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Effectiveness and safety of opicapone in parkinson’s disease patients with motor fluctuations: the OpTIpARK open-label study

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Translational Neurodegeneration 2020年第1期9卷 96-104页

作者： Heinz Reichmann Andrew Lees José-Francisco Rocha Diogo Magalhaes patrício Soares-da-Silva the OpTIpARK investigators Department of Neurology University of DresdenDresdenGermany University College London Reta Lila Weston InstituteLondonUK Global parkinson’s Disease Department BIAL–Portela&CA S.ACoronadoPortugal Research and Development Department BIAL–Portela&CA S.Ada Siderurgia Nacional4745-457 S Mamede do CoronadoPortugal Department of pharmacology and Therapeutics Faculty of MedicineUniversity PortoPortoPortugal MedInUp Center for Drug Discovery and Innovative MedicinesUniversity PortoPortoPortugal 不详

Background:The efficacy and safety of opicapone,a once-daily catechol-O-methyltransferase inhibitor,have been established in two large randomized,placebo-controlled,multinational pivotal ***,clinical evidence from routine practice is needed to complement the data from the pivotal ***:OpTIpARK(NCT02847442)was a prospective,open-label,single-arm trial conducted in Germany and the UK under clinical practice *** with parkinson’s disease and motor fluctuations were treated with opicapone 50 mg for 3(Germany)or 6(UK)months in addition to their current levodopa and other antiparkinsonian *** primary endpoint was the Clinician’s Global Impression of Change(CGI-C)after 3 *** assessments included patient Global Impressions of Change(pGI-C),the Unified parkinson’s Disease Rating Scale(UpDRS),parkinson’s Disease Questionnaire(pDQ-8),and the Non-Motor Symptoms Scale(NMSS).Safety assessments included evaluation of treatment-emergent adverse events(TEAEs)and serious adverse events(SAEs).Results:Of the 506 patients enrolled,495(97.8%)took at least one dose of *** these,393(79.4%)patients completed 3 months of ***,71.3 and 76.9%of patients experienced any improvement on CGI-C and pGI-C after 3 months,respectively(full analysis set).At 6 months,for UK subgroup only(n=95),85.3%of patients were judged by investigators as improved since commencing *** scores at 3 months showed statistically significant improvements in activities of daily living during OFF(mean±SD change from baseline:?3.0±4.6,ppprovements of?3.4±12.8 points for pDQ-8 and-6.8±19.7 points for NMSS were statistically significant versus baseline(both pidered to be at least possibly related to opicapone were reported for 45.1%of patients,with dyskinesia(11.5%)and dry mouth(6.5%)being

关键词： Levodopa Motor fluctuations Open-label Opicapone parkinson’s disease

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Molecular detection of microbial communities associated with Microcystis vs Synechococcus dominated waters in Tianjin,China

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Journal of Oceanology and Limnology 2018年第4期36卷 1145-1156页

作者： HUO da CHEN Youxin LIU ping LI Yiming QIAO Zhiyi LI Renhui Department of Fisheries Sciences Tianjin Agricultural UniversityNational Demonstration Center for Experimental Aquaecology and Aquaculture EdueationTianjin 300384China Key Laboratory of Algal Biology State Key Laboratory of Freshwater Ecology and Biotechnology of ChinaInstitute of HydrobiologyChinese Academy of SciencesWuhan 430072China Department of Basic Sciences Tianjin Agricultural UniversityTianjin 300384China University of Chinese Academy of Sciences Beijing 100049China

Harmful cyanobacterial blooms cause many ecological disasters worldwide. During the development of cyanobacterial blooms, the diversity and domination of cyanobacterial taxa are of a particular concern. In this study, the microbial community structure within a water system, such as in Yuqiao Reservoir and Haihe River in Tianjin City, China, was compared by using next-generation sequencing. A total of 5 001 operational taxonomic units were obtained and clustered from filtered 16 S rDNA V3–V4 region sequences. The cyanobacterial and microbial structures greatly differed in these two water areas. Microcystis was dominant in Yuqiao, whereas Synechococcus was dominant in Haihe. proteobacteria species were dominant among all detected samples. The relative abundances of Bacteroidetes and planctomycetes were higher in Yuqiao Reservoir than in Haihe River, whereas Firmicutes and Verrucomicrobia were relatively abundant in Haihe River. Further analyses indicated that the domination of both cyanobacteria was strongly related to several environmental factors, such as total nitrogen, total phosphorus, and dissolved oxygen, reflecting the role of trophic states in shaping the dominance of cyanobacterial taxa. The present study provided the example for Microcystis and Synechococcus dominance along a cyanobacterial bloom in north China. Applying highthroughput sequencing could offer a wide field of vision in analyzing microbial community structures.

