检索结果-南通市图书馆

Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke

Acta Pharmaceutica Sinica B 2024年第9期14卷 3983-4000页

作者： Ru Li Riqing Wei Chenxin Liu Keying Zhang Sixiao He Zhifeng Liu Junhao Huang Youyong Tang Qiyuan An Ligen Lin Lishe Gan Liying Zhao Xiaoming Zou Fudi Wang Yuan Ping Qiang ma The Seventh Affiliated Hospital Southern Medical UniversityFoshan 528244China Department of Biopharmaceutics School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhou 510000China Medical Critical Care Medicine General Hospital of Southern Theatre Command of PLAGuangzhou 510000China Guangdong Branch Center National Clinical Research Center for Geriatric Diseases(Chinese PLA General Hospital)Guangzhou 510000China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoAvenida da UniversidadeTaip1Macao 999078China School of Pharmaceutical Sciences Zhejiang Chinese Medical UniversityHangzhou 311402China Department of General Surgery Nanfang Hospitalthe First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510000China The Fourth Affiliated Hospital the First Affiliated HospitalSchool of Public HealthInstitute of Translational MedicineCancer CenterState Key Laboratory of Experimental HematologyZhejiang University School of MedicineHangzhou 310000China The First Affiliated Hospital the Second Affiliated HospitalBasic Medical SciencesSchool of Public HealthHengyang Medical SchoolUniversity of South ChinaHengyang 421200China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310000China Liangzhu Laboratory Zhejiang University Medical CenterHangzhou 310000China Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy School of Laboratory Medicine and BiotechnologySouthern Medical UniversityGuangzhou 510000China

With the escalating prevalence of global heat waves,heat stroke has become a prominent health concern,leading to substantial liver *** other forms of liver injury,heat strokeinduced damage is characterized by heat cytotoxicity and heightened inflammation,directly contributing to elevated mortality *** clinical assessments have identified elevated bilirubin levels as indicative of Kupffer cell dysfunction,their specific correlation with heat stroke liver injury remains *** hypothesis proposes the involvement of Kupffer cell ferroptosis during heat stroke,initiating IL-1bmediated *** single-cell RNA sequencing of murine macrophages,a distinct and highly susceptible Kupffer cell subtype,Clec4Ft/CD206t,emerged,with heme oxygenase 1(HMOX-1)playing a pivotal ***,heat-induced HMOX-1,regulated by early growth response factor 1,mediated ferroptosis in Kupffer cells,specifically in the Clec4F t/CD206 t subtype(KC2),activating phosphatidylinositol 4-kinase beta and promoting PI4P *** cascade triggered NLRP3 inflammasome activation and maturation of *** findings underscore the critical role of targeted therapy against HMOX-1 in ferroptosis within Kupffer cells,particularly in Clec4F t/CD206 t *** an approach has the potential to mitigate inflammation and alleviate acute liver injury in the context of heat stroke,offering a promising avenue for future therapeutic interventions.

关键词： Heat stroke Liver injury Kupffer cells Ferroptosis Heme oxygenase 1 Phosphatidylinositol 4-kinase beta NLRP3 Early growth response factor 1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ballistic impact response of resistance-spot-welded(RSW) double-layered plates for Q&P980 steel

引用

Defence Technology（防务技术） 2022年第6期18卷 1052-1064页

作者： Bo-han ma Dong-fang ma Huan-ran Wang da-nian Chen Feng-hua Zhou MOE Key Laboratory of Impact and Safety Engineering Ningbo UniversityNingbo315211China College of Science&Technology Ningbo UniversityNingbo315211China

