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Highly efficient gene silencing and bioimaging based on fluorescent carbon dots in vitro and in vivo

Nano Research 2017年第2期10卷 503-519页

作者： Seongchan Kim Yuri Choi Ginam Park Cheolhee Won Young-Joon Park Younghoon Lee Byeong-Su Kim dai-hee min Center for RNA Research Institute for Basic Sciences (IBS) Department of Chemistry Seoul National University Seou108826 Republic of Korea Department of Energy Engineering and Department of Chemistry Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea Institute of Nanobio Convergence Technology Lemonex Inc. Seou108826 Republic of Korea College of Pharmacy Ajou University Worldcuplo 206 Yeongtong-gu Suwon 16499 Republic of Korea Department of Chemistry Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

Small interfering RNA （siRNA） is an attractive therapeutic candidate for sequence- specific gene silencing to treat incurable diseases using small molecule drugs. However, its efficient intracellular delivery has remained a challenge. Here, we have developed a highly biocompatible fluorescent carbon dot （CD）, and demonstrate a functional siRNA delivery system that induces efficient gene knockdown in vitro and in vivo. We found that CD nanoparticles （NPs） enhance the cellular uptake of siRNA, via endocytosis in tumor cells, with low cytotoxicity and unexpected immune responses. Real-time study of fluorescence imaging in live cells shows that CD NPs favorably localize in cytoplasm and successfully release siRNA within 12 h. Moreover, we demonstrate that CD NP-mediated siRNA delivery significantly silences green fluorescence protein （GFP） expression and inhibits tumor growth in a breast cancer cell xenograft mouse model of tumor-specific therapy. We have developed a multifunctional siRNA delivery vehicle enabling simultaneous bioimaging and efficient downregulation of gene expression, that shows excellent potential for gene therapy.

关键词： bioimaging carbon dot gene delivery RNA interference targeted cancer therapy

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Ultralight and superelastic MXene/reduced graphene oxide aerogels for electromagnetic interference shielding

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Nano Research 2025年第1期18卷 1-9页

作者： Xinfeng Zhou Yang dai Guoyao Yue Yiman Zhang Lulu Li Zhong-Zhen Yu Peng min Hao-Bin Zhang 21 State Key Laboratory of Organic-Inorganic Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Beijing Key Laboratory of Advanced Functional Polymer Composites College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Present address:BOE Technology Innovation Center BOE Technology Group Co.Ltd.Beijing 100176China Xi’an Modern Chemistry Research Institute Xi’an 710065China

Lightweight aerogels feature multifunctionality and a high porosity,yet accompanied with poor structure recovery under large strain *** this work,we develop an air bubble-ice crystal dual template and annealing strategy to integrate low density and high resilience for the conductive transition metal carbides/nitrides(MXene)composite *** air bubbles and ice crystals synergistically exclude the nanosheets to the gas-liquid interfaces,thereby constructing unique Y-shaped junctions and robust *** annealing process greatly enhances the interlayer *** external load,the Yshaped structures prevent the stress concentration at the junctions by transferring the forces to the skeleton for maintaining structural *** addition,the wrinkled and thick cell walls,together with the enhanced interlayer interactions,endow the aerogel with exceptional structural stability and *** a result,the MXene/reduced graphene oxide(RGO)composite aerogels exhibit superelasticity with reversible compressive strains of up to 95%.In addition,the electron bridging effect of the RGO sheets affords the aerogel to deliver excellent electromagnetic interference shielding performance,as high as 46.3 dB at 2.5 ***,the remarkable reshapeability of the aerogels allows for precise regulation of structure and performance(33.5-75.1 dB)by a simple wetting compression *** summary,this work offers helpful inspirations for developing lightweight and superelasticity aerogels for extensive applications.