关键词： community structure cyanobacteria Yuqiao Reservoir Haihe River dominating patterns

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Systematic Training of Liver Imaging Reporting and data System Magnetic Resonance Imaging v2018 can Improve the Diagnosis of Hepatocellular Carcinoma for Different Radiologists

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 537-544页

作者： A-Hong Ren Hui Xu da-Wei Yang Nan Zhang Te Ba Zhen-Chang Wang Zheng-Han Yang Department of Radiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Radiology The First Hospital of Beijing Fangshan DistrictBeijingChina

Background and Aims:Liver imaging reporting and data system(LI-RADS)provides standardized lexicon and categorization for diagnosing hepatocellular carcinoma(HCC).However,there is limited knowledge about the effect of LI-RADS *** prospectively explored whether the systematic training of LI-RADS v2018 on magnetic resonance imaging(MRI)can effectively improve the diagnostic performances of different radiologists for ***:A total of 20 visiting radiologists and the multiparametric MRI of 70 hepatic observations in 61 patients with high risk of HCC were included in this *** LI-RADS v2018 training procedure included three times of thematic lectures(each lasting for 2.5 h)given by a professor specialized in imaging diagnosis of liver,with an interval of a *** each seminar,the radiologists had a month to adopt the algorithm into their daily *** diagnostic performances and interobserver agreements of these radiologists adopting the algorithm for HCC diagnosis before and after training were ***:A total of 20 radiologists(male/female,12/8;with an average age of 36.75±4.99 years)were *** training,the interobserver agreements for the LI-RADS category for all radiologists(p=0.005)were *** sensitivity,specificity,positive predictive value,negative predictive value,and coincidence rate of all radiologists for HCC diagnosis before and after training were 43%vs.54%,86%vs.88%,74%vs.81%,62%vs.67%,and 65%vs.71%,*** diagnostic performances of all radiologists(pprovement after ***:The systematic training of LI-RADS can effectively improve the diagnostic performances of radiologists with different experiences for HCC.

关键词： Magnetic resonance imaging Liver neoplasm Diagnostic imaging Training program Liver Imaging Reporting and data System

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Efficacy Observation on Auricular point Sticking Combined with Cupping in Treating Insomnia

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Journal of Acupuncture and Tuina Science 2013年第6期11卷 331-335页

作者： Li Jian-ping Zhang Hui He pei-da Deng Ying Xuhui District Central Hospital

Objective:To observe the clinical efficacy of auricular point sticking combined with cupping in treating ***:Sixty-four patients with chronic insomnia were randomly divided into two ***-two patients in the treatment group were treated with auricular point sticking combined with cupping therapy;while thirty-two patients in the control group were treated by *** pittsburgh sleep quality index(pSQI)were observed before and after treatment,and the data were statistically analyzed to evaluate the clinical ***:After treatment,pSQI scores in both groups after treatment significantly decreased(pps(pprovement of daytime function,the treatment group was more efficient than the control group(pp was higher than that of the control group(ppoint sticking combined with cupping therapy for insomnia is more effective than oral Diazepam,and it has a better effect in improving the patient's daytime function.

关键词： Auricular point Sticking Cupping Therapy Insomnia

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Optically probing molecular shuttling motion of[2]rotaxane by a conformation-adaptive fluorophore

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Chinese Chemical Letters 2022年第11期33卷 4904-4907页

作者： Chengyuan Yu Xiaodong Wang Cai-Xin Zhao Shun Yang Jiaan Gan Zhuo Wang Zhanqi Cao da-Hui Qu Key Laboratory for Advanced Materials and Joint International Research Laboratory of precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistryInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Shanghai Gantian Optical Material Co. Ltd.Shanghai 201512China College of Science Henan Agricultural UniversityZhengzhou 450002China

A bistable[2]rotaxane with a conformation-adaptive macrocycle bearing a 9,14-diphenyl-9,14-dihydrodibenzo[a,c]phenazine(DpAC)unit was synthesized,which could be utilized to optical probe the molecular shuttling motion of the functionalized rotaxane *** UV-vis,^(1) H NMR and pL spectroscopic data clearly demonstrated that the DpAC ring was interlocked onto the thread and the fluorescence intensity of the DpAC unit in the macrocycle was effectively regulated by the location change of the macrocycle along the thread under acid/base stimulation,which was attributed to the modulation of the intramolecular photo-induced electron transfer between the DpAC unit and the methyltriazole(MTA)*** bistable rotaxane system containing a conformation-adaptive fluorophore unit in the macrocycle moiety opens an alternative way to design functional bistable mechanically interlocked molecules.

