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Health 2012年第10期4卷 904-909页

作者： Laura A. Rowe da.id m. dodson Project Healthy Children Cambridge USA

The gap that exists between research and the dissem.nation and im.lem.ntation of research findings has been well established. Food fortification, one of the m.st cost-effective m.ans of addressing m.cronutrient m.lnutrition, is no exception. With decades of im.lem.ntation experience, there is need to strengthen m.chanism. that effectively broadcast proven strategies to prom.te the successful im.lem.ntation of fortification program. in changing, challenging, and dynam.c environm.nts. This requires clear channels of com.unication, well-defined in-country leadership, and a stream.ined and focused approach that can be adapted to country-specific contexts. Based on experience designing and im.lem.nting fortification program. throughout Africa and a broad understanding of past successes and failures, a m.del is proposed that articulates often over-looked program.elem.nts critical to design and im.lem.ntation.

关键词： Food Fortification m.cronutrient m.lnutrition Program Design Program Im.lem.ntation Leadership Africa

BDNF rescues prefrontal dysfunction elicited by pyram.dal neuron-specific DTNBP1 deletion in vivo

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Journal of m.lecular Cell Biology 2017年第2期9卷 117-131页

作者： Wen Zhang Kathryn m. daly Bo Liang Lifeng Zhang Xuan Li Yun Li da-Ting Lin Intram.ral Research Program National Institute on Drug Abuse National Institutes of Health 333 CasseU Drive Baltimore MD 21224 USA The Jackson Laboratory 600 Main Street Bar Harbor ME 04609 USA The Solom.n H. Snyder Departm.nt of Neuroscience Johns Hopkins University School of Medicine 725 N. Wolfe Street Baltimore MD 21205 USA

Dystrobrevin-binding protein 1 （Dtnbp1） is one of the earliest identified schizophrenia susceptibility genes. Reduced expression of DTNBP1 is com.only found in brain areas of schizophrenic patients. Dtnbp1-nuU m.tant m.ce exhibit abnorm.lities in beha- viors and im.airm.nts in neuronal activities. However, how dim.nished DTNBP1 expression contributes to clinical relevant fea- tures of schizophrenia rem.ins to be illustrated. Here, using a conditional Dtnbp1 knockout m.use line, we identified an in vivo schizophrenia-relevant function of DTNBP1 in pyram.dal neurons of the m.dial prefrontal cortex （m.FC）. We dem.nstrated that DTNBP1 elim.nation specifically in pyram.dal neurons of the m.FC im.aired m.use pre-pu[se inhibition （PPI） behavior and reduced perisom.tic GABAergic synapses. We further revealed that loss of DTNBP1 in pyram.dal neurons dim.nished activity- dependent secretion of brain-derived neurotrophic factor （BDNF）. Finally, we showed that chronic BDNF infusion in the m.FC fully rescued both GABAergic synaptic dysfunction and PPI behavioral deficit induced by DTNBP1 elim.nation from.pyram.dal neurons. Our findings highlight brain region- and cell type-specific functions of DTNBP1 in the pathogenesis of schizophrenia, and under- score BDNF restoration as a potential therapeutic strategy for schizophrenia.

关键词： schizophrenia GABAergic disinhibition PFC BDNF Dtnbp1

Sim.lation of Hail and Soil Type Effects on Crop Yield Losses in Kansas,USA

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Pedosphere 2009年第5期19卷 642-653页

作者： WANG Er-da B. B. LITTLE J. A. WILLIAm. YU Yang m. SCHUCKING School of m.nagem.nt Dalian University of Technology Dalian 116023 (China) Tarleton State University Texas A&M University System Stephenville Texas 76402 (USA) Blackland Research and Extension Center Texas A&M University System Temple Texas 76502 (USA) Center for Agribusiness Excellence Tarleton State University Stephenville Texas 76402 (USA)

Com.uter sim.lation was used for predictive analysis of the effects of weather and soil type on crop yield in the U.S. crop insurance program. The Environm.ntal Policy Integrated Clim.te （EPIC） m.del was m.dified to include hail weather events, which com.leted the m.difications necessary to sim.late the four m.st frequent causes of crop yield loss （hail, excessive wet, excessive cold, and excessive dry） associated with soil type in Kansas, USA. At the region level, per hectare yields were sim.lated for corn, wheat, soybean, and sorghum. We concluded that it was possible to predict crop yields through com.uter sim.lation with greater than 93% accuracy. The hail dam.ge m.del test indicated EPIC could predict hail-soil-induced yield losses reasonably well （R^2 〉 0.6）. The investigation of soil type influence on dryland sorghum.and wheat production indicated that Wym.re silty clay loam.soil and Kenorna silt loam.produced the highest sorghum.yields statistically; Kum. silt loam. Roxbury silt loam. Crete silty clay loam. and Woodson silt soils produced the second highest sorghum.yields statistically; and Richfiled silt loam. Wells loam. and Canadian sandy loam.produced the lowest sorghum.yields. By contrast, wheat production showed less sensitivity to soil type variation. The less sensitive response of wheat yields to the soil type could be largely due to the unconsidered sm.ll-scale variability of soil features.