关键词： lightweight superelasticity MXene aerogel electromagnetic interference shielding reshapeability

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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Energy-efficient Approach to minimizing the Energy Consumption in An Extended Job-shop Scheduling Problem

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Chinese Journal of Mechanical Engineering 2015年第5期28卷 1048-1055页

作者： TANG Dunbing dai min College of Mechanical and Electrical Engineering Nanjing University of Aeronautics & Astronautics Jiangsu Key Laboratory of Precision and Micro-manufacturing Technology Nanjing University of Aeronautics & Astronautics

The traditional production planning and scheduling problems consider performance indicators like time, cost and quality as optimization objectives in manufacturing processes. However, environmentally-friendly factors like energy consumption of production have not been completely taken into consideration. Against this background, this paper addresses an approach to modify a given schedule generated by a production plarming and scheduling system in a job shop floor, where machine tools can work at different cutting speeds. It can adjust the cutting speeds of the operations while keeping the original assignment and processing sequence of operations of each job fixed in order to obtain energy savings. First, the proposed approach, based on a mixed integer programming mathematical model, changes the total idle time of the given schedule to minimize energy consumption in the job shop floor while accepting the optimal solution of the scheduling objective, makespan. Then, a genetic-simulated annealing algorithm is used to explore the optimal solution due to the fact that the problem is strongly NP-hard. Finally, the effectiveness of the approach is performed small- and large-size instances, respectively. The experimental results show that the approach can save 5%-10% of the average energy consumption while accepting the optimal solution of the makespan in small-size instances. In addition, the average maximum energy saving ratio can reach to 13%. And it can save approximately 1%-4% of the average energy consumption and approximately 2.4% of the average maximum energy while accepting the near-optimal solution of the makespan in large-size instances. The proposed research provides an interesting point to explore an energy-aware schedule optimization for a traditional production planning and scheduling problem.

关键词： energy consumption makespan production planning and scheduling job-shop floor different cutting speeds

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BRI1-Associated Receptor Kinase 1 Regulates Guard Cell ABA Signaling Mediated by Open Stomata 1 in Arabidopsis

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Molecular Plant 2016年第3期9卷 447-460页

作者： Yun Shang Changbo dai Myeong min Lee June M. Kwak Kyoung hee Nam Department of Biological Sciences Sookmyung Women's University Seou1140-742 Republic of Korea Department of Systems Biology Yonsei University Seou1120-749 Republic of Korea Department of New Biology Center for Plant Aging Research Institute for Basic Science Daegu Gyeongbuk Institute of Science and Technology Daegu 711-873 Republic of Korea

Stomatal movements are critical in regulating gas exchange for photosynthesis and water balance between plant tissues and the atmosphere. The plant hormone abscisic acid （ABA） plays key roles in regulating stomatal closure under various abiotic stresses. In this study, we revealed a novel role of BAKI in guard cell ABA signaling. We found that the brassinosteroid （BR） signaling mutant bakl lost more water than wild- type plants and showed ABA insensitivity in stomatal closure. ABA-induced OST1 expression and reactive oxygen species （ROS） production were also impaired in bakl. Unlike direct treatment with H202, overex-pression of OST1 did not completely rescue the insensitivity of bakl to ABA. We demonstrated that BAK1 forms a complex with OST1 near the plasma membrane and that the BAKI/OST1 complex is increased in response to ABA in planta. Brassinolide, the most active BR, exerted a negative effect on ABA-induced formation of the BAK1/OST1 complex and OST1 expression. Moreover, we found that BAK1 and ABI1 oppositely regulate OST1 phosphorylation in vitro, and that ABI1 interacts with BAK1 and inhibits the interaction of BAK1 and OST1. Taken together, our results suggest that BAK1 regulates ABA-induced stomatal closure in guard cells.

关键词： BAK1 OST1 ABA-induced stomatal closure Arabidopsis thaliana

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Modular Total Synthesis of (-)-Palmyrolide A and (+)-(5S,7S)-Palmyrolide A via Ring-Closing Metathesis and Alkene Isomerization

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Chinese Journal of Chemistry 2021年第1期39卷 69-74页

作者： Yecai Lai Wei-min dai Laboratory of Advanced Catalysis and Synthesis Department of Chemistry and Hong Kong Branch of the Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina Baiyunshan Pharmaceutical General Factory Guang-zhou Baiyunshan Pharmaceutical Holdings Co.Ltd.Guangzhou 510515China

A pentamodule assembly approach has been established for total synthesis of the naturally occurring(-)-palmyrolide A and(+)-5,7-epi-palmyrolide *** using the racemic tert-butyl carbinol-containing alkyl iodide,the two diastereoisomeric macrolides could be obtained from the same sequence of reactions,demonstrating the flexibility of the multimodule assembly strategy for diverted total synthesis.

