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Reorganization of 3D genome architecture provides insights into pathogenesis of early fatty liver disease in laying hens

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1086-1100页

作者： Yanli Liu Zhuqing Zheng Chaohui Wang Yumeng Wang Xi Sun Zhouzheng ren Xin Yang Xiaojun Yang College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Institute of Agricultural Biotechnology Jingchu University of TechnologyJingmen 448000China

Background Fatty liver disease causes huge economic losses in the poultry industry due to its high occurrence and lethality ***-dimensional(3D)chromatin architecture takes part in disease processing by regulating tran-scriptional *** study is carried out to investigate the alterations of hepatic 3D genome and H3k27ac profiling in early fatty liver(FLS)and reveal their effect on hepatic transcriptional reprogramming in laying *** Results show that FLS model is constructed with obvious phenotypes including hepatic visible lipid deposi-tion as well as higher total triglyceride and cholesterol in serum.A/B compartment switching,topologically associat-ing domain(TAD)and chromatin loop changes are identified by high-throughput/resolution chromosome conforma-tion capture(HiC)*** genes of these alternations in hepatic 3D genome organization significantly enrich pathways related to lipid metabolism and hepatic damage.H3k27ac differential peaks and differential expres-sion genes(DEGs)identified through RNA-seq analysis are also enriched in these ***,certain DEGs are found to correspond with changes in 3D chromatin structure and H3k27ac binding in their *** motif analysis reveals that candidate transcription factors are implicated in regulating transcriptional ***,disturbed folate metabolism is observed,as evidenced by lower folate levels and altered enzyme *** Our findings establish a link between transcriptional reprogramming changes and 3D chromatin struc-ture variations during early FLS formation,which provides candidate transcription factors and folate as targets for FLS prevention or treatment.

关键词： 3D chromatin architecture Fatty liver disease Folate H3k27ac profiling Transcription reprogramming

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The Modified BAPG_s Method for Support Vector Machine Classifier with Truncated Loss

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Applied Mathematics 2024年第4期15卷 267-278页

作者： kexin ren School of Information Science and Technology Jinan University Guangzhou China

In this paper, we modify the Bregman APGs (BAPGs) method proposed in (Wang, L, et al.) for solving the support vector machine problem with truncated loss (HTPSVM) given in (Zhu, W, et al.), we also add an adaptive parameter selection technique based on (ren, k, et al.). In each iteration, we use the linear approximation method to get the explicit solution of the subproblem and set a function to apply the Bregman distance. Finally, numerical experiments are performed to verify the efficiency of BAPGs.

关键词： HTPSVM Bregman Distance BAPGs Algorithm

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Rattling-like behavior and band convergence induced ultra-low lattice thermal conductivity in MgAl_(2)Te_(4) monolayer

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Journal of Materiomics 2024年第5期10卷 1004-1016页

作者： da Wan Shulin Bai Xiaodong Li Jingyi Zhang Peng Ai Wanrong Guo Shuwei Tang College of Materials Science and Engineering Liaoning Technical UniversityFuxinLiaoning123000China Faculty of Chemistry Northeast Normal UniversityChangchunJilin130024China

Inspired by the excellent stability exhibited by experimentally synthesized two-dimensional(2D)MoSi_(2)N_(4) layered material,the thermal and electronic transport,and thermoelectric(TE)properties of MgAl2Te4 monolayer are systematically investigated using the First-principles calculations and Boltzmann transport *** mechanical stability,dynamic stability,and thermal stability(900 k)of the MgAl_(2)Te_(4) monolayer are demonstrated,*** MgAl_(2)Te_(4) monolayer exhibits a bandgap of 1.35 eV using the HSE06 functional in combination with spin-orbit coupling(SOC)*** convergence in the valence band is favorable to improve the thermoelectric *** rattling thermal damping effect caused by the weak bonding of Mgsingle bondTe bonds in MgAl2Te4 monolayer leads to ultra-low lattice thermal conductivity(0.95/0.38 W/(m·k)@300 k along the x-/y-direction),which is further demonstrated by the phonon group velocities,phonon relaxation time,Grüneisen parameters,and scattering *** optimal zT of 3.28 at 900 k is achieved for the p-type MgAl_(2)Te_(4) monolayer,showing the great promising prospect for the excellent p-type thermoelectric *** current work not only reveals the underlying mechanisms responsible for the excellent TE properties,but also elaborates on the promising thermoelectric application of MgAl_(2)Te_(4) monolayer material at high temperature.

