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Anomalous Sorption Kinetics of Self-Interacting Particles by a Spherical Trap

Communications in Computational Physics 2022年第3期31卷 707-738页

作者： Antonio Raudino Antonio Grassi Giuseppe Lombardo Giovanni Russo Clarissa Astuto Mario corti Department of Chemical Sciences University of CataniaViale A.Doria 6-95125CataniaItaly Department of Mathematics University of CataniaViale A.Doria 6-95125 CataniaItaly Applied Mathematics and Computational Science King Abdullah University of Science and Technology(KAUST)4700ThuwalSaudi Arabia CNR-IPCF Viale F.Stagno d’Alcontres 3798158 MessinaItaly

In this paper we propose a computational framework for the investigation of the correlated motion between positive and negative ions exposed to the attraction of a bubble surface that mimics the(oscillating)cell *** we aim to investigate the role of surface traps with substances freely diffusing around the *** physical system we want to model is an anchored gas drop submitted to a diffusive flowof charged surfactants(ions).When the diffusing surfactantsmeet the surface of the bubble,they are reversibly adsorbed and their local concentration is accurately *** correlated diffusion of surfactants is described by a Poisson-Nernst-Planck(PNP)system,in which the drift term is given by the gradient of a potential which includes both the effect of the bubble and the Coulomb interaction between the *** latter term is obtained from the solution of a self-consistent Poisson *** very short Debye lengths one can adopt the so called Quasi-Neutral limit which drastically simplifies the system,thus allowing for much faster numerical *** paper has four main *** first one is to present a PNP model that describes ion charges in presence of a *** second one is to provide benchmark tests for the validation of simplified multiscale models under current development[1].The third one is to explore the relevance of the term describing the interaction among the apolar tails of the *** last one is to quantitatively explore the validity of the Quasi-Neutral limit by comparison with detailed numerical simulation for smaller and smaller Debye *** order to reach these goals,we propose a simple and efficient Alternate Direction Implicit method for the numerical solution of the non-linear PNP system,which guarantees second order accuracy both in space and time,without requiring solution of nonlinear equation at each time *** semi-implicit scheme for a simplified PNP system near quasi neutrality is also p

关键词： Spherycal trap quasi-neutrality finite differences Coulomb potential Poisson-Nernst-Planck system ADI discretization semi-implicit scheme

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Hypergeometric equations and weighted projective spaces

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Science China Mathematics 2011年第8期54卷 1577-1590页

作者： corti Alessio GOLYSHEV Vasily Department of Mathematics Imperial College London Algebra and Number Theory Sector Institute for Information Transmission Problems

We compute the Hodge numbers of the polarised(pure) variation of Hodge structure V = grn-1WRn-1f!Z of the Landau-Ginzburg model f:Y → C mirror-dual to a weighted projective space wPn in terms of a variant of Reid's age function of the anticanonical cone over *** implies,for instance,that wPn has canonical singularities if and only if hn-1,0V = *** state a conjectural formula for the Hodge numbers of general hypergeometric *** show that a general fibre of the Landau-Ginzburg model is birational to a Calabi-Yau variety if and only if a general anticanonical section of wP is *** analyse the 104 weighted 3-spaces with canonical singularities,and show that a general anticanonical section is not a K3 surface exactly in those 9 cases where a generic fibre of the Landau-Ginzburg model is an elliptic surface of Kodaira dimension 1.