关键词： Rotaxane Optically probe Mechanical shuttling Molecular conformations Conformation-adaptive macrocycle

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Effects of living and metabolically inactive mesenchymal stromal cells and their derivatives on monocytes and macrophages

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World Journal of Stem Cells 2021年第9期13卷 1160-1176页

作者： Alexia Nedel Sant'Ana Anelise Bergmann Araújo Fabiany da Costa Gonçalves Ana Helena paz Laboratório de Células Tecidos e Genes Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903RSBrazil Centro de processamento Celular Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903RSBrazil Department of Internal Medicine Erasmus Medical CenterRotterdam 3015 GDNetherlands Departamento de Ciências Morfológicas Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do SulPorto Alegre 90035-903RSBrazil

Mesenchymal stromal cells (MSCs) are multipotent and self-renewing stem cellsthat have great potential as cell therapy for autoimmune and inflammatorydisorders, as well as for other clinical conditions, due to their immunoregulatoryand regenerative properties. MSCs modulate the inflammatory milieu by releasingsoluble factors and acting through cell-to-cell mechanisms. MSCs switch theclassical inflammatory status of monocytes and macrophages towards a nonclassicaland anti-inflammatory phenotype. This is characterized by an increasedsecretion of anti-inflammatory cytokines, a decreased release of pro-inflammatorycytokines, and changes in the expression of cell membrane molecules and inmetabolic pathways. The MSC modulation of monocyte and macrophage phenotypesseems to be critical for therapy effectiveness in several disease models, sincewhen these cells are depleted, no immunoregulatory effects are observed. Here,we review the effects of living MSCs (metabolically active cells) and metabolicallyinactive MSCs (dead cells that lost metabolic activity by induced inactivation) andtheir derivatives (extracellular vesicles, soluble factors, extracts, and microparticles)on the profile of macrophages and monocytes and the implications forimmunoregulatory and reparative processes. This review includes mechanisms ofaction exhibited in these different therapeutic appro-aches, which induce the antiinflammatoryproperties of monocytes and macrophages. Finally, we overviewseveral possibilities of therapeutic applications of these cells and their derivatives,with results regarding monocytes and macrophages in animal model studies andsome clinical trials.

关键词： Mesenchymal stromal cells Macrophage Monocyte Immunomodulation Cell therapy Immunoregulation

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Effectiveness of different biochars in remediating a salt-affected Luvisol in Northeast Brazil

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Biochar 2021年第2期3卷 149-159页

作者： Wallace Melo dos Santos Maria Isidoria Silva Gonzaga JoséAiron da Silva AndréQuintão de Almeida JoséCarlos de Jesus Santos Thomas Antonio Silva Gonzaga Idamar da Silva Lima EloáMoura Araújo Water Resources Graduate program Federal University of SergipeSão CristóvãoSE 49100‑000Brazil Agronomy Department Federal University of SergipeSão CristóvãoSE 49100‑000Brazil Agriculture Engineering Department Federal University of SergipeSão CristóvãoSE 49100‑000Brazil University of Notre dame Notre DameIN 46556USA Soils and Agricultural Engineering Department Federal University of ParanáCuritibaPR 80060‑000Brazil

Biochar has been proposed as a soil amendment to reclaim salt-affected ***,the evaluation of the different biochar types in these soils is essential due to the significant variation among biochar *** this study,biochars from sugarcane bagasse(SB),orange bagasse(OB),and corncob(CB)were applied alone and in the presence of gypsum(G)to test their potential to remediate a highly degraded saline-sodic soil in Brazil´s Northeast *** that,we conducted a laboratory column-leaching experiment and a greenhouse *** the column-leaching test,we analyzed the sodium adsorption ratio(SAR),the electrical conductivity of the saturation extract(ECe),the concentrations of major ions,and the exchangeable sodium percentage(ESp).Maize plants were grown in the leached soil in a ***-and corncob-derived biochars were more efficient than gypsum in reducing the soil salinity,bringing the indicators below threshold values,and optimizing soil reclamation *** ECe,SAR,and ESp were reduced to 3.42 dS m−1,1.64(mmolc dm−3)0.5 and 4.86%,respectively,in the SB treatment;and to 3.19 dS m−1,0.88(mmolc dm−3)0.5 and 2.53%,respectively,in the CB *** bagasse biochar did not effectively reduce the salinity *** biochar treatments improved seed germination and plant *** SB,CB,SBG,and CBG treatments increased plant height(478–558%),shoot mass(783–983%),and root mass(386–500%),***,the application of SB and CB is an effective alternative to remediate saline-sodic soils and to reduce the impact of soil salinity in the environment.