Ballistic impact response of resistance-spot-welded(RSW)double-layered(2×1.6 mm)plates(190 mm×150 mm)for Q&P980 steel impacted by a round-nosed steel bullet(12 mm diameter and 30 mm length)was investigated by using gas gun and high-speed camera *** RSW specimens were spot welded using a 6 mm diameter electrode face producing a 7.2 mm diameter fusion zone of the spot *** ballistic curve and energy balance for the tests of the spot weld of the RSW specimens at different velocity were analyzed to characterize the ballistic behavior of the RSW specimens under bullet *** fracture mechanisms of the RSW specimens under bullet impact were *** the tests below the ballistic limit,the cracks initiated from the notch-tip and propagated along the faying surface or obliquely through the thickness depending on the impact *** the tests above the ballistic limit,the plug fracture in the front plate of the RSW specimen could be caused by the thinning-induced necking in the BM near the HAZ,while the plug fracture in the rear plate of the RSW specimens may be consist of the circumferential cracking from the rear surface and the bending fracture of the hinged part of *** effects of the electrode indentation and the weld interfaces on deformation and fracture of the RSW specimens under bullet impact were *** the tests above the ballistic limit,the circumferential fracture from the rear surface of the RSW specimens was always initiated along the interior periphery of the electrode indentation and the crack paths were along the FZ/CGHAZ or CGHAZ/FGHAZ *** the circumferential crack also formed outside the electrode indentation,the fracture on the BM/HAZ interface could be *** the front plate of the RSW specimens,the shear/bending induced cracking from the notch-tip were observed and the crack paths were along the FZ/CGHAZ or CGHAZ/FGHAZ interface.

关键词： RSW Q&P980 steel Ballistic impact Deformation Fracture

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

水煤浆气化炉协同处理过程中有机物排放特征——以多环芳烃和二噁英为例

引用

中国环境科学 2024年第9期44卷 5053-5062页

作者：崔长颢章磊刘美佳李丽陈超王浩祥闫大海马晓烽中国环境科学研究院固体废物污染控制技术研究所北京100012 绍兴凤登环保有限公司浙江绍兴312300

采用工业化试验对水煤浆气化炉协同处理蒽醌染料、精馏残渣、废活性炭、废有机溶剂等多源有机废物过程中多环芳烃(PAHs)和二噁英(PCDD/Fs)的排放特征进行研究.结果表明,协同处理有机废物不会对水煤浆气化炉的气化压力、气化温度和小时... 详细信息

采用工业化试验对水煤浆气化炉协同处理蒽醌染料、精馏残渣、废活性炭、废有机溶剂等多源有机废物过程中多环芳烃(PAHs)和二噁英(PCDD/Fs)的排放特征进行研究.结果表明,协同处理有机废物不会对水煤浆气化炉的气化压力、气化温度和小时产气量产生显著影响,但合成气中CO和CO_(2)的气体体积分数较空白工况有所变化,CO的气体体积分数由40.9%下降至31.5%,而CO_(2)气体体积分数则由23.4%增加至31.0%,主要原因可能是有机废物的引入使得气化炉燃烧更充分;协同工况下气态排放物中PAHs和PCDD/Fs分别以萘和低氯代同系物为主,其中PAHs和PCDD/Fs的总毒性当量分别在0.12–0.49ng-TEQ/m^(3)和1.22–3.82pg-TEQ/m^(3)之间,较空白工况下PAHs(0.06–0.11ng-TEQ/m^(3))和PCDD/Fs(1.34–2.97ng-TEQ/m^(3))的总毒性当量无明显增加,且仍远低于相关标准限值;协同工况下固态样品中PAHs和PCDD/Fs分别以低、中环和低氯代同系物为主,硫磺(0.49ng-TEQ/kg)和炭黑(0.37ng-TEQ/kg)的PAHs总毒性当量,以及碳酸氢铵(8.3pg-TEQ/kg)的PCDD/Fs总毒性当量分别高于其他固态样品的PAHs和PCDD/Fs总毒性当量.协同工况下固态样品中PAHs和PCDD/Fs的总毒性当量较空白工况均无明显增加,环境风险可控.

关键词：水煤浆气化炉有机废物协同处理多环芳烃(PAHs) 二噁英(PCDD/Fs)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

STAT1 signaling is required for optimal Th1 cell differentiation in mice

引用

Chinese Science Bulletin 2010年第11期55卷 1032-1040页

作者： ma da HUANG Hua HUANG Zan The Key Laboratory of Developmental Genes and Human Disease of Education Ministry School of Basic Medical Science Southeast University Nanjing 210009 China Department of Cell Biology Neurology and Anatomy Stritch School of Medicine Loyola University Chicago Maywood IL 60153 USA