关键词： Thermoelectric material Mg atomic rattling Band convergence Ultra-low lattice thermal conductivity

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Mechanism of Wendan decoction in preventing obesity by regulating multiple signal pathway networks based on gene promoter methylation

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 93-100页

作者： Haiyan Yang Meiling ren Ziting Wu Jinchao Li Ping Wang School of Traditional Chinese Medicine Jiangxi University of Chinese MedicineNanchang 330004China Graduate School Jiangxi University of Chinese MedicineNanchang 330004China

Objective:To investigate the potential mechanism of Wendan decoction in obesity by screening target genes with promoter region methylation changes and constructing a multiple signaling pathways network based on promoter ***:The methylation degree of Itgad,Col8a1,Adra2b,Jund,Rab2a,Wnt8b,Fzd9,B4galt7,Pik3cd,Creb1,Stard8,and Mmp1 in the abdominal adipose tissue of obese rats was determined using the Agena MassARRAY *** blot was performed to assess protein expression *** genes were identified based on the methylation degree in the promoter region and protein *** analysis of signaling pathways was conducted to identify relevant target genes and obtain a multiple signaling pathway network associated with *** and terminal effector molecules in the pathway networks were selected as research targets for reverse transcription-polymerase chain reaction(RT-PCR)***:Four genes(Adra2b,Creb1,Itgad,and Pik3cd)showed a degree of promoter methylation consistent with their respective protein expression *** them,Adra2b,Creb1,and Pik3cd expression increased,while that of Itgad *** analysis revealed that Creb1 and Pik3cd were involved in 6 signaling pathways related to obesity:tumor necrosis factor(TNF)signaling pathway,growth hormone synthesis/secretion and action,adenosine 5'-monophosphate-activated protein kinase(AMPk)signaling pathway,relaxin signaling pathway,cyclic nucleotide(cAMP)signaling pathway,and phosphatidylinositol 3-kinase/protein kinase B(PI3k/Akt)signaling ***,a multiple signaling pathways network was constructed based on promoter *** molecules including protein kinase B(AkT),mechanistic target of rapamycin complex 1(mTORC1),and unc-51 like autophagy activating kinase 1(ULk1),as well as terminal effector molecules interleukin-1β(IL-1β),interleukin-6(IL-6),and chemokine(C-X-C motif)ligand 2(CXCL2)were selected as research *** decoct

关键词： Wendan decoction Obesity Signal pathway Methylation

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Effect of Magnetic Field Configuration on Stray-Crystal Formation with Different Platform Sizes during Directional Solidification of Single-Crystal Superalloy

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 904-914页

作者： keke Lu Congjiang Zhang Xiaotan Yuan Hongbin Yu Weili ren Biao Ding Haibiao Lu Yunbo Zhong Zuosheng Lei Hui Wang Qiuliang Wang Peter kLiaw Xuezhi Qin Lanzhang Zhou State key Laboratory of Advanced Special Steel Shanghai Key Laboratory of Advanced FerrometallurgyShanghai UniversityShanghai 200444China Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

The magnetic field is an effective means to control the solidification structure and the defects of metal and semiconductor *** work investigates the effects of Cusp magnetic field(CMF)and longitudinal magnetic field(LMF)on the stray-crystal formation in the platform regions during the directional solidification of single-crystal superalloy with the different cross section *** application of CMF reduces the formation of platform stray-crystal,while LMF increases its *** the platform size increases,the stray-crystal ratio increases regardless of whether the magnetic fields are applied or not,the effectiveness of CMF increases,while that of LMF *** reason that the effects of CMF and LMF on the platform stray-crystal formation could be attributed to the change of flow structure from the distribution characteristics of the thermoelectric magnetic force and the magnetic damping force near the liquid-solid interface.

