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Efficacy of concurrent chemoradiotherapy plus adjuvant chemotherapy on advanced cervical cancer

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Chinese Journal of Cancer 2010年第11期29卷 959-963页

作者： Shun Wang da-Shui Zhang Tao Pan sha Liu Ming-Kun Wang Department of Radiation Oncology the Affiliated Hospital of Hainan Medical College Haikou Hainan 570102 P. R. China Cancer Institute of Hainan Medical College Haikou Hainan 571101 P. R. China

Background and Objective: Concurrent chemoradiotherapy for cervical carcinoma develops rapidly and has become a common and standard therapy in recent years. Both the local control rate and survival rate of patients were increased and the risk of death fell by 30%-50%. This study aimed to explore the efficacy of concurrent chemoradiotherapy plus adjuvant chemotherapy on and the treatment compliance of the patients with advanced cervical squamous cell carcinoma. Methods: A total of 156 patients with stage IIa-IIIb cervical squamous cell carcinoma were randomly divided into the concurrent chemoradiotherapy group (experimental group) and radiotherapy group (control group). Intracavity and external beam radiation therapy were administered. At point A, 40-48 Gy were given by 10-12 fractions; at point B, 46-50 Gy were given by 23-25 fractions. In the same time, experimental group was treated by cisplatin (DDP, 40 mg) on day 1, repeated every week. Ten days after radiation therapy, TP regimen was administered as adjuvant chemotherapy. Results: For the experimental and control groups, the objective response rates were 88.61% and 75.32%, 1-year survival rates were 88.57% and 70.77%, 1-year local control rates were 81.43% and 64.62%, 3-year survival rates were 82.14% and 57.69%, and 3-year local control rates were 75.00% and 46.15%, with significant differences (P < 0.05). Quality of life of all patients were significantly improved after treatment (P< 0.05). Conclusion: Concurrent chemoradiotherapy plus adjuvant chemotherapy for advanced cervical cancer can improve short-term and long-term survival and local control rates of patients, improve the quality of life, and the toxicity can be tolerated.

关键词：子宫颈癌化疗疗效鳞状细胞癌放射治疗生活质量控制率对照组

Natural radioactivity level of associated bone-coal mining area in Zhejiang Province

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Nuclear Science and Techniques 2005年第5期16卷 310-314页

作者： YE Ji-da ZHENG Hui-Di SONG Wei-Li ZENG Guang-Jian WANG sha-Ling WU Zong-Mei Environmental Radiation Monitoring Station of Zhejiang Province Hangzhou 310012

The geographic distribution, γ-radiation level and specific activity of radionuclides of the bone-coal mines in Zhejiang Province were reported. The weighted average of γ-radiation dose rate of the bone-coal mines is 566 nGy/h for 107 main bone-coal mines. The weighted mean activity of 238U, 226Ra, 232Th and 40K in the samples are 949, 918, 34 and 554 Bq/kg for 171 samples of bone-coal, respectively.

关键词：浙江放射性物质放射性污染骨煤海洋污染

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筇竹家具创新设计研究

林产工业 2019年第12期56卷 58-61页

作者：任达宋莎莎北京林业大学木质材料科学与应用教育部重点实验室

简述了筇竹家具的现状及筇竹家具在材料、知觉、文化和加工工艺方面的基本特征;结合现代设计理念和方法,从功能、形态和表面装饰三个基本设计要素探讨了筇竹家具创新设计途径。该研究对于筇竹家具发展与创新具有一定的指导和借鉴意义。

关键词：圆竹家具筇竹创新设计家具生产工艺

Overexpression of interleukin-17 in tumor-associated macrophages is correlated with the differentiation and angiogenesis of laryngeal squamous cell carcinoma

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Chinese Medical Journal 2012年第9期125卷 1603-1607页

作者： MENG Cui-da ZHU Dong-dong JIANG Xiao-dan LI Lin sha Ji-chao DONG Zhen KONG Hong Department of Otorhinolaryngology Head&Neck SurgeryChina-Japan Union HospitalJilin UniversityChangchunJilin 130033China

