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Science China Life Sciences 2024年

作者： Dexin zhang Rui Zheng Zhoutong Chen Liren Wang Xi Chen Lei Yang Yanan Huo Shuming Yin Dan zhang Jiaxin Huang Xingang Cui dali Li Hongquan Geng Department of Urology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of Urology Children's Hospital of Fudan University Shanghai Frontiers Science Center of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University

Primary hyperoxaluria type 1(PH1) is a severe hereditary disease, leading to the accumulation of oxalate in multiple organs, particularly the kidney. Hydroxyacid oxidase 1(HAO1), a pivotal gene involved in oxalate production, is an approved target for the treatment of PH1. In this study, we demonstrated the discovery of several novel therapeutic sites of the Hao1 gene and the efficient editing of Hao1 c.290-2 A in vivo with lipid nanoparticles(LNP) delivered adenine base editing(ABE) mR NA. A single infusion of LNP-ABE resulted in a near-complete knockout of Hao1 in the liver, leading to the sustainable normalization of urinary oxalate(for at least 6 months) and complete rescue of the pathophysiology in PH1 rats. Additionally, a significant correlation between Hao1 editing efficiency and urinary oxalate levels was observed and over60% Hao1 editing efficiency was required to achieve the normalization of urinary oxalate in PH1 rats. These findings suggest that the LNPmediated base-editing of Hao1 c.290-2 A is an efficient and safe approach to PH1 therapy, highlighting its potential utility in clinical settings.

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改进萤火虫算法及其收敛性分析

系统工程与电子技术 2022年第4期44卷 1291-1300页

作者：张大力夏红伟张朝兴马广程王常虹哈尔滨工业大学航天学院黑龙江哈尔滨150001 上海航天控制技术研究所上海201109

萤火虫算法因具有结构简单、控制参数少、易于实现的特点而得到广泛的关注和应用,但其易陷入局部最优导致过早收敛,从而影响寻优精度。针对这一问题,本文在位置更新规则中加入随机扰动因子,并剔除了冗余的随机项,以提高算法搜索能力;引... 详细信息

萤火虫算法因具有结构简单、控制参数少、易于实现的特点而得到广泛的关注和应用,但其易陷入局部最优导致过早收敛,从而影响寻优精度。针对这一问题,本文在位置更新规则中加入随机扰动因子,并剔除了冗余的随机项,以提高算法搜索能力;引入位置置换变异和差分进化算法中的最优变异策略,在保持种群多样性的同时,增强算法跳出局部最优的能力。采用马尔可夫过程证明了算法以概率1收敛到全局最优。利用基准函数和装箱问题对算法进行仿真测试,结果表明,改进后的算法能够有效跳出局部最优,对给出的所有问题均能找到理论最优解,寻优精度和成功率有明显提升。

关键词：萤火虫算法随机扰动变异策略马尔可夫过程函数优化装箱问题

LAZY4 acts additively with the starch-statolithdependent gravity-sensing pathway to regulate shoot gravitropism and tiller angle in rice

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Plant Communications 2024年第10期5卷 154-165页

作者： Wenguang Wang Linzhou Huang Yuqi Song Songtao Gui Jiajia Cao Han zhang Mengchen Du Jiaze Chen Zihao Wang Jie Zhou Xiangbing Meng dali Zeng Jiayang Li Yonghong Wang National Key Laboratory of Wheat Improvement College of Life SciencesShandong Agricultural UniversityTai’an 271018China Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100039China Yazhouwan National Laboratory Sanya 572024China College of Advanced Agricultural Sciences Zhejiang A&F UniversityHangzhou 311300China

Rice tiller angle is a key agronomic trait that has significant effects on the establishment of a high-yield rice ***,the molecular mechanism underlying the control of rice tiller angle remains to be clar***,we characterized the novel tiller-angle gene LAZY4(LA4)in rice through map-based ***4 encodes a C3H2C3-type RING zinc-finger E3 ligase localized in the nucleus,and an in vitro ubiquitination assay revealed that the conserved RING finger domain is essential for its E3 ligase *** found that expression of LA4 can be induced by gravistimulation and that loss of LA4 function leads to defective shoot gravitropism caused by impaired asymmetric auxin redistribution upon *** analysis demonstrated that LA4 acts in a distinct pathway from the starch biosynthesis regulators LA2 and LA3,which function in the starch-statolith-dependent *** genetic analysis showed that LA4 regulates shoot gravitropism and tiller angle by acting upstream of LA1 to mediate lateral auxin transport upon *** studies reveal that LA4 regulates shoot gravitropism and tiller angle upstream of LA1 through a novel pathway independent of the LA2-LA3-mediated gravity-sensing mechanism,providing new insights into the rice tiller-angle regulatory network.

