检索结果-南通市图书馆

Elevated peripheral levels of receptor-interacting protein kinase 1(RIPK1)and IL-8 as biomarkers of human amyotrophic lateral sclerosis

引用

Signal Transduction and Targeted Therapy 2024年第1期9卷 271-278页

作者： Jun Wei Min Li zhi Ye Xinqian Hu Xiaoyan He Jia Wang Gaofeng Chen Chengyu Zou daichao Xu Hongbing zha.g Junying Yuan Yunhong zha Institute of Neural Regeneration and Repair and Department of Neurology The First College of Clinical Medical ScienceYichang Central HospitalCollege of Basic Medical ScienceChina Three Gorges UniversityHubei Province Clinical Medical Research Center for Rare Diseases of Nervous SystemYichang 443000China Interdisciplinary Research Center on Biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai Key Laboratory of Aging StudiesShanghai 201210China State Key Laboratory of Common Mechanism Research for Major Diseases Haihe Laboratory of Cell EcosystemDepartment of PhysiologyInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Amyotrophic lateral sclerosis(ALS)is a devastating fatal neurodegenerative disease with no ***-interacting protein kinase 1(RIPK1)has been proposed to mediate pathogenesis of *** has been identified as an old drug that can also inhibit RIPK1 *** conducted a drug-repurposing biomarker study of primidone as a RIPK1 inhibitor using SOD1G93A mice and ALS ***1G93A mice treated with primidone showed significant delay of symptomatic onset and improved motor ***-hundred-sixty-two ALS participants dosed daily with primidone(62.5 mg)completed 24-week follow-up.A significant reduction was showed in serum levels of RIPK1 and IL-8,which were significantly higher in ALS patients than that of healthy controls(P<0.0001).Serum RIPK1 levels were correlated positively with the severity of bulbar symptoms(P<0.05).Our study suggests that serum levels of RIPK1 and IL-8 in peripheral can be used as clinical biomarkers for the activation of RIPK1 in central nervous system in human ALS *** primidone may provide a promising therapeutic strategy for *** effect of primidone for the treatment of other inflammatory diseases may also be considered,since the activation of RIPK1 has been implicated in mediating a variety of inflammatory diseases including COVID-19-associated cytokine release syndrome(CRS).(ChiCTR2200060149).

关键词： RIPK1 diseases Serum

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel PIKfyve/Tubulin Dual-target Inhibitor as a Promising Therapeutic Strategy for B-cell Acute Lymphoblastic Leukemia

引用

Current Medical Science 2024年第2期44卷 298-308页

作者： Zhen LU Qian LAI zhi-feng LI Meng-ya ZHONG Yue-long JIANG Li-ying FENG Jie zha.Jing-wei YAO Yin LI Xian-ming DENG Bing XU Department of Hematology The First Affiliated Hospital of Xiamen University and Institute of HematologySchool of MedicineXiamen UniversityXiamen361005China Key Laboratory of Xiamen for Diagnosis and Treatment of Hematological Malignancy Xiamen361005China Department of Oncology The First Affiliated Hospital of Jinan UniversityJinan UniversityGuangzhou510630China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkSchool of Life SciencesXiamen UniversityXiamen361003China

Objective:In B-cell acute lymphoblastic leukemia(B-ALL),current intensive chemotherapies for adult patients fail to achieve durable responses in more than 50%of cases,underscoring the urgent need for new therapeutic regimens for this patient *** present study aimed to determine whether HZX-02-059,a novel dual-target inhibitor targeting both phosphatidylinositol-3-phosphate 5-kinase(PIKfyve)and tubulin,is lethal to B-ALL cells and is a potential therapeutic for B-ALL ***:Cell proliferation,vacuolization,apoptosis,cell cycle,and in-vivo tumor growth were *** addition,Genome-wide RNA-sequencing studies were conducted to elucidate the mechanisms of action underlying the anti-leukemia activity of HZX-02-059 in ***:HZX-02-059 was found to inhibit cell proliferation,induce vacuolization,promote apoptosis,block the cell cycle,and reduce in-vivo tumor *** of the p53 pathway and suppression of the phosphoinositide 3-kinase(PI3K)/AKT pathway and the downstream transcription factors c-Myc and NF-κB were responsible for these ***:Overall,these findings suggest that HZX-02-059 is a promising agent for the treatment of B-ALL patients resistant to conventional therapies.