Although IFN-γ alone does not prime type I T helper cell (Th1) differentiation, the loss of IFN-γ signaling leads to impaired Th1 phenotype: IFN-γ receptor-deficient (Ifngr-/-) Th1 cells fail to permanently repress IL-4 expression. They can differentiate into IL-4-producing cells under Th2-inducing conditions. These observations suggest that IFN-γ signaling plays a critical role in si- lencing Il4 gene in Th1 cells and stabilizing Th1 phenotype. IFN-γ signaling has been further shown to inhibit IL-4 expression by inhibiting STAT6 phosphorylation. This work aims to study the mechanism by which STAT1, the downstream molecule that transduces IFN-γ signaling, may mediate suppression of IL-4 expression in Th1 cells. The results show that STAT1-deficient naive CD4+ T cells express a reduced level of IFN-γ as well as an elevated level of IL-4. These cells exhibit bias to differentiate into Th2 cells under unpolarized conditions. Under Th1-inducing conditions, STAT1-deficient naive CD4+ T cells show impaired Th1 differentiation: Stat1-/- Th1 cells express reduced levels of IFN-γ and T-bet. These cells also fail to repress the expression of IL-4 and GATA-3 and retain STAT6 signaling. More importantly, Stat1-/- Th1 cells can be effectively induced to differentiate into IL-4-producing cells under Th2-inducing conditions. Ectopic expression of T-bet in Stat1-/- Th1 cells dramatically represses their ability to do so and drastically restores IFN-γ expression, suggesting that STAT1 may inhibit IL-4 expression through T-bet. Finally, histone H3 acetylation (H3AC) and histone H3 K4 dimethylation (H3K4dim) were observed in two enhancer regions of Il4 gene locus in Stat1-/- Th1 cells, suggesting a permissive status of Il4 gene locus in these cells. Thus, this study reveals new mechanisms by which STAT1 signaling may mediate repression of Il4 gene in Th1 cells: upregulating T-bet that subsequently represses GATA3 and IL-4 expression, antagonizing STAT6 signaling, and inhibiting epigen

关键词： STAT1 Th1/Th2 房间 T 赌注 STAT6 信号 transduction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Antiplatelet Effect of Active Components Derived from Chinese Herbal Medicine

引用

Chinese Journal of Integrative Medicine 2018年第8期24卷 632-640页

作者： ZHANG Ying ma Xiao-juan SHI da-zhuo Graduate School Beijing University of Chinese Medicine Cardiovascular Diseases Center Xiyuan HospitalChina Academy of Chinese Medical Sciences China Heart Institute of Chinese Medicine China Academy of Chinese Medical Sciences

Atherothrombosis is the major cause of acute coronary syndromes and cardiovascular *** participate in the processes of forming and extending atherosclerotic ***,antiplatelet therapy is a milestone in the primary and second prevention of atherothrombotic *** with the longterm use of antiplatelet agents,the safety and drug resistance has become a big concern in clinic and new drugs possessing higher effectiveness and fewer adverse effects are *** recent data support that traditional Chinese herbs may be a good alternative and complementary choice of new antiplatelet *** review highlights the progress of antiplatelet effect of active components derived from traditional Chinese herbs based on their chemical structures.

关键词： Chinese herbal medicine antiplatelet active components

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Survey of Newtonian Core-Shell Systems with Pseudo High Order Symplectic Integrator and Fast Lyapunov Indicator

引用

Chinese Journal of Astronomy and Astrophysics 2007年第4期7卷 601-610页

作者： Jun-Fang Zhu Xin Wu da-Zhu ma Department of Physics Nanchang University Nanchang 330031

Newtonian core-shell systems, as limiting cases of relativistic core-shell models under the two conditions of weak field and slow motion, could account for massive circumstellar dust shells and rings around certain types of star remnants. Because this kind of systems have Hamiltonians that can be split into a main part and a small perturbing part, a good choice of the numerical tool is the pseudo 8th order symplectic integrator of Laskar ＆ Robutel, and, to match the symplectic calculations, a good choice of chaos indicator is the fast Lyapunov indicator （FLI） with two nearby trajectories proposed by Wu, Huang ＆ Zhang. Numerical results show that the FLI is very powerful when describing not only the transition from regular motion to chaos but also the global structure of the phase space of the system.

