7.44,P<0.01),坦度螺酮组性功能障碍发生率明显高于曲唑酮组(χ2=16.03,P<0.01),坦度螺酮组嗜睡发生率明显低于曲唑酮和阿普唑仑组两组(χ2=16.51和11.94,P<0.01)。成本-效果分析示坦度螺酮组成本-效果比最高(16.78),阿普唑仑组最低(7.73)。敏感性分析示降价后成本-效果比与原分析基本一致。结论阿普唑仑治疗广泛性焦虑症治疗方案较曲唑酮和坦度螺酮为佳。

关键词：广泛性焦虑症曲唑酮坦度螺酮阿普唑仑成本-效果

奥氮平或氯丙嗪治疗首发精神分裂症患者血清心肌酶谱比较

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上海精神医学 2009年第3期21卷 147-149页

作者：贾方增陈统献张为民陈达标浙江省台州第二人民医院 317200

目的探讨第二代抗精神病药奥氮平对首发精神分裂症患者血清心肌酶谱的影响。方法回顾性病史资料分析,比较奥氮平(92例)或氯丙嗪(73例)单药治疗的住院首发精神分裂症患者治疗前、治疗第4周、第8周的血清天冬氨酸氨基转氨酶(AST)、乳酸脱... 详细信息

目的探讨第二代抗精神病药奥氮平对首发精神分裂症患者血清心肌酶谱的影响。方法回顾性病史资料分析,比较奥氮平(92例)或氯丙嗪(73例)单药治疗的住院首发精神分裂症患者治疗前、治疗第4周、第8周的血清天冬氨酸氨基转氨酶(AST)、乳酸脱氢酶(LDH)及肌酸磷酸激酶(CK)及PANSS评分。结果除治疗第8周时奥氮平组血清CK浓度高于氯丙嗪组[中位数(四分位数)分别为138U/L(82U/L,210U/L)、83U/L(54U/L,124U/L)],差异有统计学意义(Z=2.517,P=0.012)外,2组间各时点心肌酶浓度无明显差异。各时点2组间PANSS评分差异无统计学意义。结论奥氮平治疗初期,首发精神分裂症患者CK浓度可能升高。

关键词：精神分裂症奥氮平氯丙嗪肌酸磷酸激酶

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基于氨预分解的氨扩散燃烧模拟研究

中国电机工程学报 2025年第2期45卷 479-488,I0007页

作者：黄文仕王智雄林立伍泽赟王大彪罗宇陈崇启江莉龙化肥催化剂国家工程研究中心(福州大学化工学院) 福建省福州市350001 福大紫金氢能科技股份有限公司福建省福州市350108

氨部分预分解是改善氨的燃烧性能的有效手段,但对于氨预分解条件的影响仍缺乏系统的研究。该文针对基于氨预分解策略的氨扩散燃烧装置开展数值模拟研究,以分析氨预分解比例、当量比和氨分解余热对燃烧及污染物排放特性的影响。结果表明... 详细信息

氨部分预分解是改善氨的燃烧性能的有效手段,但对于氨预分解条件的影响仍缺乏系统的研究。该文针对基于氨预分解策略的氨扩散燃烧装置开展数值模拟研究,以分析氨预分解比例、当量比和氨分解余热对燃烧及污染物排放特性的影响。结果表明,随着氨预分解比例提高,火焰温度提高,火焰高温区更靠近喷嘴,NO_(x)排放量下降;NO排放在NO_(x)中占主导,并随着当量比的提高先增大后减小;N_(2)O排放主要发生在低氨预分解比例、低当量比条件下,在氨预分解比例达到50%后基本消失;利用氨分解余热预热燃料有助于稳定燃烧,并在氨预分解比例不超过30%时,明显减少氨泄漏而未增加NO_(x)排放。研究表明,提高氨预分解比例和当量比能有效改善氨燃烧及污染物排放特性,而在小比例氨预分解条件下应充分利用氨分解的余热。

关键词：氨氢燃烧氨分解当量比数值模拟 NO_(x)排放

Effects of Fe concentration on microstructure and corrosion of Mg-6Al-1Zn-xFe alloys for fracturing balls applications

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Journal of Materials Science & Technology 2019年第9期35卷 2086-2098页

作者： cheng Zhang Liang Wu Guangsheng Huang Lin chen dabiao Xia Bin Jiang Andrej Atrens Fusheng Pan State Key Laboratory of Mechanical Transmission College of Materials Science and EngineeringChongqing UniversityChongqing 400044China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China Chongqing Research Center for Advanced Materials Chongqing Academy of Science & TechnologyChongqing 401123China School of Mechanical and Mining Engineering The University of QueenslandBrisbane Qld 4072Australia