关键词： auxin shoot gravitropism tiller angle LAZY4 rice

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GEO混合推力机动目标跟踪IMM算法

宇航学报 2023年第3期44卷 443-453页

作者：王常虹张大力夏红伟马广程哈尔滨工业大学航天学院哈尔滨150001

针对交互多模型(IMM)算法求解地球静止轨道(GEO)卫星混合推力机动目标跟踪问题时模型匹配难、模型转移概率近似平均和响应速度慢的问题,从交互模型集构建和模型转移概率自适应设计两个方面出发提出一种改进IMM算法。该方法通过考虑无机... 详细信息

针对交互多模型(IMM)算法求解地球静止轨道(GEO)卫星混合推力机动目标跟踪问题时模型匹配难、模型转移概率近似平均和响应速度慢的问题,从交互模型集构建和模型转移概率自适应设计两个方面出发提出一种改进IMM算法。该方法通过考虑无机动、脉冲机动和有限推力机动三种模式,构建了覆盖目标机动状态的交互模型集,提高了模型与机动目标实际运行状态的匹配度;采用一种基于加速度估计自适应修正的模型交互概率修正方法,提升了算法对目标机动状态的响应速度和跟踪精度。仿真结果表明,所提算法是解决混合推力模式下的GEO机动目标跟踪问题的有效手段,在收敛速度和收敛精度等方面与传统方法相比有较大提高。

关键词：地球静止轨道卫星机动目标跟踪混合推力交互多模型(IMM) 轨道机动

Chiral phonon activated spin Seebeck effect in chiral materials

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 149-155页

作者： Xiao Li Jinxin Zhong Jinluo Cheng Hao Chen Huiqian Wang Jun Liu dali Sun Lifa zhang Jun Zhou Phonon Engineering Research Center of Jiangsu Province Center for Quantum Transport and Thermal Energy ScienceSchool of Physics and TechnologyNanjing Normal UniversityNanjing 210023China Center for Phononics and Thermal Energy Science China-EU Joint Lab for NanophononicsSchool of Physics Science and EngineeringTongji UniversityShanghai 200092China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of ScienceChangchun 130033China Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleigh NC 27606USA Department of Physics North Carolina State UniversityRaleigh NC 27695USA Organic and Carbon Electronics Laboratories(ORaCEL) North Carolina State UniversityRaleigh NC 27606USA

Efficient generation of spin polarization is very important for spintronics and quantum computation. In chiral materials without magnetic order nor spin-orbit coupling, we find a new spin selectivity effect—chiral phonon activated spin Seebeck(CPASS)effect. Starting with the nonequilibrium distribution of chiral phonons under a temperature gradient, the CPASS coefficients are computed based on the Boltzmann transport theory. With both the phonon-drag and band transport contributions, the spin accumulations generated by the CPASS effect exhibit quadratic dependence on the temperature gradient. The strength of the CPASS effect and the relative magnitude of both contributions are tunable by the chemical potential modulation. The CPASS effect, which gives a promising explanation on the traditional chiral-induced spin selectivity effect, provides opportunities for the exploration of advanced spintronic devices based on chiral materials even in the absence of any magnetic order and spin-orbit coupling.

关键词： spin Seebeck effect chiral phonon phonon-drag contribution efficient spin generation

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图象分析中的松驰标记法

中国图象图形学报（A辑） 1998年第2期3卷 96-99页

作者：戴剑彬张大力清华大学自动化系

松驰标记法是指对图中的每个目标进行标记指派，利用先验上下文信息进行迭代，寻求最大协调标记集的一种方法。此文推导了一种新的概率松驰法，分析了随机松驰法的迭代公式，利用马尔科夫随机场（ＭＲＦ）与吉布斯（Ｇｉｂｂｓ）分布的... 详细信息

松驰标记法是指对图中的每个目标进行标记指派，利用先验上下文信息进行迭代，寻求最大协调标记集的一种方法。此文推导了一种新的概率松驰法，分析了随机松驰法的迭代公式，利用马尔科夫随机场（ＭＲＦ）与吉布斯（Ｇｉｂｂｓ）分布的等价性来计算局部特性概率，用最大熵（ＭＥ）原理对条件邻域概率进行估计。最后对概率松驰法和随机松驰法进行了比较。

关键词：图象分析松驰标记法最大熵图象分割

基于“虚拟物流”理念的粮食物流市场运行体系建设

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粮食与饲料工业 2009年第10期 7-8页

作者：孙宏岭张大利河南工业大学经济贸易学院河南郑州450001

随着信息化、网络化的发展,物流的实体网络与虚拟网络的无缝结合已经成为现代物流需求的首要目标和物流行业的发展方向。虚拟物流就是通过信息技术和计算机网络技术整合物流服务的供给资源和需求信息,加强信用管理的产物。探讨了虚拟物... 详细信息