Background Interleukin-l7 （IL-17）, which exerts strong pro-inflammatory effects, has emerged as an important mediator in inflammation-associated cancer. The aim of this study was to clarify the relationship between IL-17 and tumor associated macrophages （TAMs）, and the correlation of the microvessel density in the development of laryngeal squamous cell carcinoma （LSCC）.Methods Histopathological observations and immunohistochemistry staining for IL-17, CD68, and CD34 were performed on 72 specimens （32 cases of LSCC, 20 cases of adjacent tissues of carcinoma as controls, and 20 cases of chronic hypertrophic laryngitis）. Double immunohistochemical staining was done to determine which cells expressed IL-17. Real-time quantitative PCR determined the mRNA expression of IL-17. ELISA was used to detect the expression of the serum level of IL-17 in the three groups.Results The inflammation response had increased in LSCC. Overexpression of IL-17 and CD68 protein were seen in LSCC （P 〈0.01）. The expression of IL-17 was different between well and poorly differentiated LSCC （P 〈0.01）. The IL-17 expressing cells were mainly located in macrophages （CD68＋/IL17＋） as demonstrated by double immunohistochemical staining. IL-17 expression significantly correlated with high microvessel density （CD34＋） in LSCC （P 〈0.05）. Relatively higher mRNA expression levels of IL-17 were seen in LSCC compared to the controls （P 〈0.05）. The serum expression of IL-17 was similar among the three groups （P 〉0.05）.Conclusion IL-17 was expressed by TAMs, and IL-17 may significantly correlate to the differentiation and angiogenesis in the development of LSCC.

关键词： laryngeal squamous cell carcinoma interleukin 17 tumor-associated macrophages inflammation microvessel density

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平移模式下挡墙塑性临界深度极限分析

岩土力学 2017年第2期38卷 428-434页

作者：刘杰黄达赵飞杨超孙莎重庆大学土木工程学院重庆400045 河北工程大学土木工程学院河北邯郸056038 中国石油天然气股份有限公司西南管道分公司四川成都610041 重庆大学力学系重庆400045

土压力的分布及大小与挡墙的位移模式密切相关。挡墙后的填土处于主动土压力状态时,塑性临界深度是设计时需要考虑的问题。应用极限分析上限原理,将弹性覆盖层以下且与挡墙相邻的三角形土体微元作为研究对象。推导了外力功率和内能耗散... 详细信息

土压力的分布及大小与挡墙的位移模式密切相关。挡墙后的填土处于主动土压力状态时,塑性临界深度是设计时需要考虑的问题。应用极限分析上限原理,将弹性覆盖层以下且与挡墙相邻的三角形土体微元作为研究对象。推导了外力功率和内能耗散功率,得到了挡墙在平移模式下塑性临界深度的计算公式,推导过程中考虑了挡墙位移方向效应。研究结果表明:朗肯等理论计算结果是推荐方法的一个特例。塑性临界深度随挡墙位移方向与水平面之间夹角、墙-土界面黏聚力和摩擦角以及填土黏聚力和内摩擦角的增大而增大。但当挡墙位移方向水平时,塑性临界深度与墙-土界面摩擦角无关。

关键词：挡墙临界深度平移模式极限分析

EV71疫苗对中国大陆地区儿童手足口病发病率影响间断时间序列分析

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中国公共卫生 2021年第9期37卷 1418-1420页

作者：王希峰朱大伟袁莎莎北京市大兴区疾病预防控制中心微生物检验科 102600 北京大学中国卫生发展研究中心中国医学科学院医学信息研究所

目的了解肠道病毒71型(EV71)疫苗对中国大陆地区儿童手足口病发病率的影响,为手足口病的预防控制提供参考依据。方法收集2015年1月—2017年12月中国疾病预防控制中心公共卫生科学数据中心手足口病数据库中中国大陆地区0.05)。除0岁~组... 详细信息

目的了解肠道病毒71型(EV71)疫苗对中国大陆地区儿童手足口病发病率的影响,为手足口病的预防控制提供参考依据。方法收集2015年1月—2017年12月中国疾病预防控制中心公共卫生科学数据中心手足口病数据库中中国大陆地区0岁~、1岁~、2岁~、3岁~、4岁~)整理,应用Stata/SE 15.0统计软件进行间断时间序列分析。结果干预前和干预后0岁~、1岁~、2岁~、3岁~、4岁~儿童手足口病发病率分别为122.54/10万和117.96/10万、350.03/10万和290.64/10万、239.99/10万和192.61/10万、213.53/10万和179.21/10万、119.49/10万和104.37/10万,干预前后儿童手足口病发病率差异均无统计学意义(均P>0.05)。除0岁~组外,1岁~、2岁~、3岁~和4岁~组儿童手足口病发病率在干预前均呈上升趋势(均P0.05),以3岁~组斜率最高。干预后手足口病月发病率瞬间水平下降最为明显的为1岁~组,瞬间水平下降了118.107/10万(P=0.044);其次为3岁~组,瞬间水平下降了101.135/10万(P=0.045);其他3组瞬间水平变化差异均无统计学意义(均P>0.05)。干预后2岁~、3岁~和4岁~组儿童手足口病发病率均由干预前的增长趋势改变为下降趋势(均P0.05),0岁~和1岁~组儿童手足口病发病率变化差异均无统计学意义(均P>0.05)。结论EV71疫苗接种可有效降低2~5岁儿童的手足口病发病率,但需要结合其他非疫苗防控措施进一步加强疫苗对<2岁低龄儿童的防控效果。

