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Liver Research 2021年第2期5卷 97-101页

作者： Zhishuo Mo Jian Tang Zeqian Wu dabiao chen Dongying Xie Peipei Wang Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Gastroenterology The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina

Interferon(IFN)is a multifaceted immunomodulator that is effective against many diseases,including chronic hepatitis B and chronic hepatitis C infection.IFN defends against viral infection,but may also cause various side effects,such as ulcerative colitis(UC).Herein,we present a case of UC triggered by pegylated interferon alpha-2b(PEG-IFN-α-2b)therapy in a patient with concurrent chronic hepatitis B(CHB)infection.The diagnosis was based on typical clinical symptoms,colonoscopy findings,colonic mucosal biopsy,and histopathology.Accordingly,treatment with mesalazine was initiated without stopping PEG-IFN-α-2b.Fortunately,UC relieved gradually without compromising the effects of treatment.Simultaneously,we conducted a literature review of previously published case reports on the side effect of UC in patients with underlying chronic hepatitis.Various reactions have been reported,including induction,exacerbation,and no change.This is the first report of UC triggered by PEG-IFN-α-2b in a CHB patient.We recommend that physicians pay attention to the rare side effect of UC during administration of PEG-IFN-α-2b.Mesalazine can relieve UC with sustained use of PEG-IFN-α-2b.

关键词： Interferon(IFN) Hepatitis Chronic hepatitis B(CHB) Chronic hepatitis C(CHC) Ulcerative colitis(UC)

Association between the nasopharyngeal microbiome and metabolome in patients with COVID-19

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Synthetic and Systems Biotechnology 2021年第3期6卷 135-143页

作者： Jing Liu Sheng Liu Zhao Zhang Xuejun Lee Wenxuan Wu Zhanlian Huang Ziying Lei Wenxiong Xu dabiao chen Xing Wu Yang Guo Liang Peng Bingliang Lin Yutian Chong Xiangyu Mou Mang Shi Ping Lan Tao chen Wenjing Zhao Zhiliang Gao Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong510630China The Center for Infection and Immunity Study(CIIS) School of MedicineSun Yat-sen UniversityShenzhenChina Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSchool of MedicineSun Yat-sen UniversityGuangzhouChina South China Institute of Biomedicine GuangzhouGuangdong510535China

SARS-CoV-2,the causative agent for COVID-19,infect human mainly via respiratory tract,which is heavily inhabited by local microbiota.However,the interaction between SARS-CoV-2 and nasopharyngeal microbiota,and the association with metabolome has not been well characterized.Here,metabolomic analysis of blood,urine,and nasopharyngeal swabs from a group of COVID-19 and non-COVID-19 patients,and metagenomic analysis of pharyngeal samples were used to identify the key features of COVID-19.Results showed lactic acid,L-proline,and chlorogenic acid methyl ester(CME)were significantly reduced in the sera of COVID-19 patients compared with non-COVID-19 ones.Nasopharyngeal commensal bacteria including Gemella morbillorum,Gemella haemolysans and Leptotrichia hofstadii were notably depleted in the pharynges of COVID-19 patients,while Prevotella histicola,Streptococcus sanguinis,and Veillonella dispar were relatively increased.The abundance of G.haemolysans and L.hofstadii were significantly positively associated with serum CME,which might be an anti-SARS-CoV-2 bacterial metabolite.This study provides important information to explore the linkage between nasopharyngeal microbiota and disease susceptibility.The findings were based on a very limited number of patients enrolled in this study;a larger size of cohort will be appreciated for further investigation.

关键词： Metabolome Nasopharyngeal microbiome COVID-19 SARS-CoV-2 Susceptibility

三种药物治疗方案治疗广泛性焦虑症的成本-效果分析

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中国现代医生 2014年第7期52卷 73-75页

作者：林雪菜陈达标浙江省台州市第二人民医院药剂科浙江台州317200

目的探讨三种药物治疗方案治疗广泛性焦虑症的成本-效果分析。方法对三种药物治疗方案治疗广泛性焦虑症进行成本-效果分析,并对可能影响因素做敏感性分析。结果阿普唑仑组不良反应总发生率明显高于曲唑酮和坦度螺酮两组(χ2=7.68和7.44,... 详细信息