随着信息化、网络化的发展,物流的实体网络与虚拟网络的无缝结合已经成为现代物流需求的首要目标和物流行业的发展方向。虚拟物流就是通过信息技术和计算机网络技术整合物流服务的供给资源和需求信息,加强信用管理的产物。探讨了虚拟物流的要素,重点分析了粮食物流市场运行体系中"虚拟物流"理念的应用,为客户提供了一体化的供应链解决方案,降低了物流成本。

关键词：虚拟物流粮食物流供应链

GR5 acts in the G protein pathway to regulate grain size in rice

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Plant Communications 2024年第1期5卷 181-195页

作者： Yueying Wang Yang Lv Haiping Yu Peng Hu Yi Wen Junge Wang Yiqing Tan Hao Wu Lixin Zhu Kaixiong Wu Bingze Chai Jialong Liu dali Zeng Guangheng zhang Li Zhu Zhenyu Gao Guojun Dong Deyong Ren Lan Shen Qiang zhang Qing Li Longbiao Guo Guosheng Xiong Qian Qian Jiang Hu State Key Laboratory of Rice Biology and Breeding China National Rice Research InstituteHangzhou 310006China Hainan Yazhou Bay Seed Laboratory Sanya 572024HainanChina National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572024China Nanjing Agricultural University Nan Jing 210000JiangsuChina

Grain size is an important determinant of grain yield in *** dozens of grain size genes have been reported,the molecular mechanisms that control grain size remain to be fully ***,we report the cloning and characterization of GR5(GRAIN ROUND 5),which is allelic to SMOS1/SHB/RLA1/NGR5 and en-codes an AP2 transcription ***5 acts as a transcriptional activator and determines grain size by influencing cell proliferation and *** demonstrated that GR5 physically interacts withfive Gg subunit proteins(RGG1,RGG2,DEP1,GS3,and GGC2)and acts downstream of the G protein *** downstream target genes of GR5 in grain development(DEP2,DEP3,DRW1,and CyCD5;2)were re-vealed and their core T/CGCAC motif identified by yeast one-hybrid,EMSA,and ChIP–PCR *** results revealed that GR5 interacts with Gg subunits and cooperatively determines grain size by regu-lating the expression of downstream target *** provide new insight into the genetic reg-ulatory network of the G protein signaling pathway in the control of grain size and provide a potential target for high-yield rice breeding.

关键词： grain size G proteinγsubunit GR5 AP2 transcription factor rice(Oryza sativa L.)

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多模式混合推进悬停控制与半物理仿真系统

中国惯性技术学报 2019年第4期27卷 538-545页

作者：任家栋张大力夏红伟曾庆双哈尔滨工业大学航天学院

随着空间任务复杂度的提高,相对运动控制地面验证系统的设计难度日益增加,尤其对于地球静止轨道卫星,相对运动构型涉及伴飞、绕飞、悬停等各种形式。针对静止轨道卫星悬停控制的新需求,基于相对轨道参数描述方法,采用半长轴差和偏心率... 详细信息

随着空间任务复杂度的提高,相对运动控制地面验证系统的设计难度日益增加,尤其对于地球静止轨道卫星,相对运动构型涉及伴飞、绕飞、悬停等各种形式。针对静止轨道卫星悬停控制的新需求,基于相对轨道参数描述方法,采用半长轴差和偏心率差两个参数对面内“水滴”悬停构型的形成进行了深入研究,提出了一种多模式混合推进模式下的面内悬停两参数设计方法,并设计了一套通用的空间运动仿真验证系统,位置精度达毫米量级。对该构型的制导控制律进行了半物理验证,半实物仿真位置估计误差约为20 m(3σ),结果表明制导控制律正确,所提出的验证方法可推广应用于其它相对运动控制技术的地面验证。

关键词：相对运动水滴悬停多模式电推进半物理仿真系统

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基于质性研究的河南省科技人才政策焦点分析

科技管理研究 2020年第9期40卷 93-97页

作者：张大力葛玉辉河南城建学院管理学院河南平顶山467036 上海理工大学管理学院上海200093

以河南省为例,对科技主管部门官网78条科技政策进行质性研究,通过关键词共词网络分析发现,高端科技人才是政策关注的焦点。高端科技人才具体包括高层次人才和高技能人才,政策重视对这两类人才的培育和使用。科技人才政策焦点既体现当前... 详细信息

以河南省为例,对科技主管部门官网78条科技政策进行质性研究,通过关键词共词网络分析发现,高端科技人才是政策关注的焦点。高端科技人才具体包括高层次人才和高技能人才,政策重视对这两类人才的培育和使用。科技人才政策焦点既体现当前科技发展的特点,也反映科技人力资源的现实矛盾,未来政策改进应更加重视政策体系的完善行、耦合性和操作性。

关键词：科技政策科技人才人才政策质性研究