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Insights into triclosan-Induced Endocrine Disruption:Evidence from the National Health and Nutrition Examination Survey and Zebrafish Models

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Environment & Health 2024年第7期2卷 424-440页

作者： Zhiming Li Hongyi Xian Xiaohu Ren Rongyi Ye Yizhou Zhong Yuji Huang Boxuan Liang Yanhong Deng Mingzhu dai Jie Guo Shuqin tang Jialiang Pan Yu Feng Ruobing Bai Xueping Chen Sahoko Ichihara Gaku Ichihara da Chen Xingfen Yang Zhenlie Huang NMPA Key Laboratory for Safety Evaluation of Cosmetics Guangdong Provincial Key Laboratory of Tropical Disease ResearchDepartment of ToxicologySchool of Public HealthSouthern Medical UniversityGuangzhou 510515China Shenzhen Key Laboratory of Modern toxicology Shenzhen Medical Key Discipline of Health ToxicologyShenzhen Center for Disease Control and PreventionShenzhen 518055China Hunter Biotechnology Inc.Hangzhou 310051China College of Environment and Climate Guangdong Provincial Key Laboratory of Environmental Pollution and HealthJinan UniversityGuangzhou 510632China Vitargent(International)Biotechnology Limited Shatin 999077Hong Kong SARChina Department of Environmental and Preventive Medicine School of MedicineJichi Medical UniversityTochigi 329-0498Japan Department of Occupational and Environmental Health Faculty of Pharmaceutical SciencesTokyo University of ScienceNoda 278-8510Japan

triclosan(tCS)has garnered significant attention due to its widespread use and associated endocrine-disrupting ***,its impact on the neuroendocrine system and underlying mechanisms remain poorly ***,we established correlations between tCS exposure and serum sex hormone levels in participants of the National Health and Nutrition Examination Survey(NHANES).Additionally,we investigated tCS’s influence on the neuroendocrine system using adult zebrafish exposed to environmentally relevant concentrations of tCS(0.361–48.2μg/L)for 21 *** of reproductive and neurotoxicity included histopathological examination and behavioral ***,proteomics analyses,and biochemical detection were employed to elucidate mechanisms underlying tCS-induced neuroendocrine *** correlations were found between tCS exposure and estradiol,testosterone,and sex hormone-binding globulin levels in NHANES *** addition,tCS exposure inhibited ovary development and spermatogenesis in *** and proteomics analysis revealed gender-specific key signaling and metabolism-related pathways implicated in tCS-induced reproductive ***,tCS exposure induced nervous system impairment,as evidenced by histological changes and altered motor behavior,possibly associated with oxidative *** analysis further highlighted the potential connection between endocrine system disruption and nervous system impairment following tCS ***,this study provided evidence supporting tCS-induced endocrine disruption and offered insights into its underlying mechanisms.

关键词： Emerging Contaminants Ecotoxicity Public Health Endocrine-Disrupting Chemicals Endocrine-Disrupting Effects

transient behaviors of a flame over a tsuji burner

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Acta Mechanica Sinica 2008年第6期24卷 645-659页

作者： Young-da Chen da-da Chen Chiun-Hsun Chen Department of Mechanical Engineering National Chiao Tung UniversityHsinChu 30056TaiwanChina

the present study investigated numerically the physical mechanisms underlying the transient behaviors of the flame over a porous cylindrical burner. the numerical results showed that a cold flow structure at a fixed inflow velocity of Uin = 0.6 m/s in a wind tunnel could be observed in two co-existing recirculation flows. Flow variations occur repeatedly until t = 4.71 s, and then a vortex existed steadily behind the burner and no shading occurred. the ignition of flammable mixture led to a rapid rise in gas temperature and a sudden gas expansion. When it reached the stable envelope flame condition, Uin is adjusted to an assigned value. two blow-off mechanisms were identified. It was also found in the study flame shapes with buoyancy effects agreed with the ones observed experimentally by tsai. Furthermore, the lift-off flame would appear briefly between the envelopes and wake ones, and was stabilized as a wake flame.

