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GSDMD与骨质疏松症中成骨细胞的相关性研究进展

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中国骨质疏松杂志 2024年第7期30卷 1028-1032,1055页

作者：麻永胜王立强蒋宜伟周玉英马晨光宋重东刘沛马俊飞史达甘肃中医药大学甘肃兰州730000 敦煌医学与转化教育部重点实验室甘肃兰州730000 甘肃中医药大学附属医院甘肃兰州730000 西安市红会医院陕西西安710054

细胞焦亡(pyroptosis)是伴炎症反应的程序性死亡方式,Gasdermin D(GSDMD)是介导细胞焦亡的关键蛋白,也是主要执行者。当病原微生物等刺激炎性小体后,激活焦亡信号半胱天冬氨酸蛋白酶(caspase),使其切割GSDMD,然后GSDMD的氨基末端(N端)... 详细信息

细胞焦亡(pyroptosis)是伴炎症反应的程序性死亡方式,Gasdermin D(GSDMD)是介导细胞焦亡的关键蛋白,也是主要执行者。当病原微生物等刺激炎性小体后,激活焦亡信号半胱天冬氨酸蛋白酶(caspase),使其切割GSDMD,然后GSDMD的氨基末端(N端)转移至细胞膜上形成允许水分子等物质进入的细胞内孔隙,从而引起细胞肿胀及裂解,导致细胞死亡,即细胞焦亡。近年来科学研究进展发现,GSDMD可能通过介导成骨细胞焦亡参与了骨代谢疾病特别是骨质疏松症的发病机制,抑制成骨细胞焦亡可调控骨质疏松症的发展。成骨细胞焦亡或许作为一种促炎性调控骨细胞死亡的方式干预骨代谢,而且对其研究是当下新颖的科研热点。笔者从细胞焦亡分析并探讨GSDMD介导成骨细胞焦亡的分子机制,对其与细胞焦亡领域之间的关系进行综述,分析成骨细胞焦亡与骨质疏松疾病之间的联系,为骨质疏松症的研究和诊疗提供关键的靶点蛋白因子机制。

关键词：细胞焦亡 GSDMD 成骨细胞分子机制骨质疏松症

Nanostructuring the electronic conducting La_(0.8)Sr_(0.2)MnO_(3-δ) cathode for high-performance in proton-conducting solid oxide fuel cells below 600℃

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Science China Materials 2018年第1期61卷 57-64页

作者： Eman Husni da'as 毕磊 Samir Boulfrad Enrico Traversa Division of physical Science and Engineering King Abdullah University of Science and Technology (KAUST) Institute of Materials for Energy and Environment Growing Base for State Key Laboratory College of Materials Science and Engineering Qingdao University College of Science & Engineering Hamad Bin Khalifa University (HBKU) School of Energy Science and Engineering University of Electronic Science and Technology of China (UESTC)

proton-conducting oxides offer a promising electrolyte solution for intermediate temperature solid oxide fuel cells（SOFCs） due to their high conductivity and low activation energy. However, the lower operation temperature leads to a reduced cathode activity and thus a poorer fuel cell performance. La_（0.8）Sr_（0.2）MnO_（3-δ）（LSM） is the classical cathode material for high-temperature SOFCs, which lack features as a proper SOFC cathode material at intermediate *** this, we here successfully couple nanostructured LSM cathode with proton-conducting electrolytes to operate below600℃ with desirable SOFC performance. Inkjet printing allows depositing nanostructured particles of LSM on Y-doped Ba ZrO_3（BZY） backbones as cathodes for proton-conducting SOFCs, which provides one of the highest power output for the BZY-based fuel cells below 600 ℃. This somehow changes the common knowledge that LSM can be applied as a SOFC cathode materials only at high temperatures（above 700 ℃）.