Mg-6 Al-1 Zn-xFe（x = 0,1,3,5 and 7 wt%）alloys were prepared by powder metallurgy and followed by hot *** of Fe element exists as insoluble particles in the *** as-extruded alloys showed higher degradable rates but less stable mechanical properties than as-annealed *** rate of all the alloys increased with increasing Fe concentration,reaching 2.4 mL cm-2h-1.0.2% yield strength of all the alloys was higher than 150 *** short,Mg-6 Al-1 Zn-xFe alloys have an attractive combination of corrosion and mechanical properties,which holds a bright future for fracturing balls applications.

关键词： Mg-6Al-1Zn-xFe alloys Fracturing balls Corrosion Mechanical properties

Significantly improve the strength and ductility of AZ31 Mg alloy by introducing pure Ti

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Journal of Materials Science & Technology 2024年第18期185卷 69-82页

作者： Xiang chen dabiao Xia Qixiang Jia Guangsheng Huang Weizhang Wang Junlei Zhang Heung Nam Han Fusheng Pan College of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Jihua Laboratory Foshan 528000China College of Intelligent Equipment Shandong University of Science and TechnologyTai’an 271000China College of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China Department of Materials Science and Engineering Seoul National UniversitySeoul08826Republic of Korea

In this work,we introduced pure Ti into AZ31 Mg alloy by extrusion process followed by annealing at 350℃ for 1 h to significantly improve the mechanical properties of AZ31 laminate,with a yield strength of 243 MPa,an ultimate tensile strength of 338 MPa and a uniform elongation of 17.7%.Microstructural characterizations showed that there was slight diffusion of elements(Al,Zn,and Mn)across the layer interface,and the interface between the constituent layers maintained ***,signifi-cant microstructure heterogeneities appeared across the hetero-interface,where the Mg layer possessed large equiaxed grains with lower dislocation density,while the Ti layer formed ultrafine grains(UFG)and unrecrystallized block grains with extensive dislocation cells and dislocation *** the digital image correlation(DIC)technique and in-situ electron backscatter diffraction(EBSD),it was found that the microstructural heterogeneities induced significant strain gradients near the layer interface during plastic deformation,which needed to be accommodated by geometrically necessary dislocations(GNDs).This resulted in hetero-deformation-induced(HDI)strengthening and HDI strain hardening to strengthen and toughen the AZ31 laminated ***,the introduction of the Ti layer effectively hin-dered the propagation of the cracks and consequently improved the ductility of the laminate.

关键词： AZ31 laminated composite Extrusion Annealing Strain gradient Mechanical properties

The Tibetan Plateau Surface–Atmosphere Coupling System and Its Weather and Climate Effects: The Third Tibetan Plateau Atmospheric Science Experiment

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Journal of Meteorological Research 2019年第3期33卷 375-399页

作者： Ping ZHAO Yueqing LI Xueliang GUO Xiangde XU Yimin LIU Shihao TANG Wenming XIAO Chunxiang SHI Yaoming MA Xing YU Huizhi LIU La JIA Yun chen Yanju LIU Jian LI dabiao LUO Yunchang CAO Xiangdong ZHENG Junming chen An XIAO Fang YUAN Donghui chen Yang PANG Zhiqun HU Shengjun ZHANG Lixin DONG Juyang HU Shuai HAN Xiuji ZHOU State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences China Meteorological Administration Beijing 100081 National Climate Center China Meteorological Administration Beijing 100081 Meteorological Observation Center China Meteorological Administration Beijing 100081 Jiangxi Meteorological Observatory Nanchang 330096 chengdu Institute of Plateau Meteorology of the China Meteorological Administration Chengdu 610072 Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 National Satellite Meteorological Center China Meteorological Administration Beijing 100081 National Meteorological Information Center China Meteorological Administration Beijing 100081 Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100101 Meteorological Institute of Shaanxi Province Xi'an 710014 Meteorological Observatory of Tibet Autonomous Region Lhasa 850000 National Meteorological Centery China Meteorological Administration Beijing 100081