目的探讨三种药物治疗方案治疗广泛性焦虑症的成本-效果分析。方法对三种药物治疗方案治疗广泛性焦虑症进行成本-效果分析,并对可能影响因素做敏感性分析。结果阿普唑仑组不良反应总发生率明显高于曲唑酮和坦度螺酮两组(χ2=7.68和7.44,P<0.01),坦度螺酮组性功能障碍发生率明显高于曲唑酮组(χ2=16.03,P<0.01),坦度螺酮组嗜睡发生率明显低于曲唑酮和阿普唑仑组两组(χ2=16.51和11.94,P<0.01)。成本-效果分析示坦度螺酮组成本-效果比最高(16.78),阿普唑仑组最低(7.73)。敏感性分析示降价后成本-效果比与原分析基本一致。结论阿普唑仑治疗广泛性焦虑症治疗方案较曲唑酮和坦度螺酮为佳。

关键词：广泛性焦虑症曲唑酮坦度螺酮阿普唑仑成本-效果

奥氮平或氯丙嗪治疗首发精神分裂症患者血清心肌酶谱比较

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上海精神医学 2009年第3期21卷 147-149页

作者：贾方增陈统献张为民陈达标浙江省台州第二人民医院 317200

目的探讨第二代抗精神病药奥氮平对首发精神分裂症患者血清心肌酶谱的影响。方法回顾性病史资料分析,比较奥氮平(92例)或氯丙嗪(73例)单药治疗的住院首发精神分裂症患者治疗前、治疗第4周、第8周的血清天冬氨酸氨基转氨酶(AST)、乳酸脱... 详细信息

目的探讨第二代抗精神病药奥氮平对首发精神分裂症患者血清心肌酶谱的影响。方法回顾性病史资料分析,比较奥氮平(92例)或氯丙嗪(73例)单药治疗的住院首发精神分裂症患者治疗前、治疗第4周、第8周的血清天冬氨酸氨基转氨酶(AST)、乳酸脱氢酶(LDH)及肌酸磷酸激酶(CK)及PANSS评分。结果除治疗第8周时奥氮平组血清CK浓度高于氯丙嗪组[中位数(四分位数)分别为138U/L(82U/L,210U/L)、83U/L(54U/L,124U/L)],差异有统计学意义(Z=2.517,P=0.012)外,2组间各时点心肌酶浓度无明显差异。各时点2组间PANSS评分差异无统计学意义。结论奥氮平治疗初期,首发精神分裂症患者CK浓度可能升高。

关键词：精神分裂症奥氮平氯丙嗪肌酸磷酸激酶

Effects of Fe concentration on microstructure and corrosion of Mg-6Al-1Zn-xFe alloys for fracturing balls applications

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Journal of Materials Science & Technology 2019年第9期35卷 2086-2098页

作者： cheng Zhang Liang Wu Guangsheng Huang Lin chen dabiao Xia Bin Jiang Andrej Atrens Fusheng Pan State Key Laboratory of Mechanical Transmission College of Materials Science and EngineeringChongqing UniversityChongqing 400044China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China Chongqing Research Center for Advanced Materials Chongqing Academy of Science & TechnologyChongqing 401123China School of Mechanical and Mining Engineering The University of QueenslandBrisbane Qld 4072Australia

Mg-6A1-1 Zn-xFe (x = 0,1,3,5 and 7 wt%) alloys were prepared by powder metallurgy and followed by hot extrusion. Majority of Fe element exists as insoluble particles in the alloys. The as-extruded alloys showed higher degradable rates but less stable mechanical properties than as-annealed alloys. Corrosion rate of all the alloys increased with increasing Fe concentration, reaching 2.4 mL cm^-2 h^-1.0.2% yield strength of all the alloys was higher than 150 MPa. In short, Mg-6A1-1 Zn-xFe alloys have an attractive combination of corrosion and mechanical properties, which holds a bright future for fracturing balls applications.

关键词： Mg-6Al-lZn-xFe alloys Fracturing balls Corrosion Mechanical properties

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柔性捻卷型纤维基人工肌肉研究综述

华中科技大学学报（自然科学版） 2023年第1期51卷 59-66页

作者：刘大彪刘磊胡炯炯陈炎明华中科技大学航空航天学院湖北武汉430074 华中科技大学工程结构分析与安全评定湖北省重点实验室湖北武汉430074 湖北省标准化与质量研究院湖北武汉430060

综述了捻卷型纤维基(TCF)人工肌肉的发展历程和研究现状.对其制备方法、拓扑结构与力学原理、工作机制及驱动方式等方面进行了总结.TCF人工肌肉的研究虽然取得了一定进展,但仍存在诸多挑战:缺乏力学引导的人工肌肉制备技术和结构设计准... 详细信息