关键词： BaZrO3 inkjet printing impregnation La0.8Sr0.2MnO3-δ solid oxide fuel cells

The Difference in Growth and Four Microelement Concentrations Between Two Rice Genotypes Differing in Grain Cadmium-Accumulating Capacity

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Agricultural Sciences in China 2004年第6期3卷 416-424页

作者： CHENGWang-da ZHANGGuo-ping YAOHai-gen peterDominy WANGRun-yi DepartmentofAgronomy ZhejiangUniversityHangzhou310029P.R.China jiaxingAcademyofAgriculturalSciences Jiaxing314016P.R.China DivisionofBiochemistryandMolecularBiology InstituteofBiomedicalandLifeScienceUniversityofGlasgowGlasgowG128QQScotlandUK

A pot experiment was conducted with two rice genotypes having different Cd concentrationsin their grains to study the effect of soil Cd level on biomass, Cd and Fe, Zn, Cr andpb accumulation in different plant parts. Cd was added into soil to form 4 levels, i.e.,0, 0.5, 2.5 and 12.5mgkg-1, respectively. The results showed that the Cd-induced reductionin biomass accumulation varied in both genotypes and growth stages. The Cd-inducedreduction in biomass became less with the progress of growth, and Xiushui63, a genotypewith relatively higher grain Cd concentration, was more severely inhibited than Xiushui217,a relatively lower Cd concentration. Both Cd concentration and accumulation in thevarious plant parts increased substantially with the increase of Cd levels. The differencebetween two genotypes in Cd concentration and accumulation became more pronounced withincreased Cd level as well as prolonged duration of exposure. Xuishui63 had much greaterCd accumulation than Xiushui217, in particular at late growth stage. Xuishui63 had aremarkably higher Cd translocation of roots to shoots than Xiushui217 in all Cd *** effect of Cd addition on four microelement concentrations in straw and milled ricealso varied in genotypes and Cd levels. Without Cd addition, Xiushui63 was significantlylower than Xiushui217 in the concentrations of all four elements in straw, while the casewas just opposite in milled rice. Zn, Fe and pb concentrations decreased in milled ricewith the increase of Cd level, although the reduction extent differed in two *** results indicated that Cd concentration in rice grain is primarily dependent on theshoot Cd concentration, which is in turn mainly determined by Cd translocation from rootsto shoots.

关键词： Rice (Oryza sativa L.) Accumulation Cadmium (Cd) Difference Genotype

Feasibility study on determining the conventional true value of gamma-ray air kerma in a minitype reference radiation

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Nuclear Science and Techniques 2017年第6期28卷 133-139页

作者： Yi-Xin Liu Biao Wei Yang Xu Meng He Ren-Hong Zhuo De-Zhi Wen da-Jie Ding Ben-Jiang Mao Key Laboratory of Optoelectronics Technology and System Ministry of EducationChongqing University Institute of Nuclear physics and Chemistry China Academy of Engineering Physics

A minitype reference radiation(MRR) with dimensions of only 1 m × 1 m × 1 m has been developed for the in situ calibration of photon *** present work conducts a feasibility study on determining the conventional true value of gamma-ray air kerma at the point of test in the *** to its smaller dimensions,the scattered gamma-rays in the MRR are expected to induce a non-negligible interference with the radiation field compared with conditions in the standard reference radiation stipulated by ISO4037-1 or GB/T12162.1.A gamma-ray spectrometer was employed to obtain the spectra of scattered gamma-rays within the MRR,and the feature components of the spectra were extracted by principal component analysis to characterize the interference of a dosimeter probe in the radiation field.A prediction model of the CAK at the point of test was built by least squares support vector machine based on the feature component data obtained from nine sample dosimeters under five different dose *** mean prediction error of the CAK prediction model was within ±4.5%,and the maximum prediction error was about ±10%.