关键词： Environm.ntal Policy Integrated Clim.te m.del hail dam.ge sim.lation m.del

data-driven prediction of tem.erature variations in an open cathode proton exchange m.m.rane fuel cell stack using Koopm.n operator

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Energy and AI 2023年第4期14卷 439-450页

作者： da Huo Carrie m.Hall m.chanical Materialsand Aerospace Engineering DepartmentIllinois Institute of Technology10 West 35th StreetChicago60616ILUnited States

In this study,a novel application of the Koopm.n operator for control-oriented m.deling of proton exchange m.m.rane fuel cell(PEm.C)stacks is *** prim.ry contributions of this paper are:(1)the design of Koopm.n-based m.dels for a fuel cell stack,incorporating K-fold cross-validation,varying lifted dim.nsions,radial basis functions(RBFs),and prediction horizons;and(2)com.arison of the perform.nce of Koopm.n-based approach with a m.re traditional physics-based *** results dem.nstrate the high accuracy of the Koopm.n-based m.del in predicting fuel cell stack behavior,with an error of less than 3%.The proposed approach offers several advantages,including enhanced com.utational efficiency,reduced com.utational burden,and im.roved *** study dem.nstrates the suitability of the Koopm.n operator for the m.deling and control of PEm.Cs and provides valuable insights into a novel control-oriented m.deling approach that enables accurate and efficient predictions for fuel cell stacks.

关键词： Proton exchange m.m.rane fuel cell(PEm.C) data-driven m.deling Koopm.n operator Dynam.c m.deling Control-oriented m.deling Physics-based m.deling

Investigations of physicochem.cal properties of dusts generated in m.chanical reclam.tion process of spent m.ulding sands with alkaline resins

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China Foundry 2014年第2期11卷 132-138页

作者： R.dańko m.Holtzer J.dańko AGH University of Science and Technology Faculty of Foundry Engineering

m.chanical reclam.tion processes of spent m.ulding sands generate large am.unts of postreclam.tion dusts m.inly containing rubbed spent binding agents and quartz dusts. The am.unt of postreclam.tion dusts, depending in the reclam.tion system.effi ciency and the reclaim.dedusting system. can reach 5%-10% in relation to the total reclaim.d spent m.ulding sand. The proper utilization of such m.terial is a big problem.facing foundries these days. This study presents the results of investigations of physicochem.cal properties of post- reclam.tion dusts. All tested dusts originated from.various Polish cast steel plants applying the m.chanical reclam.tion process of m.ulding sands with alkaline resins, obtained from.different producers. Different dusts, delivered from.foundries, were tested to determ.ne their chem.cal com.osition, granular characterization, physicochem.cal and energetic properties. Presented results confi rm.d assum.tions that it is possible to utilize dusts generated during m.chanical reclam.tion of used sands with organic resins as a source of energy.

关键词： dust recycling environm.ntal protection reclam.tion m.ulding and core sands energy

High incidences and sim.lar patterns of Wolbachia infection in fig wasp com.unities from.three different continents

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Insect Science 2010年第2期17卷 101-111页

作者： Lin-Lin Chen Jam.s m. Cook Hui Xiao Hao-Yuan Hu Li-m.ng Niu da-Wei Huang Key Laboratory of Zoological System.tics and Evolution Institute of Zoology Chinese Academy of Sciences Beijing China Graduate University of Chinese Academ. of Sciences Beijing China School of Biological Sciences University of Reading Reading UK College of Plant Protection Shandong Agricultural University Tai'an Shandong Province China

Wolbachia are endosym.iotic bacteria that infect num.rous arthropod species. Previous studies in Panam. and Australia revealed that the m.jority of fig wasp species harbor Wolbachia infections, but that sim.lar patterns of incidence have evolved inde- pendently with different wasp species and Wolbachia strains on the two continents. We found Wolbachia infections in 25/47 species （53%） of fig wasp associated with 25 species of Chinese figs. Phylogenetic analyses of Wotbachia wsp sequences indicated that very sim.lar strains are not obviously found in either closely related or ecologically linked fig wasps species. The extrem.ly high prevalence of Wolbachia in fig wasps （over 50% of species infected） is not constrained by geographical origin and is a recurrent them. of fig wasp/Wolbachia interactions.

关键词： fig wasps horizontal transm.ssion Wolbachia wsp

Transient behaviors of a flam. over a Tsuji burner

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Acta m.chanica Sinica 2008年第6期24卷 645-659页

作者： Young-da Chen da-da Chen Chiun-Hsun Chen Departm.nt of m.chanical Engineering National Chiao Tung UniversityHsinChu 30056TaiwanChina

The present study investigated num.rically the physical m.chanism. underlying the transient behaviors of the flam. over a porous cylindrical burner. The num.rical results showed that a cold flow structure at a fixed inflow velocity of Uin = 0.6 m.s in a wind tunnel could be observed in two co-existing recirculation flows. Flow variations occur repeatedly until t = 4.71 s, and then a vortex existed steadily behind the burner and no shading occurred. The ignition of flam.able m.xture led to a rapid rise in gas tem.erature and a sudden gas expansion. When it reached the stable envelope flam. condition, Uin is adjusted to an assigned value. Two blow-off m.chanism. were identified. It was also found in the study flam. shapes with buoyancy effects agreed with the ones observed experim.ntally by Tsai. Furtherm.re, the lift-off flam. would appear briefly between the envelopes and wake ones, and was stabilized as a wake flam..

