检索结果-南通市图书馆

An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-ha Jeong Jarno Hiemstra Patrick V.Blokzijl Rebeca damian-Ferrara danilo Martins dos Santos Jéssica H.L.da Fonseca Min-Ho Kang Jihyun Kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez Jeroen Leijten Su Ryon Shin Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical Engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

Ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels Extrusion printing Oxygen-generating microparticle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of Meteorological data Assimilation on Regional Air Quality Forecasts over the Korean Peninsula

引用

Journal of Meteorological Research 2024年第2期38卷 262-284页

作者： Yunjae CHO Hyun Mee KIM Eun-Gyeong YANG Yonghee LEE Jae-Bum LEE Soyoung ha Department of Atmospheric Sciences Yonsei UniversitySeoul 03722Republic of Korea Air Quality Forecasting Center National Institute of Environmental ResearchIncheon 22689Republic of Korea National Center for Atmospheric Research BoulderCO 80305USA University of Maryland Baltimore County BaltimoreMD 21250USA Global Modeling and Assimilation Office NASA Goddard Space Flight CenterGreenbeltMD 20771USA

the Weather Research and Forecasting model coupled with Chemistry(WRF-Chem),a type of online coupled chemistry-meteorology model(CCMM),considers the interaction between air quality and meteorology to improve air quality *** data assimilation(da)can be used to reduce uncertainty in meteorological field,which is one factor causing prediction uncertainty in the *** this study,WRF-Chem and three-dimensional variational da were used to examine the impact of meteorological da on air quality and meteorological forecasts over the Korean *** nesting model domains were configured over East Asia(outer domain)and the Korean Peninsula(inner domain).three experiments were conducted by using different da domains to determine the optimal model domain for the meteorological *** the meteorological da was performed in the outer domain or both the outer and inner domains,the root-mean-square error(RMSE),bias of the predicted particulate matter(PM)concentrations,and the RMSE of predicted meteorological variables against the observations were smaller than those in the experiment where the meteorological da was performed only in the inner *** indicates that the improvement of the synoptic meteorological fields by da in the outer domain enhanced the meteorological initial and boundary conditions for the inner domain,subsequently improving air quality and meteorological *** to the experiment without meteorological da,the RMSE and bias of the meteorological and PM variables were smaller in the experiments with *** effect of meteorological da on the improvement of PM predictions lasted for approximately 58-66 h,depending on the ***,the uncertainty reduction in the meteorological initial condition by the meteorological da contributed to a reduction of the forecast errors of both meteorology and air quality.

关键词： meteorological data assimilation regional air quality forecast particulate matter concentration optimal model domain forecast error WRF-Chem

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

引用

Neural Regeneration Research 2025年第2期20卷 598-608页

作者： daniella da Silva Madeleen Jansen van Rensburg Anine Crous Heidi Abrahamse Laser Research Centre Faculty of Health SciencesUniversity of JohannesburgDoornfonteinJohannesburgSouth Africa

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular *** has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of *** this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain *** investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/*** adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory *** findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control ***,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal *** biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic ***,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

关键词： differentiation inducers green photobiomodulation immortalized adipose-derived stem cell near-infrared photobiomodulation neurodegenerative disease neurogenesis photobiomodulation trans-differentiation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

拉拔自激振动方程及其数值算法分析

引用

锻压技术 2024年第5期49卷 76-83页

作者：曹益忠袁豪哈达张卫荣冯金刚太原理工大学机械与运载工程学院山西太原030024 先进金属复合材料成形技术与装备教育部工程研究中心山西太原030024

针对拉拔加工过程中常发生“追逐”或“跳跃”现象并诱发产生振动的问题,根据丁文镜教授提出的机械系统追逐现象微分控制方程,建立了拉拔自激振动的时变质量非线性微分控制方程,并利用移位的Chebyshev多项式函数对建立的微分方程进行数... 详细信息

针对拉拔加工过程中常发生“追逐”或“跳跃”现象并诱发产生振动的问题,根据丁文镜教授提出的机械系统追逐现象微分控制方程,建立了拉拔自激振动的时变质量非线性微分控制方程,并利用移位的Chebyshev多项式函数对建立的微分方程进行数值求解。另外,给出3个具体的工况模拟问题,每个问题分别考虑了不同的阻尼系数、刚度系数、变质量函数和摩擦力,并绘制了相应的无量纲位移图和相图,通过数值仿真研究了质量模块和摩擦力分别变化时对拉拔过程的影响。结果表明:摩擦力呈线性或者周期性等变化时,对拉拔过程的振动位移产生较大的影响,而质量模块变化不会对拉拔结果产生影响。