关键词： Stray-crystal Magnetic field Single-crystal superalloy Cross section change Directional solidification

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Zero thermal expansion in Cs_(2)W_(3)O_(10)

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Chinese Chemical Letters 2024年第7期35卷 538-541页

作者： Juan Guo Mingyuan Fang Qingsong Liu Xiao ren Yongqiang Qiao Mingju Chao Erjun Liang Qilong Gao School of Physics&Microelectronics Key Laboratory of Materials Physics of Ministry of Education of ChinaZhengzhou UniversityZhengzhou 450052China

Zero thermal expansion materials are important for the practical applications due to their shape stability as changing *** reported concept of average atomic volume is an available method to hunt new zero thermal expansion ***,according to this concept,a tetragonal tungstate Cs_(2)W_(3)O_(10)with zero expansion has been *** is no structure phase transition as increasing temperature from 150 k to 573 *** coefficient of thermal expansion of axes and volume areαa=0.0074×10^(-6)k^(-1),αc=1.63×10^(-6)k^(-1),andαV=1.60×10^(-6)k^(-1),respectively,in the temperature range of 150~573 *** temperature-and pressure-dependent Raman spectra reveal that the vibrations of WO6octahedra libration modes with positive total anharmonicity and W-O-W bending mode with negative Grüneisen parameter are possibly the origin of zero thermal expansion in Cs_(2)W_(3)O_(10).

关键词： Zero thermal expansion Cesium tungstate Raman spectra Average atomic volume Temperature-dependent X-ray diffraction

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Discovering the ultralow thermal conductive A_(2)B_(2)O_(7)-type high-entropy oxides through the hybrid knowle dge-assiste d data-driven machine learning

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Journal of Materials Science & Technology 2024年第1期168卷 131-142页

作者： Ying Zhang ke ren William Yi Wang Xingyu Gao Ruihao Yuan Jun Wang Yiguang Wang Haifeng Song Xiubing Liang Jinshan Li State key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Innovation Center NPU ChongqingChongqing 401135China Institute of Advanced Structure Technology Beijing Institute of TechnologyHaidian DistrictBeijing 100081China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China Defense Innovation Institute Academy of Military Sciences of the PLA of ChinaBeijing 100071China

Lattice engineering and distortion have been considered one kind of effective strategies for discovering advanced *** instinct chemical flexibility of high-entropy oxides(HEOs)motivates/accelerates to tailor the target properties through phase transformations and lattice ***,a hybrid knowledge-assisted data-driven machine learning(ML)strategy is utilized to discover the A_(2)B_(2)O_(7)-type HEOs with low thermal conductivity(κ)through 17 rare-earth(RE=Sc,Y,La-Lu)solutes optimized A-site.A designing routine integrating the ML and high throughput first principles has been proposed to predict the key physical parameter(kPPs)correlated to the targetedκof advanced *** the smart-designed 6188(5RE_(0.2))_(2)Zr_(2)O_(7)HEOs,the best candidates are addressed and validated by the princi-ples of severe lattice distortion and local phase transformation,which effectively reduceκby the strong multi-phonon scattering and weak interatomic ***,(Sc_(0.2)Y_(0.2)La_(0.2)Ce_(0.2)Pr_(0.2))_(2)Zr_(2)O_(7)with predictedκbelow 1.59 Wm^(−1)k^(−1)is selected to be verified,which matches well with the ex-perimentalκ=1.69 Wm^(−1)k^(−1)at 300 k and could be further decreased to 0.14 Wm^(−1)k^(−1)at 1473 ***,the coupling effects of lattice vibrations and charges on heat transfer are revealed by the cross-validations of various models,indicating that the weak bonds with low electronegativity and few bond-ing charge density and the lattice distortion(r∗)identified by cation radius ratio(r A/r B)should be the kPPs to decreaseκ*** work supports an intelligent designing strategy with limited atomic and electronic kPPs to accelerate the development of advanced multi-component HEOs with proper-ties/performance at multi-scales.

关键词： High-entropy oxides Thermal conductivity Pyrochlore key physical parameter First-Principles

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Wear-resistant CoCrNi multi-principal element alloy at cryogenic temperature

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Science Bulletin 2024年第2期69卷 227-236页

作者： Yue ren Qing Zhou Dongpeng Hua Zhuobin Huang Yulong Li Qian Jia Peter Gumbsch Christian Greiner Haifeng Wang Weimin Liu State key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an 710072China Institute for Applied Materials Karlsruhe Institute of TechnologyKarlsruhe 76131Germany IAM-ZM MicroTribology CenterμTC Karlsruhe Institute of TechnologyKarlsruhe 76131Germany Fraunhofer IWM Freiburg 79108Germany State key Laboratory of Solid Lubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