关键词：射影空间几何方程加权 Landau 模型椭圆面奇点纤维

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Hydrogen evolution kinetics on Ni cathodes modified by spontaneous deposition of Ag or Cu

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Journal of Energy Chemistry 2017年第3期26卷 466-475页

作者： Esteban A.Franceschini Gabriela I.Lacconi Horacio R.corti INFIQC-CONICET Departamento de Fisicoquímica–Facultad de Ciencias QuímicasUniversidad Nacional de CórdobaCiudad Universitaria5000 CórdobaArgentina Departamento de Física de la Materia Condensada Centro Atómico ConstituyentesComisión Nacional de Energía AtómicaAv.Gral.Paz 1499(B1650KNA)San MartínBuenos AiresArgentina INQUIMAE-CONICET Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresCiudad UniversitariaPabellón IIC1428EHABuenos AiresArgentina

Nickel modification by spontaneous deposition of transition metals such as Ag and Cu is shown as an economic and simple alternative for the activation of hydrogen evolution reaction（HER） on cathodes in alkaline media. The kinetics of HER is studied on Ni/Ag and Ni/Cu catalysts by cyclic voltammetry and electrochemical impedance spectroscopy（EIS） using a rotating disk electrode（RDE）. Freshly synthesized catalysts, as well as catalysts subjected to a short chronoamperometric ageing procedure, are analyzed and the kinetic and thermodynamic parameters of the HER are obtained. The nickel surface modified with transition metals with an outer shell electronic configuration [xd;（x+1）s;], such as Cu(3d;4s;)and Ag(4d;5s;), shows an improved activity for the HER compared to bare nickel. Furthermore, the Ni/Cu catalyst presents a decreased onset potential. The hydrogen evolution rate, measured as current density at –1.5 V（vs. SCE）, is similar on Ni/Cu and Ni/Ag electrodes.

关键词： Hydrogen evolution reaction Spontaneous deposition Nickel/Silver Nickel/Copper Electrochemical impedance spectroscopy

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NGR-tagged nano-gold： A new CD13-selective carrier for cytokine delivery to tumors

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Nano Research 2016年第5期9卷 1393-1408页

作者： Flavio Curnis Martina Fiocch Angelina Sacchi Alessandro Gori Anna Gasparri Angelo corti Division of Experimental Oncology IRCCS San Raffaele Scientific Institute Milan 20132 Italy Istituto di Chimica del Riconoscimento Molecolare CNR Milan 20131 Italy Vita Salute San Raffaele University Milan 20132 Italy

Colloidal gold （Au）, a well-tolerated several applications in nanomedicine. nanomaterial, is currently exploited for We show that gold nanoparticles tagged with a novel tumor-homing peptide containing Asn-Gly-Arg （NGR）, a ligand of CD13 expressed by the tumor neovasculature, can be exploited as carriers for cytokine delivery to tumors. Biochemical and functional studies showed that the NGR molecular scaffoldflinker used for gold functionalization is critical for CD13 recognition. Using fibrosarcorna-bearing mice, NGR-tagged nanodrugs could deliver extremely low, yet pharmacologically active doses of tumor necrosis factor （TNF）, an anticancer cytokine, to tumors with no evidence of toxicity. Mechanistic studies confirmed that CD13 targeting was a primary mechanism of drug delivery and excluded a major role of integrin targeting consequent to NGR deamidation, a degradation reaction that generates the isoAsp-Gly-Arg （isoDGR） integrin ligand. NGR-tagged gold nanoparticles can be used, in principle, as a novel platform for single- or multi-cytokine delivery to tumor endothelial cells for cancer therapy.

关键词： Asn-Gly-Arg (NGR) isoAsp-Gly-Arg (isoDGR) CD13 integrin tumor necrosis factor albumin gold nanoparticles

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Soil bacterial communities under slash and burn in Mozambique as revealed by a metataxonomic approach

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Pedosphere 2023年第3期33卷 508-520页

作者： Dominique SERRANI Ilario FERROCINO Cristiana GAROFALO Andrea OSIMANI Maria Rita CORVAGLIA Vesna MILANOVIĆ Lucia AQUILANTI Stefania COCCO Valeria CARDELLI Rogério Borguete Alves RAFAEL Elena FRANCIOSI Kieran TUOHY Francesca CLEMENTI Giuseppe corti Department of Agriculture Food and Environmental SciencesPolytechnic University of MarcheAncona 60131(Italy) Department of Agriculture Forest and Food SciencesUniversity of TurinGrugliasco 10095(Italy) Department of Rural Engineering Faculty of Agronomy and Forestry EngineeringUniversidade Eduardo MondlaneMaputo 257(Mozambique) Research and Innovation Center Fondazione Edmund Mach(FEM)San Michele all'Adige 38010(Italy)