关键词：机械系统追逐现象拉拔质量模块摩擦力振动

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

少捕慎诉慎押政策下逮捕制度的优化研究

引用

泰山学院学报 2024年第1期46卷 54-62页

作者：苦打哈孙华鑫云南财经大学法政学院云南昆明650000

近年来,由于逮捕要件缺乏客观准确的证明标准、逮捕实践理念有失偏颇、非羁押强制措施运行状况不佳等原因,导致司法实践中逮捕数量较多、逮捕率较高。较高逮捕率不但违背了逮捕作为预防性措施的本质功能,也违背了少捕慎诉慎押政策初衷,... 详细信息

近年来,由于逮捕要件缺乏客观准确的证明标准、逮捕实践理念有失偏颇、非羁押强制措施运行状况不佳等原因,导致司法实践中逮捕数量较多、逮捕率较高。较高逮捕率不但违背了逮捕作为预防性措施的本质功能,也违背了少捕慎诉慎押政策初衷,未能实现打击犯罪与保障人权的有机统一。因此,在少捕慎诉慎押政策下优化逮捕制度,分别从逮捕制度的观念层面、逮捕制度的实质要件层面和逮捕制度配套要件层面提出优化路径。

关键词：少捕慎诉慎押非羁押强制措施逮捕羁押必要性审查

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Neural Wiskott-Aldrich syndrome protein(N-WASP)promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2

引用

Oncology Research 2024年第4期32卷 615-624页

作者： HYUNG SUN KIM YUN SUN LEE SEUNG MYUNG DONG HYO JUNG KIM da EUN LEE HYEON WOONG KANG MYEONG JIN KIM JOON SEONG PARK Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoulKorea Department of Surgery Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulKorea Gibiome Co. Ltd.Gyeonggi-doKorea

Pancreatic ductal adenocarcinoma(PdaC)is one of the most aggressive solid malignancies.A specific mechanism of its metastasis has not been *** this study,we investigated whether Neural Wiskott-Aldrich syndrome protein(N-WASP)plays a role in distant metastasis of *** found that N-WASP is markedly expressed in clinical patients with *** analysis showed a notably more distant metastatic pattern in the N-WASP-high group compared to the N-WASP-low group.N-WASP was noted to be a novel mediator of epithelialmesenchymal transition(EMt)via gene expression profile *** of N-WASP in pancreatic cancer cells significantly inhibited cell invasion,migration,and *** also observed positive association of lysyl oxidase-like 2(LOXL2)and focal adhesion kinase(FAK)with the N-WASP-mediated response,wherein EMt and invadopodia function were *** N-WASP and LOXL2 depletion significantly reduced the incidence of liver and lung metastatic lesions in orthotopic mouse models of pancreatic *** results elucidate a novel role for N-WASP signaling associated with LOXL2 in EMt and invadopodia function,with respect to regulation of intercellular communication in tumor cells for promoting pancreatic cancer *** findings may aid in the development of therapeutic strategies against pancreatic cancer.

关键词： Pancreatic cancer Neural Wiskott-Aldrich syndrome protein(N-WASP)signaling Metastasis Epithelial-mesenchymal transition(EMt) Lysyl oxidase-like 2(LOXL2)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Estimation of hydraulic parameters from pumping tests in a multiaquifer system

引用

Underground Space 2020年第3期5卷 210-222页

作者： da ha Gang Zheng haizuo Zhou Chaofeng Zeng Huihui Zhang School of Civil Engineering Tianjin UniversityTianjin 300072China Key Laboratory of Coast Civil Structure Safety of Ministry of Education Tianjin UniversityTianjin 300072China Hunan Provincial Key Laboratory of Geotechnical Engineering for Stability Control and Health Monitoring School of Civil EngineeringHunan University of Science and TechnologyXiangtanHunan 411201China School of Resources and Environmental Sciences Wuhan UniversityWuhan 430079China

the hydrogeologic conditions in tianjin,China,are characterized by a system of multiple alternating aquifers and aquitards and a high groundwater ***,the groundwater system to a depth of 70 m includes one phreatic aquifer and three semiconfined aquifers(AqI–AqIII).the distribution of aquifers varies *** estimates of aquifer parameters from pumping tests are essential in geotechnical engineering *** this study,the applicability of different models for estimating hydraulic parameters in a multiaquifer system is *** avoid errors in the graphic-analytical process and to enhance the efficiency and accuracy,a hybrid algorithm,called GALMA(a genetic algorithm(GA)combined with the Levenberg–Marquardt(LM)algorithm),is used with the Neuman and Witherspoon model and ratio *** estimated values in the second and third semiconfined aquifers(AqII and AqIII)from various solutions are compared with the measured *** validations based on the prediction of the drawdown values are performed via a three dimensional numerical simulation.