关键词： B-cell acute lymphoblastic leukemia dual-target inhibitor NF-kB c-Myc PI3K/AKT p53

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High percentage of bone marrow CD8^(+)tissue-resident-like memory T cells predicts inferior survival in patients with acute myeloid leukemia

引用

Blood Science 2024年第3期6卷 23-32页

作者： Letong Cai Wenpu Lai danlin Yao Yinfeng Gu Chaofeng Liang Lian Liu Jing Lai zhi Yu Xianfeng zha.Xibao Yu Xiuli Wu Shaohua Chen Oscar Junhong Luo Yangqiu Li Chunyan Wang Pengfei Qin Xin Huang Ling Xu Key Laboratory for Regenerative Medicine of Ministry of Education Institute of HematologySchool of MedicineDepartment of HematologyThe First Affiliated Hospital Jinan UniversityGuangzhou 510632China b Department of Systems Biomedical Sciences School of MedicineJinan UniversityGuangzhou 510632China Department of Clinical Laboratory First Affiliated HospitalJinan UniversityGuangzhou 510632China Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University) Ministry of EducationGuangzhou 510632China Department of Hematology First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouGuangdongChina Department of Hematology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdongChina

Tissue-resident memory T(TRM)cells infiltrating solid tumors could influence tumor progression and the response to immune ***,the proportion and prognostic value of TRM cells in the bone marrow(BM)of patients with acute myeloid leukemia(AML)are *** this study,we used flow cytometry to assay the phenotype of 49 BM samples from patients newly diagnosed with AML(ND-AML).We found that the BM CD8^(+)effector memory(TEM)cells highly expressed CD69(CD8^(+)TRM-like T cells),and their percentage was significantly increased in patients with ND-AML compared with that in healthy individuals(HI).The high percentage of CD8^(+)TRM-like subset was associated with poor overall survival in our ND-AML *** Kaplan–Meier Plotter database verified a significantly reduced survival rate among patients with high expression of CD8^(+)TRM-like T cell characteristic genes(CD8A,CD69,and TOX),especially the M4 and M5 *** analysis revealed that the BM CD8^(+)TRM-like subpopulation exhibited exhausted T cell characteristics,but its high expression of CD27 and CD28 and low expression of CD57 suggested its high proliferative *** single-cell proteogenomic dataset confirmed the existence of TRM-like CD8^(+)T cells in the BM of patients with AML and verified the high expression of immune checkpoints and costimulatory *** conclusion,we found that the accumulation of BM CD8^(+)TRM-like cells could be an immune-related survival prediction marker for patients with AML.

关键词： Acute myeloid leukemia Bone marrow CD69 Tissue-resident-like memory T cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

艰难梭菌致病机制研究进展

引用

微生物学杂志 2024年第3期44卷 113-122页

作者：查志强黄莉萍南方医科大学南方医院妇产科广东广州510515

艰难梭菌(Clostridium difficile)属于革兰阳性厌氧菌,可以导致艰难梭菌感染(Clostridium difficile infection,CDI),是伪膜性结肠炎和抗生素相关性腹泻的主要病原体,并与结肠癌、帕金森病、子痫前期等疾病相关,严重影响患者的健康。研... 详细信息

艰难梭菌(Clostridium difficile)属于革兰阳性厌氧菌,可以导致艰难梭菌感染(Clostridium difficile infection,CDI),是伪膜性结肠炎和抗生素相关性腹泻的主要病原体,并与结肠癌、帕金森病、子痫前期等疾病相关,严重影响患者的健康。研究表明,艰难梭菌可以通过毒素影响MAPK、NF-κB、TLR和ERS等信号转导,由鞭毛和膜囊泡介导炎症反应,与肠道微生物相互作用调节菌群代谢产物水平等途径参与致病。本文总结了艰难梭菌感染引起的相关疾病、致病机理和治疗现状。

关键词：艰难梭菌艰难梭菌感染信号转导肠道微生物膜囊泡

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

分级梯度蜂窝结构的面内压溃行为

引用

塑性工程学报 2024年第8期31卷 240-253页

作者：查曙光王士龙裴文杰黄志来安徽工业大学建筑工程学院安徽马鞍山243002 安徽工业大学机械工程学院安徽马鞍山243002

通过逐层在六边形胞元中引入次级结构的方式构建了4种具有分级梯度特性的蜂窝结构,采用ABAQUS/Explicit有限元软件对4种分级梯度构型蜂窝结构的面内压溃性能进行了数值模拟。结果表明,分级梯度的引入能够有效控制蜂窝结构准静态加载下... 详细信息