Traditional high strength engineering alloys suffer from serious surface brittleness and inferior wear performance when servicing under sliding contact at cryogenic ***,we report that the recently emerging CoCrNi multi-principal element alloy defies this trend and presents dramatically enhanced wear resistance when temperature decreases from 273 to 153 k,surpassing those of cryogenic austenitic *** temperature-dependent structure characteristics and deformation mechanisms influencing the cryogenic wear resistance of CoCrNi are clarified through microscopic observation and atomistic *** is found that sliding-induced subsurface structures show distinct scenarios at different deformation *** cryogenic condition,significant grain refinement and a deep plastic zone give rise to an extended microstructural gradient below the surface,which can accommodate massive sliding deformation,in direct contrast to the strain localization and delamination at 273 ***,the temperature-dependent cryogenic deformation mechanisms(stacking fault networks and phase transformation)also provide additional strengthening and toughening of the subsurface *** features make the CoCrNi alloy particularly wear resistant at cryogenic conditions and an excellent candidate for safety–critical applications.

关键词： Multi-principal element alloy Cryogenic temperature Wear CoCrNi

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基于模拟-建模研究化学与温度对难熔高熵合金力学行为和变形机制的影响

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Acta Mechanica Sinica 2024年第2期40卷 103-115页

作者：李甲任思危刘彬 Peter k.Liaw 方棋洪 State key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha410082China State key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China Department of Materials Science and Engineering The University of TennesseeKnoxville37996USA

难熔高熵合金在高温下表现出优异的性能,突破了传统高温合金的工作温度上限.我们采用原子模拟研究了化学元素分布和温度对等原子比MoNbTaW难熔高熵合金变形机制的影响.根据微观结构演化,建立了基于微观结构的本构模型,定量评估多种强化... 详细信息

难熔高熵合金在高温下表现出优异的性能,突破了传统高温合金的工作温度上限.我们采用原子模拟研究了化学元素分布和温度对等原子比MoNbTaW难熔高熵合金变形机制的影响.根据微观结构演化,建立了基于微观结构的本构模型,定量评估多种强化机制的贡献.结果表明,应变硬化后,流动应力随应变呈锯齿状剧烈波动.由于退火结构的溶质浓度降低,温度升高降低了应变硬化率和流动应力波动幅度.变形孪晶在变形机制中起着关键作用,能够通过位错基塑性和晶粒中的非晶形核进一步调节局部变形.有序结构的存在强烈影响了应力和应变分配.固溶强化和晶界强化对流动应力的贡献很大,孪晶强化对流动压力的贡献很小.原子模拟和力学模型为深入理解难熔高熵合金变形行为及性能的精确预测提供依据.

关键词：流动应力固溶强化强化机制高温合金高熵合金变形机制晶界强化溶质浓度

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Effects of Diamond on the Mechanical Properties and Thermal Conductivity of Si_(3)N_(4)Composites Fabricated Using Spark Plasma Sintering

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Journal of Wuhan University of Technology(Materials Science) 2024年第5期39卷 1319-1324页

作者： GAO Ying LIU Di WANG Aiyang ZHANG Song HE Qianglong ren Shifeng FANG Jie WANG Zihan WANG Weimin State key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Jingdezhen Huaxun Special Ceramics Co.ltd. Jingdezhen 333000China Aerospace Science&Industry Defense Technology Research and Test Center Beijing 100854China

Micrometer-sized diamonds were incorporated into silicon nitride(Si_(3)N_(4))matrix to manufacture high-performance Si_(3)N_(4)-based composites using spark plasma sintering at 1500℃under 50 *** effects of the diamond content on the phase composition,microstructure,mechanical properties and thermal conductivity of the composites were *** results showed that the addition of diamond could effectively improve the hardness of the *** thermal conductivity of Si_(3)N_(4)increased to 52.97 W/m·k at the maximum with the addition of 15 wt%diamond,which was 27.5%higher than that of the monolithic Si_(3)N_(4).At this point,the fracture toughness was 7.54 MPa·m^(1/2).Due to the addition of diamond,the composite material generated a new substance,MgSiN2,which effectively combined Si_(3)N_(4)with ***2 might improve the hardness and thermal conductivity of the materials.

关键词： spark plasma sintering Si_(3)N_(4) diamond thermal conductivity mechanical properties

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