关键词： Hydraulic parameter Leaky aquifer Pumping test Optimal approach

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development of a coupled supersonic inlet-fan Navier–Stokes simulation method

引用

Chinese Journal of Aeronautics 2018年第2期31卷 237-246页

作者： Qiushi LI Yongzhao LYU tianyu PAN da LI ha'nan LU Yifang GONG National Key Laboratory of Science and technology on Aero-Engine Aero-thermodynamics Beihang UniversityBeoing 100191 China School of Energy and Power Engineering Beihang University Beijing 100083 China Collaborative Innovation Center of Advanced Aero-Engine Beihang University Beijing 100083 China GL-turbo Compressor Company Wuxi 214106 China

A coupled supersonic inlet-fan Navier–Stokes simulation method was developed by using COMSOL-CFD code. the flow turning, pressure rise and loss effects across blade rows of the fan and the inlet-fan interactions were taken into account as source terms of the governing equations without a blade geometry by a body force model. In this model, viscous effects in blade passages can also be calculated directly, which include the exchange of momentum between fluids and detailed viscous flow close to walls. NASA Rotor 37 compressor test rig was used to validate the ability of the body force model to estimate the real performance of blade rows. Calculated pressure ratio characteristics and the distribution of the total pressure, total temperature, and swirl angle in the span direction agreed well with experimental and numerical data. It is shown that the body force model is a promising approach for predicting the flow field of the turbomachinery. then, coupled axisymmetric mixed compression supersonic inlet-fan simulations were conducted at Mach number 2.8 operating conditions. the analysis includes coupled steady-state performance, and effects of the fan on the inlet. the results indicate that the coupled simulation method is capable of simulating behavior of the supersonic inlet-fan system.

关键词： Body force model Coupled simulation Rapid numerical method Supersonic inlet-fan Viscous flow

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

tHE StUDY ON NOVEL MICROELECtRODE ARRAY CHIPS FOR tHE DEtECtION OF HEAVY MEtALS IN WAtER POLLUtION

引用

Journal of Innovative Optical Health Sciences 2012年第1期5卷 11-17页

作者： HUI-XIN ZhaO WEI CAI da ha haO WAN PING WANG Biosensor National Special Laboratory Key Laboratory for Biomedical Engineering of Education Ministry Department of Biomedical Engineering Zhejiang University Hangzhou 310027P.R.China

Qualitative and quantitative analysis of trace heavy metals in aqueous environment are rapidly assuming significance along with the rapid development of *** this paper,gold microelectrode array(MEA)plated with mercury film was used for simultaneous voltammetric detection of zinc,cadmium,lead and copper ions in *** electrochemical behavior and the actual surface area of the MEA were investigated by cyclic voltammetry in K_(3)[Fe(CN)_(6)].Electrochemical impedance spectrum(EIS)was utilized to examine the deposition of mercury on the electrode *** on anodic stripping voltammetry,mercury filmAu MEA was applied to the detection of heavy metals in artificial analyte,where good calibrate linearity was obtained for cadmium,lead and copper ions,but with zinc exhibiting poor linearity.

关键词： Microelectrode array(MEA)chip heavy metals detection water pollution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

可降解生物材料应用于修复感染性骨缺损的研究进展

引用

生物骨科材料与临床研究 2024年第5期21卷 71-76页

作者：梁枭吴锦秋袁凌伟唐兆鹏哈达甘肃中医药大学研究生院甘肃兰州730000 甘肃省中医院运动医学科甘肃兰州730000

与不可降解生物材料相比,可降解生物材料在严重骨缺损的修复中发挥着越来越重要的作用,受到研究者的广泛关注。在骨缺损的治疗中,由可降解生物材料制成的支架可以为新骨组织生长提供爬行的桥梁,并为细胞和生长因子发挥作用提供平台,这... 详细信息

与不可降解生物材料相比,可降解生物材料在严重骨缺损的修复中发挥着越来越重要的作用,受到研究者的广泛关注。在骨缺损的治疗中,由可降解生物材料制成的支架可以为新骨组织生长提供爬行的桥梁,并为细胞和生长因子发挥作用提供平台,这些细胞和生长因子最终将在体内降解吸收并被新生骨组织替代。现阶段研究较多的可降解生物材料主要有6种,包括聚乳酸-羟基乙酸共聚物(PLGA)、聚己内酯(PCL)、聚乳酸(PLA)、聚乙醇酸(PGA)、β-磷酸三钙(β-tCP)、羟基磷灰石(ha)。这是一类无毒、具有良好生物相容性和血液相容性的可降解生物材料。本文就可降解生物材料修复感染性骨缺损的研究进展作一系统综述。

关键词：骨髓炎可降解生物材料感染性骨缺损复合支架

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：