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Washed microbiota transplantation for Crohn’s disease:A metagenomic,metatranscriptomic,and metabolomic-based study

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World Journal of Gastroenterology 2024年第11期30卷 1572-1587页

作者： Shi-Ju Chen da-Ya Zhang Xia Wu Fa-Ming Zhang Bo-ta Cui Yi-Hao Huang Zu-Lun Zhang Rui Wang Fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Microbiota Medicine&Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina

BACKGROUND Fecal microbiota transplantation(FMT)is a promising therapeutic approach for treating Crohn’s disease(CD).The new method of FMT,based on the automatic washing process,was named as washed microbiota transplantation(WMT).Most existing studies have focused on observing the clinical ***,the mechanism of action of FMT for the effective management of CD-particularly in-depth multi-omics analysis involving the metagenome,metatranscriptome,and metabolome-has not yet been *** To assess the efficacy of WMT for CD and explore alterations in the microbiome and metabolome in response to *** We conducted a prospective,open-label,single-center clinical *** CD patients underwent *** clinical responses(defined as a decrease in their CD Activity Index score of>100 points)and their microbiome(metagenome,metatranscriptome)and metabolome profiles were evaluated three months after the *** Seven of the 11 patients(63.6%)showed an optimal clinical response three months *** microbiome diversity significantly increased after WMT,consistent with improved clinical *** of the metagenome and metatranscriptome analyses revealed consistent alterations in certain strains,such as Faecalibac-terium prausnitzii,Roseburia intestinalis,and Escherichia *** addition,metabolomics analyses demonstrated that CD patients had elevated levels of various amino acids before treatment compared to the ***,levels of vital amino acids that may be associated with disease progression(e.g.,L-glutamic acid,gamma-glutamyl-leucine,and prolyl-glutamine)were reduced after *** WMT demonstrated therapeutic efficacy in CD treatment,likely due to the effective reconstruction of the patient’s ***-omics techniques can effectively help decipher the potential mechanisms of WMT in treating CD.

关键词： Crohn’s disease Clinical trials Fecal microbiota transplant Metagenome Metatranscriptome Metabolome

Exponentially Bounded C-semigroup and the Cauchy Initial Value Problems in Complete Random Normed Modules

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2195-2212页

作者： Son ta CONG Thang dang HUNG Oanh Le THI Department of Mathematics University of ScienceVietnam National University 334 Nguyen TraiThanh XuanHanoiVietnam Faculty of Natural Sciences Hong Duc University565 Quang TrungDong VeThanh HoaVietnam

In this paper,the notion of C-semigroup of continuous module homomorphisms on a complete random normal(RN)module is introduced and *** existence and uniqueness of solution to the Cauchy problem with respect to exponen... 详细信息

关键词： C-semigroup Cauchy problem random normed modules L^(0)-Lipschitz

A robust vector tracking loop structure based on potential bias analysis

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Chinese Journal of Aeronautics 2024年第4期37卷 405-420页

作者： Qiongqiong Jia Yiran LUO Bing XU Li-ta HSU Renbiao WU Tianjin Key Lab for Advanced Signal Processing Civil Aviation University of ChinaTianjin 300300China Interdisciplinary Division of Aeronautical and Aviation Engineering The Hong Kong Polytechnic University999077Hong KongChina Department of Geomatics Engineering University of CalgaryCalgary T2N1N4Canada

This paper proposes a robust vector tracking loop structure based on potential bias analysis. The influence of four kinds of biases on the existing two implementations of Vector Tracking Loops(VTLs) is illustrated by theoretical analysis and numerical simulations, and the following findings are obtained. Firstly, the initial user state bias leads to steady navigation solution bias in the relative VTL, while new measurements can eliminate it in the absolute VTL. Secondly, the initial code phase bias is transferred to the following navigation solutions in the relative VTL, while new measurements can eliminate it in the absolute VTL. Thirdly, the user state bias induced by erroneous navigation solution of VTLs can be eliminated by both of the two VTLs. Fourthly,the multipath/NLOS likely affects the two VTLs, and the induced tracking bias in the duration of the multipath/NLOS would decrease the performance of VTLs. Based on the above analysis,a robust VTL structure is proposed, where the absolute VTL is selected for its robustness to the two kinds of initialization biases;meanwhile, the instant bias detection and correction method is used to improve the performance of VTLs in the duration of the multipath/NLOS. Numerical simulations and experimental results verify the effectiveness of the proposed robust VTL structure.

关键词： Global Navigation Satellite System(GNSS) Vector Tracking Loop(VTL) Multipath Non-Line-of-Sight(NLOS) Tracking bias propagation Least Absolute Shrinkage and Selection Operator(LASSO)

The Influence of Significant Public Health Events on Offline Consumption and Its Pathways

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Journal of Systems Science and Systems Engineering 2024年第5期33卷 627-648页

作者： Baile Lu Kewei Zhou Shuai Hao La ta Hongyan dai Weihua Zhou College of Systems Engineering National University of Defense TechnologyChangsha 410073China Business School Central University of Finance and EconomicsBeijing 100081China Department of Marketing and Operations Management College of BusinessSouthern University of Science and TechnologyShenzhen 518055China School of Management Zhejiang UniversityHangzhou 310058China

In the face of a significant public health event,consumers may either increase their panic buying or decrease their willingness to make *** study focuses on the impact of a significant public health event on offline store sales and consumer consumption,utilizing data from chain convenience stores in Hefei and Wuhu during early 2019 and early 2020 in *** a difference-in-differences model,the study investigates the effect of the significant public health event outbreak on weekly store sales,order numbers,and consumer consumption in terms of product quantities,transaction amount,average amount per order,and transaction *** from prior literature that finds hoarding behavior of consumers online,the findings of this paper indicate a significant reduction in stores’offline weekly sales and order numbers,as well as consumers’offline weekly consumption across the four dimensions,as a result of the significant public health event ***,employing a mediation model,the study explores the pathway of population mobility through which the significant public health event adversely affects offline ***,subset analysis is conducted for stores located in different areas and consumers with varying characteristics,revealing that the aforementioned conclusions predominantly apply to stores situated in office areas and residential areas,as well as consumers with either no apparent preference for different product categories or a noticeable preference for food.