关键词： tsuji burner Lift-off flame Recirculation flow

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互联网信用支付对零售商库存决策的影响研究

中国管理科学 2024年第2期32卷 119-128页

作者：王大澳王欢赵士南菅利荣南京财经大学管理科学与工程学院南京210023 南京师范大学金陵女子学院南京210097 江苏科技大学经济与管理学院镇江212003 南京航空航天大学经济与管理学院南京211106

互联网信用支付能够帮助对商品有高期望但自身预算有限的消费者立即购买到心怡的商品。本文在考虑消费者行为的基础上研究了零售商提供互联网信用支付对零售商的最优订货量以及期望利润的影响。首先,分别构建了零售商在面临随机市场需... 详细信息

互联网信用支付能够帮助对商品有高期望但自身预算有限的消费者立即购买到心怡的商品。本文在考虑消费者行为的基础上研究了零售商提供互联网信用支付对零售商的最优订货量以及期望利润的影响。首先,分别构建了零售商在面临随机市场需求时选择提供和不提供互联网信用支付的利润函数,给出了在两种情况下零售商的最优订货量的解析解。其次,运用灵敏度分析分别研究了市场违约率、消费者的期望和预算、日服务费率等对零售商最优订货量和期望利润的影响。结果表明,零售商在对商品定价时需要综合考虑最优订货量和期望利润,因为获得最优订货量的零售价格不一定使得零售商获得最大期望利润。此外,当提供互联网信用支付时,日服务费率和违约金费率都存在着临界阈值,使得高于临界值时零售商选择提供互联网信用支付比不提供互联网信用支付获得更多的利润。本文最后以京东白条为算例,对不提供和提供互联网信用支付的最优订货量和期望利润进行了对比分析。

关键词：互联网信用支付消费者行为随机市场需求最优订货量期望利润

数据要素集聚对企业就业的影响——基于就业规模与就业结构的双重视角

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山西财经大学学报 2024年第4期46卷 54-67页

作者：刘达王晓丹石玉堂东北师范大学经济与管理学院吉林长春130024

基于2007—2021年的A股上市企业数据,采用双重差分模型探究数据要素集聚对企业就业规模与就业结构的影响。研究表明:数据要素集聚对高、低人力资本劳动者均呈现出显著的促进效应,但对高、中、低等职能劳动者表现出岗位极化效应,并且在... 详细信息

基于2007—2021年的A股上市企业数据,采用双重差分模型探究数据要素集聚对企业就业规模与就业结构的影响。研究表明:数据要素集聚对高、低人力资本劳动者均呈现出显著的促进效应,但对高、中、低等职能劳动者表现出岗位极化效应,并且在劳动密集型部门及非国有制企业中更为显著;数据要素集聚通过推动企业数字化转型、加快劳动力要素流动、提升地区人力资本水平和创新创业活跃度,作用于企业就业规模与就业结构;数据要素集聚未通过就业职能结构的极化效应,加剧企业内部收入不均等现象。

关键词：大数据综合试验区数据要素就业规模就业技能结构就业职能结构

Decoding the evolution and transmissions of the novel pneumonia coronavirus(SARS-CoV-2/HCoV-19)using whole genomic data

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Zoological Research 2020年第3期41卷 247-257页

作者： Wen-Bin Yu Guang-da tang Li Zhang Richard t.Corlett Center for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China Center of Conservation Biology Core Botanical GardensChinese Academy of SciencesMenglaYunnan 666303China Henry Fok College of Biology and Agriculture Shaoguan UniversityShaoguanGuangdong 512005China College of Forestry and Landscape Architecture South China Agricultural UniversityGuangzhouGuangdong 510642China Chinese Institute for Brain Research Beijing 102206China

the outbreak of COVid-19 started in mid-December2019 in Wuhan, China. Up to 29 February 2020,SARS-CoV-2(HCoV-19/2019-nCoV) had infected more than 85 000 people in the world. In this study,we used 93 complete genomes of SARS-CoV-2 from the GISAid EpiFlu tM database to investigate the evolution and human-to-human transmissions of SARS-CoV-2 in the first two months of the *** constructed haplotypes of the SARS-CoV-2 genomes, performed phylogenomic analyses and estimated the potential population size changes of the virus. the date of population expansion was calculated based on the expansion parameter tau(τ)using the formula t=τ/2 u. A total of 120 substitution sites with 119 codons, including 79 non-synonymous and 40 synonymous substitutions, were found in eight coding-regions in the SARS-CoV-2 *** non-synonymous substitutions are potentially associated with virus adaptation. No combinations were detected. the 58 haplotypes(31 found in samples from China and 31 from outside China)were identified in 93 viral genomes under study and could be classified into five groups. By applying the reported bat coronavirus genome(bat-RatG13-CoV)as the outgroup, we found that haplotypes H13 and H38 might be considered as ancestral haplotypes,and later H1 was derived from the intermediate haplotype H3. the population size of the SARS-CoV-2 was estimated to have undergone a recent expansion on 06 January 2020, and an early expansion on 08 December 2019. Furthermore,phyloepidemiologic approaches have recovered specific directions of human-to-human transmissions and the potential sources for international infected cases.