The slash-and-burn system is a subsistence agronomical practice widespread in tropical areas *** system has been extensively studied,especially for its impacts on agronomical aspects and soil physicochemical properties;however,knowledge of soil microbial diversity under slash and bum is *** this study,for the first time,soil bacterial diversity of three locations from Central Mozambique,where slash and burn has been practiced for different durations of the forest fallow period(ca.25,35,and 50 years),was elucidated through a metataxonomic *** communities were evaluated in the genetic horizons of soils under charcoal kilns,crop fields,and *** aim of this study was to examine the influence of spatial(location and land use),temporal(forest fallow period),and vertical(horizon)variations on bacterial community structure in relation to soil physicochemical *** analysis detected 25 different phyla whose distribution varied horizontally and vertically in relation to soil properties(i.e.,p H,easily oxidizable organic carbon,total nitrogen,and available phosphorus),as well as particle size distribution and mineralogical *** properties were strongly affected and altered by land-use management;in particular,charcoal kilns exhibited better soil properties and greater differences in bacterial community than crop fields and forests,which were quite *** might suggest the inability of a forest fallow period shorter than 50 years to improve soil fertility and induce changes in bacterial *** uncommon application of the pedological approach for microbial evaluation facilitated the detection of a clear separation in bacterial composition along the soil profile,with eutrophic bacteria mainly located in the A horizon whereas oligotrophic bacteria were found in the Bo *** horizontal and vertical heterogeneities in the same study represent a novelty for bacterial metataxonomic analysis.

关键词： 16S rRNA gene agroforestry land use soil microbiota soil physicochemical property

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Nature-derived compounds modulating Wnt/β-catenin pathway:a preventive and therapeutic opportunity in neoplastic diseases

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Acta Pharmaceutica Sinica B 2020年第10期10卷 1814-1834页

作者： Gianluca Sferrazza Marco corti Gloria Brusotti Pasquale Pierimarchi Caterina Temporini Annalucia Serafino Enrica Calleri Department of Drug Sciences University of PaviaPavia 27100Italy Institute of Translational Pharmacology National Research Council of ItalyRome 03018Italy

The Wnt/β-catenin signaling is a conserved pathway that has a crucial role in embryonic and adult *** of the Wnt/β-catenin pathway has been associated with diseases including cancer,and components of the sisnaling have been proposed as innovative therapeutic targets,mainly for cancer *** attention of the worldwide researchers paid to this issue is increasing,also in view of the therapeutic potential of these agents in diseases,such as Parkinson’s disease(PD),for which no cure is existing *** evidence indicates that abnormal Wnt/β-catenin signaling is involved in tumor immunology and the targeting of Wnt/β-catenin pathway has been also proposed as an attractive strategy to potentiate cancer *** the last decade,several products,including naturally occurring dietary agents as well as a wide variety of products from plant sources,including curcumin,quercetin,berberin,and ginsenosides,have been identified as potent modulators of the Wnt/β-catenin signaling and have gained interest as promising candidates for the development of chemopreventive or therapeutic drugs for *** this review we make an overview of the nature-derived compounds reported to have antitumor activity by modulating the Wnt/β-catenin signaling,also focusing on extraction methods,chemical features,and bio-activity assays used for the screening of these compounds.