关键词：手足口病发病率肠道病毒71型(EV71)疫苗影响儿童中国大陆地区间断时间序列分析

A two-year(2020–2021)observation of marine phycotoxins in phytoplankton in typical mariculture areas of East China Sea

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Journal of Oceanology and Limnology 2022年第6期40卷 2256-2266页

作者： Xiaoqing TIAN Chengqi FAN Yunyu TANG Haiyan ZHANG Wei KANG sha CHEN Chongbin LI Ya’nan LU Key Laboratory of East China Sea&Oceanic Fishery Resources Exploitation and Utilization Ministry of Agriculture and Rural AffairsEast China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesShanghai 200090China shanghai Ocean University Shanghai 201306China

To learn the marine phycotoxins(MPTs)contamination status in mariculture areas in the East China Sea(ECS),from May 2020 to October 2021,80 net-concentrated phytoplankton samples were collected from 12 stations in three typical areas with high incidence of red tides,namely,Gouqi Island,Sandu’ao-Lianjiang,and Zhangzhou-Dongshan Island in ECS,and MPTs of the samples were *** types of toxins were detected in 24 samples from 9 *** marine toxins(LMTs)were more common and diverse in these *** 2(PTX2)was the main lipophilic marine toxin(LMT)in the concentrated phytoplankton samples and the occurrence showed seasonal differences from north to *** to the potential risks of pectenotoxin(PTXs)to seafood safety,it is suggested to execute regular monitoring on PTXs in ECS and a mandatory standard should be formulated based on the comprehensive analysis of in-situ monitoring and lab ***,contamination risks of cyclic imine toxins in the north and domoic acid(da)in the south of ECS should also be paid with attention *** 2 paralytic shellfish toxins(PSTs),N-sulfocarbamoyl toxin C2(C2),and decarbamoyl gonyatoxin 3(dcGTX3),were found from spring samples in the north of *** the biggest mussel culture county of China,Gouqi Island showed higher toxin diversity and the toxin detection rate was higher than the other two *** Gouqi Island area,PSTs were a serious potential threat in spring,and LMTs instead of PSTs became the main risk in summer-autumn *** ensure the safety of seafood and marine environmental health,it is recommended to conduct long-term targeted tracking and monitoring of MPTs in this and similar mariculture areas.

关键词： marine phycotoxins(MPTs) pectenotoxin 2(PTX2) mariculture areas East China Sea seafood safety

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一种更为可靠的测量不确定度评定方法

计量学报 2001年第4期22卷 272-275页

作者：沙定国苏大图北京理工大学北京100081

ISO 1 993《测量不确定度表示指南》只规定了测量结果的一般评定和表示方法 ,没有涉及多渠道测量结果信息如何综合评定的问题。本文从信息论和自由度理论出发 ,提出一种按自由度加权定值及其不确定度评定的新方法 ,并成功地用于一个光... 详细信息

ISO 1 993《测量不确定度表示指南》只规定了测量结果的一般评定和表示方法 ,没有涉及多渠道测量结果信息如何综合评定的问题。本文从信息论和自由度理论出发 ,提出一种按自由度加权定值及其不确定度评定的新方法 ,并成功地用于一个光学精密测量仪器的不确定度评定和一个光学标准器具的精密定值。这种方法充分利用了各种渠道获得的测量结果信息 ,统一了以往有分歧的处理方法。

关键词：自由度测量不确定度评定测量结果计量学光学计量数据处理

生态学思维方式:辩证思维方式的当代典型形态

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湘潭大学学报（哲学社会科学版） 2012年第2期36卷 139-144,148页

作者：彭新沙田大伦中南林业科技大学生命科学与技术学院湖南长沙410004 湖南商学院旅游管理学院湖南长沙410205 南方林业生态应用技术国家工程实验室湖南长沙410004

可持续发展攸关全人类前途命运,离不开辩证思维方式的引导。辩证思维方式并非是一成不变的,而是具有历史性。迄今为止,已表现出四种基本形态:即矛盾思维形态、系统思维形态、信息思维形态和生态思维形态。生态学思维方式的崛起是现代科... 详细信息

可持续发展攸关全人类前途命运,离不开辩证思维方式的引导。辩证思维方式并非是一成不变的,而是具有历史性。迄今为止,已表现出四种基本形态:即矛盾思维形态、系统思维形态、信息思维形态和生态思维形态。生态学思维方式的崛起是现代科技革命和生态危机的必然产物,因其不仅具有辩证思维方式的基本特征即对立统一性、普遍联系性和永恒发展性,而且是在吸收、借鉴、综合当代科学和哲学最新理论成果及其思维方式精华的基础上形成发展起来的,所以是辩证思维方式的当代典型形态。

关键词：辩证思维方式矛盾思维形态系统思维形态信息思维形态生态思维形态