综述了捻卷型纤维基(TCF)人工肌肉的发展历程和研究现状.对其制备方法、拓扑结构与力学原理、工作机制及驱动方式等方面进行了总结.TCF人工肌肉的研究虽然取得了一定进展,但仍存在诸多挑战:缺乏力学引导的人工肌肉制备技术和结构设计准则;采用不同材料和不同卷绕方式制作的人工肌肉,其驱动性能各异,难以确定驱动性能最佳的拓扑结构;面向人工肌肉力学性能和致动特性的表征手段尚不完备.单纤维的拉扭力学性能决定了纤维基人工肌肉的致动特性,目前仍缺乏完备的面向人工肌肉纤维的力学表征方法和致动特性测试手段,纤维基人工肌肉的精确驱动控制难以实现.人工肌肉纤维具有较强的时变非线性,缺乏精确描述其机械输出特性的迟滞模型.

关键词：人工肌肉高性能纤维力学表征柔性驱动扭转失稳

植物多糖对内质网应激介导的动物细胞凋亡、炎症和氧化损伤的影响及其作用机制

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动物营养学报 2023年第12期35卷 7641-7647页

作者：陈宇郑彦楷李大彪邢媛媛内蒙古农业大学动物科学学院内蒙古自治区高校动物营养与饲料科学重点实验室呼和浩特010018

内质网是细胞内负责蛋白质折叠和修饰的重要细胞器。内质网应激是由于蛋白质异常累积而引起的细胞应激反应,可导致炎症、氧化损伤和细胞凋亡等动物机体的不良反应。近年来的研究表明,植物多糖可通过内质网应激介导的内质网过载反应和未... 详细信息

内质网是细胞内负责蛋白质折叠和修饰的重要细胞器。内质网应激是由于蛋白质异常累积而引起的细胞应激反应,可导致炎症、氧化损伤和细胞凋亡等动物机体的不良反应。近年来的研究表明,植物多糖可通过内质网应激介导的内质网过载反应和未折叠蛋白质反应相关通路,缓解内质网应激,进而保护动物机体免受损伤。本文综述了植物多糖在缓解内质网应激导致的动物机体炎症、氧化损伤和细胞凋亡等方面的相关机制和研究进展。

关键词：植物多糖内质网应激免疫抗氧化细胞凋亡

The Tibetan Plateau Surface–Atmosphere Coupling System and Its Weather and Climate Effects: The Third Tibetan Plateau Atmospheric Science Experiment

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Journal of Meteorological Research 2019年第3期33卷 375-399页

作者： Ping ZHAO Yueqing LI Xueliang GUO Xiangde XU Yimin LIU Shihao TANG Wenming XIAO Chunxiang SHI Yaoming MA Xing YU Huizhi LIU La JIA Yun chen Yanju LIU Jian LI dabiao LUO Yunchang CAO Xiangdong ZHENG Junming chen An XIAO Fang YUAN Donghui chen Yang PANG Zhiqun HU Shengjun ZHANG Lixin DONG Juyang HU Shuai HAN Xiuji ZHOU State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences China Meteorological Administration Beijing 100081 National Climate Center China Meteorological Administration Beijing 100081 Meteorological Observation Center China Meteorological Administration Beijing 100081 Jiangxi Meteorological Observatory Nanchang 330096 chengdu Institute of Plateau Meteorology of the China Meteorological Administration Chengdu 610072 Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 National Satellite Meteorological Center China Meteorological Administration Beijing 100081 National Meteorological Information Center China Meteorological Administration Beijing 100081 Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100101 Meteorological Institute of Shaanxi Province Xi'an 710014 Meteorological Observatory of Tibet Autonomous Region Lhasa 850000 National Meteorological Centery China Meteorological Administration Beijing 100081