The Tibetan Plateau(TP) is a key area affecting forecasts of weather and climate in China and occurrences of extreme weather and climate events over the world. The China Meteorological Administration, the National Natural Science Foundation of China, and the Chinese Academy of Sciences jointly initiated the Third Tibetan Plateau Atmospheric Science Experiment(TIPEX-Ⅲ) in 2013, with an 8–10-yr implementation plan. Since its preliminary field measurements conducted in 2013, routine automatic sounding systems have been deployed at Shiquanhe, Gaize, and Shenzha stations in western TP, where no routine sounding observations were available previously. The observational networks for soil temperature and soil moisture in the central and western TP have also been established. Meanwhile, the plateau-scale and regional-scale boundary layer observations, cloud–precipitation microphysical observations with multiple radars and aircraft campaigns, and tropospheric–stratospheric air composition observations at multiple sites, were performed. The results so far show that the turbulent heat exchange coefficient and sensible heat flux are remarkably lower than the earlier estimations at grassland, meadow, and bare soil surfaces of the central and western TP. Climatologically, cumulus clouds over the main body of the TP might develop locally instead of originating from the cumulus clouds that propagate northward from South Asia. The TIPEX-Ⅲ observations up to now also reveal diurnal variations, macro-and microphysical characteristics, and water-phase transition mechanisms, of cumulus clouds at Naqu station. Moreover, TIPEX-Ⅲ related studies have proposed a maintenance mechanism responsible for the Asian "atmospheric water tower" and demonstrated the effects of the TP heating anomalies on African, Asian, and North American climates. Additionally, numerical modeling studies show that the Γ distribution of raindrop size is more suitable for depicting the TP raindrop characteristics compar

关键词： Tibetan Plateau field observation data processing weather and climate numerical forecasting

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柔性捻卷型纤维基人工肌肉研究综述

华中科技大学学报（自然科学版） 2023年第1期51卷 59-66页

作者：刘大彪刘磊胡炯炯陈炎明华中科技大学航空航天学院湖北武汉430074 华中科技大学工程结构分析与安全评定湖北省重点实验室湖北武汉430074 湖北省标准化与质量研究院湖北武汉430060

综述了捻卷型纤维基(TCF)人工肌肉的发展历程和研究现状.对其制备方法、拓扑结构与力学原理、工作机制及驱动方式等方面进行了总结.TCF人工肌肉的研究虽然取得了一定进展,但仍存在诸多挑战:缺乏力学引导的人工肌肉制备技术和结构设计准... 详细信息

综述了捻卷型纤维基(TCF)人工肌肉的发展历程和研究现状.对其制备方法、拓扑结构与力学原理、工作机制及驱动方式等方面进行了总结.TCF人工肌肉的研究虽然取得了一定进展,但仍存在诸多挑战:缺乏力学引导的人工肌肉制备技术和结构设计准则;采用不同材料和不同卷绕方式制作的人工肌肉,其驱动性能各异,难以确定驱动性能最佳的拓扑结构;面向人工肌肉力学性能和致动特性的表征手段尚不完备.单纤维的拉扭力学性能决定了纤维基人工肌肉的致动特性,目前仍缺乏完备的面向人工肌肉纤维的力学表征方法和致动特性测试手段,纤维基人工肌肉的精确驱动控制难以实现.人工肌肉纤维具有较强的时变非线性,缺乏精确描述其机械输出特性的迟滞模型.

关键词：人工肌肉高性能纤维力学表征柔性驱动扭转失稳

植物多糖对内质网应激介导的动物细胞凋亡、炎症和氧化损伤的影响及其作用机制

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动物营养学报 2023年第12期35卷 7641-7647页

作者：陈宇郑彦楷李大彪邢媛媛内蒙古农业大学动物科学学院内蒙古自治区高校动物营养与饲料科学重点实验室呼和浩特010018

内质网是细胞内负责蛋白质折叠和修饰的重要细胞器。内质网应激是由于蛋白质异常累积而引起的细胞应激反应,可导致炎症、氧化损伤和细胞凋亡等动物机体的不良反应。近年来的研究表明,植物多糖可通过内质网应激介导的内质网过载反应和未... 详细信息

内质网是细胞内负责蛋白质折叠和修饰的重要细胞器。内质网应激是由于蛋白质异常累积而引起的细胞应激反应,可导致炎症、氧化损伤和细胞凋亡等动物机体的不良反应。近年来的研究表明,植物多糖可通过内质网应激介导的内质网过载反应和未折叠蛋白质反应相关通路,缓解内质网应激,进而保护动物机体免受损伤。本文综述了植物多糖在缓解内质网应激导致的动物机体炎症、氧化损伤和细胞凋亡等方面的相关机制和研究进展。

关键词：植物多糖内质网应激免疫抗氧化细胞凋亡