关键词： COVid-19 HCoV-19 SARS-CoV-2 Novel pneumonia outbreak Human-to-human transmission Phyloepidemiology

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高性能、光冲击稳定的钙钛矿室内光伏器件

Science Bulletin 2024年第3期69卷 334-344页

作者：李宸孙浩轩王旻甘山豆达李亮 School of Physical Science and technology Jiangsu Key Laboratory of Thin FilmsCenter for Energy Conversion Materials&Physics(CECMP)Soochow UniversitySuzhou 215006China

Perovskite solar cells offer great potential as a sustainable power source for distributed electronic devices that operate ***,the impact of advanced lighting technology,especially the widely used pulse width modulation(PWM)technology,on perovskite photovoltaics has been ***,for the first time in photovoltaics,we find that the light impact emitted by the PWM lighting system caused dynamic strain in perovskite thin films,induced phase separation,and accelerated the generation of metallic lead(Pb^(0))defects,leading to irreversible degradation of the cell performance after 27 h(t_(80)).to address this issue,formamidinium triiodide(FAI_(3))is chosen to treat the surface of the perovskite and release residual stress,resulting in reduced lattice deformation during dynamic strain ***,it suppresses harmful Pb0 defects and reduces Voc loss at low light *** champion device achieves impressive power conversion efficiency(PCE)of 35.14%and retains 99.5%of the initial PCE after continuous strobe light soaking for 2160 h.

关键词： Perovskite solar cells Indoor photovoltaics Interface engineering Micro-strain releasing

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四阶两点边值问题n个对称正解的存在性

华南师范大学学报（自然科学版） 2024年第1期56卷 123-127页

作者：李宪达举霞章欢兰州财经大学信息工程学院兰州730020 兰州资源环境职业技术大学基础教学部兰州730070

应用单调迭代法,研究了四阶两点边值问题u^((4))(t)=f(u(t))(t?[0,1]),u(0)=u(1)=0,u"(0)=u"(1)=0正解的存在性。在边值问题满足特定的条件下,证明了该问题存在n个对称正解。

关键词：四阶边值问题格林函数单调迭代法对称正解

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人防工程电气专业平战功能转换设计要点探讨

建筑电气 2024年第5期43卷 36-41页

作者：笪良飞中铁四局集团有限公司合肥市230022

结合安徽省地方标准DB34/t4628-2023《人民防空工程平战转换技术规范》,对其中与电气专业相关的内容进行梳理归纳,并结合现行人防工程相关规范及设计通常做法,对DB34/t4628-2023的新要求新规定进行分析,给出相应的解决办法。

关键词：人防工程设计要点平战结合平战功能转换土建条件战时电源照明系统弱电系统

盾构淤泥质废弃黏土氧化镁固化-碳化试验及碳化机制研究

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岩土力学 2024年第2期45卷 364-374页

作者：闵凡路申政李彦澄袁大军陈健李凯河海大学土木与交通学院江苏南京210098 北京交通大学土木建筑工程学院北京100091 中铁十四局集团有限公司山东济南250014

盾构隧道施工产生的废弃土面临堆放、运输及处理等难题,将原材料丰富、生产耗能少、环境友好的MgO用于废弃土固化处理是一个值得探索的方法。通过改变MgO掺量a_(m)、养护龄期t、碳化时间H研究MgO固化-碳化淤泥质废弃黏土界限含水率w、... 详细信息

盾构隧道施工产生的废弃土面临堆放、运输及处理等难题,将原材料丰富、生产耗能少、环境友好的MgO用于废弃土固化处理是一个值得探索的方法。通过改变MgO掺量a_(m)、养护龄期t、碳化时间H研究MgO固化-碳化淤泥质废弃黏土界限含水率w、无侧限抗压强度q_(u)、弹性模量E_(50),结合微观形貌及矿物成分变化规律探讨其固化-碳化机制。结果表明:MgO固化-碳化具有明显的加固土体效果,加固效果随a_(m)、t呈先上升后趋于稳定的趋势,随H呈先上升后下降的趋势;不同a_(m)、t下,碳化4h会使土体塑性指数I_(P)降低57%以上,土体可塑性显著下降;不同a_(m)和t的固化-碳化土q_(u)均在H为4h时取得峰值,最高可达1.4MPa,比碳化前强度提升了220%~350%;固化-碳化反应对土体的E_(50)提升受a_(m)影响较大,当a_(m)超过9%时,碳化4h试样的E_(50)增幅在500%左右;MgO固化-碳化过程中水化产物、碳化产物不断生成和发育,形成网状、花朵聚集状的形貌,填充土颗粒间的孔隙,增强了土颗粒间的胶结作用,土体结构更为密实。该研究为长三角地区土压盾构产生的淤泥质废弃黏土的固化-碳化处理与再利用提供了思路。

关键词：废弃土处理活性氧化镁加速碳化微观形貌矿物成分碳化机制