关键词： Biochar Soil remediation Soil salinity Corn growth

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湿热环境下变压器套管绝缘特性劣化及机理分析

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环境技术 2024年第8期42卷 182-190页

作者：苏超黄石华应丽云王伟赖俊驹谢达广东电网清远供电局清远511500

为研究湿热环境下变压器套管绝缘特性的劣化及机理,针对在湿热环境中长期运行已产生缺陷的油纸绝缘套管,进行了不同温度和电压下高压介损、电容和频域介电谱(FDS)试验。对缺陷套管解剖采样,测试纸样含水率和聚合度,分析套管受潮老化过... 详细信息

为研究湿热环境下变压器套管绝缘特性的劣化及机理,针对在湿热环境中长期运行已产生缺陷的油纸绝缘套管,进行了不同温度和电压下高压介损、电容和频域介电谱(FDS)试验。对缺陷套管解剖采样,测试纸样含水率和聚合度,分析套管受潮老化过程。结果表明:高压介损、电容和FDS试验能够显著反映套管内部存在的受潮老化缺陷。与正常套管相比,缺陷套管高压介损和电容与外施电压和温度均具有较强的相关性,FDS中在整个频段内增大,曲线形状改变,电容数值变大。套管受潮部位主要是导杆头部密封圈以及末屏,大部分水分被绝缘纸吸收,高水分区域集中在电容芯子下端和最内层,水分与外界高温共同作用下,绝缘纸加速老化,产生放电。该研究为湿热环境下套管优化设计与运行维护提供参考。

关键词：湿热环境变压器套管高压介损频域介电谱劣化机理

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Light-fueled dissipative self-assembly at molecular and macro-scale enabled by a visible-light-responsive transient hetero-complementary quadruple hydrogen bond

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Chinese Chemical Letters 2023年第3期34卷 308-312页

作者： Shi-Tao Han Hong-Ying Duan Tian-Guang Zhan Xiao-Bo Hu Li-Chun Kong Kang-da Zhang Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Life ScienceZhejiang Normal UniversityJinhua 321004China Key Laboratory of precise Synthesis of Functional Molecules of Zhejiang province School of ScienceWestlake UniversityHangzhou 310024China

The development of out-of-equilibrium self-assembly systems using light as input fuel is highly desirable and promising for the fabrication of smart supramolecular materials. Herein, we report the construction of new artificial light-fueled dissipative molecular and macroscopic self-assembly systems based on a visible-light-responsive transient quadruple H-bonding array, which consists of an azobenzene-modified ureidopyrimidinone(Upy) module(Azo-O-Upy) and a nonphotoactive diamidonaphthyridine(daN) derived competitive binder(Napy-1). The visible light(410 nm) irradiation can induce the E to Z isomerization of the azobenzene unit of E-Azo-O-Upy to produce Z-Azo-O-Upy with an opened Upy binding site, which can complex with Napy-1 to form a quadruply H-bonded heterodimer. The heterodimer is metastable and can be quickly disassembled in dark, owing to the fast thermal relaxation of Z-Azo-O-Upy to E-Azo-O-Upy. While introducing such transient quadruple H-bonding interaction into a linear polymer system or a polymeric gel system, light-fueled out-of-equilibrium polymeric assembly both at molecular and macro-scale can be achieved.

关键词： Dissipative self-assembly Macroscopic self-assembly photo-responsiveness Quadruple hydrogen bonds Supramolecular chemistry

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菊苣TCp基因家族鉴定与分析

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草地学报 2024年第8期32卷 2428-2439页

作者：杜洋张智韦陆爽刘雪李大勇徐朝阳王晨晨张彬许立新北京林业大学草业与草原学院北京100083 北京市农林科学院蔬菜所北京100083 中煤科工生态环境科技股份有限公司北京100020

TCp转录因子参与调控植物多种生理过程,包括植物叶片发育、花发育、分枝的形成等方面。菊苣(Cichorium intybus L.)是一种优良牧草,但目前还未有关于其TCp基因家族研究的报道。本研究基于菊苣全基因组数据,利用拟南芥(Arabidopsis thali... 详细信息

TCp转录因子参与调控植物多种生理过程,包括植物叶片发育、花发育、分枝的形成等方面。菊苣(Cichorium intybus L.)是一种优良牧草,但目前还未有关于其TCp基因家族研究的报道。本研究基于菊苣全基因组数据,利用拟南芥(Arabidopsis thaliana)、生菜(Lactuca sativa L.)TCp基因家族的氨基酸序列,对菊苣TCp基因家族成员进行鉴定筛选,最终得到39个菊苣TCp基因家族成员。接着利用生物信息学方法对这些成员进行分析发现,39个成员不均匀分布在9条染色体上;氨基酸数目为113~498,分子量为12425.84~56266.57da;所有成员分为3个亚家族;均含有保守的basic-helix-loop-helix(bHLH)结构域;顺式作用元件分析发现,菊苣TCp家族成员具有多种激素、非生物胁迫和生长发育响应元件;对CIN类TCp基因在菊苣各组织和高温胁迫下进行表达分析发现,这些成员可能参与菊苣的叶片发育调控且对高温胁迫响应。本研究可以为改良菊苣牧草品质提供理论依据。

关键词： TCp基因家族菊苣表达分析家族分析

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