关键词： Significant public health event offline consumption population mobility mediating effect

The impact of broad glutamine metabolism inhibition on the tumor microenvironment

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Genes & Diseases 2024年第3期11卷 2-4页

作者： Tianhe Li Yun-ta Chuang Tian-Li Wang Departments of Pathology Oncologyand Gynecology and ObstetricsThe Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21231USA

Glutamine is an importantα-amino acid that provides carbon and nitrogen sources for the biosynthesis of nucleotides,proteins,and *** also generates metabolites that fuel the tricarboxylic acid cycle and maintain intracellular redox *** cells have a heightened metabolic dependence on glutamine to support incessant tumor growth and mitigate tumor microenvironmental stresses including hypoxia,nutrient depletion.

关键词： metabolism tumor microenvironment

Study on 6-DOF active vibration-isolation system of the ultra-precision turning lathe based on GA-BP-PID control for dynamic loads

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Advances in Manufacturing 2024年第1期12卷 33-60页

作者： Bo Wang Zhong Jiang Pei-da Hu Department of Precision Instrument Tsinghua UniversityBeijing100084People’s Republic of China Institute of Machinery Manufacturing Technology China Academy of Engineering PhysicsMianyang621900SichuanPeople’s Republic of China

The vibration disturbance from an external environment affects the machining accuracy of ultra-precision machining *** active vibration-isolation systems(AVIS)have been developed based on static *** a vibration-isolation load changes dynamically during ultra-precision turning lathe machining,the system parameters change,and the efficiency of the active vibration-isolation system based on the traditional control strategy *** solve this problem,this paper proposes a vibration-isolation control strategy based on a genetic algorithm-back propagation neural network-PID control(GA-BP-PID),which can automatically adjust the control parameters according to the machining ***-isolation simulations and experiments based on passive vibration isolation,a PID algorithm,and the GA-BP-PID algorithm under dynamic load machining conditions were *** experimental results demonstrated that the active vibration-isolation control strategy designed in this study could effectively attenuate vibration disturbances in the external environment under dynamic load *** design is reasonable and feasible.

关键词： Ultra-precision diamond turning lathe Active vibration isolation Six degrees of freedom Dynamic load Genetic algorithm-back propagation neural network-PID(GA-BP-PID)control

Small-scale self-driving cars:A systematic literature review

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 271-292页

作者： Felipe Caleffi Lauren da Silva Rodrigues Joice da Silva Stamboroski Brenda Medeiros Pereira Autonomous Vehicles Laboratory Federal University of Santa MariaCachoeira do Sul 96503-205Brazil Mobility and Logistics Laboratory Federal University of Santa MariaCachoeira do Sul 96503-205Brazil

The autonomous vehicle(AV)technology has the potential to significantly improve safety and efficiency of the transportation and logistics ***-scale AV testing is limited by time,space,and cost,while simulation-based testing often lacks the necessary accuracy of AV and environmental *** recent years,several initiatives have emerged to test autonomous software and hardware on scaled *** systematic literature review provides an overview of the literature surrounding small-scale self-driving cars,summarizing the current autonomous platforms deployed and focusing on the software and hardware developments in this *** studies published in English-language journals or conference papers that present small-scale testing of self-driving cars were *** of Science,Scopus,Springer Link,Wiley,ACM Digital Library,and TRID databases were used for the literature *** systematic literature search found 38 eligible *** gaps in the reviewed papers were identified to provide guidance for future *** key takeaway emerging from this manuscript are:(i)there is a need to improve the models and neural network architectures used in autonomous driving systems,as most papers present only preliminary results;(ii)increasing datasets and sharing databases can help in developing more reliable control policies and reducing bias and variance in the training process;(iii)small-scaled vehicles to ensure safety is a major benefit,and incorporating data about unsafe driving behaviors and infrastructure problems can improve the accuracy of predictive models.

关键词： Self-driving car Autonomous vehicle Small-scale vehicle Systematic literature review

On the global smooth solutions of 3D incompressible Hall-MHD equations

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Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 319-327页

作者： YUE Gao-cheng SUN Wen-da School of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 211106China

The present paper is devoted to the well-posedness issue for the 3D incompressible Hall-MHD system obtained from kinetic models. Our analysis strongly relies on the use of the Fourier analysis. We establish the global existence of smooth solutions for a class of large initial data, this result implies the initial velocity and magnetic field can be arbitrarily large.

关键词： 3D Hall-MHD well-posedness Fourier analysis

On entire solutions of some Fermat type differential-difference equations

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Applied Mathematics(A Journal of Chinese Universities) 2024年第1期39卷 69-88页

作者： LONG Jian-ren QIN da-zhuan School of Mathematical Sciences Guizhou Normal UniversityGuiyang 550025China

On one hand,we study the existence of transcendental entire solutions with finite order of the Fermat type difference *** the other hand,we also investigate the existence and growth of solutions of nonlinear different... 详细信息

关键词： entire solutions differential-difference equations existence finite order