关键词： celestial mechanics - chaos - methods: numerical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

L^p Bounds for Singular Integrals with Rough Kernels on Product Domains

引用

Acta mathematica Sinica,English Series 2012年第1期28卷 133-144页

作者： Li ma da Shan FAN Huo Xiong WU School of mathematics and Computer Sciences Gannan Normal UniversityGanzhou 341000P.R.China Department of mathematics University of Wisconsin-MilwaukeeMilwaukeeWI 53201USA School of mathematical Sciences Xiamen UniversityXiamen 361005P.R.China

This paper is concerned with singular integral operators on product domains with rough kernels both along radial direction and on spherical surface. Some rather weaker size conditions, which imply the L^P-boundedness ... 详细信息

关键词： Singular integral rough kernel product domain Littlewood-Paley theory Fourier transform estimate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of the cosmological constant on chaos in an FRW scalar field universe

引用

Research in Astronomy and Astrophysics 2009年第11期9卷 1185-1191页

作者： da-Zhu ma Xin Wu Shuang-Ying Zhong Department of Physics Nanchang University Nanchang 330031 China Department of Physics Hubei University for Nationalities Enshi 445000 China

The dependence of chaos on two parameters of the cosmological constant and the self-interacting coefficient in the imaginary phase space for a closed Friedman- Robertson-Walker （FRW） universe with a conformally coupled scalar field, as the full understanding of the dependence in real phase space, is investigated numerically. It is found that Poincar6 plots for the two parameters less than 1 are almost the same as those in the absence of the cosmological constant and self-interacting terms. For energies below the energy threshold of 0.5 for the imaginary problem in which there are no cosmological constant and self-interacting terms, an abrupt transition to chaos occurs when at least one of the two parameters is 1. However, the strength of the chaos does not increase for energies larger than the threshold. For other situations of the two parameters larger than 1, chaos is weaker, and even disappears as the two parameters increase.

关键词： cosmology cosmological parameters -- methods numerical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于ILSO-DELM的燃气轮机压气机故障预警方法

引用

电工电气 2024年第5期 63-68页

作者：马梦甜茅大钧蒋欢春上海电力大学自动化工程学院上海200090 上海明华电力科技有限公司上海200090

压气机结构复杂,运行特性为非线性的特点加大了燃气轮机压气机故障预警的难度,为了提高燃气轮机压气机故障预警能力,提出了一种基于改进的狮群优化算法(ILSO)优化深度极限学习机(DELM)的故障预警方法。通过皮尔逊相关分析得到与预警参... 详细信息

压气机结构复杂,运行特性为非线性的特点加大了燃气轮机压气机故障预警的难度,为了提高燃气轮机压气机故障预警能力,提出了一种基于改进的狮群优化算法(ILSO)优化深度极限学习机(DELM)的故障预警方法。通过皮尔逊相关分析得到与预警参数相关性高的测点,构建ILSO-DELM预测模型,得到正常状态下预警参数的绝对值,通过参数估计确定阈值,根据残差绝对值是否超过预警线来间接判断压气机的运行情况。以上海某燃机电厂的运行数据进行分析,通过验证表明:该方法能够对压气机故障提前预警,并且相比于DELM模型预测精度更高。

关键词：压气机深度极限学习机狮群优化算法故障预警

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A fuzzy PID-controlled Sma actuator for a two-DOF joint

引用

Chinese Journal of Aeronautics 2014年第2期27卷 453-460页

作者： Shi Zhenyun Wang Tianmiao Liu da ma Chen Yuan Xiangnan Robotic Laboratory Beihang University

Shape memory alloy （Sma） actuator is a potential advanced component for servo- systems of aerospace vehicles and aircraft. This paper presents a joint with two degrees of freedom （DOF） and a mobility range close to ±60° when driven by Sma triple wires. The fuzzy proportional-integral-derivative （PID）-controlled actuator drive was designed using antagonistic Sma triple wires, and the resistance feedback signal made a closed loop. Experiments showed that, with the driving responding frequency increasing, the overstress became harder to be avoided at the position under the maximum friction force. Furthermore, the hysteresis gap between the heating and cooling paths of the strain-to-resistance curve expanded under this condition. A fuzzy logic control was considered as a solution, and the curves of the wires were then modeled by fitting polynomials so that the measured resistance was used directly to determine the control signal. Accurate control was demonstrated through the step response, and the experimental results showed that under the fuzzy PID-control program, the mean absolute error （maE） of the rotation angle was about 3.147°. In addition, the investigation of the external interference to the system proved the controllable maximum output.

关键词： Fuzzy PID control Mechanical Joint Self-sensing Shape memory alloySmart structure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：