关键词： Wnt/β-catenin pathway Nature-derived compounds Anticancer therapy Cancer prevention

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Leukocytoclastic Vasculitis Following Ceftriaxone Exposure

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Open Journal of Nephrology 2022年第2期12卷 222-227页

作者： Alyssa damstrom Saira Khan Urma Jalil Eno-Obong Effiong Michael corti Hanady Zainah Lake Erie College of Osteopathic Medicine Erie USA Department of Internal Medicine St Johns’ Riverside Hospital Yonkers USA Department of Hospital Medicine St. John’s Riverside Hospital Yonkers USA St. John’s Riverside Hospital Yonkers USA

Leukocytoclastic vasculitis (LCV) is an immune-complex mediated inflammation of dermal capillaries and venules that can occur after infections, drugs, autoimmune disorders, neoplasms, or idiopathically. We present the case of a 59-year-old male who was treated with ceftriaxone for an abscess, S. aureus cellulitis, and osteomyelitis of his right second toe. Biopsy confirmed the diagnosis of LCV and symptoms resolved after ceftriaxone was discontinued and systemic corticosteroids were introduced.

关键词： Leukocytoclastic Vasculitis Immune-Complex Ceftriaxone LCV

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Clinical features of AIDS patients with Hodgkin's lymphoma with isolated bone marrow involvement:report of 12 cases at a single institution

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Cancer Biology & Medicine 2015年第1期12卷 41-45页

作者： Marcelo corti Maria Villafa?e Gonzalo Minue Ana Campitelli Marina Narbaitz Leonardo Gilardi HIV/AIDS Department F.J.Mu?iz Hospital Hematology Unit F.J.Mu?iz Hospital Histopathology Laboratory F.J.Mu?iz Hospital National Academy of Medicine Histopathology Laboratory Sociedad Iberoamericana de Informacion Cientifica Scientific Coordination

Objective: To study the main clinical and histopathological features of 12 patients with Hodgkin's lymphoma(HL) diagnosed primarily from bone marrow(BM) ***: We included 12 acquired immunodeficiency syndrome(AIDS) patients with HL assisted in the F. J. Mu?iz Infectious Diseases Hospital since January 2002 to December 2013. The diagnosis of HL with primary BM involvement in patients was confirmed by clinical, histopathological, and immunohistochemical ***: All patients presented "B" symptoms and pancytopenia. All of them had stage IV neoplasm disease because of BM infiltration. The median of CD4+ T-cell counts was 114 cells/μL, and mixed cellularity(MC) was the most frequent histopathological subtype of 92% ***: When other causes are excluded, BM biopsy should be performed in AIDS patients with "B" symptoms and pancytopenia to evaluate BM infiltration by atypical lymphocytes.

关键词：临床特征淋巴瘤艾滋病患者骨髓组织病理学机构分离

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Benefits of Biochars and NPK Fertilizers for Soil Quality and Growth of Cowpea (Vigna unguiculata L. Walp.) in an Acid Arenosol

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Pedosphere 2019年第3期29卷 311-333页

作者： Rogerio Borguete Alves RAFAEL Maria Luisa FERNANDEZ-MARCOS Stefania COCCO Maria Letizia RUELLO Flavio FORNASIER Giuseppe corti Department of Rural Engineering Faculty of Agronomy and Forestry Engineering Universidade Eduardo Mondlane Maputo 257 (Mozambique) Department of Agriculture Food and Environmental Sciences Univ er sit a Politecnica delle Marche Ancona 60131 (Italy) Department of Soil Science and Agricultural Chemistry Universidad de Santiago de Compostela Lugo 27002 (Spain) Department of Materials Environmental Sciences and Urban Planning Universita Politecnica delle Marche Ancona 60131 (Italy) Centro di Ricerca Viticoltura ed Enologia Gorizia 34170 (Italy) Instituto de Biodiv ersidade Agraria e Desenvolvimento Rural Universidad de Santiago de Compostela Lugo 27002 (Spain)