The Tibetan Plateau(TP) is a key area affecting forecasts of weather and climate in China and occurrences of extreme weather and climate events over the world. The China Meteorological Administration, the National Natural Science Foundation of China, and the Chinese Academy of Sciences jointly initiated the Third Tibetan Plateau Atmospheric Science Experiment(TIPEX-Ⅲ) in 2013, with an 8–10-yr implementation plan. Since its preliminary field measurements conducted in 2013, routine automatic sounding systems have been deployed at Shiquanhe, Gaize, and Shenzha stations in western TP, where no routine sounding observations were available previously. The observational networks for soil temperature and soil moisture in the central and western TP have also been established. Meanwhile, the plateau-scale and regional-scale boundary layer observations, cloud–precipitation microphysical observations with multiple radars and aircraft campaigns, and tropospheric–stratospheric air composition observations at multiple sites, were performed. The results so far show that the turbulent heat exchange coefficient and sensible heat flux are remarkably lower than the earlier estimations at grassland, meadow, and bare soil surfaces of the central and western TP. Climatologically, cumulus clouds over the main body of the TP might develop locally instead of originating from the cumulus clouds that propagate northward from South Asia. The TIPEX-Ⅲ observations up to now also reveal diurnal variations, macro-and microphysical characteristics, and water-phase transition mechanisms, of cumulus clouds at Naqu station. Moreover, TIPEX-Ⅲ related studies have proposed a maintenance mechanism responsible for the Asian "atmospheric water tower" and demonstrated the effects of the TP heating anomalies on African, Asian, and North American climates. Additionally, numerical modeling studies show that the Γ distribution of raindrop size is more suitable for depicting the TP raindrop characteristics compared to the M–P distribution, the overestimation o

关键词： Tibetan Plateau field observation data processing weather and climate numerical forecasting

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广西秸秆露天焚烧源排放清单及时空分布研究

环境污染与防治 2022年第5期44卷 631-638页

作者：刘慧琳莫招育覃纹穆奕君黄炯丽陈志明杨俊超李宏姣张达标吴影段炼广西壮族自治区环境保护科学研究院广西南宁530022 广西西江流域生态环境与一体化发展协同创新中心广西南宁530022 复旦大学环境科学与工程系上海200433 南宁师范大学自然资源与测绘学院广西南宁530001 南宁师范大学健康地理教育与信息中心广西南宁530001

秸秆露天焚烧一直是影响广西冬季环境空气质量的主要因素,秸秆露天焚烧具有地方特色,是大气污染防治工作中的重中之重。基于大气污染源排放清单编制,采用排放因子法测算了广西秸秆露天焚烧源排放清单,利用环境空气质量数据和火点监控数... 详细信息

秸秆露天焚烧一直是影响广西冬季环境空气质量的主要因素,秸秆露天焚烧具有地方特色,是大气污染防治工作中的重中之重。基于大气污染源排放清单编制,采用排放因子法测算了广西秸秆露天焚烧源排放清单,利用环境空气质量数据和火点监控数据,分析了秸秆露天焚烧污染物的时空分布特征。结果表明,广西2019年秸秆露天焚烧排放污染物量为CO 80.7万t、可吸入颗粒物(PM_(10))14.8万t、细颗粒物(PM_(2.5))14.5万t、挥发性有机物(VOCs)15.9万t、SO_(2)1.1万t、NO_(x) 5.1万t、黑碳(BC)1.9万t、有机碳(OC)8.3万t和NH_(3)1.0万t,其中甘蔗秸秆焚烧污染物排放贡献占比为82.1%~87.8%,是广西主要的大气污染源。每年11月至次年2月是广西甘蔗秸秆焚烧主要时段,该季节气象条件利于焚烧且不易扩散,对环境空气质量影响较大。来宾市22:00和崇左市9:00左右秸秆露天焚烧特征明显。

关键词：甘蔗秸秆露天焚烧排放清单时空分布

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通达之家微信小程序开发

信息技术与信息化 2021年第6期 78-80页

作者：蔡达标陈红刘庆渝贾霞南京邮电大学通达学院江苏扬州225129

随着互联网的发展,“智慧校园”建设取得了不错的成果,但依然存在着不小的问题,比如,用户为实现查询成绩和查询空余自习室功能,来回切换花费大量时间和占用手机大量的内存。针对以上问题,运用所学知识及上网翻阅的资料,采用javascript、... 详细信息

随着互联网的发展,“智慧校园”建设取得了不错的成果,但依然存在着不小的问题,比如,用户为实现查询成绩和查询空余自习室功能,来回切换花费大量时间和占用手机大量的内存。针对以上问题,运用所学知识及上网翻阅的资料,采用javascript、css、html等语言,研发了以南京邮电大学通达学院校园生活为主体的微信小程序平台使用微信开发者工具进行开发,从技术要点、开发背景、程序设想、程序框架结构的搭建以及软件系统中涉及的主要功能模块,进行详细阐述。

关键词：多功能功能模块微信小程序