关键词： Air kerma Reference radiation Calibration principal component analysis Support vector machine

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藤黄酸在乳腺癌治疗中的研究进展

安徽医药 2024年第1期28卷 1-5页

作者：达梦婷陈道桢杨蕊宿晨张瑾沈国双青海大学附属医院乳腺疾病诊疗中心青海西宁810000 海东市第二人民医院院长办公室青海海东810600 无锡妇幼保健院优生优育遗传医学研究所江苏无锡214002

藤黄酸作为中药藤黄的主要生物活性成分,通过多种机制发挥抗肿瘤作用,包括诱导细胞凋亡、抑制肿瘤血管的生成和转移以及逆转肿瘤的多药耐药等;尤其是在乳腺癌治疗中可发挥多种抗肿瘤作用,有望成为乳腺癌的治疗药物。但藤黄酸自身存在缺... 详细信息

藤黄酸作为中药藤黄的主要生物活性成分,通过多种机制发挥抗肿瘤作用,包括诱导细胞凋亡、抑制肿瘤血管的生成和转移以及逆转肿瘤的多药耐药等;尤其是在乳腺癌治疗中可发挥多种抗肿瘤作用,有望成为乳腺癌的治疗药物。但藤黄酸自身存在缺陷,如水溶性差、半衰期短等,限制其临床应用。随着纳米载药制剂的不断发展,有望改善藤黄酸的不足,发挥藤黄酸强大的抗肿瘤作用。因此,综述近五年藤黄酸治疗乳腺癌的相关文献,以期为最大化藤黄酸抗乳腺癌奠定基础。

关键词：藤黄属乳腺癌抗肿瘤作用纳米制剂药物载体综述

Influence factor analysis of field-free molecular orientation

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Chinese physics B 2018年第3期27卷 231-237页

作者： Jing-Song Liu Qi-Yuan Cheng da-Guang Yue Xu-Cong Zhou Qing-Tian Meng School of physics and Electronics Shandong Normal University Ji＇ nan 250358 China

The effects of the characteristics of molecules and external fields on field-free molecular orientation are investigated through the comparison of HBr with LiH driven by the combination of a two-color laser pulse and a time-delayed THz laser pulse. It is shown that the dipole interaction has greater influence on field-free orientation than the hyperpolarizability interaction. In addition to the temperature dependence of orientation degree, the effects of the amplitudes of the two-color laser pulse and THz laser pulse, rising time, and THz laser frequency on molecular orientation are also discussed.

关键词： molecular orientation external fields LiH HBr

运动在延缓脑衰老中的作用:从大脑可塑性到神经保护

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生理科学进展 2024年第4期55卷 361-368页

作者：樊饶孔健达丁国诏徐明壮张加豪孔文博杨竣婷朱磊曲阜师范大学体育科学学院济宁272000

随着全球人口老龄化,脑衰老(brain aging)成为一个日益突出的问题。脑衰老涉及神经元数量减少、突触连接减弱和脑区功能改变,导致记忆力下降和认知功能受损等症状。本综述详细回顾了运动通过改善大脑可塑性延缓脑衰老的研究进展。运动... 详细信息

随着全球人口老龄化,脑衰老(brain aging)成为一个日益突出的问题。脑衰老涉及神经元数量减少、突触连接减弱和脑区功能改变,导致记忆力下降和认知功能受损等症状。本综述详细回顾了运动通过改善大脑可塑性延缓脑衰老的研究进展。运动通过影响突触可塑性相关蛋白质和神经递质、调控脑源性神经营养因子表达、逆转神经细胞减少和改善线粒体功能,对脑衰老产生积极影响。然而,未来的研究需要关注不同运动类型和强度对脑衰老的影响,以及运动与其他干预措施的协同作用。本综述将有助于理解运动延缓脑衰老的机制并对制定相关预防和干预策略至关重要。

关键词：脑衰老大脑可塑性脑衰老运动

Risk assessment of fault reactivation considering the heterogeneity of friction strength in the BZ34-2 Oilfield,Huanghekou Sag,Bohai Bay Basin,China

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petroleum Science 2023年第5期20卷 2695-2708页

作者： Ye-Jun Jin Ling-Dong Meng Ding-You Lyu Xiao-Fei Fu Jiang-Bo Huang Si-Jia Cao Jian-da Li School of Earth Sciences Northeast Petroleum UniversityDaqing 163318HeilongjiangChina Key Laboratory of Oil&Gas Reservoir and Underground Gas Storage Integrity Evaluation of Heilongjiang province Northeast Petroleum UniversityDaqing 163318HeilongjiangChina Bohai Rim Energy Research Institute Northeast Petroleum UniversityQinhuangdao066004HebeiChina CNOOC Tianjin Company Tianjin 300459China