关键词： Alkene B-Alky Suzuki-Miyaura cross-coupling Modular total synthesis Cross coupling Ring-closing metathesis

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An Adaptive Lagrangian Algorithm for Optimal Portfolio Deleveraging with Cross-Impact

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Journal of Systems Science & Complexity 2017年第5期30卷 1121-1135页

作者： XU Fengmin SUN min dai Yuhong School of Economics and Finance Xi'an Jiaotong UniversityXi'an 710049China School of Mathematics and Statistics Xi'an Jiaotong UniversityXi'an 710049China The State Key Laboratory of Scientific and Engineering Computing Institute of Computational Mathematics and Science//Engineering ComputingAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China

This paper considers the problem of optimal portfolio deleveraging, which is a crucial problem in finance. Taking the permanent and temporary price cross-impact into account, the authors establish a quadratic program with box constraints and a singly quadratic constraint. Under some assumptions, the authors give an optimal trading priority and show that the optimal solution must be achieved when the quadratic constraint is active. Further, the authors propose an adaptive Lagrangian algorithm for the model, where a piecewise quadratic root-finding method is used to find the Lagrangian multiplier. The convergence of the algorithm is established. The authors also present some numerical results, which show the usefulness of the algorithm and validate the optimal trading priority.

关键词： Adaptive Lagrangian algorithm deleveraging price cross-impact

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NEW CONSERVATION LAWS OF ENERGY AND C-D INEQUALITIES IN CONTINUA WITH MICROSTRUCTURE

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Applied Mathematics and Mechanics(English Edition) 2001年第2期22卷 135-143页

作者： dai Tian-min(戴天民) Center for the Application of Mathematics & Department of Mathematics Liaoning University Shenyang 110036 P R China

Existing fundamental laws, balance equations and Clausius-Duhem inequalities in continua with microstructure are systematically restudied, and the incomplete formulations of conservation laws of energy and related C-D inequalities are pointed out. Some remarks on existing results are made, and new conservation laws of energy and related C-D inequalities are presented.

关键词： continua with microstructure new conservation laws of energy new C-D inequalities

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NEW PRINCIPLES OF POWER AND ENERGY RATE OF INCREMENTAL RATE TYPE FOR GENERALIZED CONTINUUM FIELD THEORIES

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Applied Mathematics and Mechanics(English Edition) 2001年第12期22卷 1383-1389页

作者： dai Tian-min(戴天民) Center for the Application of Mathematics and Depertment of Mathematics Liaoning University Shenyang 110036 P R China

The aim of this paper is to establish new principles of power and energy rate of incremental type in generalized continuum mechanics BY combining new principles of virtual velocity and virtual angular velocity as well as of virtual stress anti virtual couple stress with c ross terms of incremental rate type a new principle of power anti energy rate of incremental rate type with cross terms for micropolar continuum field theories is presented and from it all corresponding equations of motion and boundary conditions as well as power and energy rate equations of incremental rate type for micropolar and nonlocal micropolar continua with the help of generalized Piola's theorems in all and without any additional requirement are derived. Complete results for micromorphic continua could be similarly derived. The derived results in the present paper are believed to be new. They could be used to establish corresponding finite element methods of incremental rate type for generalized continuum mechanics.

关键词： generalized continua incremental rate type principles of power and energy rate generalized Piola's theorem

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RESTUDY OF THEORIES FOR ELASTIC SOLIDS WITH MICROSTRUCTURE

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Applied Mathematics and Mechanics(English Edition) 2002年第8期23卷 867-874页

作者： dai Tian- min(戴天民) Department of Mathematics and Center for the Application of Mathematics Liaoning University Shenyang 110036 P R China

The dynamical theories of elastic solids with microstructure are restudied and the reason why so many notations have been introduced for derivation of basic equations for such theories is given. In view of the existing problems in those theories the rather general principle of power and energy rate is postulated and the equations of motion, the balance equations of energy rate and energy and the boundary conditions for local and nonlocal theories are naturally derived with help of that principle and the generalized Piola's theorem. These basic equations and the boundary conditions together with the initial conditions may be. used to solve the mixed problems of the dynamical theory of elastic solids with microstructure.

关键词： elastic solid microstructure principle of power and energy rate mixed problem

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