通过逐层在六边形胞元中引入次级结构的方式构建了4种具有分级梯度特性的蜂窝结构,采用ABAQUS/Explicit有限元软件对4种分级梯度构型蜂窝结构的面内压溃性能进行了数值模拟。结果表明,分级梯度的引入能够有效控制蜂窝结构准静态加载下变形带的产生和发展,使得不同分级阶数胞元的压溃失效进程以不同的平台应力水平反映在分级梯度蜂窝结构的宏观力学响应中。结合细观变形机制,分析了冲击速度和胞壁厚度对分级梯度蜂窝结构压溃响应和能量吸收性能的影响规律。在低速冲击下,采用中间高阶两端低阶胞元布置的对称分级梯度蜂窝结构表现出优异的吸能性能,与传统蜂窝结构相比,比吸能提高了95.66%。在高速冲击下,不同分级胞元的梯度设计能够改善蜂窝结构在压溃过程中的吸能性能,使得吸能结构的压溃过程能够得到有效调控。

关键词：分级梯度蜂窝结构面内压溃变形模式能量吸收

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ZnCl_2-assisted Synthesis of ZnSe Polycrystal

引用

Journal of Materials Science & Technology 2012年第4期28卷 373-378页

作者： Changyou Liu Tao Wang Gangqiang zha.zhi Gu Wanqi Jie State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710072China

A chemical-assisted element direct-reaction method is developed to synthesize ZnSe compound semiconductor material at a relatively low temperature （-1000 ℃）. ZnSe polycrystal was obtained in the closed-tube systems with Zn-Se, Zn-Se-Zn（NHa）2CI2, ZnoSe-NH4CI and Zn-Se-ZnCI2. The as-synthesized samples were tested by X-ray diffraction （XRD）, thermogravimetric analysis （TGA） and analyzed by thermodynamic numerical method. The results demonstrate that the synthesis efficiency is higher than 99.96% for Zn-Se-ZnCl2 system at around 1000 ℃ for 3 weeks. It also exhibits that not only temperature, but also low apparent ratio of volume and surface area of the source materials and higher ZnCl2 content are required to achieve high synthesis efficiency. A SeCI transporting reaction synthesis process is proposed based on the thermodynamic analysis.

关键词： Crystallites Growth from vapor Zinc compounds Semiconducting II-VI materials

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Surfactant-enhanced electrochemical detection of bisphenol A based on Au on ZnO/reduced graphene oxide sensor

引用

Rare Metals 2023年第4期42卷 1274-1282页

作者： Ai-Yun zha.Qing-Bing zha.zhi Li Hong-Min zha.g Xue-Feng Ma Wen Xie Ming-Shan Zhu Department of Nephrology The First Affiliated Hospital of Jinan UniversityGuangzhou510630China Department of Clinical Laboratory The Fifth Affiliated Hospital of Jinan University(Heyuan Shenhe People’s Hospital)Heyuan517000China Department of Obstetrics and Gynecology The First Affiliated Hospital of Jinan UniversityGuangzhou510630China Guangdong Key Laboratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou511443China

Bisphenol A(BPA),one of the most commonly used plastic organic monomers,is widely used in manufacturing food packaging and ***,the gradual emissions of BPA from manufacturing plastic products bring great potential in human health threats,which urgently need to develop a simple and rapid method for detecting *** bromide(CTAB),a typical surfactant,is used to enhance the electrochemical detection of trace endocrine disruptors due to the fact that it can effectively enrich and absorb hydrophobic phenolic compounds through the hydrophobicity of its long-chain *** on these,the present study reports a ternary composite of Au on zinc oxide/reduced graphene oxide nanosheets(Au/ZnO/rGO)as electrochemical sensor for detecting BP *** the addition of CTAB,the analytic performances toward BP A detection are significantly improved 3.8 times compared with those without *** pH,accumulation potential and time are ***,the electrochemical activity of CTAB/Au/ZnO/rGO sensor is also evaluated by cyclic voltammetry(CV),electrochemical impedance spectroscopy(EIS),differential pulse voltammetry(DPV)and scan *** sensor displays two linear range from 10to 1340 nmol·L^(-1)and 1340 to 10,000 nmol·L^(-1),and a low detection limit of 4.95 nmol·L^(-1).Lastly,the sensor also exhibits good reproducibility,selectivity and potential practical application for BPA detection in real samples.