The hazards of fault reactivation caused by fluid injection are a growing ***,traditional evaluation methods of fault stability are likely to underestimate the risk in fault segments with a high clay ***,an extended evaluation method of fault stability(ECpp)incorporating the heterogeneity in friction strength caused by variation in the clay content within the fault zone is established in this *** characterizing the current stress field of the BZ34-2 Oilfield in the Huanghekou Sag,Bohai Bay Basin,the reactivation potential of faults is evaluated using both traditional and ECpp *** evaluation of fault stability shows that all faults are stable in the present stress *** oriented ENE have a relatively high *** maximum sustainable fluid pressure Δp is approximately 8.8-8.9 Mpa and 9.3-9.9 *** considering the heterogeneity in fault friction strength,the fault stability is clearly controlled by the clay content of the *** high-risk fault segments assessed using traditional methods are no longer obvious,which reflects the importance of incorporating friction strength heterogeneity in the process of fault ***,the results also show that most fault segments are activated when the fault zone is dominated by montmorillonite,reflecting the strong influence of clay mineral types on fault *** factors influencing the heterogeneity of fault friction strength are very complicated in actual ***,future work should focus on establishing a database through a large number of experiments and investigating the relationship between the friction coefficient and the main controlling factors.

关键词： Faultreactivation In-situ stress Strength heterogeneity of fault friction Huanghekou Sag

Decipher hydrocarbon generation and accumulation based on fluid inclusion and chronology:A case study from the Upper paleozoic buried-hills in Huanghua Depression,Bohai Bay Basin

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petroleum Science 2023年第4期20卷 1998-2008页

作者： Li-Hong Zhou Yong Li Feng-Ming Jin Jin-Feng Xie Xiu-Gang pu Li-Xin Fu da Lou Yang Tian petroChina dagang Oilfield Company Tianjin300280China State Key Laboratory of Coal Resources and Safe Mining and College of Geosciences and Surveying Engineering China University of Mining and TechnologyBeijing100083China

Deciphering hydrocarbon generation and accumulation stage is of significance to understand oil and gas evolution and seek exploration *** the Upper paleozoic buried-hills in the Huanghua Depression,Bohai Bay Basin,as a case study,hydrocarbon generation environment and detailed accumulation process are revealed by fluid inclusions observations,Laser Raman spectroscopy,Fourier Infrared spectroscopy,and K-Ar isotope *** results show that both oil and gas inclusion were captured in the quartz overgrowth,dissolved feldspar and calcite microfractures,showing blue to dark brown *** grains containing oil inclusions index(GOI)of oil,oil&gas and gas being 25%,65%,and 10%and the inclusions with abundant methyl groups and short chains,both indicate high thermal *** series of fluids inclusion is generally observed,evidenced by the concentrated homogenization temperature of 135-145℃ and salinity of 3%-15 w.t.%NaCl equiv,indicating one primary charging *** gas and gas&liquid inclusions mainly contain CH_(4),with also peaks indicating CO_(2) and N_(2.)The Carboniferous and permian biomarkers show reducing environment with brackish water,with organic matter sources both from marine and *** relative content ofααα20RC_(27),ααα20RC_(28),andααα20RC_(29) exhibit source contributions both from algae and higher plants,and mainly of II2 to III *** coal derived gas and oil associated hydrocarbons are identified from most of the *** the fluid homogenization temperature and salinity,as well as the thermal evolution history,the hydrocarbon generated from the Upper paleozoic was concentrated at the end of the Eocene(40 Ma±),while the beginning of charging is 60 Ma±.The Wumaying Buried-hill is of only coal derived gas and has potential for inner coal measure natural gas *** results provide a detailed understanding of hydrocarbon accumulations in the study area,which can also be reference for impro

关键词： petroleum accumulation Buried hills K–Ar isotope Fluid inclusions Huanghua depression Bohai Bay Basin