Fertilization is required for optimum plant growth, particularly in unfertile soils, while optimizing nutrient use effciency is an alternative to reduce inorganic fertilizer needs and reduce environmental problems caused by nutrient leaching. This study investigated soil properties and cowpea yield responses to biochars(BCs) made from different feedstocks, baby corn peel biochar(BC1), branches of mango tree biochar(BC2), and rice husk biochar(BC3), applied in combination with nitrogen-phosphorus-potassium(NPK) *** experiment was conducted in a greenhouse, using an acid sandy soil(Arenosol) that was submitted for 70 d to the following eight treatments: i) control;ii) full dose of NPK(a commercial compound fertilizer(12-24-12 of N-P2O5-K2O)+ urea(46% N));iii) BC1+ half dose of NPK;iv) BC1 + full dose of NPK;v) BC2 + half dose of NPK;vi) BC2 + full dose of NPK;vii) BC3 + half dose of NPK;and viii) BC3 + full dose of NPK. All biochars were applied at a rate of 0.9%(weight/weight), and each type of biochar was combined with half and full doses of NPK fertilizers. Soil pH increased significantly(P < 0.05) in treatments with BC1 and BC2,while cation exchange capacity(CEC) and available P were higher in the treatments with BC1;BC1 and BC2 also induced higher activity of enzymes related to the P cycle and higher cowpea yield. Similar soil properties and cowpea yield parameters were obtained with the full and half doses of NPK fertilizers for each type of biochar used. In conclusion, biochars in the combination with NPK fertilizers improved soil chemistry and enzymatic activities, allowing reduced fertilizer application and food production costs in the acid soil studied.

关键词： acid soil nutrient use effciency organic amendment plant growth potential enzyme activity soil fertility soil pH

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One step minilaparotomy-assisted transmesenteric portal vein recanalization combined with transjugular intrahepatic portosystemic shunt placement: A novel surgical proposal in pediatrics

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World Journal of Gastroenterology 2017年第15期23卷 2811-2818页

作者： Gloria Pelizzo Pietro Quaretti Lorenzo Paolo Moramarco Riccardo corti Marcello Maestri Giulio Iacob Valeria Calcaterra Department of Clinical SurgicalDiagnostic and Pediatric SciencesUniversity of Pavia Pediatric Surgery Unit Ospedale dei Bambini“G.di Cristina”Istituto Mediterraneo di Eccellenza Pediatrica Unit of Interventional Radiology Fondazione IRCCS Policlinico San Matteo Radiology Department IRCCS Policlinico San Matteo Foundation Department of Surgery IRCCS Policlinico San Matteo Foundation Pediatric Unit Department of Maternal and Children's HealthFondazione IRCCS Policlinico San Matteo Department of Internal Medicine and Therapeutics University of Pavia

Transjugular intrahepatic portosystemic shunt(TIPS) placement is a standard procedure for the treatment of portal hypertension complications. When this conventional approach is not feasible, alternative procedures for systemic diversion of portal blood have been proposed. A one-step interventional approach, combining minilaparotomy-assisted transmesenteric(MAT) antegrade portal recanalization and TIPS, is described in an adolescent with recurrent esophageal varice bleeding and portal cavernoma(PC). A 16-yearold girl was admitted to our Unit because of repeated bleeding episodes over a short period of time due to esophageal varices in the context of a PC. A portal vein recanalization through an ileocolic vein isolation with the MAT approach followed by TIPS during the same session was performed. In the case of failed portal recanalization, this approach, would also be useful for varice endovascular embolization. Postoperative recovery was uneventful. Treatment consisting of propanolol, enoxaparin and a proton pump inhibitor was prescribed after the procedure. One month post-op, contrast enhanced computed tomography confirmed the patency of the portal and intrahepatic stent grafts. No residual peritoneal fluid was detected nor opacification of the large varices. Endoscopy showed good improvement of the varices. Doppler ultrasound confirmed the accelerated flow in the portal stent and hepatopetal flow inside the intrahepatic portal branches. Three months post-op, TIPS maintained its hourglass shape despite a slight expansion. Portal hypertension and life threatening conditions related to PC would benefit from one-step portal recanalization. MAT-TIPS is feasible and safe for the treatment of PC even in children. This minimally invasive procedure avoids or delays surgical treatment or re-transplantation when necessary in pediatric patients.

关键词：门 cavernoma 儿科 Transjugular intrahepatic portosystemic 分流帮助 Minilaparotomy 的 transmesenteric

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