关键词： Bisphenol A(BPA) Cetyltrimethylammonium bromide(TAB) Electrochemical detection(ED) Electron transmission

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于神经网络算法的LCDs模组强度提升研究

引用

现代电子技术 2024年第1期47卷 181-186页

作者：余平甲刘巍孙艳生查国平张智耿玉旭重庆京东方光电科技有限公司重庆400000 联想(上海)电子科技有限公司上海200000

针对超轻薄窄边框笔电显示模组强度不足导致的破片问题,提出一种基于神经网络的模组强度预测模型,旨在设计阶段评估LCDs模组强度表现,并指导系统设计。首先,基于系统组装受力分析,建立模组强度单体评价标准和实验平台;其次,基于有限元... 详细信息

针对超轻薄窄边框笔电显示模组强度不足导致的破片问题,提出一种基于神经网络的模组强度预测模型,旨在设计阶段评估LCDs模组强度表现,并指导系统设计。首先,基于系统组装受力分析,建立模组强度单体评价标准和实验平台;其次,基于有限元力学仿真,研究不同设计对模组强度的影响规律,确认模组强度关键影响因子;然后,基于单因子交叉实验研究,并通过神经网络算法对数据进行训练学习,建立模组强度预测模型。实验值与预测值对比表明,该模型可准确预测不同设计条件下的模组强度,为前期的强度优化和系统设计提供有效技术指导。

关键词：破片强度因子强度评价标准有限元仿真实验平台单因子试验神经网络强度预测

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

灌注球囊在动静脉瘘狭窄中的临床前可行性研究

引用

中国医疗器械信息 2024年第15期30卷 61-63,123页

作者：邢智凯范亚倩查城上海微创心脉医疗科技(集团)股份有限公司上海201318

目前,每年全国都有大量的终末期肾病患者接受维持性血液透析,自体动静脉瘘是其首选的血液通路之一,长期反复的透析会造成部分患者不同程度的透析通路的狭窄。尽管有一些解决方案被用于临床实践中,但这些方案存在效果不佳或者价格昂贵的... 详细信息

目前,每年全国都有大量的终末期肾病患者接受维持性血液透析,自体动静脉瘘是其首选的血液通路之一,长期反复的透析会造成部分患者不同程度的透析通路的狭窄。尽管有一些解决方案被用于临床实践中,但这些方案存在效果不佳或者价格昂贵的缺点,开发一种具有较低价格并临床收益良好的器械刻不容缓。该文章通过设计一种新型灌注球囊,结合抗增殖药物紫杉醇注射液,通过体外模拟实验,初步验证了该新型设备存在临床可行性,为后续的动物体内验证以及未来的临床实验提供了有效的理论支撑。

关键词：灌注球囊自体动静脉瘘血液透析紫杉醇

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Physical simulation of bubble refinement in bottom blowing process with mechanical agitation

引用

Journal of Iron and Steel Research International 2020年第10期27卷 1137-1144页

作者： Jian-ming Su zhi-he Dou Ting-an zha.Yan Liu Key Laboratory of Ecological Metallurgy of Multi-metal Intergrown Ores of Ministry of Education Northeastern UniversityShenyang 110819LiaoningChina

In order to increase the contact area and promote the mass transfer process of gas and liquid,the process of the bubble refine-ment in a metallurgical reactor with mechanical agitation was studied by physical *** on the capillary number,a prediction equation for the bubble refinement was *** effects of the gas flow rate,the stirring speed and thestirring depth on the bubble refinement in the reactor were discussed in *** distribution of the bubble diameter in thereactor was obtained under different *** results show that when the stirring speed reaches 300 r/min,the bubblediamcter mainly distributes in the range of 1-2 mm.A higher gas flow rate may increase the number of bubbles in the meltand promote the bubble refinement *** mechanism of bubble refinement under mechanical agitation was *** the results indicated that the stirring speed.,the blade area and the blade inclination are the main influencing factors.

关键词： Physical simulation Bottom blowing process Mechanical agitation Gas-liquid two-phase flow Bubble refinement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：