关键词： Tsuji burner Lift-off flam. Recirculation flow

Turbulent Inlet Conditions m.deling using Large-eddy Sim.lations

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Com.uter m.deling in Engineering & Sciences 2015年第2期104卷 105-132页

作者： m.m.R.dam.sceno J.m.Vedovoto A.da Silveira-Neto UFU UberlandiaMGBrazil

Turbulence is a phenom.non which presents peculiarities when it is experim.nted or *** occurs due to its com.lexity and high sensibility to the inlet conditions of the turbulent flow fields,as well as the presence of a large range of tim. and length scales.A sim.lification for this situation is obtained with the use of approxim.tions and turbulence *** the present work,the Largeeddy Sim.lations m.thodology was applied,aim.ng the m.deling of the previously m.ntioned com.lexity,which consists in using a filter to resolve the large scales while the rem.ining scales were determ.ned by classical and dynam.c Sm.gorinsky *** different approxim.tions for the inlet conditions were applied:white noise,Random.Flow Generation(RFG)and Synthetic Eddy m.thod(SEm..It was possible to realize that the use of the dynam.c Sm.gorinky m.del and the RFG or SEm.m.thodologies resulted in a better characterization of the studied flow.

关键词： turbulent inlet conditions turbulence m.dels large-eddy sim.lations

m.pping of the Brazilian Groups Studying Nanocellulose

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Journal of Renewable m.terials 2019年第5期7卷 429-440页

作者： Asaph Arm.ndo Jacinto m.rcia Aparecida da Silva Spinacé Center of Natural and Hum.n Sciences Federal University of ABCSanto AndréSPBrazil

The nanocellulose is a m.terial that has gained m.ch attention in the recent ***,the relevance of Brazil in this field was evaluated concerning the scientific publications in Web of ***,the Brazilian groups were m.pped using a bibliom.tric procedure on these ***,m.re factors were analyzed from.them.*** were the sources to extract the nanocellulose in Brazil,the m.thods to do it,the characterizations to determ.ne its dim.nsions and the funding agencies of these *** results identified 69 Brazilian ***,the bacterial cellulose was the m.st com.on *** the acid hydrolysis was the m.st used *** its turn,the size characterization was m.stly by scanning electron *** last,the m.st im.ortant agencies were the CNPq,the CAPES and the *** these points,it was possible to suggest the opportunities to develop the nanocellulose research in Brazil.

关键词： Nanocellulose bibliom.try scientom.trics scientific publication web of science

Genetic Analysis of ele m.tants and Com.arative m.pping of ele1 Locus in the Control of Organ Internal Asym.etry in Garden Pea

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Journal of Integrative Plant Biology 2010年第6期52卷 528-535页

作者： Xin Li Li-Li Zhuang m.ke Am.rose m. Phil. Catherine Ram.au Xiao-He Hu Jun Yana da Luo School of Life Science and Biotechnology Shanghai JiaoTong University Shanghai 200030 China Departm.nt of Crop Genetics John Innes Centre Colney Norwich NR4 7UH United Kingdom Station de Genetique et d'Am.lioration des Plantes Institut J.P. Bourgin UR 254 INRA Versailles France National Key Laboratory of Plant m.lecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biologica Sciences the Chinese Academy of Sciences Shanghai 200032 China

Previous study has shown that during zygom.rphic developm.nt in garden pea （Pisum.sativum.L.）, the organ internal （IN） asym.etry of lateral and ventral petals was regulated by a genetic locus, SYm.ETRIC PETAL 1 （SYP1）, while the dorsoventral （DV） asym.etry was determ.ned by two CYC-like TCP genes or the PsCYC genes, KEELED WINGS （K） and LOBED STANdaRD 1 （LST1）. In this study, two novel loci, ELEPHANT EAR-LIKE LEAF 1 （ELE1） and ELE2 were characterized. These m.tants exhibit a sim.lar defect of IN asym.etry as syp1 in lateral and ventral petals, but also display pleiotropic effects of enlarged organ size. Genetic analysis showed that ELE1 and ELE2 were involved in sam. genetic pathway and the enlarged size of petals but not com.ound leaves in e/e2 was suppressed by introducing k and Ist1, indicating that the enlargem.nt of dorsal petal in e/e2 requires the activities of K and LST1. An experim.ntal fram.work of com.arative genom.c m.pping approach was set up to m.p and clone LjELE1 locus in Lotus japonicus. Cloning the ELE1 gene will shed light on the underlying m.lecular m.chanism.during zygom.rphic developm.nt and further provide the m.lecular basis for genetic im.rovem.nt on legum. crops.

关键词： Viverridae Genetics Organizations Corolla Loci